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公开(公告)号:US08153671B2
公开(公告)日:2012-04-10
申请号:US11995683
申请日:2006-07-14
申请人: Phillip B. Alper , Thomas Marsilje , Arnab Chatterjee , Wenshuo Lu , Daniel Mutnick , Michael Roberts , Yun He
发明人: Phillip B. Alper , Thomas Marsilje , Arnab Chatterjee , Wenshuo Lu , Daniel Mutnick , Michael Roberts , Yun He
IPC分类号: A61K31/404 , C07D487/02
CPC分类号: C08J7/04 , C07D209/80 , C07D209/94 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D491/04 , C07D495/04 , C08J7/045 , C08J2369/00
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TPO活性相关的疾病或病症的方法,特别是涉及血小板减少症的疾病或病症。
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公开(公告)号:US20090075996A1
公开(公告)日:2009-03-19
申请号:US11995683
申请日:2006-07-14
申请人: Phillip B. Alper , Thomas Marsilje , Arnab Chatterjee , Wenshuo Lu , Daniel Mutnick , Michael Roberts , Yun He
发明人: Phillip B. Alper , Thomas Marsilje , Arnab Chatterjee , Wenshuo Lu , Daniel Mutnick , Michael Roberts , Yun He
IPC分类号: A61K31/5377 , C07D209/82 , C07D413/08 , A61K31/403
CPC分类号: C08J7/04 , C07D209/80 , C07D209/94 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D491/04 , C07D495/04 , C08J7/045 , C08J2369/00
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TPO活性相关的疾病或病症的方法,特别是涉及血小板减少症的疾病或病症。
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公开(公告)号:US20050049244A1
公开(公告)日:2005-03-03
申请号:US10868459
申请日:2004-06-10
申请人: Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人: Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号: A61K20060101 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/47 , A61K31/495 , A61K31/4965 , A61K31/537 , A61K31/54 , C07D277/82 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号: C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号:US07307095B2
公开(公告)日:2007-12-11
申请号:US11620608
申请日:2007-01-05
申请人: Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人: Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号: A61K31/423 , A61K31/403 , A61K31/428
CPC分类号: C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
摘要翻译: 本发明提供了选择性抑制组织蛋白酶S的化合物,组合物和方法。在优选的方面,组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。
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公开(公告)号:US07173051B2
公开(公告)日:2007-02-06
申请号:US10868459
申请日:2004-06-10
申请人: Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人: Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号: A61K31/423 , A61K31/403 , A61K31/428 , C07D263/58 , C07D227/04 , C07D417/02 , C07D498/02
CPC分类号: C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号:US20070123523A1
公开(公告)日:2007-05-31
申请号:US11620608
申请日:2007-01-05
申请人: Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人: Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号: A61K31/165 , A61K31/54 , A61K31/497 , A61K31/445
CPC分类号: C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号:US09155809B2
公开(公告)日:2015-10-13
申请号:US13249633
申请日:2011-09-30
IPC分类号: A61L2/18
CPC分类号: A61L2/18 , A61L2202/121 , A61L2202/122
摘要: A pen sterilization device includes a main body having a first end, a second end and a plurality of opposing sides defining a watertight reservoir for containing a sterilization agent. A pair of watertight valves are positioned along each end of the main body and function to allow ingress and egress of a pen to be cleaned. A central partition may be provided within the watertight reservoir having one or more brushes that are suspended in the sterilization agent for scrubbing a pen that is passing through the device.
摘要翻译: 笔式灭菌装置包括具有第一端,第二端和限定用于容纳灭菌剂的防水容器的多个相对侧的主体。 一对防水阀门沿着主体的每个端部定位,并且具有允许笔的进入和流出被清洁的功能。 可以在水密储存器内设置一个中央隔板,其中一个或多个刷子悬挂在消毒剂中,用于擦洗正在穿过该装置的笔。
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公开(公告)号:US20050032967A1
公开(公告)日:2005-02-10
申请号:US10888214
申请日:2004-07-09
申请人: Michael Roberts , Michael Roberts
发明人: Michael Roberts , Michael Roberts
IPC分类号: B32B25/04 , C08K3/00 , C09D5/00 , C09D5/02 , C09D201/00 , E02D31/06 , E04B1/66 , E04F13/02 , E04F21/00
CPC分类号: C09D5/02 , C09D201/00 , Y10T428/31826 , C08L2666/04
摘要: A wall comprising a first surface, and a protective coating covering at least a portion of the first surface, where the coating is the dried film of an aqueous composition comprising a first set of polymer particles characterized by having a glass transition temperature that is less than about −40° C., and a second set of polymer particles characterized by having a glass transition temperature in excess of about −25° C.
摘要翻译: 包括第一表面和覆盖第一表面的至少一部分的保护涂层的壁,其中涂层是包含第一组聚合物颗粒的水性组合物的干燥膜,其特征在于玻璃化转变温度小于 约-40℃,以及第二组聚合物颗粒,其特征在于玻璃化转变温度超过约-25℃。
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公开(公告)号:US09968992B2
公开(公告)日:2018-05-15
申请号:US14686906
申请日:2015-04-15
申请人: Michael Roberts
发明人: Michael Roberts
摘要: The present invention is a multipart system and method for using cloth filters in automated vertical molding. The system includes a filter setter, a filter print plate and a filter back shelf. The filter setter removably mounts to a mechanical arm and releasably carries at least one cloth filter between upper and lower jaws. The filter print plate mounts to a ram plate while the filter back shelf mounts to a swing plate. During vertical molding, the ram plate and swing plate compress sand to create a mold. The mounted filter print plate creates at least part of a print aperture into which the filter setter inserts the cloth filter. The apertures created by the filter print plate and the filter back shelf support the cloth filter during the founding process.
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公开(公告)号:US20180131788A1
公开(公告)日:2018-05-10
申请号:US15435188
申请日:2017-02-16
申请人: Michael Roberts
发明人: Michael Roberts
IPC分类号: H04L29/06 , G06F3/0481 , H04L29/08
CPC分类号: H04L67/38 , G06F3/04815 , H04L67/1095
摘要: One embodiment provides a system that facilitates shared virtual reality space. During operation, the system receives a first message associated with a first virtual reality object, wherein the first message includes a first address for the first virtual reality object and indicates a first action to be performed on the first virtual reality object. The system performs the first action on the first virtual reality object. The system determines a second address for a second virtual reality object that is remotely maintained and corresponds to the first virtual reality object. The system constructs a second message, which includes the second address and indicates the first action, thereby allowing the first action to be performed on the second virtual reality object.
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