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公开(公告)号:US06525036B2
公开(公告)日:2003-02-25
申请号:US09754962
申请日:2001-01-05
申请人: Renata Marcella Oballa , Petpiboon Prasit , Joel Stephane Robichaud , Elise Isabel , Eduardo Setti , Dan-Xiong Wang , Rohan V. Mendonca , Shankar Venkatraman
发明人: Renata Marcella Oballa , Petpiboon Prasit , Joel Stephane Robichaud , Elise Isabel , Eduardo Setti , Dan-Xiong Wang , Rohan V. Mendonca , Shankar Venkatraman
IPC分类号: A61K31277
CPC分类号: C07D207/08 , C07C255/25 , C07C255/41 , C07C2601/04 , C07C2601/14 , C07C2602/02 , C07D207/14 , C07D209/16 , C07D209/30 , C07D211/34 , C07D213/56 , C07D213/61 , C07D215/12 , C07D239/42 , C07D263/22 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/48 , C07D277/58 , C07D277/68 , C07D295/155 , C07D319/18 , C07D333/34 , C07D417/04 , C07D471/04
摘要: The present invention relates to novel cysteine protease inhibitors of Formula I: the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and methods of making them.
摘要翻译: 本发明涉及式I的新型半胱氨酸蛋白酶抑制剂:其药学上可接受的盐和N-氧化物衍生物,它们作为治疗剂的用途及其制备方法。
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公开(公告)号:US06476026B1
公开(公告)日:2002-11-05
申请号:US09526485
申请日:2000-03-15
申请人: Clifford M. Bryant , James T. Palmer , Robert M. Rydzewski , Eduardo L. Setti , Zong-Qiang Tian , Shankar Venkatraman , Dan-Xiong Wang
发明人: Clifford M. Bryant , James T. Palmer , Robert M. Rydzewski , Eduardo L. Setti , Zong-Qiang Tian , Shankar Venkatraman , Dan-Xiong Wang
IPC分类号: A61K314439
CPC分类号: C07D213/70 , C07B2200/07 , C07C255/24 , C07C255/29 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/09 , C07C317/50 , C07C323/60 , C07C323/62 , C07C2601/14 , C07D207/16 , C07D209/06 , C07D209/26 , C07D209/52 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/26 , C07D239/28 , C07D277/30 , C07D277/42 , C07D277/56 , C07D295/155 , C07D295/215 , C07D307/68 , C07D333/20 , C07D333/38 , C07D417/04 , C07D417/12
摘要: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
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公开(公告)号:US06593327B2
公开(公告)日:2003-07-15
申请号:US10017851
申请日:2001-12-14
申请人: Clifford M. Bryant , James T. Palmer , Robert M. Rydzewski , Eduardo L. Setti , Zong-Qiang Tian , Shankar Venkatraman , Dan-Xiong Wang
发明人: Clifford M. Bryant , James T. Palmer , Robert M. Rydzewski , Eduardo L. Setti , Zong-Qiang Tian , Shankar Venkatraman , Dan-Xiong Wang
IPC分类号: A61K314439
CPC分类号: C07D213/70 , C07B2200/07 , C07C255/24 , C07C255/29 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/09 , C07C317/50 , C07C323/60 , C07C323/62 , C07C2601/14 , C07D207/16 , C07D209/06 , C07D209/26 , C07D209/52 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/26 , C07D239/28 , C07D277/30 , C07D277/42 , C07D277/56 , C07D295/155 , C07D295/215 , C07D307/68 , C07D333/20 , C07D333/38 , C07D417/04 , C07D417/12
摘要: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
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