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公开(公告)号：US08895601B2
公开(公告)日：2014-11-25
申请号：US13643741
申请日：2011-04-28
申请人： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
发明人： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
IPC分类号： A61K31/415 , C07D231/10 , C07D231/12 , C07D405/14 , C07D403/04 , C07D487/08 , C07D413/14 , C07D403/14 , C07D409/14
CPC分类号： C07D403/04 , A61K31/498 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/08 , C07D491/113 , C07F9/6524
摘要： The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的喹喔啉衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US20130072457A1
公开(公告)日：2013-03-21
申请号：US13643741
申请日：2011-04-28
申请人： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , Michael Reader , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Johan Erwin Edmond Weerts , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
发明人： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Christopher Norbert Johnson , Steven John Woodhead , Michael Reader , David Charles Rees , Laurence Anne Mevellec , Patrick René Angibaud , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Johan Erwin Edmond Weerts , Timothy Pietro Suren Perera , Ronaldus Arnodus Hendrika Joseph Gilissen , Berthold Wroblowski , Jean Fernand Armand Lacrampe , Alexandra Papanikos , Oliver Alexis Georges Querolle , Elisabeth Thérèse Jeanne Pasquier , Isabelle Noëlle Constance Pilatte , Pascal Ghislain André Bonnet , Werner Constant Johan Embrechts , Rhalid Akkari , Lieven Meerpoel
IPC分类号： C07D403/04 , C07D405/14 , C07D491/113 , C07D401/14 , C07D413/14 , A61K31/5377 , C07D487/08 , C07F9/6558 , A61K31/675 , C07D491/107 , C07D471/04 , C07D403/14 , A61K31/506 , A61P35/00 , A61K31/498
CPC分类号： C07D403/04 , A61K31/498 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/08 , C07D491/113 , C07F9/6524
摘要： The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的喹喔啉衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
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3.发明授权Bicyclic heterocyclyl derivatives as FGFR kinase inhibitors for therapeutic use 有权双环杂环基衍生物作为治疗用途的FGFR激酶抑制剂公开(公告)号：US08481531B2
公开(公告)日：2013-07-09
申请号：US13264593
申请日：2010-04-15
申请人： Gordon Saxty , Valerio Berdini , Eddy Jean Edgard Freyne , Alexandra Papanikos , Pascal Benderitter , Werner Constant Johan Embrechts , Berthold Wroblowski , Rhalid Akkari
发明人： Gordon Saxty , Valerio Berdini , Eddy Jean Edgard Freyne , Alexandra Papanikos , Pascal Benderitter , Werner Constant Johan Embrechts , Berthold Wroblowski , Rhalid Akkari
IPC分类号： A61K31/5377 , A61K31/437 , A61K31/496 , C07D413/02 , C07D471/04 , C07D401/02 , C07D239/20
CPC分类号： C07D471/04
摘要： The invention relates to new bicyclic heterocyclyl derivatives of formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及式（I）的新的双环杂环基衍生物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途，例如， 癌症。
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4.发明申请BICYCLIC HETEROCYCLYL DERIVATIVES AS FGFR KINASE INHIBITORS FOR THERAPEUTIC USE 有权作为用于治疗用途的FGFR激酶抑制剂的双相间苯二酚衍生物公开(公告)号：US20120035171A1
公开(公告)日：2012-02-09
申请号：US13264593
申请日：2010-04-15
申请人： Gordon Saxty , Valerio Berdini , Eddy Jean Edgard Freyne , Alexandra Papanikos , Pascal Benderitter , Werner Constant Johan Embrechts , Berthold Wroblowski , Rhalid Akkari
发明人： Gordon Saxty , Valerio Berdini , Eddy Jean Edgard Freyne , Alexandra Papanikos , Pascal Benderitter , Werner Constant Johan Embrechts , Berthold Wroblowski , Rhalid Akkari
IPC分类号： A61K31/5377 , A61P35/00 , A61K31/496 , A61K31/513 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to new bicyclic heterocyclyl derivatives of formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及式（I）的新的双环杂环基衍生物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途，例如， 癌症。
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![IMIDAZO [1,2-A]PYRIDINE DERIVATIVES AS FGFR KINASE INHIBITORS FOR USE IN THERAPY](/abs-image/US/2012/02/16/US20120041000A1/abs.jpg.150x150.jpg)
5.发明申请IMIDAZO [1,2-A]PYRIDINE DERIVATIVES AS FGFR KINASE INHIBITORS FOR USE IN THERAPY 有权作为用于治疗的FGFR激酶抑制剂的咪唑并[1,2-A]吡啶衍生物公开(公告)号：US20120041000A1
公开(公告)日：2012-02-16
申请号：US13264596
申请日：2010-04-15
申请人： Gordon Saxty , Valerio Berdini , Christopher William Murray , Eddy Jean Edgard Freyne , Yannick Aimé Eddy Ligny , Pascal Ghislain André Bonnet , Berthold Wroblowski , Alexandra Papanikos
发明人： Gordon Saxty , Valerio Berdini , Christopher William Murray , Eddy Jean Edgard Freyne , Yannick Aimé Eddy Ligny , Pascal Ghislain André Bonnet , Berthold Wroblowski , Alexandra Papanikos
IPC分类号： A61K31/437 , A61K31/506 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to new bicyclic heterocyclyl derivatives of formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及式（I）的新的双环杂环基衍生物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途，例如， 癌症。
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![Imidazo [1,2-A]pyridine derivatives as FGFR kinase inhibitors for use in therapy](/abs-image/US/2014/05/13/US08722687B2/abs.jpg.150x150.jpg)
6.发明授权Imidazo [1,2-A]pyridine derivatives as FGFR kinase inhibitors for use in therapy 有权咪唑并[1,2-A]吡啶衍生物作为FGFR激酶抑制剂用于治疗公开(公告)号：US08722687B2
公开(公告)日：2014-05-13
申请号：US13264596
申请日：2010-04-15
申请人： Gordon Saxty , Valerio Berdini , Christopher William Murray , Eddy Jean Edgard Freyne , Yannick Aimé Eddy Ligny , Pascal Ghislain André Bonnet , Berthold Wroblowski , Alexandra Papanikos
发明人： Gordon Saxty , Valerio Berdini , Christopher William Murray , Eddy Jean Edgard Freyne , Yannick Aimé Eddy Ligny , Pascal Ghislain André Bonnet , Berthold Wroblowski , Alexandra Papanikos
IPC分类号： C07D239/42 , C07D401/04 , A61K31/44 , A01N43/42 , C07D513/02 , C07D515/02 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00
CPC分类号： C07D471/04
摘要： The invention relates to new bicyclic heterocyclyl derivatives of formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及式（I）的新的双环杂环基衍生物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途，例如， 癌症。
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7.发明授权公开(公告)号：US08796244B2
公开(公告)日：2014-08-05
申请号：US12997754
申请日：2009-06-12
申请人： Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud , Marian Williams
发明人： Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Brian John Williams , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud
IPC分类号： A61K31/5025 , C07D413/02
CPC分类号： C07D471/04 , C07D513/04
摘要： The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的双环杂环衍生物化合物，包含该化合物的药物组合物和该化合物在治疗疾病中的用途。 癌症。
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8.发明申请公开(公告)号：US20120208791A1
公开(公告)日：2012-08-16
申请号：US12997754
申请日：2009-06-12
申请人： Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Brian John Williams , Marian Williams , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud
发明人： Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Brian John Williams , Marian Williams , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud
IPC分类号： A61K31/437 , A61K31/501 , A61P35/00 , C07D513/04 , A61K31/53 , A61K31/506 , C07D471/04 , A61K31/5377
CPC分类号： C07D471/04 , C07D513/04
摘要： The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的双环杂环衍生物化合物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US09145394B2
公开(公告)日：2015-09-29
申请号：US13990193
申请日：2011-11-29
申请人： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Steven John Woodhead , Yannick Aime Eddy Ligny , Patrick René Angibaud
发明人： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Steven John Woodhead , Yannick Aime Eddy Ligny , Patrick René Angibaud
IPC分类号： A61K31/498 , C07D241/40 , C07D403/04 , C07D401/14 , C07D403/14
摘要： The invention relates to new quinoxaline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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10.发明申请SUBSTITUTED BENZOPYRAZIN DERIVATIVES AS FGFR KINASE INHIBITORS FOR THE TREATMENT OF CANCER DISEASES 有权作为FGFR激酶抑制剂治疗癌症疾病的替代苯并噻嗪衍生物公开(公告)号：US20130267525A1
公开(公告)日：2013-10-10
申请号：US13990193
申请日：2011-11-29
申请人： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Steven John Woodhead , Yannick Aime Eddy Ligny , Patrick René Angibaud
发明人： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Steven John Woodhead , Yannick Aime Eddy Ligny , Patrick René Angibaud
IPC分类号： C07D403/04 , C07D401/14 , C07D403/14
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14
摘要： The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及新的喹喔啉衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
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