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    RNA complexes, methods of their production and sensors and analytical methods involving same
    1.
    发明授权
    RNA complexes, methods of their production and sensors and analytical methods involving same 有权
    RNA复合物，其生产方法和传感器以及涉及其的分析方法

    公开(公告)号：US08809512B2

    公开(公告)日：2014-08-19

    申请号：US13585225

    申请日：2012-08-14

    Applicant: Neocles Leontis

    Inventor： Neocles Leontis

    IPC: C07H21/02

    CPC classification number: C12Q1/6813 ,  Y10S977/728 ,  Y10S977/773 ,  C12Q2525/307 ,  C12Q2525/205

    Abstract: The invention includes RNA complexes comprising at least three monomeric units of an RNA molecule, each monomeric unit comprising an RNA polymer having first and second helical domains that have respective first and second binding sites, wherein the first binding sites are adapted to binding to one another and are not adapted to bind to the second binding sites, and the second binding sites are adapted to binding to one another and are not adapted to bind to the first binding sites; such that the at least three monomeric units are adapted to self-assemble by forming pairs of cognate interactions and so as to form the RNA complex in a circular closed complex. The invention also includes derivatives of these complexes including aptamers, and analytical methods and devices using same.

    Abstract translation: 本发明包括包含RNA分子的至少三个单体单元的RNA复合物，每个单体单元包含具有第一和第二螺旋结构域的RNA聚合物，其具有相应的第一和第二结合位点，其中第一结合位点适于彼此结合 并且不适于结合第二结合位点，并且第二结合位点适于彼此结合并且不适于结合第一结合位点; 使得所述至少三个单体单元适于通过形成一对同源相互作用而自组装，从而在环状闭合复合物中形成RNA复合物。 本发明还包括这些复合物的衍生物，包括适体，以及使用其的分析方法和装置。

    Controlled alignment of nano-barcodes encoding specific information for scanning probe microscopy (SPM)
    4.
    发明申请
    Controlled alignment of nano-barcodes encoding specific information for scanning probe microscopy (SPM) 失效
    用于扫描探针显微镜（SPM）的编码特定信息的纳米条形码的可控比对

    公开(公告)号：US20060281119A1

    公开(公告)日：2006-12-14

    申请号：US11446273

    申请日：2006-06-02

    Applicant: Selena Chan ,  Xing Su ,  Mineo Yamakawa

    Inventor： Selena Chan ,  Xing Su ,  Mineo Yamakawa

    IPC: C12Q1/68 ,  C12M1/34

    CPC classification number: C12Q1/6816 ,  Y10S977/704 ,  Y10S977/728 ,  Y10S977/734 ,  Y10S977/742 ,  Y10S977/773 ,  Y10S977/774 ,  C12Q2565/601 ,  C12Q2563/155 ,  C12Q2537/143

    Abstract: The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nano-barcodes may be allowed to bind to one or more target molecules. After binding and separation from unbound coded probes, the bound coded probes may be aligned on a surface and analyzed by scanning probe microscopy. The nano-barcodes may be any molecule or complex that is distinguishable by SPM, such as carbon nanotubes, fullerenes, submicrometer metallic barcodes, nanoparticles or quantum dots. Where the probes are oligonucleotides, adjacent coded probes hybridized to a target nucleic acid may be ligated together before alignment and SPM analysis. Compositions comprising coded probes are also disclosed herein. Systems for biomolecule analysis may comprise an SPM instrument and at least one coded probe attached to a surface.

    Abstract translation: 本文公开的方法，装置和组合物涉及生物分子如核酸或蛋白质的检测，鉴定和/或测序。 在本发明的某些实施方案中，包含与一个或多个纳米条形码连接的探针分子的编码探针可以被允许与一个或多个靶分子结合。 在结合和分离未结合的编码探针之后，结合编码的探针可以在表面上对准并通过扫描探针显微镜进行分析。 纳米条形码可以是通过SPM可区分的任何分子或复合物，例如碳纳米管，富勒烯，亚微米金属条形码，纳米粒子或量子点。 当探针是寡核苷酸时，与靶核酸杂交的相邻编码探针可以在对准和SPM分析之前连接在一起。 包含编码探针的组合物也在本文中公开。 用于生物分子分析的系统可以包括SPM仪器和附接到表面的至少一个编码探针。

    Controlled alignment of nano-barcodes encoding specific information for scanning probe microscopy (SPM) reading
    6.
    发明申请
    Controlled alignment of nano-barcodes encoding specific information for scanning probe microscopy (SPM) reading 失效
    用于扫描探针显微镜（SPM）读数的纳米条形码的控制对准编码特定信息

    公开(公告)号：US20040126820A1

    公开(公告)日：2004-07-01

    申请号：US10667004

    申请日：2003-09-19

    Inventor： Selena Chan ,  Xing Su ,  Mineo Yamakawa

    IPC: G01N033/573

    CPC classification number: C12Q1/6816 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  Y10S977/702 ,  Y10S977/704 ,  Y10S977/705 ,  Y10S977/728 ,  Y10S977/729 ,  Y10S977/734 ,  Y10S977/742 ,  Y10S977/773 ,  Y10S977/774 ,  Y10S977/924 ,  C12Q2565/601 ,  C12Q2563/185

    Abstract: The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nano-barcodes may be allowed to bind to one or more target molecules. After binding and separation from unbound coded probes, the bound coded probes may be aligned on a surface and analyzed by scanning probe microscopy. The nano-barcodes may be any molecule or complex that is distinguishable by SPM, such as carbon nanotubes, fullerenes, submicrometer metallic barcodes, nanoparticles or quantum dots. Where the probes are oligonucleotides, adjacent coded probes hybridized to a target nucleic acid may be ligated together before alignment and SPM analysis. Compositions comprising coded probes are also disclosed herein. Systems for biomolecule analysis may comprise an SPM instrument and at least one coded probe attached to a surface.

    Abstract translation: 本文公开的方法，装置和组合物涉及生物分子如核酸或蛋白质的检测，鉴定和/或测序。 在本发明的某些实施方案中，包含与一个或多个纳米条形码连接的探针分子的编码探针可以被允许与一个或多个靶分子结合。 在结合和分离未结合的编码探针之后，结合编码的探针可以在表面上对准并通过扫描探针显微镜进行分析。 纳米条形码可以是通过SPM可区分的任何分子或复合物，例如碳纳米管，富勒烯，亚微米金属条形码，纳米粒子或量子点。 当探针是寡核苷酸时，与靶核酸杂交的相邻编码探针可以在对准和SPM分析之前连接在一起。 包含编码探针的组合物也在本文中公开。 用于生物分子分析的系统可以包括SPM仪器和连接到表面的至少一个编码探针。

    Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
    7.
    发明申请
    Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading 有权
    用于扫描探针显微镜（SPM）读数的编码特定信息的纳米棒的受控比对

    公开(公告)号：US20040058328A1

    公开(公告)日：2004-03-25

    申请号：US10251152

    申请日：2002-09-20

    Inventor： Selena Chan ,  Xing Su ,  Mineo Yamakawa

    IPC: C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

    CPC classification number: C12Q1/6816 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  Y10S977/702 ,  Y10S977/704 ,  Y10S977/705 ,  Y10S977/728 ,  Y10S977/729 ,  Y10S977/734 ,  Y10S977/742 ,  Y10S977/773 ,  Y10S977/774 ,  Y10S977/924 ,  C12Q2565/601 ,  C12Q2563/185

    Abstract: The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nanobarcodes may be allowed to bind to one or more target molecules. After binding and separation from unbound coded probes, the bound coded probes may be aligned on a surface and analyzed by scanning probe microscopy. The nanobarcodes may be any molecule or complex that is distinguishable by SPM, such as carbon nanotubes, fullerenes, submicrometer metallic barcodes, nanoparticles or quantum dots. Where the probes are oligonucleotides, adjacent coded probes hybridized to a target nucleic acid may be ligated together before alignment and SPM analysis. Compositions comprising coded probes are also disclosed herein. Systems for biomolecule analysis may comprise an SPM instrument and at least one coded probe attached to a surface.

    Abstract translation: 本文公开的方法，装置和组合物涉及生物分子如核酸或蛋白质的检测，鉴定和/或测序。 在本发明的某些实施方案中，包含连接至一个或多个纳米糖基的探针分子的编码探针可以被允许与一个或多个靶分子结合。 在结合和分离未结合的编码探针之后，结合编码的探针可以在表面上对准并通过扫描探针显微镜进行分析。 纳米线可以是通过SPM可区分的任何分子或复合物，例如碳纳米管，富勒烯，亚微米金属条形码，纳米颗粒或量子点。 当探针是寡核苷酸时，与靶核酸杂交的相邻编码探针可以在对准和SPM分析之前连接在一起。 包含编码探针的组合物也在本文中公开。 用于生物分子分析的系统可以包括SPM仪器和附接到表面的至少一个编码探针。

    RNA complexes, method of their production and sensors and analytical methods involving same
    9.
    发明授权
    RNA complexes, method of their production and sensors and analytical methods involving same 失效
    RNA复合物，其生产方法和传感器以及涉及其的分析方法

    公开(公告)号：US08268556B2

    公开(公告)日：2012-09-18

    申请号：US12459342

    申请日：2009-06-29

    Applicant: Neocles Leontis

    Inventor： Neocles Leontis

    IPC: C12Q1/68 ,  C07H21/02

    CPC classification number: C12Q1/6813 ,  Y10S977/728 ,  Y10S977/773 ,  C12Q2525/307 ,  C12Q2525/205

    Abstract: The invention includes RNA complexes comprising at least three monomeric units of an RNA molecule, each monomeric unit comprising an RNA polymer having first and second helical domains that have respective first and second binding sites, wherein the first binding sites are adapted to binding to one another and are not adapted to bind to the second binding sites, and the second binding sites are adapted to binding to one another and are not adapted to bind to the first binding sites; such that the at least three monomeric units are adapted to self-assemble by forming pairs of cognate interactions and so as to form the RNA complex in a circular closed complex. The invention also includes derivatives of these complexes including aptamers, and analytical methods and devices using same.

    Abstract translation: 本发明包括包含RNA分子的至少三个单体单元的RNA复合物，每个单体单元包含具有第一和第二螺旋结构域的RNA聚合物，其具有相应的第一和第二结合位点，其中第一结合位点适于彼此结合 并且不适于结合第二结合位点，并且第二结合位点适于彼此结合并且不适于结合第一结合位点; 使得所述至少三个单体单元适于通过形成一对同源相互作用而自组装，从而在环状闭合复合物中形成RNA复合物。 本发明还包括这些复合物的衍生物，包括适体，以及使用其的分析方法和装置。

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