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公开(公告)号：US09328081B2
公开(公告)日：2016-05-03
申请号：US14342348
申请日：2012-08-29
申请人： Xiangping Qian
发明人： Xiangping Qian
IPC分类号： C07D295/192 , C07D295/205 , C07C271/44 , C07D211/60
CPC分类号： A61K31/325 , A61K31/4453 , A61K31/495 , A61K31/535 , C07C271/44 , C07D211/60 , C07D295/192 , C07D295/205
摘要： Chemical entities that are curcumin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
摘要翻译： 描述了姜黄素衍生物，药物组合物和癌症治疗方法的化学实体。
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公开(公告)号：US20150072984A1
公开(公告)日：2015-03-12
申请号：US14342348
申请日：2012-08-29
申请人： Xiangping Qian
发明人： Xiangping Qian
IPC分类号： C07D295/192 , C07D211/60 , C07C271/44
CPC分类号： A61K31/325 , A61K31/4453 , A61K31/495 , A61K31/535 , C07C271/44 , C07D211/60 , C07D295/192 , C07D295/205
摘要： Chemical entities that are curcumin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
摘要翻译： 描述了姜黄素衍生物，药物组合物和癌症治疗方法的化学实体。
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公开(公告)号：US08969346B2
公开(公告)日：2015-03-03
申请号：US13642207
申请日：2011-04-22
申请人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey M Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey M Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
IPC分类号： A61K31/50 , C07D237/20 , C07D401/12 , C07D237/24 , C07D401/04 , C07D403/04 , C07D403/06 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , C07D401/14 , C07D405/14
CPC分类号： A61K31/50 , A61K31/16 , A61K31/166 , C07D207/26 , C07D211/76 , C07D213/16 , C07D231/56 , C07D237/06 , C07D237/20 , C07D237/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，X和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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公开(公告)号：US08962632B2
公开(公告)日：2015-02-24
申请号：US13642206
申请日：2011-04-22
申请人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
发明人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
IPC分类号： A61K31/505 , A61K31/4965 , C07D401/12 , C07D239/42 , C07D403/10 , A61K9/00 , C07D239/48 , C07D401/04 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
CPC分类号： A61K9/0014 , A61K9/0019 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/0053 , A61K9/006 , A61K9/007 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US08895582B2
公开(公告)日：2014-11-25
申请号：US13612713
申请日：2012-09-12
申请人： Xiangping Qian , Chihyuan (Grace) Chuang , Pu-Ping Lu , Bing Yao , Qing (Kevin) Lu , Hong Jiang , Wenyue Wang , Bradley P. Morgan , David J. Morgans, Jr.
发明人： Xiangping Qian , Chihyuan (Grace) Chuang , Pu-Ping Lu , Bing Yao , Qing (Kevin) Lu , Hong Jiang , Wenyue Wang , Bradley P. Morgan , David J. Morgans, Jr.
IPC分类号： C07D217/22 , A61K31/472 , C07H21/04 , C07D401/12 , C07D487/04 , C07D213/75 , C07D261/14 , C07D277/82 , C07D471/04
CPC分类号： C07H21/04 , C07D213/75 , C07D217/22 , C07D261/14 , C07D277/82 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
摘要翻译： 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体，治疗与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的药物组合物和方法。
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6.发明申请CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE 有权某些氨基吡啶和氨基三氮杂，其组合物及其使用方法公开(公告)号：US20130150368A1
公开(公告)日：2013-06-13
申请号：US13642227
申请日：2011-04-22
申请人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
IPC分类号： C07D213/74 , C07D253/07 , C07D417/14 , C07D403/10 , C07D401/12 , C07D401/14 , C07D215/38 , C07D213/75
CPC分类号： C07D213/74 , C07D213/75 , C07D213/78 , C07D213/82 , C07D215/38 , C07D215/48 , C07D253/07 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D417/04 , C07D417/14
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R2, R4, R5, R6, R7, R8, R9, X, Z1, Z2, Z3, Z4 and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 2，R 4，R 5，R 6，R 7，R 8，R 9，X，Z 1，Z 2，Z 3，Z 4和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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7.发明申请公开(公告)号：US20130143862A1
公开(公告)日：2013-06-06
申请号：US13642207
申请日：2011-04-22
申请人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey M. Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey M. Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
IPC分类号： A61K31/501 , C07D401/12 , C07D413/14 , C07D513/04 , C07D487/04 , C07D405/14 , C07D417/14 , C07D401/14 , C07D409/14 , A61K31/50 , C07D237/06 , C07D403/04
CPC分类号： A61K31/50 , A61K31/16 , A61K31/166 , C07D207/26 , C07D211/76 , C07D213/16 , C07D231/56 , C07D237/06 , C07D237/20 , C07D237/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 提供式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，X和m如本文所定义。 还提供了包含式I化合物或其药学上可接受的盐的药学上可接受的组合物。 还提供了使用式I化合物或其药学上可接受的盐的方法。
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公开(公告)号：US20130096315A1
公开(公告)日：2013-04-18
申请号：US13612690
申请日：2012-09-12
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： C07D233/64
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20120135964A1
公开(公告)日：2012-05-31
申请号：US13308287
申请日：2011-11-30
申请人： Xiangping QIAN , Chihyuan (Grace) CHUANG , Pu-Ping LU , Bing YAO , Qing (Kevin) LU , Hong JIANG , Wenyue WANG , Bradley P. MORGAN , David J. MORGANS, JR.
发明人： Xiangping QIAN , Chihyuan (Grace) CHUANG , Pu-Ping LU , Bing YAO , Qing (Kevin) LU , Hong JIANG , Wenyue WANG , Bradley P. MORGAN , David J. MORGANS, JR.
IPC分类号： A61K31/675 , A61K31/496 , A61K31/4985 , A61K31/4725 , A61K31/5377 , A61K31/551 , A61P21/00 , A61P9/12 , A61P11/06 , A61P11/00 , A61P11/08 , A61P27/06 , A61P13/10 , A61P7/04 , A61P15/00 , A61K31/472
CPC分类号： C07H21/04 , C07D213/75 , C07D217/22 , C07D261/14 , C07D277/82 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
摘要翻译： 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体，治疗与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的药物组合物和方法。
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公开(公告)号：US20100069370A1
公开(公告)日：2010-03-18
申请号：US12553311
申请日：2009-09-03
申请人： Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
发明人： Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
IPC分类号： A61K31/551 , A61K31/4965 , C07D243/08 , C07D241/04
CPC分类号： C07D295/26 , C07D207/14 , C07D213/75 , C07D233/88 , C07D257/06 , C07D261/14 , C07D263/48 , C07D277/46 , C07D285/135 , C07D295/18 , C07D403/12
摘要： Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的磺酰胺衍生物可选择性调节心脏肌节，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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