公开(公告)号：US06261848B1

公开(公告)日：2001-07-17

申请号：US09074644

申请日：1998-05-08

申请人： Charles W. Anderson ,  C. Brent Bargeron ,  Richard C. Benson ,  Micah A. Carlson ,  Allan B. Fraser ,  John D. Groopman ,  Harvey W. Ko ,  David R. Kohler ,  Terry E. Phillips ,  Paul T. Strickland

发明人： Charles W. Anderson ,  C. Brent Bargeron ,  Richard C. Benson ,  Micah A. Carlson ,  Allan B. Fraser ,  John D. Groopman ,  Harvey W. Ko ,  David R. Kohler ,  Terry E. Phillips ,  Paul T. Strickland

IPC分类号： G01N33543

CPC分类号： G01N1/40 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2400/0481 ,  G01N1/405 ,  G01N21/6428 ,  G01N21/645 ,  G01N30/02 ,  G01N33/54373 ,  G01N33/582 ,  G01N2001/022 ,  G01N2201/0221 ,  B01D15/3804

摘要： A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined. The rinsing and elution fluids, and/or the affinity column can be placed in a module for easy insertion and removal from the sensor when depleted or when the sensor is to be used against a different analyte.

公开(公告)号：US06969605B2

公开(公告)日：2005-11-29

申请号：US09906243

申请日：2001-07-16

申请人： Charles W. Anderson ,  C. Brent Bargeron ,  Richard C. Benson ,  Micah A. Carlson ,  Allan B. Fraser ,  John D. Groopman ,  Harvey W. Ko ,  David R. Kohler ,  Terry E. Phillips ,  Paul T. Strickland

发明人： Charles W. Anderson ,  C. Brent Bargeron ,  Richard C. Benson ,  Micah A. Carlson ,  Allan B. Fraser ,  John D. Groopman ,  Harvey W. Ko ,  David R. Kohler ,  Terry E. Phillips ,  Paul T. Strickland

IPC分类号： B01L3/00 ,  G01N1/02 ,  G01N1/40 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N30/02 ,  G01N33/543 ,  G01N33/58 ,  C12M3/00

CPC分类号： G01N1/40 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2400/0481 ,  G01N1/405 ,  G01N21/6428 ,  G01N21/645 ,  G01N30/02 ,  G01N33/54373 ,  G01N33/582 ,  G01N2001/022 ,  G01N2201/0221 ,  B01D15/3804

摘要： A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined. The rinsing and elution fluids, and/or the affinity column can be placed in a module for easy insertion and removal from the sensor when depleted or when the sensor is to be used against a different analyte.

摘要翻译： 用于检测和量化多种分析物的手持式，独立的，自动的，低功率和快速的传感器平台。 可能含有未知量的分析物的样品溶液通过亲和柱，其包含分析物结合的抗体，从而提取分析物。 然后漂洗亲和柱以除去可能发荧光的任何其他化学物质。 然后用已知体积的洗脱液洗脱漂洗的亲和柱，使得分析物从抗体中释放并溶解在流体（洗脱剂）中。 然后将洗脱液置于荧光计的石英比色杯中。 悬浮在洗脱液中的分析物以与激发它的光源不同的波段发出荧光。 测量荧光的量并测定分析物的水平。 冲洗和洗脱流体和/或亲和柱可以放置在模块中，以便在耗尽时或当传感器用于抵抗不同分析物时容易地从传感器中插入和移除。

公开(公告)号：US20080254502A1

公开(公告)日：2008-10-16

申请号：US12141298

申请日：2008-06-18

申请人： George M. Murray ,  Cheryl S. Schein ,  David R. Kohler ,  Jennifer L. Sample ,  Jennifer A. Nix ,  Protagoras N. Cutchis ,  Adam K. Arabian ,  Harvey W. Ko ,  Micah A. Carlson ,  Michael P. McLoughlin

发明人： George M. Murray ,  Cheryl S. Schein ,  David R. Kohler ,  Jennifer L. Sample ,  Jennifer A. Nix ,  Protagoras N. Cutchis ,  Adam K. Arabian ,  Harvey W. Ko ,  Micah A. Carlson ,  Michael P. McLoughlin

IPC分类号： C12Q1/04 ,  C12M1/00

CPC分类号： G01N21/645 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6486 ,  G01N2021/6413 ,  G01N2021/6421

摘要： A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.

摘要翻译： 提供了一种用于评估生物气溶胶样品的方法和装置，其包括检测频率和/或时间分辨率因子，其允许区分由生物气溶胶发射的多个信号，以从非生物来源的材料中选择性地检测生物气溶胶样品中包含的生物材料 并且可能与致病性生物气溶胶相关。

公开(公告)号：US20110049390A1

公开(公告)日：2011-03-03

申请号：US12939265

申请日：2010-11-04

申请人： George M. Murray ,  Cheryl S. Schein ,  David R. Kohler ,  Jennifer L. Sample ,  Jennifer A. Nix ,  Protagoras N. Cutchis ,  Adam K. Arabian ,  Harvey W. Ko ,  Micah A. Carlson ,  Michael P. McLoughlin

发明人： George M. Murray ,  Cheryl S. Schein ,  David R. Kohler ,  Jennifer L. Sample ,  Jennifer A. Nix ,  Protagoras N. Cutchis ,  Adam K. Arabian ,  Harvey W. Ko ,  Micah A. Carlson ,  Michael P. McLoughlin

IPC分类号： G01N21/64 ,  G01J1/58

CPC分类号： G01N21/645 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6486 ,  G01N2021/6413 ,  G01N2021/6421

摘要： A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.

摘要翻译： 提供了一种用于评估生物气溶胶样品的方法和装置，其包括检测频率和/或时间分辨率因子，其允许区分由生物气溶胶发射的多个信号，以从非生物来源的材料中选择性地检测生物气溶胶样品中包含的生物材料 并且可能与致病性生物气溶胶相关。

公开(公告)号：US07494769B2

公开(公告)日：2009-02-24

申请号：US10503168

申请日：2003-04-16

申请人： George M. Murray ,  Cheryl S. Schein ,  David R. Kohler ,  Jennifer L. Sample ,  Jennifer A. Nix ,  Protagoras N. Cutchis ,  Adam K. Arabian ,  Harvey W. Ko ,  Micah A. Carlson ,  Michael P. McLoughlin

发明人： George M. Murray ,  Cheryl S. Schein ,  David R. Kohler ,  Jennifer L. Sample ,  Jennifer A. Nix ,  Protagoras N. Cutchis ,  Adam K. Arabian ,  Harvey W. Ko ,  Micah A. Carlson ,  Michael P. McLoughlin

IPC分类号： C12Q1/70

CPC分类号： G01N21/645 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6486 ,  G01N2021/6413 ,  G01N2021/6421

摘要： A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.

摘要翻译： 提供了一种用于评估生物气溶胶样品的方法和装置，其包括检测频率和/或时间分辨率因子，其允许区分由生物气溶胶发射的多个信号，以从非生物来源的材料中选择性地检测生物气溶胶样品中包含的生物材料 并且可能与致病性生物气溶胶相关。

公开(公告)号：US07830515B2

公开(公告)日：2010-11-09

申请号：US12141298

申请日：2008-06-18

申请人： George M. Murray ,  Cheryl S. Schein ,  David R. Kohler ,  Jennifer L. Sample ,  Jennifer A. Nix ,  Protagoras N. Cutchis ,  Adam K. Arabian ,  Harvey W. Ko ,  Micah A. Carlson ,  Michael P. McLoughlin

发明人： George M. Murray ,  Cheryl S. Schein ,  David R. Kohler ,  Jennifer L. Sample ,  Jennifer A. Nix ,  Protagoras N. Cutchis ,  Adam K. Arabian ,  Harvey W. Ko ,  Micah A. Carlson ,  Michael P. McLoughlin

IPC分类号： G01N21/25

CPC分类号： G01N21/645 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6486 ,  G01N2021/6413 ,  G01N2021/6421

摘要： A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.

摘要翻译： 提供了一种用于评估生物气溶胶样品的方法和装置，其包括检测频率和/或时间分辨率因子，其允许区分由生物气溶胶发射的多个信号，以从非生物来源的材料中选择性地检测生物气溶胶样品中包含的生物材料 并且可能与致病性生物气溶胶相关。

公开(公告)号：US06841773B2

公开(公告)日：2005-01-11

申请号：US10069894

申请日：2001-05-23

申请人： Michael P. McLoughlin ,  William R. Allmon ,  Charles W. Anderson ,  Micah A. Carlson ,  Nicholas H. Evancich ,  Wayne A. Bryden ,  Scott A. Ecelberger ,  James T. Velky ,  Daniel J. DeCicco ,  Timothy J. Cornish

发明人： Michael P. McLoughlin ,  William R. Allmon ,  Charles W. Anderson ,  Micah A. Carlson ,  Nicholas H. Evancich ,  Wayne A. Bryden ,  Scott A. Ecelberger ,  James T. Velky ,  Daniel J. DeCicco ,  Timothy J. Cornish

IPC分类号： G01N27/62 ,  G01N1/00 ,  G01N1/02 ,  H01J49/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/16 ,  H01J49/24 ,  H01J49/40

CPC分类号： H01J49/0409 ,  H01J49/0022 ,  H01J49/40 ,  Y10T436/24

摘要： A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.

摘要翻译： 一种现场便携式质谱仪系统，包括样品收集器和样品转运器。 样品转运器与样品收集器接口以在其上接收样品沉积物。 该系统还包括飞行时间（TOF）质谱仪。 飞行时间质谱仪具有可密封的开口，其接收在质谱仪的提取区域中通过样品转运器传送的样品。 该系统还包括控制单元，其处理由质谱仪输出的时间序列用于接收的样本，并识别样品中包含的一种或多种试剂。

公开(公告)号：US07125437B2

公开(公告)日：2006-10-24

申请号：US10473530

申请日：2003-04-14

申请人： Wayne A. Bryden ,  Peter F. Scholl ,  Micah A. Carlson ,  Michael P. McLoughlin

发明人： Wayne A. Bryden ,  Peter F. Scholl ,  Micah A. Carlson ,  Michael P. McLoughlin

IPC分类号： G01N1/00 ,  B01D53/14

CPC分类号： G01N15/0255 ,  G01N1/2202 ,  G01N1/24 ,  G01N15/065 ,  G01N2001/2223 ,  G01N2015/0261

摘要： A method and apparatus for particle collection (30) that is characterized by co-aerosolizing fluids (62) into an air stream (34) containing the particles to be analyzed to significantly enhance their collection and identification efficiency is provided.

摘要翻译： 提供了一种用于颗粒收集（30）的方法和装置，其特征在于将流体（62）共同雾化成含有要分析的颗粒的空气流（34）以显着增强其收集和识别效率。

公开(公告)号：US06957592B2

公开(公告)日：2005-10-25

申请号：US10419340

申请日：2003-04-21

申请人： Wayne I. Sternberger ,  Stuart A. Goemmer ,  Rebecca F. Vertes ,  Micah A. Carlson ,  William R. Allmon ,  Alexander E. Dence ,  Stanley G. Reach ,  Adam K. Arabian

发明人： Wayne I. Sternberger ,  Stuart A. Goemmer ,  Rebecca F. Vertes ,  Micah A. Carlson ,  William R. Allmon ,  Alexander E. Dence ,  Stanley G. Reach ,  Adam K. Arabian

IPC分类号： B01L3/00 ,  G01N1/14 ,  G01N1/40 ,  G01N33/18 ,  G01N1/00

CPC分类号： B01L3/502 ,  B01L2200/18 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2400/086 ,  G01N1/14 ,  G01N1/405 ,  G01N33/18 ,  G01N2001/021

摘要： The invention comprises a vessel for solid phase micro-extraction chemical sampling. The vessel includes a container having an open end and a cap used to close the open end. The cap has a holder to hold a solid phase coated fiber within an interior of the container. There also is an inlet at a first location of the vessel and an outlet at a second location of the vessel. The inlet and the outlet are adapted to fill the vessel with a material to be exposed to the solid phase coated fiber. The vessel also includes a diffuser plate attached to the container. The plate is adapted to reduce fluid forces exerted on the solid phase coated fiber as material flows from the inlet to the outlet. The purpose of the diffuser plate is both to assure that forces are reduced and to provide laminar flow to assure rapid and complete exchange of the fluid in the vessel.

摘要翻译： 本发明包括用于固相微萃取化学取样的容器。 容器包括具有开口端的容器和用于封闭开口端的盖子。 盖具有用于将固相涂布纤维保持在容器内部的保持器。 在容器的第一位置还有在容器的第二位置处的出口。 入口和出口适于将容器暴露于固相涂覆纤维的材料填充。 容器还包括附接到容器的扩散板。 该板适于当材料从入口流到出口时减少施加在固相涂覆纤维上的流体力。 扩散板的目的是确保力减少并提供层流以确保容器中的流体的快速和完全的更换。

公开(公告)号：US06796164B2

公开(公告)日：2004-09-28

申请号：US10288128

申请日：2002-11-04

申请人： Michael P. McLoughlin ,  Micah A. Carlson

发明人： Michael P. McLoughlin ,  Micah A. Carlson

IPC分类号： G01N100

CPC分类号： G01N1/2273 ,  G01N35/1004 ,  G01N2001/2217

摘要： An integrated fluidics system for simplified analysis of aerosolize biological particles has a unitary self-contained ticket provided with a sample fluid reservoir, an array of particle-detection strips, which is located adjacent to the sample reservoir, and, optionally, a cleaning fluid reservoir and an impinging nozzle. The fluidics system is, thus, configured to substantially minimize the fluid paths between the components of the system.

摘要翻译： 用于简化气雾化生物颗粒分析的集成流体系统具有一个单独的独立票，其中提供有样品流体储存器，位于样本储存器附近的颗粒检测条的阵列，以及可选地，清洁流体储存器 和冲击喷嘴。 因此，流体系统构造成基本上最小化系统的部件之间的流体路径。