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    PRESERVATIVE-FREE SINGLE DOSE INHALER SYSTEMS
    1.
    发明申请
    PRESERVATIVE-FREE SINGLE DOSE INHALER SYSTEMS 审中-公开

    公开(公告)号：US20200078539A1

    公开(公告)日：2020-03-12

    申请号：US16685382

    申请日：2019-11-15

    Applicant: Dance Biopharm Inc.

    Inventor： John S. Patton ,  Ryan S. Patton ,  Mei-chang Kuo ,  Yehuda Ivri

    IPC: A61M15/00 ,  A61M11/00 ,  A61K9/00 ,  A61K38/28 ,  A61K9/12 ,  A61K33/30

    Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.

    LIQUID INSULIN FORMULATIONS AND METHODS RELATING THERETO
    4.
    发明申请
    LIQUID INSULIN FORMULATIONS AND METHODS RELATING THERETO 审中-公开
    液体胰岛素制剂及其相关方法

    公开(公告)号：US20160243199A1

    公开(公告)日：2016-08-25

    申请号：US14977137

    申请日：2015-12-21

    Applicant: Dance BioPharm, Inc.

    Inventor： Blaine Bueche ,  Mei-Chang Kuo ,  John Patton ,  Matthew Sander

    IPC: A61K38/28 ,  A61K9/00

    CPC classification number: A61K38/28 ,  A61K9/0073

    Abstract: Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery.

    Abstract translation: 提供含有物理和化学稳定的胰岛素但不含防腐剂或稳定剂的胰岛素的液体制剂。 制剂也缺乏表面活性剂。 该制剂可用于各种递送方式，包括肺部输送。

    LIQUID NEBULIZATION SYSTEMS AND METHODS
    5.
    发明申请
    LIQUID NEBULIZATION SYSTEMS AND METHODS 审中-公开
    液体渗透系统和方法

    公开(公告)号：US20160001019A1

    公开(公告)日：2016-01-07

    申请号：US14743711

    申请日：2015-06-18

    Applicant: Dance Biopharm Inc.

    Inventor： Jim Fink ,  Lisa Molloy ,  Ronan MacLoughlin ,  Claire Elizabeth Lillis ,  Michael Joseph Casey ,  John Matthew Mullins ,  Kieran James Hyland ,  Joesph Martin Grehan ,  Niall Scott Smith

    IPC: A61M15/00

    CPC classification number: A61M15/0021 ,  A61M11/005 ,  A61M15/002 ,  A61M15/0085 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2205/3331 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/584 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/6072 ,  A61M2205/8206 ,  A61M2206/11

    Abstract: Embodiments provide aerosolization device for providing aerosolized medicament to user. The aerosolization device includes conduit, aerosol generator, fluid receiving chamber, restrictor within the conduit, and indicator mechanism. Conduit has an inner wall and a mouthpiece end for causing an inspiratory flow. Aerosol generator includes a vibratable mesh laterally offset from the inner wall. Fluid receiving chamber receives liquid medicament. At least a portion of chamber is tapered such that liquid medicament is directed onto vibratable mesh for aerosolization. Restrictor defines a plurality of apertures that provide increases in pressure differential that vary with inspiratory flow rate within conduit and provide relatively laminar flow downstream of restrictor. Indicator mechanism indicates a state of flow parameters relative to a predefined range. Aerosol generator is configured to aerosolize at least a portion of liquid medicament only when flow parameters of the inspiratory flow are within range.

    Abstract translation: 实施例提供了用于向使用者提供气雾化药物的雾化装置。 雾化装置包括导管，气溶胶发生器，流体接收室，导管内的限流器和指示器机构。 导管具有用于引起吸气流动的内壁和接口端。 气溶胶发生器包括从内壁横向偏移的可振动网。 流体接收室接收液体药物。 室的至少一部分是锥形的，使得液体药物被引导到用于雾化的可振动网。 限制器限定了多个孔，其提供随着管道内的吸气流速而变化的压差的增加，并且在节流器下游提供相对层流。 指示器机构指示相对于预定义范围的流量参数的状态。 气溶胶发生器被配置成仅当吸气流量的流动参数在范围内时才雾化至少一部分液体药物。

    PRESERVATIVE-FREE SINGLE DOSE INHALER SYSTEMS
    9.
    发明申请
    PRESERVATIVE-FREE SINGLE DOSE INHALER SYSTEMS 有权
    无保护的单剂量吸入系统

    公开(公告)号：US20150196721A1

    公开(公告)日：2015-07-16

    申请号：US14606623

    申请日：2015-01-27

    Applicant: Dance Biopharm Inc.

    Inventor： John S. Patton ,  Ryan S. Patton ,  Mei-chang Kuo ,  Yehuda Ivri

    IPC: A61M11/00 ,  A61M15/00

    CPC classification number: A61M11/008 ,  A61M11/001 ,  A61M11/005 ,  A61M15/0021 ,  A61M15/0045 ,  A61M15/009 ,  H04L1/00 ,  H04W72/1242

    Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.

    Abstract translation: 雾化系统包括容器，其被配置为在挤压单次时输送单位剂量的液体。 该系统还包括由限定了接口管的壳体和设置在壳体中的气溶胶发生器构成的雾化器。 气溶胶发生器包括具有前表面和后表面的可振动膜，以及用于振动膜的可振动元件。 此外，壳体包括适于从容器接收单位剂量的液体的开口。 开口提供到可振动膜的后表面的液体路径。

    METHODS AND SYSTEMS FOR SUPPLYING AEROSOLIZATION DEVICES WITH LIQUID MEDICAMENTS
    10.
    发明申请
    METHODS AND SYSTEMS FOR SUPPLYING AEROSOLIZATION DEVICES WITH LIQUID MEDICAMENTS 审中-公开

    公开(公告)号：US20190015611A1

    公开(公告)日：2019-01-17

    申请号：US16133484

    申请日：2018-09-17

    Applicant: Dance Biopharm Inc.

    Inventor： Ryan S. Patton ,  John S. Patton ,  Mei-chang Kuo ,  Yehuda Ivri

    IPC: A61M15/00 ,  A61M11/00

    Abstract: A method is described for supplying a metered amount of a liquid medicament to an aerosolizing device. The method utilizes a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed. The dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed. The dispenser is grasped with one hand such that the fingers wrap around the dispenser body, with the thumb closest to the proximal end and the last finger closest to the tip. The tip is inserted into an opening of an inhaler and the elongate body is forced toward the tip to cause the dispenser body to compress, thereby operating the dispensing mechanism and causing a metered quantity of the liquid medicament to eject into the inhaler.

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