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公开(公告)号：US09040262B2
公开(公告)日：2015-05-26
申请号：US13695856
申请日：2011-05-04
申请人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
发明人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
CPC分类号： C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
摘要： The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译： 本公开涉及可用于制备依泽替米贝的非天然存在的多肽，编码多肽的多核苷酸以及使用多肽的方法。
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公开(公告)号：US08889380B2
公开(公告)日：2014-11-18
申请号：US13604323
申请日：2012-09-05
CPC分类号： C12P17/182 , C12N9/1096 , C12N15/52 , C12N15/62 , C12P13/001 , C12Y206/01018 , Y02P20/52
摘要： The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译： 本公开涉及具有转氨酶活性的多肽，编码多肽的多核苷酸以及使用该多肽的方法。
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公开(公告)号：US08748143B2
公开(公告)日：2014-06-10
申请号：US12210195
申请日：2008-09-13
申请人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
CPC分类号： C12N9/0006 , C12P7/22 , C12Y101/01 , C12Y101/01184 , Y02E50/17 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号：US08569013B2
公开(公告)日：2013-10-29
申请号：US13542835
申请日：2012-07-06
申请人： Behnaz Behrouzian , Anke Krebber , Emily Mundorff
发明人： Behnaz Behrouzian , Anke Krebber , Emily Mundorff
CPC分类号： C12N9/84 , C12P7/22 , C12P37/06 , C12P41/004
摘要： The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
摘要翻译： 本公开涉及具有改进性质的工程青霉素G酰基转移酶（PGA）酶，编码这些酶的多核苷酸，包含酶的组合物和使用酶的方法。
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公开(公告)号：US20130052699A1
公开(公告)日：2013-02-28
申请号：US13695856
申请日：2011-05-04
申请人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
发明人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
CPC分类号： C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
摘要： The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
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公开(公告)号：US20120322136A1
公开(公告)日：2012-12-20
申请号：US13590882
申请日：2012-08-21
申请人： Emily Mundorff , Erik De Vries
发明人： Emily Mundorff , Erik De Vries
CPC分类号： C12N9/0006 , C12N15/00 , C12N15/75 , C12P7/02 , C12P17/10 , C12P17/14 , C12P41/002 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe.
摘要翻译： 本发明提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶，其包括还原5 - （（4S）-2-氧代-4-苯基（1,3-恶唑烷-3-基） ）） - 1-（4-氟苯基）戊烷-1,5-二酮转化为（4S）-3 - [（5S）-5-（4-氟苯基）-5-羟基戊酰基] -4-苯基-1,3- 恶唑烷-2-酮。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞和使用工程化酮还原酶合成中间体（4S）-3 - [（5S）-5-（4-氟苯基） -5-羟基戊酰基] -4-苯基-1,3-恶唑烷-2-酮在制备依泽替米贝的方法中。
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公开(公告)号：US08257952B2
公开(公告)日：2012-09-04
申请号：US12977825
申请日：2010-12-23
申请人： Onorato Campopiano , Emily Mundorff , Birthe Borup , Rama Voladri
发明人： Onorato Campopiano , Emily Mundorff , Birthe Borup , Rama Voladri
CPC分类号： C12N9/0006 , C12P17/10 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。
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公开(公告)号：US20120178142A1
公开(公告)日：2012-07-12
申请号：US13290773
申请日：2011-11-07
CPC分类号： C12N9/0006 , C12N15/00 , C12N15/70 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。
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公开(公告)号：US08071347B2
公开(公告)日：2011-12-06
申请号：US12881734
申请日：2010-09-14
CPC分类号： C12N9/0006 , C12N15/00 , C12N15/70 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。
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10.发明申请KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE 有权用于生产AZETIDINONE的KETOREDUCTASE POLYPEPTIDES公开(公告)号：US20110159567A1
公开(公告)日：2011-06-30
申请号：US12977825
申请日：2010-12-23
申请人： Onorato Campopiano , Emily Mundorff , Birthe Borup , Rama Voladri
发明人： Onorato Campopiano , Emily Mundorff , Birthe Borup , Rama Voladri
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12P17/10 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。
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