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公开(公告)号:US20120172372A1
公开(公告)日:2012-07-05
申请号:US13341413
申请日:2011-12-30
申请人: Bradley Paul Morgan , Alex Muci , Pu-Ping Lu , Erica Anne Kraynack , Todd Tochimoto , David J. Morgans, JR.
发明人: Bradley Paul Morgan , Alex Muci , Pu-Ping Lu , Erica Anne Kraynack , Todd Tochimoto , David J. Morgans, JR.
IPC分类号: A61K31/496 , A61P9/04 , A61K31/5377 , C07D401/12 , C07D413/12
CPC分类号: C07D213/75 , C07D211/56 , C07D239/42 , C07D261/14 , C07D263/48 , C07D271/113 , C07D295/26 , C07D401/10 , C07D401/12 , C07D417/00 , C07D417/10 , C07D417/12 , C07D487/04 , C07D491/04 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US20100069370A1
公开(公告)日:2010-03-18
申请号:US12553311
申请日:2009-09-03
申请人: Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
发明人: Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
IPC分类号: A61K31/551 , A61K31/4965 , C07D243/08 , C07D241/04
CPC分类号: C07D295/26 , C07D207/14 , C07D213/75 , C07D233/88 , C07D257/06 , C07D261/14 , C07D263/48 , C07D277/46 , C07D285/135 , C07D295/18 , C07D403/12
摘要: Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的磺酰胺衍生物可选择性调节心脏肌节,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US20090176307A1
公开(公告)日:2009-07-09
申请号:US12348786
申请日:2009-01-05
申请人: Bradley Paul Morgan , Kathleen A. Elias , Erica Anne Kraynack , Pu-Ping Lu , Fady Malik , Alex Muci , Xiangping Qian , Whitney Walter Smith , Todd Tochimoto , Adam Lewis Tomasi , David J. Morgans, JR.
发明人: Bradley Paul Morgan , Kathleen A. Elias , Erica Anne Kraynack , Pu-Ping Lu , Fady Malik , Alex Muci , Xiangping Qian , Whitney Walter Smith , Todd Tochimoto , Adam Lewis Tomasi , David J. Morgans, JR.
IPC分类号: C12N5/08
CPC分类号: A61K31/44 , A61K31/17 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/40 , C07D207/12 , C07D211/42 , C07D213/65 , C07D213/70 , C07D213/75 , C07D217/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D498/04 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号:US07491826B2
公开(公告)日:2009-02-17
申请号:US10890829
申请日:2004-07-14
申请人: Bradley Paul Morgan , Kathleen A. Elias , Erica Anne Kraynack , Pu-Ping Lu , Fady Malik , Alex Muci , Xiangping Qian , Whitney Walter Smith , Todd Tochimoto , Adam Lewis Tomasi , David J. Morgans, Jr.
发明人: Bradley Paul Morgan , Kathleen A. Elias , Erica Anne Kraynack , Pu-Ping Lu , Fady Malik , Alex Muci , Xiangping Qian , Whitney Walter Smith , Todd Tochimoto , Adam Lewis Tomasi , David J. Morgans, Jr.
IPC分类号: C07D211/68 , C07D401/04 , C07D401/14
CPC分类号: A61K31/44 , A61K31/17 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/40 , C07D207/12 , C07D211/42 , C07D213/65 , C07D213/70 , C07D213/75 , C07D217/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D498/04 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US06908923B2
公开(公告)日:2005-06-21
申请号:US10327219
申请日:2002-12-20
申请人: Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
发明人: Fady Malik , Adam Lewis Tomasi , Bainian Feng , Erica Anne Kraynack , Kathleen A. Elias , Pu-Ping Lu , Whitney Walter Smith , Xiangping Qian , David J. Morgans, Jr.
IPC分类号: C07D333/40 , A61K31/381 , A61K31/42 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/455 , A61K31/497 , A61P9/00 , A61P9/04 , C07D213/64 , C07D213/65 , C07D213/75 , C07D213/78 , C07D213/81 , C07D261/18 , C07D333/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12 , A61K31/4965 , A01N43/40 , A01N43/80 , A61K31/44
CPC分类号: C07D401/12 , A61K31/4412 , A61K31/444 , A61K31/513 , C07D213/65 , C07D261/18 , C07D333/38 , C07D409/12 , C07D413/12
摘要: Certain substituted benzamide derivatives of Formula I: selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的式I的苯甲酰胺衍生物:选择性调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US20130267537A1
公开(公告)日:2013-10-10
申请号:US13759903
申请日:2013-02-05
申请人: Bradley Paul MORGAN , Fady MALIK , Erica Anne KRAYNACK , Alexander Ramon MUCI , Xiangping QIAN , David J. MORGANS, JR.
发明人: Bradley Paul MORGAN , Fady MALIK , Erica Anne KRAYNACK , Alexander Ramon MUCI , Xiangping QIAN , David J. MORGANS, JR.
IPC分类号: C07D295/26 , C07D285/135 , C07D233/88
CPC分类号: C07D295/26 , C07D207/14 , C07D213/75 , C07D233/88 , C07D257/06 , C07D261/14 , C07D263/48 , C07D277/46 , C07D285/135 , C07D295/18 , C07D403/12
摘要: Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的磺酰胺衍生物可选择性调节心脏肌节,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US08367661B2
公开(公告)日:2013-02-05
申请号:US13474824
申请日:2012-05-18
申请人: Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, Jr.
发明人: Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, Jr.
IPC分类号: C07D265/30
CPC分类号: C07D295/26 , C07D207/14 , C07D213/75 , C07D233/88 , C07D257/06 , C07D261/14 , C07D263/48 , C07D277/46 , C07D285/135 , C07D295/18 , C07D403/12
摘要: Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的磺酰胺衍生物可选择性调节心脏肌节,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US20120232092A1
公开(公告)日:2012-09-13
申请号:US13474824
申请日:2012-05-18
申请人: Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
发明人: Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
IPC分类号: A61K31/496 , C07D403/12 , A61P9/04 , C07D417/12
CPC分类号: C07D295/26 , C07D207/14 , C07D213/75 , C07D233/88 , C07D257/06 , C07D261/14 , C07D263/48 , C07D277/46 , C07D285/135 , C07D295/18 , C07D403/12
摘要: Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的磺酰胺衍生物可选择性调节心脏肌节,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:US20120088779A1
公开(公告)日:2012-04-12
申请号:US13330356
申请日:2011-12-19
申请人: Bradley Paul MORGAN , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
发明人: Bradley Paul MORGAN , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
IPC分类号: A61K31/495 , A61P9/04 , A61K31/496 , C07D403/12 , C07D295/26 , C07D413/12
CPC分类号: C07D295/26 , C07D207/14 , C07D213/75 , C07D233/88 , C07D257/06 , C07D261/14 , C07D263/48 , C07D277/46 , C07D285/135 , C07D295/18 , C07D403/12
摘要: Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号:US08110595B2
公开(公告)日:2012-02-07
申请号:US11630062
申请日:2005-06-16
申请人: Bradley Paul Morgan , Alex Muci , Pu-Ping Lu , Erica Anne Kraynack , Todd Tochimoto , David J. Morgans, Jr.
发明人: Bradley Paul Morgan , Alex Muci , Pu-Ping Lu , Erica Anne Kraynack , Todd Tochimoto , David J. Morgans, Jr.
IPC分类号: A61K31/40 , C07D261/02 , C07D295/04
CPC分类号: C07D213/75 , C07D211/56 , C07D239/42 , C07D261/14 , C07D263/48 , C07D271/113 , C07D295/26 , C07D401/10 , C07D401/12 , C07D417/00 , C07D417/10 , C07D417/12 , C07D487/04 , C07D491/04 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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