公开(公告)号：US5037013A

公开(公告)日：1991-08-06

申请号：US430341

申请日：1989-11-02

申请人： David J. Howlett

发明人： David J. Howlett

IPC分类号： B65D83/44 ,  B05B9/04 ,  B65D83/14

CPC分类号： B65D83/54

摘要： Dispensing apparatus (1) for dispensing a liquid product (24) from a pressurized dispensing container (21) comprises a collapsible chamber metering valve (2) in which an elastomeric sleeve (4) overlays an external surface (53) of the valve body (6) to define a metering chamber (7) therebetween and is collapsible on actuation of the valve into substantially conformal contact with the external surface such that a volume of liquid is dispensed which is equal to the volume of liquid displaced from the metering chamber. The valve is nestably received within a cup (3) with seal means (15) operable between the mouth of the cup and an outer end of the valve such that a closed collecting chamber (11) is defined between the valve and the cup. Means (25) are provided to communicate in use between the collecting chamber and that part of the container in which a liquid product is contained when the container is held in a predetermined orientation for operation of the valve. The apparatus allows accurate doses of liquids to be dispensed using compressed gas propellant such as nitrogen.

公开(公告)号：US4858790A

公开(公告)日：1989-08-22

申请号：US236398

申请日：1988-08-25

申请人： David J. Howlett

发明人： David J. Howlett

IPC分类号： F16K21/04 ,  B65D83/14 ,  F16K7/00 ,  F16K7/02 ,  F16K21/00

CPC分类号： B65D83/54

摘要： A collapsible chamber metering valve for use in a pressurized dispensing container 2 comprises a generally cylindrical body 3, an elastomeric sleeve 12 coaxially overlaying the body and defining a collapsible chamber 14 therebetween, the body defining an internal chamber 18, channel means 31 providing a fluid flowpath between the internal chamber and the collapsible chamber, an axially slidable valve actuating stem 6 extending coaxially through the internal chamber, outlet valve means 33 operable between the stem and the body at the outer end of the internal chamber so as to dispense fluid therefrom in an open condition of the valve and inlet valve means 21 operable between the body and the stem at the inner end of the internal chamber to admit fluid thereto in a closed condition of the valve wherein the inlet valve means comprises an annular seal portion 29 of the sleeve cooperating with an inner end portion 8 of the stem extending therethrough and wherein the sleeve further comprises an annular shoulder portion 16 nestably receiving the inner end 15 of the body, the shoulder portion and the seal portion being integrally formed of relatively thick and thin material respectively whereby the shoulder portion and seal portion are relatively rigid and flexible respectively so as to positively locate the sleeve upon the valve body while permitting deformation of the seal portion.

公开(公告)号：US07146977B2

公开(公告)日：2006-12-12

申请号：US10670924

申请日：2003-09-25

申请人： Russell Beavis ,  Larry B. Gray ,  David J. Howlett

发明人： Russell Beavis ,  Larry B. Gray ,  David J. Howlett

IPC分类号： A61M15/00 ,  A62B7/00

CPC分类号： A61M15/008 ,  A61M15/0003 ,  A61M15/002 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0065 ,  A61M15/0066 ,  A61M15/0068 ,  A61M15/0085 ,  A61M15/009 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2202/03 ,  A61M2205/3306 ,  A61M2205/3368 ,  A61M2205/3375 ,  A61M2205/3379 ,  A61M2205/50 ,  A61M2205/52 ,  B05B12/006 ,  B05B12/085 ,  G01F1/007 ,  G01F17/00 ,  G01F22/00 ,  G01F23/14 ,  G01H3/00 ,  G10K9/04

摘要： An apparatus comprises a variable acoustic source and a microphone, both acoustically coupled to a volume having a fluid region and an air region. The apparatus also can include a processor to determine a volume of the air region based on signals received from the microphone and the variable acoustic source. A fluid valve is coupled to the processor, and is configured to allow an amount of fluid to exit the fluid region associated with the volume of the air region. An atomizer, coupled to the fluid region, is configured to aerosolize at least a portion of the fluid.

摘要翻译： 一种装置包括声音耦合到具有流体区域和空气区域的体积的可变声源和麦克风。 该装置还可以包括处理器，用于基于从麦克风和可变声源接收的信号来确定空气区域的体积。 流体阀联接到处理器，并且被配置为允许一定量的流体离开与空气区域的体积相关联的流体区域。 耦合到流体区域的雾化器被配置为使至少一部分流体雾化。

公开(公告)号：US4896832A

公开(公告)日：1990-01-30

申请号：US236397

申请日：1988-08-25

申请人： David J. Howlett

发明人： David J. Howlett

IPC分类号： G01F11/28 ,  A61M15/00 ,  B65D83/14 ,  G01F13/00 ,  B05B11/02

CPC分类号： A61M15/0065 ,  A61M15/009 ,  B65D83/38 ,  B65D83/386 ,  B65D83/62 ,  B65D83/64 ,  A61M2205/07

摘要： A dispensing apparatus comprises a pressurised dispensing container (3), a housing (2) for the container defining a bore, the container having a body (50) which is axially slidable in the bore, the container having a collapsible metering valve (8) located at a first end (6) of the body for dispensing metered quantities of fluid and actuated by axial depression of a valve stem (9) defining a dispensing flowpath, a valve actuator (11) fixedly connected to the housing at a corresponding first end (7) thereof and defining a further dispensing flowpath for product fluid dispensed through the stem, and trigger means (30) operable to urge the container body axially towards the first end of the housing such that the valve stem is depressed by relative movement together of the valve and actuator and thereby dispensing a metered quantity of fluid, wherein the container body defines a chamber (4) and the container includes means (5) dividing the chamber into a product fluid reservoir (25) communicating with the valve and a propellant fluid reservoir (26), the dividing means being movable such that propellant pressure is applied to the product fluid without mixing of the respective fluids. The apparatus is suitable for the nasal administration of insulin.

摘要翻译： 分配装置包括加压分配容器（3），用于容器的壳体（2），其限定孔，所述容器具有可在所述孔中轴向滑动的主体（50），所述容器具有可折叠的计量阀（8） 位于主体的第一端（6），用于分配计量的流体并通过限定分配流路的阀杆（9）的轴向压下致动;阀致动器（11），其在相应的第一端处固定地连接到壳体 （7）并且限定用于通过所述杆分配的产品流体的另外的分配流路，以及触发装置（30），其可操作以朝向所述壳体的第一端轴向推动所述容器主体，使得所述阀杆通过相对运动 阀和致动器，从而分配计量的流体，其中容器主体限定腔室（4），并且容器包括将腔室分成产品流体储存器（25）的装置（5） 与阀门和推进剂流体储存器（26）对齐，分隔装置可移动，使得推进剂压力施加到产品流体而不混合各流体。 该装置适用于鼻内施用胰岛素。

公开(公告)号：US4842495A

公开(公告)日：1989-06-27

申请号：US111548

申请日：1987-10-23

申请人： David J. Howlett

发明人： David J. Howlett

IPC分类号： F04B53/10 ,  B05B11/00 ,  B65D47/34 ,  F04B9/14 ,  F04B53/12

CPC分类号： B05B11/3074 ,  B05B11/0059 ,  B05B11/0097 ,  B05B11/3026 ,  B05B11/3039

摘要： A pump assembly (1) for an atomizing piston pump comprising a piston (16) slidably located in a cylinder (4), a variable volume fluid storage chamber (5) in communication with the cylinder on one side of the piston, means (18) for varying the volume of the chamber, resilient means (17) urging the varying means into a position corresponding to the minimum volume of the chamber, a fluid flow passageway (30, 31) through the piston, a resilient valve member (25) normally closing the passageway and deforming means (23) for deforming the valve member so as to open the passageway only after the piston has moved relative to the cylinder by a predetermined amount greater than zero. The pump assembly has application to dispensing metered doses of medicinal products and ensures that the dispensed dose is independent of finger pressure applied to the actuator.

摘要翻译： 一种用于雾化活塞泵的泵组件（1），包括可滑动地位于气缸（4）中的活塞（16），与活塞一侧的气缸连通的可变体积流体储存室（5） ），用于改变所述腔室的体积;弹性装置（17），其将所述变化装置推动到对应于所述腔室的最小体积的位置;通过所述活塞的流体流动通道（30,31）;弹性阀构件（25） 通常关闭通道和变形装置（23），用于使阀构件变形，以便仅在活塞相对于气缸移动大于零的预定量之后才打开通道。 泵组件可用于分配计量剂量的药用产品，并确保分配剂量与施加到致动器上的手指压力无关。