利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

76 条记录 (耗时 0.077 秒)

    Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia
    7.
    发明授权
    Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia 有权
    从相思树中分离双重COX-2和5-脂氧合酶抑制剂

    公开(公告)号：US08124134B2

    公开(公告)日：2012-02-28

    申请号：US11457388

    申请日：2006-07-13

    申请人： Qi Jia ,  Timothy C. Nichols ,  Eric Rhoden ,  Scott Waite

    发明人： Qi Jia ,  Timothy C. Nichols ,  Eric Rhoden ,  Scott Waite

    IPC分类号： A01N65/00

    CPC分类号： A61K31/353 ,  A61K31/33 ,  A61K36/00 ,  A61K36/48

    摘要： The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.

    摘要翻译： 本发明提供了同时抑制环氧合酶COX-2和5-脂氧合酶（5-LO）酶的新方法。 同时双重抑制COX-2和5-LO的方法包括将含有单个植物或多种植物的多种黄烷的个体和/或混合物的组合物施用于植物相思树属植物中的宿主 需要。 本发明还包括预防和治疗COX-2和5-LO介导的疾病和病症的新方法。 预防和治疗COX-2和5-LO介导的疾病和病症的方法包括向有需要的宿主施用有效量的组合物，其包含从单一植物分离的个体和/或多种黄烷的混合物或 植物相思树属植物多种植物和药学上可接受的载体。 本发明包括分离和纯化来自植物相思树属的COX-2和5-LO双重特异性的黄烷组合物的方法。

    IDENTIFICATION OF FREE-B-RING FLAVONOIDS AS POTENT COX-2 INHIBITORS
    9.
    发明申请
    IDENTIFICATION OF FREE-B-RING FLAVONOIDS AS POTENT COX-2 INHIBITORS 审中-公开
    作为COCO-2抑制剂的自由B环氟虫酯的鉴定

    公开(公告)号：US20110245333A1

    公开(公告)日：2011-10-06

    申请号：US13084419

    申请日：2011-04-11

    申请人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Walte

    发明人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Walte

    IPC分类号： A61K31/352 ,  A61P29/00

    CPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K36/539

    摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供抑制环加氧酶COX-2的新方法。 该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。 本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。 预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物 和药学上可接受的载体。

    FORMULATION OF DUAL CYCLOXYGENASE (COX) AND LIPOXYGENASE (LOX) INHIBITORS FOR MAMMAL SKIN CARE
    10.
    发明申请
    FORMULATION OF DUAL CYCLOXYGENASE (COX) AND LIPOXYGENASE (LOX) INHIBITORS FOR MAMMAL SKIN CARE 有权

    公开(公告)号：US20110207806A1

    公开(公告)日：2011-08-25

    申请号：US13028853

    申请日：2011-02-16

    申请人： Qi Jia

    发明人： Qi Jia

    IPC分类号： A61K31/353 ,  A61K8/49 ,  A61P17/00 ,  A61Q19/08

    CPC分类号： A61K8/97 ,  A61K8/498 ,  A61K8/67 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7048 ,  A61K36/11 ,  A61K36/15 ,  A61K36/185 ,  A61K36/28 ,  A61K36/47 ,  A61K36/48 ,  A61K36/484 ,  A61K36/486 ,  A61K36/53 ,  A61K36/539 ,  A61K36/54 ,  A61K36/60 ,  A61K36/906 ,  A61K36/9062 ,  A61K45/06 ,  A61K2800/782 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/08 ,  A61K2300/00

    摘要： The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-Ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX). The method for preventing and treating COX and LOX mediated diseases and conditions of the skin is comprised of topically administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of COX and LOX mediated diseases and conditions, including but not limited to sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial and viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma, as well as other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind and dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin. Use of the composition described herein also affords the benefit of smooth and youthful skin with improved elasticity, reduced and delayed aging, enhanced youthful appearance and texture, and increased flexibility, firmness, smoothness and suppleness.