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公开(公告)号：USD469181S1
公开(公告)日：2003-01-21
申请号：US29149767
申请日：2001-10-15
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公开(公告)号：US06901279B2
公开(公告)日：2005-05-31
申请号：US10912022
申请日：2004-08-04
申请人： Michael D. Cable , Michael Bo Nelson , Bradley W. Rice , Christopher A. Rasco , David N Sprague , David G. Nilson , Rick Dalgetty
发明人： Michael D. Cable , Michael Bo Nelson , Bradley W. Rice , Christopher A. Rasco , David N Sprague , David G. Nilson , Rick Dalgetty
CPC分类号： G02B27/0018 , G01N21/01 , G02B21/16
摘要： An improved imaging apparatus is disclosed that allows a user to perform numerous imaging operations. The imaging apparatus may include one or more improvements to imaging box design to improve illumination control within the imaging box, such as improved door seal arrangements, improved door closing mechanisms, and improved light seals. The present invention may also include one or more improvements to imaging apparatus design to facilitate image capture, such as: an automated filter select device, a moveable stage, automated focus control, f-stop adjustment and stage height, and improved internal illumination for capturing photographic images.
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公开(公告)号：US07555334B2
公开(公告)日：2009-06-30
申请号：US10969230
申请日：2004-10-19
CPC分类号： G01N21/6456 , G01J1/42 , G01N21/763 , G01N2021/6439
摘要： Disclosed are methods and apparatus for collecting light emitted from an animal, where a luminescent reporter has been injected into the animal is disclosed. The apparatus includes a chamber for receiving the animal, wherein the chamber is light tight preventing a substantial portion of light emitted from the animal from escaping the chamber when the chamber is closed and the animal is inside the chamber and a light monitoring device for collecting light from different portions of the animal when the animal is inside the closed chamber. The light monitoring device is arranged to collect light over substantially the entire surface area of the body and head of the animal, and the light monitoring device generates a quantified value based on the light collected from the animal. The animal does not have to be under anesthesia.
摘要翻译： 公开了用于收集从动物发射的光的方法和装置，其中发光报告物已经注射到动物中。 所述装置包括用于接收动物的腔室，其中，所述腔室是不透光的，以防止当所述腔室关闭并且所述动物在所述腔室内时从所述动物发射的大部分光逸出所述腔室;以及用于收集光的光监测装置 当动物在封闭室内时，来自动物的不同部分。 光监视装置被布置成在动物的身体和头部的基本上整个表面区域上收集光，并且光监视装置基于从动物收集的光产生量化值。 动物不必在麻醉下。
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公开(公告)号：US06775567B2
公开(公告)日：2004-08-10
申请号：US09795056
申请日：2001-02-21
申请人： Michael D. Cable , Michael Bo Nelson , Bradley W. Rice , Christopher A. Rasco , David N Sprague , David G. Nilson , Rick Dalgetty
发明人： Michael D. Cable , Michael Bo Nelson , Bradley W. Rice , Christopher A. Rasco , David N Sprague , David G. Nilson , Rick Dalgetty
IPC分类号： A61B505
CPC分类号： G02B27/0018 , G01N21/01 , G02B21/16
摘要： An improved imaging apparatus is disclosed that allows a user to perform numerous imaging operations. The imaging apparatus may include one or more improvements to imaging box design to improve illumination control within the imaging box, such as improved door seal arrangements, improved door closing mechanisms, and improved light seals. The present invention may also include one or more improvements to imaging apparatus design to facilitate image capture, such as: an automated filter select device, a moveable stage, automated focus control, f-stop adjustment and stage height, and improved internal illumination for capturing photographic images.
摘要翻译： 公开了一种改进的成像装置，其允许用户执行许多成像操作。 成像装置可以包括对成像盒设计的一个或多个改进以改善成像盒内的照明控制，例如改进的门密封装置，改进的门关闭机构和改进的光密封。 本发明还可以包括对成像装置设计的一个或多个改进以便于图像捕获，例如：自动滤波器选择装置，可移动台，自动对焦控制，f-停止调整和台高度，以及用于捕获的改进的内部照明 摄影图像。
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公开(公告)号：US07649185B2
公开(公告)日：2010-01-19
申请号：US11682710
申请日：2007-03-06
申请人： Bradley W. Rice , David G. Nilson , Tamara L. Troy
发明人： Bradley W. Rice , David G. Nilson , Tamara L. Troy
CPC分类号： G01N21/278 , A61B5/0071 , A61B5/0073 , A61B5/0084 , A61B2560/0233 , G01J1/08 , G01N21/4795 , G01N21/643 , G09B23/30
摘要： Described herein is a phantom device that simplifies usage, testing, and development of light imaging systems. The phantom device includes a body and a fluorescent light source internal to the body. The body comprises an optical material designed to at least partially resemble the optical behavior of mammalian tissue. The phantom device has many uses. One use of the phantom device permits testing of tomography software in the imaging system, such as software configured for 3D reconstruction of the fluorescent light source. Another use tests spectral unmixing software in the imaging system. The phantom device also allows a user to compare trans- and epi-fluorescent illumination imaging results.
摘要翻译： 这里描述的是简化光成像系统的使用，测试和开发的幻影装置。 幻影装置包括身体和身体内部的荧光光源。 身体包括设计成至少部分类似于哺乳动物组织的光学行为的光学材料。 幻影装置有很多用途。 幻影设备的一个用途允许对成像系统中的断层摄影软件进行测试，例如配置用于荧光光源的3D重建的软件。 另一种用途是在成像系统中测试光谱解混合软件。 幻影装置还允许用户比较透射和外荧光照明成像结果。
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公开(公告)号：US07629573B2
公开(公告)日：2009-12-08
申请号：US10997324
申请日：2004-11-24
CPC分类号： A61B5/0073 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B2560/0233 , G01N21/278 , G01N21/4795 , G01N21/6428 , G01N21/645 , G01N21/6456 , G01N21/763 , G01N2021/6484
摘要： The present invention relates to a phantom device that simplifies usage and testing of a low intensity light imaging system. The phantom device includes a body and a light source internal to the body. The body comprises an optically selective material designed to at least partially resemble the optical behavior of mammalian tissue. Imaging the light source or phantom device may incorporate known properties of the optically selective material. Testing methods described herein assess the performance of a low-level light imaging system (such as the software) by processing light output by the phantom device and comparing the output against known results. The assessment builds a digital representation of the light source or test device and compares one or more components of the digital representation against one or more known properties for the light source or the test device.
摘要翻译： 本发明涉及简化低强度光成像系统的使用和测试的幻影装置。 幻影装置包括身体和身体内部的光源。 身体包括设计成至少部分类似于哺乳动物组织的光学行为的光学选择性材料。 成像光源或幻影装置可以结合光学选择性材料的已知性质。 本文所述的测试方法通过处理幻影装置的光输出并将输出与已知结果进行比较来评估低级光成像系统（例如软件）的性能。 评估建立光源或测试设备的数字表示，并将数字表示的一个或多个组件与光源或测试设备的一个或多个已知属性进行比较。
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公开(公告)号：US09314218B2
公开(公告)日：2016-04-19
申请号：US13164640
申请日：2011-06-20
IPC分类号： G01B11/24 , G01N21/17 , G06G7/48 , A61B6/00 , G01N23/04 , A61B6/03 , A61B5/00 , G01N21/76 , A61B6/04
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0073 , A61B6/032 , A61B6/035 , A61B6/0457 , A61B6/4405 , A61B6/508 , A61B6/5247 , A61B2503/40 , G01N21/763 , G01N23/046 , G01N2223/419
摘要： An integrated microtomography and optical imaging system includes a rotating table that supports an imaging object, an optical stage, and separate optical and microtomography imaging systems. The table rotates the imaging object about a vertical axis running therethrough to a plurality of different rotational positions during a combined microtomography and optical imaging process. The optical stage can be a trans-illumination, epi-illumination or bioluminescent stage. The optical imaging system includes a camera positioned vertically above the imaging object. The microtomography system includes an x-ray source positioned horizontally with respect to the imaging object. Optical and x-ray images are both obtained while the imaging object remains in place on the rotating table. The stage and table are included within an imaging chamber, and all components are included within a portable cabinet. Multiple imaging objects can be imaged simultaneously, and side mirrors can provide side views of the object to the overhead camera.
摘要翻译： 集成的微影像学和光学成像系统包括支持成像对象的旋转台，光学平台以及单独的光学和微影像成像系统。 在组合的微影像学和光学成像过程期间，桌子将成像对象围绕其穿过的垂直轴旋转到多个不同的旋转位置。 光学舞台可以是反照，外照明或生物发光阶段。 光学成像系统包括垂直地位于成像对象上方的照相机。 微图像系统包括相对于成像对象水平定位的x射线源。 当成像对象保持在旋转台上的适当位置时，都获得光学和X射线图像。 舞台和桌子包括在成像室内，所有组件都包含在便携式机柜中。 可以同时对多个成像对象进行成像，并且侧视镜可以向顶置摄像机提供对象的侧视图。
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公开(公告)号：US08279334B2
公开(公告)日：2012-10-02
申请号：US11871062
申请日：2007-10-11
申请人： David Nilson , Michael D. Cable , Bradley W. Rice , Kevin Kearney
发明人： David Nilson , Michael D. Cable , Bradley W. Rice , Kevin Kearney
CPC分类号： G01B11/2513 , A61B5/0059 , A61B5/0064 , A61B5/107 , A61B5/6888 , A61B2503/40 , G01B11/2518 , G01N21/6456 , G01N21/763 , G06T7/521 , H04N13/254
摘要： The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.
摘要翻译： 本发明将结构化光源集成到成像系统中，用于重建被成像物体的表面形貌。 结构化光源包括用于从一角度将一组线传送到物体上的机构。 当它们遇到具有有限高度的对象（例如鼠标）时，线相对于舞台移位或相移。 该相移提供了对象的结构光信息。 相机拍摄结构光信息。 使用采用结构光分析的软件，根据线的相移确定物体的表面形貌数据。
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公开(公告)号：US07589786B2
公开(公告)日：2009-09-15
申请号：US11486239
申请日：2006-07-12
申请人： David Nilson , Michael D. Cable , Bradley W. Rice
发明人： David Nilson , Michael D. Cable , Bradley W. Rice
CPC分类号： G01N21/6456 , A61B5/0059 , A61B2503/40 , G01N21/763
摘要： Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a processor. Structured light images obtained from one or more views within the imaging box may be used to build a structured light representations of the sample.
摘要翻译： 提供了用于拍摄样本图像的系统和方法。 将样品放置在包括可移动台的成像盒中，该移动台允许从成像盒内的各种位置和角度拍摄样品的图像。 图像由相机拍摄并发送到处理器。 可以使用从成像盒内的一个或多个视图获得的结构化光图像来构建样品的结构光表示。
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公开(公告)号：US20110090316A1
公开(公告)日：2011-04-21
申请号：US12947794
申请日：2010-11-16
CPC分类号： G01N21/763 , A61K49/0013 , G01B9/02004 , G01B9/0203 , G01B9/02041 , G01B11/24 , G01B11/2518 , G01N21/6456 , H04N13/204 , H04N13/25 , H04N13/271
摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
摘要翻译： 本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。 哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。 在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。 使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。
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