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11 条记录 (耗时 0.022 秒)

    Apparatus and cooling system
    1.
    发明授权
    Apparatus and cooling system 失效
    设备和冷却系统

    公开(公告)号：US06212899B1

    公开(公告)日：2001-04-10

    申请号：US09284034

    申请日：1999-04-01

    申请人： Dale Cameron Ward

    发明人： Dale Cameron Ward

    IPC分类号： B67D562

    CPC分类号： A23C3/04 ,  A01J9/04 ,  F28D7/024 ,  F28F9/00 ,  F28F9/26 ,  F28F27/00 ,  F28F2280/02

    摘要： A cooling system particularly but not exclusively for cooling milk transferred for a milking station to a vat along a first flow path, the system including an apparatus for heat exchange with milk passing therethrough, wherein a second flow path is provided for circulating milk in the vat through the apparatus and the second flow path isolated from the first flow path.

    摘要翻译： 一种冷却系统，特别地但不仅限于用于将奶粉转移到沿着第一流动路径的大桶的挤奶站的冷却系统，该系统包括用于通过其中的牛奶进行热交换的装置，其中提供第二流动路径用于在桶中循环牛奶 通过与第一流动路径隔离的装置和第二流动路径。

    Dab9 DERIVATIVES OF LIPOPEPTIDE ANTIBIOTICS AND METHODS OF MAKING AND USING THE SAME
    3.
    发明申请
    Dab9 DERIVATIVES OF LIPOPEPTIDE ANTIBIOTICS AND METHODS OF MAKING AND USING THE SAME 失效
    Dab9 LIPOPEPTIDE抗生素的衍生物及其制备和使用方法

    公开(公告)号：US20070167357A1

    公开(公告)日：2007-07-19

    申请号：US11539139

    申请日：2006-10-05

    申请人： Maria Fardis ,  Dale Cameron ,  Vincent Boyd

    发明人： Maria Fardis ,  Dale Cameron ,  Vincent Boyd

    IPC分类号： A61K38/00

    CPC分类号： C07K7/56 ,  A61K38/00

    摘要： The present invention provides Dab9 derivatives of amphomycin-type lipopepetide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.

    摘要翻译： 本发明提供显示抗革兰氏阳性细菌的抗微生物活性的两性霉素型脂蛋白抗生素的Dab 9+衍生物，用于合成化合物的方法和中间体以及在各种情况下使用化合物的方法，包括 在治疗和预防感染。

    Hepatitis C inhibitor tri-peptides
    4.
    发明授权
    Hepatitis C inhibitor tri-peptides 有权
    丙型肝炎抑制剂三肽

    公开(公告)号：US06323180B1

    公开(公告)日：2001-11-27

    申请号：US09368866

    申请日：1999-08-05

    申请人： Montse Llinas-Brunet ,  Murray D. Bailey ,  Dale Cameron ,  Elise Ghiro ,  Nathalie Goudreau ,  Marc-André Poupart ,  Jean Rancourt ,  Youla S. Tsantrizos ,  Anne-Marie Faucher ,  Teddy Halmos ,  Dominik M. Wernic ,  Bruno Simoneau

    发明人： Montse Llinas-Brunet ,  Murray D. Bailey ,  Dale Cameron ,  Elise Ghiro ,  Nathalie Goudreau ,  Marc-André Poupart ,  Jean Rancourt ,  Youla S. Tsantrizos ,  Anne-Marie Faucher ,  Teddy Halmos ,  Dominik M. Wernic ,  Bruno Simoneau

    IPC分类号： A61K3800

    CPC分类号： C12P13/02 ,  A61K38/21 ,  A61K45/06 ,  C07D207/16 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/081 ,  C07K5/0812 ,  C12P41/005 ,  A61K2300/00

    摘要： A racemate, diastereoisomer and optical isomer of a compound of formula (I): wherein B is H, a C6 or C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which may be optionally substituted with C1-6 alkyl; C1-6 alkoxy; C1-6 alkanoyl; hydroxy; hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with C1-6 alkyl; amido; or (lower alkyl)amide; or B is an acyl derivative of formula R4—C(O)—; a carboxyl derivative of formula R4—O—C(O)—; an amide derivative of formula R4—N(R5)—C(O)—; a thioamide derivative of formula R4—N(R5)—C(S)—; or a sulfonyl of formula R4—SO2; R5 is H or C1-6 alkyl; and Y is H or C1-6 alkyl; R3 is C1-8 alkyl, C3-7 cycloalkyl, or C4-10 alkylcycloalkyl, all optionally substituted with hydroxy, C1-6 alkoxy, C1-6 thioalkyl, amido, (lower alkyl)amido, C6 or C10 aryl, or C7-16 aralkyl; R2 is CH2—R20, NH—R20, O—R20 or S—R20, wherein R20 is a saturated or unsaturated C3-7 cycloalkyl or C4-10 (alkylcycloalkyl), all of which being optionally mono-, di- or tri-substituted with R21, or R20 is a C6 or C10 aryl or C7-14 aralkyl optionally substituted, or R20 is Het or (lower alkyl)-Het, both optionally substituted, Het or (lower alkyl)-Het; carboxyl; carboxy(lower alkyl); C6 or C10 aryl, C7-14 aralkyl or Het, said aryl, aralkyl or Het being optionally substituted; and R1 is H; C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl, or C2-6 alkynyl, all optionally substituted with halogen; or a pharmaceutically acceptable salt or ester thereof.

    摘要翻译： 式（I）化合物的外消旋物，非对映异构体和旋光异构体：其中B为H，C6或C10芳基，C7-16芳烷基; Het或（低级烷基）-Het，其全部可以任选被C 1-6烷基取代; C 1-6烷氧基 C 1-6烷酰基; 羟基; 羟烷基 光环; 卤代烷基 硝基 氰基; 氰基烷基 任选被C 1-6烷基取代的氨基; 氨基酸 或（低级烷基）酰胺; 或B是式R4-C（O） - 的酰基衍生物; 式R4-O-C（O） - 的羧基衍生物; 式R 4 -N（R 5）-C（O） - 的酰胺衍生物; 式R 4 -N（R 5）-C（S） - 的硫代酰胺衍生物; 或式R4-SO2的磺酰基; R5是H或C1-6烷基; 并且Y是H或C 1-6烷基; R 3是C 1-8烷基，C 3-7环烷基或C 4-10烷基环烷基，全部被羟基，C 1-6烷氧基，C 1-6硫烷基，酰氨基，（低级烷基） ，C6或C10芳基或C7-16芳烷基; R2是CH2-R20，NH-R20，O-R20或S-R20，其中R20是饱和或不饱和的C3-7环烷基或C4-10（烷基环烷基），全部 其任选被R 21单取代，二取代或三取代，或R 20为任选取代的C 6或C 10芳基或C 7-14芳烷基，或R 20为Het或（低级烷基）-Het，均为任选取代的Het或 （低级烷基）-Het; 羧基; 羧基（低级烷基）; C6或C10芳基，C7-14芳烷基或Het，所述芳基，芳烷基或Het任选被取代; 且R1为H; C 1-6烷基，C 3-7环烷基，C 2-6烯基或C 2-6炔基，全部被卤素取代; 或其药学上可接受的盐或酯。

    Conveying apparatus with piezoelectric driver
    9.
    发明申请
    Conveying apparatus with piezoelectric driver 有权
    带压电驱动器的输送装置

    公开(公告)号：US20060027443A1

    公开(公告)日：2006-02-09

    申请号：US11242405

    申请日：2005-10-03

    申请人： Randy Baird ,  Jeffery Cable ,  Garry Kostel ,  Henry Nicolo ,  Dale Cameron

    发明人： Randy Baird ,  Jeffery Cable ,  Garry Kostel ,  Henry Nicolo ,  Dale Cameron

    IPC分类号： B65G27/24

    CPC分类号： B65G27/24 ,  B65G2201/04

    摘要： A conveying apparatus comprises an elongated conveying bed which includes a proximal end and a distal end. A support structure for the conveying bed accommodates vibratory motion of a portion of the conveying bed extending from the proximal end a substantial distance toward the distal end but dampens vibratory motion at the distal end. In addition, a piezoelectric driver is operatively connected to the conveying bed adjacent the proximal end. Consequently, operation of the piezoelectric driver will induce a wave motion in the conveying bed which will effectively convey a material from the proximal end to the distal end.

    摘要翻译： 输送装置包括细长的输送床，其包括近端和远端。 用于输送床的支撑结构容纳输送床的一部分的振动运动，其从近端延伸相当远的距离朝向远端，但是抑制在远端的振动运动。 此外，压电驱动器可操作地连接到邻近近端的输送床。 因此，压电驱动器的操作将在输送床中引起波浪运动，这将有效地将材料从近端传送到远端。

    Hepatitis C inhibitor peptides
    10.
    发明授权
    Hepatitis C inhibitor peptides 有权
    丙型肝炎抑制肽

    公开(公告)号：US06767991B1

    公开(公告)日：2004-07-27

    申请号：US09368670

    申请日：1999-08-05

    申请人： Montse Llinas-Brunet ,  Murray D. Bailey ,  Dale Cameron ,  Elise Ghiro ,  Nathalie Goudreau ,  Marc-André Poupart ,  Jean Rancourt ,  Youla S. Tsantrizos ,  Bruno Simoneau ,  Dominik M. Wernic

    发明人： Montse Llinas-Brunet ,  Murray D. Bailey ,  Dale Cameron ,  Elise Ghiro ,  Nathalie Goudreau ,  Marc-André Poupart ,  Jean Rancourt ,  Youla S. Tsantrizos ,  Bruno Simoneau ,  Dominik M. Wernic

    IPC分类号： C07K700

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/06139 ,  C07K5/0808 ,  C07K5/101 ,  C07K5/1016 ,  C07K7/08 ,  C07K14/005 ,  C12N2770/24222

    摘要： Disclosed herein are hepatitis C viral protease inhibitors of formula (I): wherein a is 0 or 1; b is 0 or 1; Y is H or C1-6 alkyl; B is H, an acyl derivative or a sulfonyl derivative; R6, when present, is C1-6 alkyl substituted with carboxyl; R5, when present, is C1-6 alkyl optionally substituted with carboxyl; R4 is C1-10 alkyl, C3-7 cycloalkyl or C4-10 (alkylcycloalkyl); R3 is C1-10 alkyl optionally substituted with carboxyl, C3-7 cycloalkyl or C4-10 (alkylcycloalkyl); R2 is CH2—R20, NH—R20, O—R20 or S—R20; wherein R20 is a saturated or unsaturated C3-7 cycloalkyl or C4-10 (alkyl cycloalkyl) being optionally mono-, di- or tri-substituted with R21, or R20 is a C6 or C10aryl, C7-16 aralkyl, Het or (lower alkyl)-Het, all optionally mono-, di- or tri-substituted with R21, wherein R21 is as defined herein; R1 is C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, all optionally substituted with halogen; and W is hydroxy or a N-substituted amino: or W taken together with the carbonyl group to which it is bonded represents an ester group, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本文公开了式（I）的丙型肝炎病毒蛋白酶抑制剂：其中a为0或1; b为0或1; Y是H或C 1-6烷基; B是H，酰基衍生物或磺酰基衍生物;当存在时，R 6是被羧基取代的C 1-6烷基;当存在时，R 5是任选被羧基取代的C 1-6烷基; R4是C1-10烷基，C3-7环烷基或C4-10（烷基环烷基）; R3是任选被羧基取代的C1-10烷基，C3-7环烷基或C4-10（烷基环烷基）; R2是CH2-R20，NH- R20，O-R20或S-R20; 其中R 20是饱和或不饱和的C 3-7环烷基或任选被R 21单取代，二或三取代的C 4-10（烷基环烷基），或R 20是C 6或C 10芳基，C 7-16芳烷基，Het或（低级烷基 ）-Het，全部任选被R 21单取代，二取代或三取代，其中R 21如本文所定义; R 1是C 1-6烷基，C 2-6烯基或C 2-6炔基，全部被卤素取代; 和W是羟基或N-取代的氨基：或W与其键合的羰基一起代表酯基或其药学上可接受的盐。