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公开(公告)号：US07745150B2
公开(公告)日：2010-06-29
申请号：US12400061
申请日：2009-03-09
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/325
摘要： Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart failure can be of any etiology, such as systolic or diastolic heart failure, ischemic or non-ischemic cardiomyopathy.
摘要翻译： 本文公开了通过检测诸如p17片段或p12片段的半胱天冬酶-3的蛋白水解片段来检测和/或预测充血性心力衰竭的方法。 充血性心力衰竭可以是任何病因，如收缩期或舒张期心力衰竭，缺血性或非缺血性心肌病。
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公开(公告)号：US20060180609A1
公开(公告)日：2006-08-17
申请号：US10527230
申请日：2003-09-08
申请人： David Hager , Patrick Kearney
发明人： David Hager , Patrick Kearney
IPC分类号： B67D5/56
CPC分类号： G01F11/34 , B01J2219/00315 , B01J2219/00364 , B01J2219/00414 , B01J2219/00416 , B01J2219/00745 , B01J2219/00756 , B01L3/021 , B01L2200/0657 , B01L2300/0681 , B01L2300/0829 , B01L2400/049 , B65B1/38 , C40B40/18 , C40B60/14 , G01N2035/00188
摘要： The present invention provides apparatus and methods for collecting a plurality of measured quantities of a powdered material and dispensing each of the measured quantities to, for example, a multi-well vessel. Vacuum is used to collect the powdered material and at least one of gravity, a gas push, or a physical push is used to dispense the powdered material. Apparatus and methods of the invention are particularly useful for collection and delivery of powdered materials in high throughput chemical synthesis and biological assay environments where accurate measurement and dispensing of powders is critical.
摘要翻译： 本发明提供了用于收集多个测量量的粉末材料并将每个测量量分配到例如多孔容器的装置和方法。 真空用于收集粉末材料，并且使用重力，气体推动或物理推动中的至少一种来分配粉末材料。 本发明的装置和方法对于在高通量化学合成和生物测定环境中的粉末材料的收集和递送特别有用，其中粉末的精确测量和分配至关重要。
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公开(公告)号：US20090226937A1
公开(公告)日：2009-09-10
申请号：US12400061
申请日：2009-03-09
IPC分类号： G01N33/573 , C12Q1/34
CPC分类号： G01N33/6893 , G01N2800/325
摘要： Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart failure can be of any etiology, such as systolic or diastolic heart failure, ischemic or non-ischemic cardiomyopathy.
摘要翻译： 本文公开了通过检测诸如p17片段或p12片段的半胱天冬酶-3的蛋白水解片段来检测和/或预测充血性心力衰竭的方法。 充血性心力衰竭可以是任何病因，如收缩期或舒张期心力衰竭，缺血性或非缺血性心肌病。
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公开(公告)号：US08575855B2
公开(公告)日：2013-11-05
申请号：US12982749
申请日：2010-12-30
申请人： Sunita Carrasco , David Hager , Tack-Boon Yee
发明人： Sunita Carrasco , David Hager , Tack-Boon Yee
IPC分类号： H01J17/06
CPC分类号： H01J61/78 , G01N21/3103 , G01N2021/3118 , G07C3/08 , H01J61/09 , H01J61/56
摘要： A hollow cathode lamp is described with an end cap, an anode, and a cathode. A data storage device is part of the end cap and communicates data to and from a computing device. The data communicated with the computing device may include identification information and usage information corresponding to the hollow cathode lamp. Additionally, a method is described that includes activating a power supply to a hollow cathode lamp and communicating data with a memory device located in the hollow cathode lamp. The data communicated with the memory device includes usage information about an amount of time the hollow cathode lamp has been in use.
摘要翻译： 用端盖，阳极和阴极描述空心阴极灯。 数据存储设备是端盖的一部分，并将数据传送到计算设备和从计算设备传送数据。 与计算设备通信的数据可以包括与空心阴极灯对应的识别信息和使用信息。 此外，描述了一种方法，其包括激活到空心阴极灯的电源并且与位于中空阴极灯中的存储器件通信数据。 与存储装置通信的数据包括关于中空阴极灯已经使用的时间量的使用信息。
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公开(公告)号：US20100203566A1
公开(公告)日：2010-08-12
申请号：US12765351
申请日：2010-04-22
IPC分类号： C12Q1/37
CPC分类号： G01N33/6893 , G01N2800/325
摘要： Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart failure can be of any etiology, such as systolic or diastolic heart failure, ischemic or non-ischemic cardiomyopathy.
摘要翻译： 本文公开了通过检测诸如p17片段或p12片段的半胱天冬酶-3的蛋白水解片段来检测和/或预测充血性心力衰竭的方法。 充血性心力衰竭可以是任何病因，如收缩期或舒张期心力衰竭，缺血性或非缺血性心肌病。
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公开(公告)号：US20050226786A1
公开(公告)日：2005-10-13
申请号：US10797978
申请日：2004-03-10
申请人： David Hager , Jeffrey Donaldson , Patrick Kearney , Douglas Keller , James Leahy , Robert Mercer , Michael Morrissey , Troy Swartwood
发明人： David Hager , Jeffrey Donaldson , Patrick Kearney , Douglas Keller , James Leahy , Robert Mercer , Michael Morrissey , Troy Swartwood
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00313 , B01J2219/00319 , B01J2219/00333 , B01J2219/00423 , B01L3/5025 , B01L3/50255 , B01L3/563 , B01L3/5635 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/0642 , B01L2400/0487 , B01L2400/049 , C40B60/14 , G01N35/1074 , Y10T436/25
摘要： A multi-well assembly according to one embodiment comprises a multi-well block and a guide plate. The multi-well block defines a plurality of wells, with each well having a fluid-impermeable bottom surface. The guide plate defines a plurality of fluid passageways corresponding to the wells of the multi-well block. The guide plate is configured such that, whenever the guide plate is registered with the multi-well block, fluid communication is established between each well and an associated fluid passageway. The guide plate enables iterative chemical or biological processes using multiple multi-well blocks. A seal plate is configured to cut fluid communication conferred by the guide plate via registration with the guide plate, or via registration with the multi-well block (once the guide plate is removed). The seal plate allows iterative chemical or biological processes within a single multi-well block.
摘要翻译： 根据一个实施例的多孔组件包括多孔块和引导板。 多孔块限定多个井，每个井具有不透液体的底表面。 引导板限定对应于多井区块的井的多个流体通道。 引导板被构造成使得每当导板与多孔块对准时，在每个井和相关联的流体通道之间建立流体连通。 引导板使得能够使用多个多孔块的迭代化学或生物过程。 密封板构造成通过与引导板对准或者通过与多孔块对准（一旦导板被移除）来切割由引导板赋予的流体连通。 密封板允许单个多孔块内的迭代化学或生物过程。
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公开(公告)号：US20120169237A1
公开(公告)日：2012-07-05
申请号：US12982749
申请日：2010-12-30
申请人： Sunita Carrasco , David Hager , Tack-Boon Yee
发明人： Sunita Carrasco , David Hager , Tack-Boon Yee
CPC分类号： H01J61/78 , G01N21/3103 , G01N2021/3118 , G07C3/08 , H01J61/09 , H01J61/56
摘要： A hollow cathode lamp is described with an end cap, an anode, and a cathode. A data storage device is part of the end cap and communicates data to and from a computing device. The data communicated with the computing device may include identification information and usage information corresponding to the hollow cathode lamp. Additionally, a method is described that includes activating a power supply to a hollow cathode lamp and communicating data with a memory device located in the hollow cathode lamp. The data communicated with the memory device includes usage information about an amount of time the hollow cathode lamp has been in use.
摘要翻译： 用端盖，阳极和阴极描述空心阴极灯。 数据存储设备是端盖的一部分，并将数据传送到计算设备和从计算设备传送数据。 与计算设备通信的数据可以包括与空心阴极灯对应的识别信息和使用信息。 此外，描述了一种方法，其包括激活到空心阴极灯的电源并且与位于中空阴极灯中的存储器件通信数据。 与存储装置通信的数据包括关于中空阴极灯已经使用的时间量的使用信息。
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公开(公告)号：US07998690B2
公开(公告)日：2011-08-16
申请号：US12765351
申请日：2010-04-22
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/325
摘要： Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart failure can be of any etiology, such as systolic or diastolic heart failure, ischemic or non-ischemic cardiomyopathy.
摘要翻译： 本文公开了通过检测诸如p17片段或p12片段的半胱天冬酶-3的蛋白水解片段来检测和/或预测充血性心力衰竭的方法。 充血性心力衰竭可以是任何病因，如收缩期或舒张期心力衰竭，缺血性或非缺血性心肌病。
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