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公开(公告)号:US08895601B2
公开(公告)日:2014-11-25
申请号:US13643741
申请日:2011-04-28
申请人: Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
发明人: Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
IPC分类号: A61K31/415 , C07D231/10 , C07D231/12 , C07D405/14 , C07D403/04 , C07D487/08 , C07D413/14 , C07D403/14 , C07D409/14
CPC分类号: C07D403/04 , A61K31/498 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/08 , C07D491/113 , C07F9/6524
摘要: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及新的喹喔啉衍生物化合物,包含所述化合物的药物组合物,用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号:US20130072457A1
公开(公告)日:2013-03-21
申请号:US13643741
申请日:2011-04-28
申请人: Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , Michael Reader , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Johan Erwin Edmond Weerts , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
发明人: Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , Michael Reader , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Johan Erwin Edmond Weerts , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
IPC分类号: C07D403/04 , C07D405/14 , C07D491/113 , C07D401/14 , C07D413/14 , A61K31/5377 , C07D487/08 , C07F9/6558 , A61K31/675 , C07D491/107 , C07D471/04 , C07D403/14 , A61K31/506 , A61P35/00 , A61K31/498
CPC分类号: C07D403/04 , A61K31/498 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/08 , C07D491/113 , C07F9/6524
摘要: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及新的喹喔啉衍生物化合物,包含所述化合物的药物组合物,用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
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3.Bicyclic heterocyclyl derivatives as FGFR kinase inhibitors for therapeutic use 有权
标题翻译: 双环杂环基衍生物作为治疗用途的FGFR激酶抑制剂公开(公告)号:US08481531B2
公开(公告)日:2013-07-09
申请号:US13264593
申请日:2010-04-15
申请人: Gordon Saxty , Valerio Berdini , Eddy Jean Edgard Freyne , Alexandra Papanikos , Pascal Benderitter , Werner Constant Johan Embrechts , Berthold Wroblowski , Rhalid Akkari
发明人: Gordon Saxty , Valerio Berdini , Eddy Jean Edgard Freyne , Alexandra Papanikos , Pascal Benderitter , Werner Constant Johan Embrechts , Berthold Wroblowski , Rhalid Akkari
IPC分类号: A61K31/5377 , A61K31/437 , A61K31/496 , C07D413/02 , C07D471/04 , C07D401/02 , C07D239/20
CPC分类号: C07D471/04
摘要: The invention relates to new bicyclic heterocyclyl derivatives of formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及式(I)的新的双环杂环基衍生物,包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途,例如, 癌症。
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4.BICYCLIC HETEROCYCLYL DERIVATIVES AS FGFR KINASE INHIBITORS FOR THERAPEUTIC USE 有权
标题翻译: 作为用于治疗用途的FGFR激酶抑制剂的双相间苯二酚衍生物公开(公告)号:US20120035171A1
公开(公告)日:2012-02-09
申请号:US13264593
申请日:2010-04-15
申请人: Gordon Saxty , Valerio Berdini , Eddy Jean Edgard Freyne , Alexandra Papanikos , Pascal Benderitter , Werner Constant Johan Embrechts , Berthold Wroblowski , Rhalid Akkari
发明人: Gordon Saxty , Valerio Berdini , Eddy Jean Edgard Freyne , Alexandra Papanikos , Pascal Benderitter , Werner Constant Johan Embrechts , Berthold Wroblowski , Rhalid Akkari
IPC分类号: A61K31/5377 , A61P35/00 , A61K31/496 , A61K31/513 , C07D471/04 , A61K31/437
CPC分类号: C07D471/04
摘要: The invention relates to new bicyclic heterocyclyl derivatives of formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及式(I)的新的双环杂环基衍生物,包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途,例如, 癌症。
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公开(公告)号:US20130059899A1
公开(公告)日:2013-03-07
申请号:US13407512
申请日:2012-02-28
申请人: Evi Kostenis , Andreas Spinrath , Stephanie Hennen , Lucas Peters , Christa E. Müller , Rhalid Akkari , Younis Baqi , Kirsten Ritter
发明人: Evi Kostenis , Andreas Spinrath , Stephanie Hennen , Lucas Peters , Christa E. Müller , Rhalid Akkari , Younis Baqi , Kirsten Ritter
IPC分类号: A61K31/405 , G01N33/567 , G01N21/75 , A61P9/00 , C07D405/10 , C07D409/10 , A61P9/10 , A61P25/00 , C12Q1/02 , C07D209/42
CPC分类号: C07D209/42 , A61K31/405 , C07D405/04 , C07D409/04 , C07K14/723 , C12Q1/025 , G01N33/5041 , G01N33/566 , G01N33/6896 , G01N33/74 , G01N2333/4719 , G01N2500/00 , G01N2800/285 , G01N2800/2871
摘要: The present invention is related to a method of determining a test compound's ability to modify the biological activity of a GPR17. Said method comprises, among others, the step of contacting the test compound with a GPR17, or a functional GPR17 fragment in the presence of a suitable amount of a GPR17 agonist of formula I.
摘要翻译: 本发明涉及测定化合物改变GPR17的生物学活性的能力的方法。 所述方法尤其包括在合适量的式I的GPR17激动剂存在下使测试化合物与GPR17或功能性GPR17片段接触的步骤。
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公开(公告)号:US08404436B1
公开(公告)日:2013-03-26
申请号:US13407512
申请日:2012-02-28
申请人: Evi Kostenis , Andreas Spinrath , Stephanie Hennen , Lucas Peters , Christa E. Muller , Rhalid Akkari , Younis Baqi , Kirsten Ritter
发明人: Evi Kostenis , Andreas Spinrath , Stephanie Hennen , Lucas Peters , Christa E. Muller , Rhalid Akkari , Younis Baqi , Kirsten Ritter
IPC分类号: C12Q1/00 , G01N33/53 , C07D209/04
CPC分类号: C07D209/42 , A61K31/405 , C07D405/04 , C07D409/04 , C07K14/723 , C12Q1/025 , G01N33/5041 , G01N33/566 , G01N33/6896 , G01N33/74 , G01N2333/4719 , G01N2500/00 , G01N2800/285 , G01N2800/2871
摘要: The present invention is related to a method of determining a test compound's ability to modify the biological activity of a GPR17. Said method comprises, among others, the step of contacting the test compound with a GPR17, or a functional GPR17 fragment in the presence of a suitable amount of a GPR17 agonist of formula I.
摘要翻译: 本发明涉及测定化合物改变GPR17的生物学活性的能力的方法。 所述方法尤其包括在合适量的式I的GPR17激动剂存在下使测试化合物与GPR17或功能性GPR17片段接触的步骤。
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