-
1.发明授权Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents 失效磷酸酶活化交联，共轭和还原剂; 使用这种药剂的方法; 和包含磷酸酶活化的交联和缀合剂的试剂
公开(公告)号：US5736624A
公开(公告)日：1998-04-07
申请号：US349167
申请日：1994-12-02
IPC分类号： A61K47/48 , C07F9/165 , C07F9/553 , G01N33/543 , C07K16/26 , C07K17/00 , C12N9/96 , C12N11/08
CPC分类号： G01N33/54353 , C07F9/1651 , C07F9/1652 , C07F9/5537 , Y10S530/811 , Y10S530/816
摘要： The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.-2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided. Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n is at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality. Q--(S--PO.sub.3.sup.-2)n (I) The reducing agents that are provided conform to a compound of the formula (Y), shown below, wherein (A) and (Z) can be independently selected from C.sub.1 -C.sub.5 alkyl and CONH(CH.sub.2).sub.p wherein p is an integer between 1 and 5. ##STR1##
摘要翻译： 本发明提供了与至少一种硫代磷酸酯单酯基团（-SPO3-2）起作用的交联，缀合和还原剂。 还提供了可用于免疫测定的交联和缀合方法以及固相试剂和缀合物。 本发明的交联和缀合剂通常包含对应于下面所示的式（I）的化合物，其中n至少为1，Q为直链或支链单体，平均分子量为约200至约200的聚合物或低聚物 1,000,000。 另外，当n为1时，Q包含至少1个额外的反应性官能团。Q-（S-PO3-2）n（I）提供的还原剂符合下面所示的式（Y）化合物，其中 （A）和（Z）可以独立地选自C 1 -C 5烷基和CONH（CH 2）p，其中p是1和5之间的整数。
-
2.发明授权Phosphatase activated crosslinking conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents 失效磷酸酶活化交联，共轭和还原剂; 使用这种药剂的方法; 和包含磷酸酶活化的交联和缀合剂的试剂
公开(公告)号：US5789219A
公开(公告)日：1998-08-04
申请号：US655067
申请日：1996-05-29
申请人： Christopher Bieniarz , Douglas F. Young , Michael J. Cornwell , Mazhar Husain , Zbigniew Skrzypczynski
发明人： Christopher Bieniarz , Douglas F. Young , Michael J. Cornwell , Mazhar Husain , Zbigniew Skrzypczynski
IPC分类号： A61K47/48 , C07F9/165 , C07F9/553 , G01N33/543 , C12N11/14 , C07K17/06 , C12N11/06 , C12N11/08
CPC分类号： G01N33/54353 , C07F9/1651 , C07F9/1652 , C07F9/5537 , Y10S530/811 , Y10S530/816
摘要： The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.-2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided. Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality. Q--(S--PO.sub.3 .sup.-2)n (I) The reducing agents that are provided conform to a compound of the formula (Y), shown below, wherein (A) and (Z) can be independently selected from C.sub.1 -C.sub.5 alkyl and CONH(CH.sub.2)p wherein p is an integer between 1 and 5. ##STR1##
摘要翻译： 本发明提供了与至少一种硫代磷酸酯单酯基团（-SPO3-2）起作用的交联，缀合和还原剂。 还提供了可用于免疫测定的交联和缀合方法以及固相试剂和缀合物。 本发明的交联和缀合剂通常包含对应于下式（I）的化合物，其中n至少为1且Q为直链或支链单体，平均分子量为约200至约1,000,000的聚合物或低聚物 。 另外，当n为1时，Q包含至少1个额外的反应性官能团。Q-（S-PO3-2）n（I）提供的还原剂符合下面所示的式（Y）化合物，其中 （A）和（Z）可以独立地选自C 1 -C 5烷基和CONH（CH 2）p，其中p是1至5之间的整数。
-
3.发明授权Phosphatase activated crosslinking conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating 失效磷酸酶活化交联共轭和还原剂; 使用这种药剂的方法; 和包含磷酸酶活化的交联和缀合剂的试剂
公开(公告)号：US6160153A
公开(公告)日：2000-12-12
申请号：US498388
申请日：2000-02-03
IPC分类号： A61K47/48 , C07F9/165 , C07F9/553 , G01N33/543
CPC分类号： G01N33/54353 , C07F9/1651 , C07F9/1652 , C07F9/5537 , Y10S530/811 , Y10S530/816
摘要： The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.--2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided.Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality.Q--(S--PO.sub.3.sup.-2).sub.n (I)The reducing agents that are provided conform to a compound of the formula (Y), shown below, wherein (A) and (Z) can be independently selected from C.sub.1 -C.sub.5 alkyl and CONH(CH.sub.2).sub.p wherein p is an integer between 1 and 5. ##STR1##
摘要翻译： 本发明提供了与至少一种硫代磷酸酯单酯基团（-SPO3-2）起作用的交联，缀合和还原剂。 还提供了可用于免疫测定的交联和缀合方法以及固相试剂和缀合物。 本发明的交联和缀合剂通常包含对应于下式（I）的化合物，其中n至少为1且Q为直链或支链单体，平均分子量为约200至约1,000,000的聚合物或低聚物 。 另外，当n为1时，Q包含至少1个额外的反应性官能团。Q-（S-PO3-2）n（I）提供的还原剂符合下面所示的式（Y）化合物，其中 （A）和（Z）可以独立地选自C 1 -C 5烷基和CONH（CH 2）p，其中p是1和5之间的整数。
-
4.发明授权Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents 失效磷酸酶活化交联，共轭和还原剂; 使用这种药剂的方法; 和包含磷酸酶活化的交联和缀合剂的试剂
公开(公告)号：US6057429A
公开(公告)日：2000-05-02
申请号：US657695
申请日：1996-05-29
CPC分类号： G01N33/54353 , C07F9/1651 , C07F9/1652 , C07F9/5537 , Y10S530/811 , Y10S530/816
摘要： The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.-2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided.Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality.Q--(S--PO.sub.3.sup.-2).sub.n (I)The reducing agents that are provided conform to a compound of the formula (Y), shown below, wherein (A) and (Z) can be independently selected from C.sub.1 -C.sub.5 alkyl and CONH(CH.sub.2).sub.p wherein p is an integer between 1 and 5. ##STR1##
摘要翻译： 本发明提供了与至少一种硫代磷酸酯单酯基团（-SPO3-2）起作用的交联，缀合和还原剂。 还提供了可用于免疫测定的交联和缀合方法以及固相试剂和缀合物。 本发明的交联和缀合剂通常包含对应于下式（I）的化合物，其中n至少为1且Q为直链或支链单体，平均分子量为约200至约1,000,000的聚合物或低聚物 。 另外，当n为1时，Q包含至少1个附加的反应性官能团。 Q-（S-PO3-2）n（I）提供的还原剂符合如下所示的式（Y）化合物，其中（A）和（Z）可以独立地选自C 1 -C 5烷基 和CONH（CH 2）p，其中p是1和5之间的整数。
-
公开(公告)号：US4978613A
公开(公告)日：1990-12-18
申请号：US298098
申请日：1989-01-17
CPC分类号： C12Q1/34 , G01N33/581 , C12Q2326/92 , C12Q2334/00 , G01N2333/986 , G01N2415/00
摘要： A method for detecting .beta.-lactamases which may be present in a sample by using a disclosed chromogenic precipitating substrate. A sample is exposed to a disclosed .beta.-lactamase substrate and a colored precipitate forms in the presence of an active .beta.-lactamase.
-
6.发明授权Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment 失效通过提供疏水和构象限制性微环境的部分增强的聚合物荧光团
公开(公告)号：US5994143A
公开(公告)日：1999-11-30
申请号：US595092
申请日：1996-02-01
IPC分类号： C09B69/10 , G01N21/78 , G01N33/533 , G01N33/00 , C09B5/00
CPC分类号： C09B69/10 , G01N33/533 , Y10S436/80 , Y10T436/14 , Y10T436/141111 , Y10T436/17 , Y10T436/18
摘要： Fluorescent conjugates suitable for use in flow cytometry and other biological applications. The fluorescent conjugates comprise an antibody having a polymeric dye bound thereto. The polymeric dye is preferably enhanced by a hydrophobic and conformationally restrictive moiety either bound thereto or in close association therewith. The hydrophobic and conformationally restrictive moiety is preferably derived from a cyclodextrin. The polymeric dye comprises a polymeric entity having signal-generating groups, such as aminostyryl pyridinium dye residues attached thereto. The fluorescent conjugates exhibit exceptional stability characteristics and avoid many of the problems of energy transfer, bio-conjugability, and solubility.
摘要翻译： 适用于流式细胞术和其他生物应用的荧光偶联物。 荧光共轭物包含具有与其结合的聚合染料的抗体。 聚合染料优选通过与其结合或与其紧密结合的疏水性和构象限制性部分增强。 疏水和构象限制性部分优选衍生自环糊精。 聚合染料包括具有信号产生基团的聚合物，例如与其连接的氨基苯乙烯基吡啶鎓染料残基。 荧光共轭物表现出优异的稳定性特征，并避免能量转移，生物共轭性和溶解度的许多问题。
-
公开(公告)号：US08356231B2
公开(公告)日：2013-01-15
申请号：US13406122
申请日：2012-02-27
IPC分类号： G11C29/00
CPC分类号： G11C29/52 , G11C11/5628 , G11C11/5642 , G11C16/0483 , G11C16/26 , G11C29/00 , G11C2211/5641
摘要： A system and method, including computer software, allows reading data from a flash memory cell. Voltages from a group of memory cells are detected. The group of memory cells have associated metadata for error detection, and each memory cell stores a voltage representing a data value selected from multiple possible data values. Each possible data value corresponds to one range of multiple non-overlapping ranges of analog voltages. Memory cells having uncertain data values are identified based on the detected voltages. Alternative data values for the memory cells having the uncertain data values are determined, and a combination of alternative data values is selected. An error detection test is performed using the metadata associated with the multiple memory cells and the selected combination of alternative data values.
-
公开(公告)号：US20120250422A1
公开(公告)日：2012-10-04
申请号：US13524862
申请日：2012-06-15
申请人： Michael J. Cornwell
发明人： Michael J. Cornwell
IPC分类号： G11C16/04
摘要： Systems and methods, including computer software for performing operations enable interleaving of charging operations in a charging pump. A first charge pump is charged to a predetermined level, and a first operation is performed using a charge stored in the first charge pump after it reaches the predetermined level. A second charge pump is charged during a time that overlaps with performing the first operation. A second operation is performed using a charge stored in the second charge pump as a result of charging the second charge pump.
-
公开(公告)号：US20120092249A1
公开(公告)日：2012-04-19
申请号：US13336811
申请日：2011-12-23
CPC分类号： G06F1/1694
摘要： Systems and processes for accessing acceleration data may include an accelerometer coupled to a nonvolatile memory. The nonvolatile memory may be coupled to a processor. Acceleration data may be obtained from the accelerometer via a bus coupling the nonvolatile memory to the accelerometer. Acceleration data may be sent from the nonvolatile memory to a processor. One or more operations may be performed based on the acceleration data.
摘要翻译： 用于访问加速度数据的系统和过程可以包括耦合到非易失性存储器的加速度计。 非易失性存储器可以耦合到处理器。 可以通过将非易失性存储器耦合到加速度计的总线从加速度计获得加速度数据。 加速数据可以从非易失性存储器发送到处理器。 可以基于加速度数据执行一个或多个操作。
-
公开(公告)号：US08116133B2
公开(公告)日：2012-02-14
申请号：US12624020
申请日：2009-11-23
IPC分类号： G11C11/34
CPC分类号： G11C16/26 , G11C11/5628 , G11C11/5642 , G11C16/30 , G11C16/3418 , G11C16/3431 , G11C16/349 , G11C29/00 , G11C2211/5641
摘要： Systems and methods, including computer software, for reading data from a flash memory cell involve detecting voltages from a group of memory cells. The group of memory cells have associated metadata for error detection, and each memory cell stores a voltage representing a data value selected from a plurality of possible data values. Each possible data value corresponds to one range of multiple non-overlapping ranges of analog voltages. Memory cells having uncertain data values are identified based on the detected voltages. Alternative data values for the memory cells having the uncertain data values are determined. A combination of alternative data values is selected, and an error detection test is performed using the metadata associated with the memory cells and the selected combination of alternative data values.
摘要翻译： 包括用于从闪存单元读取数据的计算机软件的系统和方法涉及检测来自一组存储器单元的电压。 存储器单元组具有用于错误检测的相关联的元数据，并且每个存储器单元存储表示从多个可能数据值中选择的数据值的电压。 每个可能的数据值对应于模拟电压的多个非重叠范围的一个范围。 基于检测到的电压来识别具有不确定数据值的存储单元。 确定具有不确定数据值的存储单元的替代数据值。 选择替代数据值的组合，并且使用与存储器单元相关联的元数据和所选择的备选数据值的组合来执行错误检测测试。
-
-
-
-
-
-
-
-
-
搜索结果
108 条记录 (耗时 0.033 秒)
