公开(公告)号：US20130091933A1

公开(公告)日：2013-04-18

申请号：US13704247

申请日：2011-05-18

申请人： Nobuhiro Tsukada ,  Yoshihiro Nagaoka ,  Hironori Kaji ,  Daisuke Akieda

发明人： Nobuhiro Tsukada ,  Yoshihiro Nagaoka ,  Hironori Kaji ,  Daisuke Akieda

IPC分类号： G01N30/02

CPC分类号： G01N30/02 ,  B01F5/0646 ,  G01N30/34

摘要： A liquid mixing device that decreases a concentration non-uniformity in the flow direction of a mobile phase and a liquid chromatograph that uses the liquid mixing device are provided. The liquid mixing device is configured to include a flow channel unit that is made from an introduction channel, a branch portion that is positioned in a downstream of the introduction channel, multiple branched flow channels that branch from the branch portion, a junction portion in which the multiple branched flow channels join together, and a discharge channel of the downstream of the junction portion. The multiple branched flow channels are different in terms of any one of, or several of width, depth, and length that are associated with an external shape, and a structure filling the inside of the flow channel and thus the times for the liquid to pass through the branched flow channels are different from each other.

摘要翻译： 提供了降低流动相的流动方向的浓度不均匀性和使用液体混合装置的液相色谱仪的液体混合装置。 液体混合装置被构造成包括由引入通道制成的流动通道单元，位于引入通道下游的分支部分，从分支部分分支的多个分支流动通道，其中连接部分 多个分支流动通道连接在一起，以及连接部分下游的排出通道。 多个分支流动通道在与外部形状相关联的宽度，深度和长度中的任何一个或几个方面是不同的，以及填充流动通道内部的结构，因此液体通过的时间 通过分支流动通道彼此不同。

公开(公告)号：US20120291531A1

公开(公告)日：2012-11-22

申请号：US13575191

申请日：2012-01-25

申请人： Daisuke Akieda ,  Tomohiro Shoji

发明人： Daisuke Akieda ,  Tomohiro Shoji

IPC分类号： G01N30/16

CPC分类号： G01N30/34 ,  G01N30/26 ,  G01N2030/326 ,  G01N2030/347

摘要： Provided is a liquid chromatograph of a gradient type capable of promoting the mixture of a plurality of solvents without increasing flow passage volume. To this end, the liquid chromatograph includes: a Pump configured to suck a plurality of solvents and feed the solvents to a sample injection device, a separation column that separates a sample to be analyzed into components; and a detector that detects a component of the sample fed from the separation column. The Pump is configured to suck the plurality of solvents through an intake port and feed the solvents to a sample injection device through a discharge port and mix the plurality of solvents at between the intake port and the discharge port. The Pump further includes a cylinder and a plunger that reciprocates inside the cylinder, and the cylinder has an inner wall provided with a recess to generate a whirl in the plurality of solvents.

摘要翻译： 本发明提供能够促进多种溶剂的混合而不增加流路体积的梯度型液相色谱仪。 为此，液相色谱仪包括：泵，被配置为吸取多种溶剂并将溶剂供给到样品注入装置;分离柱，将待分析的样品分离成成分; 以及检测器，其检测从分离塔供给的样品的成分。 泵被配置为通过进气口吸收多个溶剂，并且通过排出口将溶剂供给到样品注射装置，并且在进气口和排出口之间混合多个溶剂。 该泵还包括一个气缸和一个柱塞，其在气缸内往复运动，气缸具有设置有凹槽的内壁，以在多个溶剂中产生旋转。

公开(公告)号：US09410543B2

公开(公告)日：2016-08-09

申请号：US13808660

申请日：2011-07-20

申请人： Kenichiro Tokuo ,  Kenji Hiraku ,  Hironori Kaji ,  Daisuke Akieda ,  Kimihiko Ishii ,  Naoya Yasuhara

发明人： Kenichiro Tokuo ,  Kenji Hiraku ,  Hironori Kaji ,  Daisuke Akieda ,  Kimihiko Ishii ,  Naoya Yasuhara

IPC分类号： F04B17/03 ,  F04B13/00 ,  F04B23/06 ,  F04B49/06 ,  G01N30/32 ,  G01N30/02 ,  F04B49/08 ,  G01N30/34

CPC分类号： F04B17/03 ,  F04B13/00 ,  F04B23/06 ,  F04B49/06 ,  F04B49/065 ,  F04B49/08 ,  F04B2203/0202 ,  F04B2205/03 ,  F04B2205/05 ,  G01N30/02 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/326

摘要： A pump controller causes a first plunger pump and a second plunger pump connected in series or in parallel to perform intake and compression actions alternately at substantially constant cycles, sets a pressurizing chamber of one of the plunger pumps to a state of a higher pressure than the pressurizing chamber of the other plunger pump, and performs flow rate control by adjusting lift amounts of the first plunger and the second plunger. Thus, it is possible to provide a pump for liquid chromatograph, and a liquid chromatograph, which are capable of reducing pulsations even when an ejection flow rate is changed.

摘要翻译： 泵控制器使得串联或并联连接的第一柱塞泵和第二柱塞泵以基本恒定的循环交替进行进入和压缩动作，将柱塞泵之一的加压室设定为比 通过调节第一柱塞和第二柱塞的升程量来进行流量控制。 因此，即使在喷射流量变化的情况下，也能够提供能够降低脉动的液相色谱泵和液相色谱仪。

公开(公告)号：US08551423B2

公开(公告)日：2013-10-08

申请号：US13386789

申请日：2010-05-26

申请人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

发明人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

IPC分类号： B01L3/02

CPC分类号： F04B23/06 ,  F04B13/00 ,  F04B49/08 ,  F04B49/22 ,  F04B2205/05 ,  F16K15/04 ,  F16K37/0058 ,  G01N30/32 ,  G01N30/74 ,  G01N2030/328 ,  G01N2030/8435 ,  Y10T137/7838

摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.

摘要翻译： 可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。 在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接 检测到。 止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

公开(公告)号：US20130104631A1

公开(公告)日：2013-05-02

申请号：US13808660

申请日：2011-07-20

申请人： Kenichiro Tokuo ,  Kenji Hiraku ,  Hironori Kaji ,  Daisuke Akieda ,  Kimihiko Ishii ,  Naoya Yasuhara

发明人： Kenichiro Tokuo ,  Kenji Hiraku ,  Hironori Kaji ,  Daisuke Akieda ,  Kimihiko Ishii ,  Naoya Yasuhara

IPC分类号： F04B17/03 ,  G01N30/02

CPC分类号： F04B17/03 ,  F04B13/00 ,  F04B23/06 ,  F04B49/06 ,  F04B49/065 ,  F04B49/08 ,  F04B2203/0202 ,  F04B2205/03 ,  F04B2205/05 ,  G01N30/02 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/326

摘要： A pump controller causes a first plunger pump and a second plunger pump connected in series or in parallel to perform intake and compression actions alternately at substantially constant cycles, sets a pressurizing chamber of one of the plunger pumps to a state of a higher pressure than the pressurizing chamber of the other plunger pump, and performs flow rate control by adjusting lift amounts of the first plunger and the second plunger. Thus, it is possible to provide a pump for liquid chromatograph, and a liquid chromatograph, which are capable of reducing pulsations even when an ejection flow rate is changed.

摘要翻译： 泵控制器使得串联或并联连接的第一柱塞泵和第二柱塞泵以基本恒定的循环交替进行进入和压缩动作，将柱塞泵之一的加压室设定为比 通过调节第一柱塞和第二柱塞的升程量来进行流量控制。 因此，即使在喷射流量变化的情况下也能够提供能够降低脉动的液相色谱泵和液相色谱仪。

公开(公告)号：US09128071B2

公开(公告)日：2015-09-08

申请号：US13704247

申请日：2011-05-18

申请人： Nobuhiro Tsukada ,  Yoshihiro Nagaoka ,  Hironori Kaji ,  Daisuke Akieda

发明人： Nobuhiro Tsukada ,  Yoshihiro Nagaoka ,  Hironori Kaji ,  Daisuke Akieda

IPC分类号： G01N30/02 ,  B01F5/06 ,  G01N30/34

CPC分类号： G01N30/02 ,  B01F5/0646 ,  G01N30/34

摘要： A liquid mixing device that decreases a concentration non-uniformity in the flow direction of a mobile phase and a liquid chromatograph that uses the liquid mixing device are provided. The liquid mixing device is configured to include a flow channel unit that is made from an introduction channel, a branch portion that is positioned in a downstream of the introduction channel, multiple branched flow channels that branch from the branch portion, a junction portion in which the multiple branched flow channels join together, and a discharge channel of the downstream of the junction portion. The multiple branched flow channels are different in terms of any one of, or several of width, depth, and length that are associated with an external shape, and a structure filling the inside of the flow channel and thus the times for the liquid to pass through the branched flow channels are different from each other.

摘要翻译： 提供了降低流动相的流动方向的浓度不均匀性和使用液体混合装置的液相色谱仪的液体混合装置。 液体混合装置被构造成包括由引入通道制成的流动通道单元，位于引入通道下游的分支部分，从分支部分分支的多个分支流动通道，其中连接部分 多个分支流动通道连接在一起，以及连接部分下游的排出通道。 多个分支流动通道在与外部形状相关联的宽度，深度和长度中的任何一个或几个方面是不同的，以及填充流动通道内部的结构，因此液体通过的时间 通过分支流动通道彼此不同。

公开(公告)号：US20130091935A1

公开(公告)日：2013-04-18

申请号：US13805337

申请日：2011-07-05

申请人： Daisuke Akieda

发明人： Daisuke Akieda

IPC分类号： G01N30/02

CPC分类号： G01N30/02 ,  G01N30/34

摘要： In a liquid chromatograph and a pump unit for liquid chromatograph whereby a sample is analyzed while changing the mixing ratio of multiple kinds of solvents, mixing of the solvents can be accelerated without adding any novel device such as a mixer. The pump unit for liquid chromatograph has a configuration which comprises cylinders for introducing a multiple kinds of solvents thereinto and plungers that are reciprocated so as to introduce the solvents and discharge the same for sending, wherein a plurality of channels are formed in the cylinders for mixing the solvents.

摘要翻译： 在液相色谱仪和用于液相色谱仪的泵装置中，在改变多种溶剂的混合比的同时分析样品，可以加速溶剂的混合，而不需要添加任何新颖的装置如混合器。 用于液相色谱仪的泵单元具有包括用于将多种溶剂引入其中的气缸和往复运动以便引入溶剂并将其排出以用于发送的柱塞的构造，其中在用于混合的气缸中形成多个通道 溶剂。

公开(公告)号：US20120128533A1

公开(公告)日：2012-05-24

申请号：US13386789

申请日：2010-05-26

申请人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

发明人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

IPC分类号： G01N31/00 ,  F16K15/00

CPC分类号： F04B23/06 ,  F04B13/00 ,  F04B49/08 ,  F04B49/22 ,  F04B2205/05 ,  F16K15/04 ,  F16K37/0058 ,  G01N30/32 ,  G01N30/74 ,  G01N2030/328 ,  G01N2030/8435 ,  Y10T137/7838

摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.

摘要翻译： 可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。 在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接 检测到。 止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

公开(公告)号：US20120055581A1

公开(公告)日：2012-03-08

申请号：US13319111

申请日：2010-05-24

申请人： Daisuke Akieda ,  Kisaburo Deguchi ,  Hironori Kaji

发明人： Daisuke Akieda ,  Kisaburo Deguchi ,  Hironori Kaji

IPC分类号： B65B1/04 ,  B01D15/08

CPC分类号： G01N30/32 ,  G01N2030/326

摘要： In a liquid delivery device, when an inlet-side check valve and an outlet-side check valve of a first cylinder are both closed, and compression of an eluent inside the first cylinder is started by means of a first plunger inside the first cylinder, a control unit doubles the rotational speed of a step motor, and measures the amount of change in the pressure inside the first cylinder which changes for a prescribed time by means of a first cylinder internal pressure detector. The time elapsed until the pressure inside the first cylinder is the same as the pressure inside a discharge-side flow passage is predicted using the rate of change over time of the pressure of the eluent. When the predicted elapsed time has elapsed, the rotational speed of the step motor is returned to the original speed, and the compression of the eluent inside the first cylinder is completed.

摘要翻译： 在液体输送装置中，当第一气缸的入口侧止回阀和出口侧止回阀都被关闭时，借助于第一气缸内的第一柱塞开始第一气缸内的洗脱液的压缩， 控制单元使步进电机的转速加倍，并且通过第一气缸内压检测器来测量第一气缸内的压力变化达规定时间的变化量。 使用洗脱液的压力随时间的变化率预测在第一气缸内的压力与放电侧流路内的压力相同的时间。 当预测经过时间过去时，步进电机的转速恢复到原来的速度，并且完成了第一气缸内的洗脱液的压缩。