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公开(公告)号：US20130028954A1
公开(公告)日：2013-01-31
申请号：US13630890
申请日：2012-09-28
CPC分类号： A61F13/00034 , A61F13/00029 , A61F13/00063 , A61F13/00991 , A61F2013/00106 , A61F2013/00463 , A61F2013/00472 , A61F2013/0054 , A61F2013/0091 , A61F2013/00927 , A61K38/4833 , A61L15/225 , A61L15/32 , A61L15/64 , A61L2400/04 , C08L89/00
摘要： The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue.
摘要翻译： 本发明涉及一种止血敷料，其包含含有可再吸收材料和/或凝结蛋白质的多个层。 特别地，本发明包括敷料，其中一层凝血酶夹在第一和第二层纤维蛋白原之间，其中凝血酶层与纤维蛋白原的第一和/或第二层不共同延伸。 止血敷料可用于治疗伤口组织。
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公开(公告)号：US20120321692A1
公开(公告)日：2012-12-20
申请号：US13302019
申请日：2012-02-07
申请人： Martin MacPhee , Jerry Kanellos , Belinda Wilmer , Dawson Beall
发明人： Martin MacPhee , Jerry Kanellos , Belinda Wilmer , Dawson Beall
IPC分类号： A61K38/36 , A61K9/127 , A61K38/19 , A61K39/395 , A61K38/48 , A61K38/18 , A61K38/22 , A61P31/00 , A61P7/02 , A61P9/00 , A61P35/00 , A61P31/12 , A61P31/10 , A61P33/00 , A61P29/00 , A61P3/02 , A61P17/02 , A61B17/03 , A61K9/70
CPC分类号： A61L15/64 , A61B17/00491 , A61B17/0057 , A61B2017/0065 , A61F2013/00472 , A61K38/363 , A61K38/4833 , A61L15/28 , A61L15/32 , A61L15/44 , A61L26/0042 , A61L26/009 , A61L2300/23 , A61L2300/252 , A61L2300/254 , A61L2400/04 , C12Y304/21005
摘要： Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings.
摘要翻译： 披露了基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的固体和冷冻止血材料和敷料。 还公开了通过应用这些止血材料和敷料中的一种或多种来治疗哺乳动物的内部受伤组织的方法。
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公开(公告)号：US20110196421A1
公开(公告)日：2011-08-11
申请号：US13080086
申请日：2011-04-05
申请人： Martin MacPhee , Jerry Kanellos , Belinda Wilmer , Dawson Beall
发明人： Martin MacPhee , Jerry Kanellos , Belinda Wilmer , Dawson Beall
IPC分类号： A61B17/03
CPC分类号： A61L15/64 , A61B17/00491 , A61B17/0057 , A61B2017/0065 , A61F2013/00472 , A61K38/363 , A61K38/4833 , A61L15/28 , A61L15/32 , A61L15/44 , A61L26/0042 , A61L26/009 , A61L2300/23 , A61L2300/252 , A61L2300/254 , A61L2400/04 , C12Y304/21005
摘要： Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings.
摘要翻译： 披露了基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的固体和冷冻止血材料和敷料。 还公开了通过应用这些止血材料和敷料中的一种或多种来治疗哺乳动物的内部受伤组织的方法。
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公开(公告)号：US20080033331A1
公开(公告)日：2008-02-07
申请号：US11882874
申请日：2007-08-06
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator, wherein the haemostatic layer(s) is cast or formed from a single aqueous solution containing the fibrinogen component and the fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen compositions useful for preparing the haemostatic layer(s) of these dressings.
摘要翻译： 公开了用于哺乳动物患者例如人的治疗伤口组织的固体敷料，其包含基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的止血层，其中止血层由含有 纤维蛋白原组分和纤维蛋白原激活剂。 还公开了使用这些敷料和用于制备这些敷料的止血层的冷冻组合物来治疗伤口组织的方法。
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公开(公告)号：US06762336B1
公开(公告)日：2004-07-13
申请号：US09890795
申请日：2002-03-22
申请人： Martin J. MacPhee , William H. Drohan , Dawson Beall , Stanley A. Friedman , David Tuthill , Valdislav Bayer
发明人： Martin J. MacPhee , William H. Drohan , Dawson Beall , Stanley A. Friedman , David Tuthill , Valdislav Bayer
IPC分类号： A61F1300
CPC分类号： A61L15/32 , A61L15/225 , A61L15/26 , A61L2400/04 , C08L89/00 , C08L67/04
摘要： The present invention relates to a haemostatic multilayer bandage that comprises preferably a thrombin layer between two fibrinogen layers. The dressing may contain other resorbable materials such as glycolic acid or lactic acid based polymers or copolymers. The inventive haemostatic bandage is useful for the treatment of wounded tissue.
摘要翻译： 本发明涉及一种止血性多层绷带，其优选地包含两个纤维蛋白原层之间的凝血酶层。 敷料可以含有其它可再吸收的材料，例如乙醇酸或乳酸基聚合物或共聚物。 本发明的止血绷带可用于治疗受伤组织。
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6.发明申请COMPOSITIONS HAVING ABSORBABLE MATERIALS, METHODS, AND APPLICATORS FOR SEALING INJURIES 审中-公开具有可吸收材料的组合物，密封伤口的方法和应用公开(公告)号：US20160022861A1
公开(公告)日：2016-01-28
申请号：US14776721
申请日：2014-03-15
申请人： Martin MACPHEE , Dawson BEALL , Jennifer BRICHETTI , Belinda WILMER , STB, LTD.
CPC分类号： A61F13/15 , A61F13/00034 , A61F13/2002 , A61F13/26 , A61F13/266 , A61F2013/00357 , A61F2013/00472 , A61F2013/15008 , A61F2013/15284 , A61F2013/2014 , A61L15/32 , A61L15/44 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/0073 , A61L24/106 , A61L2300/00 , A61L2300/418 , A61L2300/60 , A61L2400/04
摘要： Disclosed are solid and frozen haemostatic materials utilizing an absorbable scaffolding material and consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings, particularly for the treatment of injured tissue via endoscopic or minimally-invasive surgical techniques.
摘要翻译： 公开了使用可吸收脚手架材料并基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的固体和冷冻止血材料。 还公开了通过应用一种或多种这些止血材料和敷料来治疗哺乳动物的内部受伤组织的方法，特别是通过内窥镜或微创手术技术治疗损伤的组织。
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公开(公告)号：US20120150087A1
公开(公告)日：2012-06-14
申请号：US13364837
申请日：2012-02-02
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
IPC分类号： A61F13/02 , A61K9/00 , A61K39/395 , A61P7/04 , A61K39/00 , A61K9/127 , A61P17/02 , A61K38/48 , A61K38/19
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and thrombin, wherein the thrombin is present in an amount between 0.250 Units/mg of fibrinogen component and 0.062 Units/mg of fibrinogen component. Also disclosed are methods for treating wounded tissue.
摘要翻译： 公开了哺乳动物患者（例如人）中治疗的受伤组织的固体敷料，其包含基本上由纤维蛋白原成分和凝血酶组成的止血层，其中凝血酶以0.250单位/ mg纤维蛋白原成分和0.062单位/ mg纤维蛋白原成分。 还公开了治疗伤口组织的方法。
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公开(公告)号：US20080033332A1
公开(公告)日：2008-02-07
申请号：US11882876
申请日：2007-08-06
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
IPC分类号： A61F13/00
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of fibrinogen and a fibrinogen activator, wherein the fibrinogen is present in an amount between 3.0 mg/cm2 of the wound facing surface of the dressing and 13.0 mg/cm2 of the wound facing surface of the dressing. Also disclosed are methods for treating wounded tissue.
摘要翻译： 公开了用于哺乳动物患者例如人的治疗伤口组织的固体敷料，其包含基本上由纤维蛋白原和纤维蛋白原激活剂组成的止血层，其中纤维蛋白原以3.0mg / cm 2 / >敷料的面向伤口的表面和敷料的面向伤口表面的13.0mg / cm 2。 还公开了治疗伤口组织的方法。
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公开(公告)号：US20130287837A1
公开(公告)日：2013-10-31
申请号：US13843604
申请日：2013-03-15
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
IPC分类号： A61L26/00
CPC分类号： A61L15/44 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0206 , A61F13/0223 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00927 , A61F2013/00931 , A61L15/225 , A61L15/32 , A61L15/38 , A61L15/64 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L2300/418 , A61L2400/04 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator, wherein the haemostatic layer(s) is cast or formed from a single aqueous solution containing the fibrinogen component and the fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen compositions useful for preparing the haemostatic layer(s) of these dressings.
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10.发明授权公开(公告)号：US08445009B2
公开(公告)日：2013-05-21
申请号：US11882872
申请日：2007-08-06
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are processes for preparing solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen and liquid compositions useful for preparing the haemostatic layer(s) of these dressings or for treating wounded tissue in a mammal.
摘要翻译： 公开的是在哺乳动物患者（例如人）中制备用于治疗的受伤组织的固体敷料的方法，其包含基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的止血层。 还公开了使用这些敷料处理伤口组织的方法以及用于制备这些敷料的止血层或用于治疗哺乳动物中伤口组织的冷冻和液体组合物。
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