公开(公告)号：US20190060368A1

公开(公告)日：2019-02-28

申请号：US16112282

申请日：2018-08-24

申请人： Ryang Hwa LEE ,  Joo Youn OH ,  Darwin J. PROCKOP ,  Dong-ki KIM ,  Taeko Shigemoto KURODA

发明人： Ryang Hwa LEE ,  Joo Youn OH ,  Darwin J. PROCKOP ,  Dong-ki KIM ,  Taeko Shigemoto KURODA

IPC分类号： A61K35/28 ,  A61K9/08 ,  A61P37/06

摘要： Pharmaceutically acceptable preparations of extracellular vesicles derived from activated MSCs are provided. These preparations are essentially free of MSCs, and demonstrate anti-inflammatory inhibiting pharmacological activity in vivo. Methods for using the preparations to prevent the onset of autoimmune diseases are presented. The MSC derived extracellular vesicles are provided in pharmaceutically acceptable preparations with a carrier, such as saline, and may be used to inhibit activation of antigen presenting cells. These preparations may also be used to suppress the development of T helper 1 (Th1) and Th17 cells. The disclosed activated MSC-derived extracellular vesicle preparations are essentially free of MSCs and other cells. Methods and preparations for treating and/or inhibiting the inflammatory response attendant organ transplant, diseases including human uveitis, type 1 diabetes, scleroderma, rheumatoid arthritis, lupus, Sjorgren's syndrome, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholipid syndrome, multiple sclerosis, anti-glomerular basement membrane disease, and pemphigoid diseases, are also provided.

公开(公告)号：US20150265675A1

公开(公告)日：2015-09-24

申请号：US14435800

申请日：2013-10-17

申请人： Darwin J. Prockop ,  Dong-Ki Kim ,  Jun Watanabe ,  Ashok Shetty ,  Bharathi Hattiangady ,  Jessica Foraker ,  Barry Berkowitz

发明人： Darwin J. Prockop ,  Dong-Ki Kim ,  Jun Watanabe ,  Ashok Shetty ,  Bharathi Hattiangady ,  Jessica Foraker ,  Barry Berkowitz

IPC分类号： A61K38/17 ,  A61K45/06

CPC分类号： A61K38/1709 ,  A61K45/06 ,  A61K2300/00

摘要： A method of treating brain injury or brain trauma in an animal by administering to an animal TSG-6 protein or a biologically active fragment, derivative, or analogue thereof.

摘要翻译： 一种通过对动物TSG-6蛋白或其生物活性片段，衍生物或类似物施用来治疗动物的脑损伤或脑外伤的方法。

公开(公告)号：US09048430B2

公开(公告)日：2015-06-02

申请号：US13330657

申请日：2011-12-19

申请人： Seon-Il Kim ,  Shin-Il Choi ,  Ji-Young Park ,  Sang-Gab Kim ,  O-Byoung Kwon ,  Dong-Ki Kim ,  Sang-Tae Kim ,  Young-Chul Park ,  In-Ho Yu ,  Young-Jin Yoon ,  Suck-Jun Lee ,  Joon-Woo Lee ,  Min-Ki Lim ,  Sang-Hoon Jang ,  Young-Jun Jin

发明人： Seon-Il Kim ,  Shin-Il Choi ,  Ji-Young Park ,  Sang-Gab Kim ,  O-Byoung Kwon ,  Dong-Ki Kim ,  Sang-Tae Kim ,  Young-Chul Park ,  In-Ho Yu ,  Young-Jin Yoon ,  Suck-Jun Lee ,  Joon-Woo Lee ,  Min-Ki Lim ,  Sang-Hoon Jang ,  Young-Jun Jin

IPC分类号： H01L21/00 ,  H01L51/00

CPC分类号： H01L51/0023 ,  H01L2251/308

摘要： Exemplary embodiments of the present invention disclose a non-halogenated etchant for etching an indium oxide layer and a method of manufacturing a display substrate using the non-halogenated etchant, the non-halogenated etchant including nitric acid, sulfuric acid, a corrosion inhibitor including ammonium, a cyclic amine-based compound, and water.

摘要翻译： 本发明的示例性实施方案公开了用于蚀刻氧化铟层的非卤化蚀刻剂和使用非卤化蚀刻剂制造显示衬底的方法，非卤化蚀刻剂包括硝酸，硫酸，包括铵的腐蚀抑制剂 ，环胺类化合物和水。

公开(公告)号：US20160075750A1

公开(公告)日：2016-03-17

申请号：US14793086

申请日：2015-07-07

申请人： Darwin J. Prockop ,  Jun Watanabe ,  Dong-Ki Kim ,  Rwang Hwa Lee ,  Hosoon Choi

发明人： Darwin J. Prockop ,  Jun Watanabe ,  Dong-Ki Kim ,  Rwang Hwa Lee ,  Hosoon Choi

IPC分类号： C07K14/525

CPC分类号： C07K14/4718 ,  C07K2319/21

摘要： A method of producing a protein or polypeptide, such as, for example, TSG-6 protein, or a biologically active fragment, derivative or analogue thereof, by introducing into mammalian cells a polynucleotide encoding the biologically active protein or polypeptide or biologically active fragment, derivative, or analogue thereof. The cells then are suspended in a protein-free medium that includes at least one agent that suppresses production of hyaluronic acid, hyaluronan, or a salt thereof by the cells. The cells are cultured for a time sufficient to express the biologically active protein or polypeptide or biologically active fragment, derivative or analogue thereof. The biologically active protein or polypeptide, or fragment, derivative, or analogue thereof then is recovered from the cells, such as, for example, by recovering the protein or polypeptide secreted by the cells from the cell culture medium.

公开(公告)号：US08564397B2

公开(公告)日：2013-10-22

申请号：US13421945

申请日：2012-03-16

申请人： Jong Ho Kim ,  Min Seok Kim ,  Yon-Kyu Park ,  Dae Im Kang ,  Dong-Ki Kim

发明人： Jong Ho Kim ,  Min Seok Kim ,  Yon-Kyu Park ,  Dae Im Kang ,  Dong-Ki Kim

IPC分类号： H01C10/10

CPC分类号： G01L1/205 ,  A61B2562/0247 ,  A61B2562/046 ,  A61B2562/164 ,  G01L1/146

摘要： The present invention relates to a structure for attaching tactile sensors to a curved surface, comprising a sensor fixing unit configured to have at least part of one surface curved and to have a plurality of sensor insertion grooves, crossing each other, formed in the one surface in a matrix form; tactile sensor units formed in a matrix form, inserted into the respective sensor insertion grooves, and configured to detect external force; sealing units configured to seal the respective sensor insertion grooves; and a support unit configured to come in contact with one face of the sealing units or the sensor fixing units and to support the sensor fixing units. Accordingly, the tactile sensors can be easily attached to a curved surface, and mass production is possible.

摘要翻译： 本发明涉及一种用于将触觉传感器附接到曲面的结构，包括传感器固定单元，该传感器固定单元被构造成具有至少部分一个曲面的曲面，并且具有彼此交叉的多个传感器插入槽， 以矩阵形式; 以矩阵形式形成的触觉传感器单元，插入相应的传感器插入槽中，并构造成检测外力; 密封单元，其构造成密封各个传感器插入槽; 以及支撑单元，其构造成与所述密封单元或所述传感器固定单元的一个面接触并支撑所述传感器固定单元。 因此，触觉传感器可以容易地附接到弯曲表面，并且可以批量生产。

公开(公告)号：US08785935B2

公开(公告)日：2014-07-22

申请号：US13168408

申请日：2011-06-24

申请人： Hong-Sick Park ,  Wang-Woo Lee ,  Sang-Tae Kim ,  Joon-Woo Lee ,  Young-Chul Park ,  Young-Jun Jin ,  Kyong-Min Kang ,  Young-Jin Yoon ,  Suck-Jun Lee ,  O-Byoung Kwon ,  In-Ho Yu ,  Sang-Hoon Jang ,  Min-Ki Lim ,  Dong-Ki Kim

发明人： Hong-Sick Park ,  Wang-Woo Lee ,  Sang-Tae Kim ,  Joon-Woo Lee ,  Young-Chul Park ,  Young-Jun Jin ,  Kyong-Min Kang ,  Young-Jin Yoon ,  Suck-Jun Lee ,  O-Byoung Kwon ,  In-Ho Yu ,  Sang-Hoon Jang ,  Min-Ki Lim ,  Dong-Ki Kim

IPC分类号： H01L29/04 ,  H01L27/12

CPC分类号： H01L27/127 ,  H01L21/32134 ,  H01L27/124 ,  H01L27/1259 ,  H01L29/41733

摘要： An etchant includes: 5 to 20 wt % of persulfate, 1 to 10 wt % of at least one compound of an inorganic acid, an inorganic acid salt, or a mixture thereof, 0.3 to 5 wt % of a cyclic amine compound, 1 to 10 wt % of at least one compound of an organic acid, an organic acid salt, or a mixture thereof, 0.1 to 5 wt % of p-toluenesulfonic acid, and water, based on the total weight of the etchant. A copper-titanium etchant further includes 0.01 to 2 wt % of a fluoride-containing compound. A method of forming a display device using the etchant, and a display device, are also disclosed.

摘要翻译： 蚀刻剂包括：5〜20重量％的过硫酸盐，1〜10重量％的至少一种无机酸化合物，无机酸盐或其混合物，0.3〜5重量％的环状胺化合物，1〜 10重量％的至少一种有机酸化合物，有机酸盐或其混合物，0.1至5重量％的对甲苯磺酸和水，基于蚀刻剂的总重量。 另外，铜 - 钛蚀刻剂还含有0.01〜2重量％的含氟化合物。 还公开了使用蚀刻剂形成显示装置的方法和显示装置。

公开(公告)号：US20220175842A1

公开(公告)日：2022-06-09

申请号：US16346806

申请日：2017-11-02

申请人： Darwin J. PROCKOP ,  Ashok K. SHETTY ,  Qianfa LONG ,  Dinesh UPADHYA ,  Bharathi HATTIANGADY ,  Dong-ki KIM

发明人： Darwin J. PROCKOP ,  Ashok K. SHETTY ,  Qianfa LONG ,  Dinesh UPADHYA ,  Bharathi HATTIANGADY ,  Dong-ki KIM

IPC分类号： A61K35/28 ,  A61P25/00 ,  A61K9/127

摘要： Disclosed are medicaments and methods for inhibiting brain inflammation and the cognitive memory loss attendant brain disease and damage in an animal. Status epilepticus, stroke and Alzheimer's disease are particular pathologies that are treated employing pharmaceutically acceptable preparations of the A1 exosomes. The preparations comprise an enriched population of A1 exosomes, such as exosomes derived from culture medium from mesenchymal stem cells. Medicaments and methods for inhibiting pattern recognition and/or memory impairment attendant a brain injury event or degenerative brain disease are also disclosed, comprising administering a pharmaceutically acceptable preparation of exosomes, particularly A1 exosomes, that are CD9− and that prevent the elevation of pro-inflammatory cytokines attendant a brain injury or disease.

公开(公告)号：US20130168336A1

公开(公告)日：2013-07-04

申请号：US13421945

申请日：2012-03-16

申请人： Jong Ho KIM ,  Min Seok KIM ,  Yon-Kyu PARK ,  Dae Im KANG ,  Dong-Ki KIM

发明人： Jong Ho KIM ,  Min Seok KIM ,  Yon-Kyu PARK ,  Dae Im KANG ,  Dong-Ki KIM

IPC分类号： H05K7/00 ,  B23P17/00

CPC分类号： G01L1/205 ,  A61B2562/0247 ,  A61B2562/046 ,  A61B2562/164 ,  G01L1/146

摘要： The present invention relates to a structure for attaching tactile sensors to a curved surface, comprising a sensor fixing unit configured to have at least part of one surface curved and to have a plurality of sensor insertion grooves, crossing each other, formed in the one surface in a matrix form; tactile sensor units formed in a matrix form, inserted into the respective sensor insertion grooves, and configured to detect external force; sealing units configured to seal the respective sensor insertion grooves; and a support unit configured to come in contact with one face of the sealing units or the sensor fixing units and to support the sensor fixing units. Accordingly, the tactile sensors can be easily attached to a curved surface, and mass production is possible.

摘要翻译： 本发明涉及一种用于将触觉传感器附接到曲面的结构，包括传感器固定单元，该传感器固定单元被构造成具有至少部分一个表面弯曲并且具有彼此交叉的多个传感器插入槽， 以矩阵形式; 以矩阵形式形成的触觉传感器单元，插入相应的传感器插入槽中，并构造成检测外力; 密封单元，其构造成密封各个传感器插入槽; 以及支撑单元，其构造成与所述密封单元或所述传感器固定单元的一个面接触并支撑所述传感器固定单元。 因此，触觉传感器可以容易地附接到弯曲表面，并且可以批量生产。

公开(公告)号：US20120208310A1

公开(公告)日：2012-08-16

申请号：US13330657

申请日：2011-12-19

申请人： Seon-Il KIM ,  Shin-Il Choi ,  Ji-Young Park ,  Sang-Gab Kim ,  O-Byoung Kwon ,  Dong-Ki Kim ,  Sang-Tae Kim ,  Young-Chul Park ,  In-Ho Yu ,  Young-Jin Yoon ,  Suck-Jun Lee ,  Joon-Woo Lee ,  Min-Ki Lim ,  Sang-Hoon Jang ,  Young-Jun JIN

发明人： Seon-Il KIM ,  Shin-Il Choi ,  Ji-Young Park ,  Sang-Gab Kim ,  O-Byoung Kwon ,  Dong-Ki Kim ,  Sang-Tae Kim ,  Young-Chul Park ,  In-Ho Yu ,  Young-Jin Yoon ,  Suck-Jun Lee ,  Joon-Woo Lee ,  Min-Ki Lim ,  Sang-Hoon Jang ,  Young-Jun JIN

IPC分类号： H01L33/08

CPC分类号： H01L51/0023 ,  H01L2251/308

摘要： Exemplary embodiments of the present invention disclose a non-halogenated etchant for etching an indium oxide layer and a method of manufacturing a display substrate using the non-halogenated etchant, the non-halogenated etchant including nitric acid, sulfuric acid, a corrosion inhibitor including ammonium, a cyclic amine-based compound, and water.

摘要翻译： 本发明的示例性实施方案公开了用于蚀刻氧化铟层的非卤化蚀刻剂和使用非卤化蚀刻剂制造显示衬底的方法，非卤化蚀刻剂包括硝酸，硫酸，包括铵的腐蚀抑制剂 ，环胺类化合物和水。

公开(公告)号：US20110107850A1

公开(公告)日：2011-05-12

申请号：US12651007

申请日：2009-12-31

申请人： Jong Ho Kim ,  Hyun Joon Kwon ,  Dong-Ki Kim

发明人： Jong Ho Kim ,  Hyun Joon Kwon ,  Dong-Ki Kim

IPC分类号： G01D7/00

CPC分类号： G01L5/16

摘要： A 6-axis force sensor includes bumper 10 with bumper axis 12 and press member 11 which has four horizontal beams 11a, 11b, 11c and 11d in a cross shape with end, side and bottom faces. Sensors 31, 32, 33, and 34 on end faces sense force in one direction and sense a moment acting on opposite end faces. Sensors 41, 42, 43, and 44 on side faces sense force in a second direction transverse to the first direction and sense a moment acting on opposite side faces. A film 20 on the bottom faces has four sensors 21, 22, 23, and 24, one on each bottom face, for sensing force in a direction transverse to the first and the second directions and sensing a moment acting on opposite sensors on the film.

摘要翻译： 6轴力传感器包括具有保险杠轴线12的缓冲器10和具有四个具有端面，侧面和底面的十字形的水平梁11a，11b，11c和11d的按压构件11。 端面上的传感器31,32,33和34在一个方向上感测力并且感测作用在相对端面上的力矩。 侧面上的传感器41,42,43和44在与第一方向相交的第二方向上感测力并感测作用在相对侧面上的力矩。 在底面上的薄膜20具有四个传感器21,22,23和24，每个底面上有一个传感器21,22,23和24，用于在横向于第一和第二方向的方向上感测力，并感测作用在薄膜上相对的传感器上的力矩 。