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公开(公告)号:US08895601B2
公开(公告)日:2014-11-25
申请号:US13643741
申请日:2011-04-28
申请人: Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
发明人: Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
IPC分类号: A61K31/415 , C07D231/10 , C07D231/12 , C07D405/14 , C07D403/04 , C07D487/08 , C07D413/14 , C07D403/14 , C07D409/14
CPC分类号: C07D403/04 , A61K31/498 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/08 , C07D491/113 , C07F9/6524
摘要: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及新的喹喔啉衍生物化合物,包含所述化合物的药物组合物,用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号:US20130072457A1
公开(公告)日:2013-03-21
申请号:US13643741
申请日:2011-04-28
申请人: Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , Michael Reader , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Johan Erwin Edmond Weerts , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
发明人: Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , Michael Reader , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Johan Erwin Edmond Weerts , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
IPC分类号: C07D403/04 , C07D405/14 , C07D491/113 , C07D401/14 , C07D413/14 , A61K31/5377 , C07D487/08 , C07F9/6558 , A61K31/675 , C07D491/107 , C07D471/04 , C07D403/14 , A61K31/506 , A61P35/00 , A61K31/498
CPC分类号: C07D403/04 , A61K31/498 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/08 , C07D491/113 , C07F9/6524
摘要: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及新的喹喔啉衍生物化合物,包含所述化合物的药物组合物,用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号:US08299256B2
公开(公告)日:2012-10-30
申请号:US12529142
申请日:2008-03-07
申请人: Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
发明人: Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
IPC分类号: C07D215/38
CPC分类号: C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
摘要翻译: 本发明提供式(I)化合物,它们作为PARP抑制剂的用途以及包含所述式(I)化合物的药物组合物,其中R1,R2,R3,R4,R5,R6,R7,n,m和X具有 定义含义。
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公开(公告)号:US08778966B2
公开(公告)日:2014-07-15
申请号:US13617686
申请日:2012-09-14
申请人: Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thèrése Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
发明人: Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Bruno Roux , Elisabeth Thèrése Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Françoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet
IPC分类号: A61K31/04 , C07D413/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D215/227 , C07D417/06
CPC分类号: C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
摘要翻译: 本发明提供式(I)化合物,它们作为PARP抑制剂的用途以及包含所述式(I)化合物的药物组合物,其中R1,R2,R3,R4,R5,R6,R7,n,m和X具有 定义含义。
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5.AZA-BICYCLOHEXYL SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权
标题翻译: AZA-BICYCLOHEXYL取代的吲哚基氨基酸衍生物作为HISTONE DEACETYLASE的新型抑制剂公开(公告)号:US20110015218A1
公开(公告)日:2011-01-20
申请号:US12934894
申请日:2009-03-26
IPC分类号: A61K31/506 , C07D403/14 , A61P35/00
CPC分类号: C07D403/14 , C07D401/14 , C07D405/14
摘要: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, A and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中R1,R2,R3,R4,A和X具有定义的含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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6.Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylace 有权
标题翻译: 氮杂双环己基取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰基的新型抑制剂公开(公告)号:US08476289B2
公开(公告)日:2013-07-02
申请号:US12934894
申请日:2009-03-26
IPC分类号: C07D401/14 , A61K31/506
CPC分类号: C07D403/14 , C07D401/14 , C07D405/14
摘要: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, A and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中R1,R2,R3,R4,A和X具有定义的含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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公开(公告)号:US08343988B2
公开(公告)日:2013-01-01
申请号:US12372785
申请日:2009-02-18
申请人: Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Peter Ten Holte , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Alexey Borisovich Dyatkin
发明人: Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Peter Ten Holte , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Alexey Borisovich Dyatkin
IPC分类号: A01N43/54 , A61K31/505 , C07D401/00
CPC分类号: C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要: This invention comprises the novel compounds of formula (I) wherein n, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括其中n,t,R 1,R 2,R 3,R 4,L,Q,X,Y,Z并具有定义的具有组蛋白脱乙酰酶抑制酶活性的式(I)化合物。 其制剂,含有它们的组合物及其作为药物的用途。
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公开(公告)号:US08268833B2
公开(公告)日:2012-09-18
申请号:US12372801
申请日:2009-02-18
申请人: Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Peter Ten Holte , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Alexey Borisovich Dyatkin
发明人: Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Peter Ten Holte , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Alexey Borisovich Dyatkin
IPC分类号: C07D417/00 , C07D413/00 , C07D295/00 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , A61K31/445
CPC分类号: C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要: This invention comprises the novel compounds of formula (I) wherein n, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括其中n,t,R 1,R 2,R 3,R 4,L,Q,X,Y,Z并具有定义的具有组蛋白脱乙酰酶抑制酶活性的式(I)化合物。 其制剂,含有它们的组合物及其作为药物的用途。
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9.
公开(公告)号:US08119650B2
公开(公告)日:2012-02-21
申请号:US12160140
申请日:2007-01-16
IPC分类号: C07D401/14 , A61K31/4439
CPC分类号: C07D401/14 , C07D405/14 , C07D409/14
摘要: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中R1,R2,R3,R4,R5,R6,R7,R8,R9,X和Y具有定义含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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10.SULFONYLAMINO-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权
标题翻译: 磺酰胺衍生物作为HISTONE脱乙酰基酶的新型抑制剂公开(公告)号:US20100234353A1
公开(公告)日:2010-09-16
申请号:US12724273
申请日:2010-03-15
申请人: Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden
发明人: Kristof Van Emelen , Leo Jacobus Jozef Backx , Sven Franciscus Anna Van Brandt , Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Marc Gustaaf Celine Verdonck , Hans Louis Jos De Winter , Jimmy Arnold Viviane Van Heusden
IPC分类号: A61K31/55 , C07D211/98 , A61K31/4468 , C07D239/32 , A61K31/506 , C07D401/14 , A61K31/496 , C07D401/04 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号: C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48
摘要: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括其中n,m,t,R 1,R 2,R 3,R 4,R 5,L,Q,X,Y,Z并具有定义的含有组蛋白脱乙酰酶抑制酶活性的式(I) 其制剂,含有它们的组合物及其作为药物的用途。
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