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公开(公告)号：US20130267537A1
公开(公告)日：2013-10-10
申请号：US13759903
申请日：2013-02-05
申请人： Bradley Paul MORGAN , Fady MALIK , Erica Anne KRAYNACK , Alexander Ramon MUCI , Xiangping QIAN , David J. MORGANS, JR.
发明人： Bradley Paul MORGAN , Fady MALIK , Erica Anne KRAYNACK , Alexander Ramon MUCI , Xiangping QIAN , David J. MORGANS, JR.
IPC分类号： C07D295/26 , C07D285/135 , C07D233/88
CPC分类号： C07D295/26 , C07D207/14 , C07D213/75 , C07D233/88 , C07D257/06 , C07D261/14 , C07D263/48 , C07D277/46 , C07D285/135 , C07D295/18 , C07D403/12
摘要： Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的磺酰胺衍生物可选择性调节心脏肌节，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US20130053348A1
公开(公告)日：2013-02-28
申请号：US13612713
申请日：2012-09-12
申请人： Xiangping Qian , Chihyuan (Grace) Chuang , Pu-Ping Lu , Sing Yao , Qing (Kevin) Lu , Hong Jiang , Wenyue Wang , Bradley P. Morgan , David J. Morgans, JR.
发明人： Xiangping Qian , Chihyuan (Grace) Chuang , Pu-Ping Lu , Sing Yao , Qing (Kevin) Lu , Hong Jiang , Wenyue Wang , Bradley P. Morgan , David J. Morgans, JR.
IPC分类号： A61K31/472 , C07F9/62 , A61K31/675 , C07D401/12 , A61K31/496 , C07D471/04 , A61K31/4375 , C07D487/04 , A61K31/4985 , A61K31/437 , C07D413/12 , A61K31/5377 , A61K31/551 , A61K31/655 , A61P21/00 , A61P9/12 , A61P11/06 , A61P11/00 , A61P27/06 , A61P1/00 , A61P13/10 , A61P27/02 , A61P7/04 , A61P15/00 , C07D217/22
CPC分类号： C07H21/04 , C07D213/75 , C07D217/22 , C07D261/14 , C07D277/82 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
摘要翻译： 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体，治疗与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的药物组合物和方法。
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公开(公告)号：US08367661B2
公开(公告)日：2013-02-05
申请号：US13474824
申请日：2012-05-18
申请人： Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, Jr.
发明人： Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, Jr.
IPC分类号： C07D265/30
CPC分类号： C07D295/26 , C07D207/14 , C07D213/75 , C07D233/88 , C07D257/06 , C07D261/14 , C07D263/48 , C07D277/46 , C07D285/135 , C07D295/18 , C07D403/12
摘要： Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的磺酰胺衍生物可选择性调节心脏肌节，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US20120232092A1
公开(公告)日：2012-09-13
申请号：US13474824
申请日：2012-05-18
申请人： Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
发明人： Bradley Paul Morgan , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
IPC分类号： A61K31/496 , C07D403/12 , A61P9/04 , C07D417/12
CPC分类号： C07D295/26 , C07D207/14 , C07D213/75 , C07D233/88 , C07D257/06 , C07D261/14 , C07D263/48 , C07D277/46 , C07D285/135 , C07D295/18 , C07D403/12
摘要： Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的磺酰胺衍生物可选择性调节心脏肌节，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US20120088779A1
公开(公告)日：2012-04-12
申请号：US13330356
申请日：2011-12-19
申请人： Bradley Paul MORGAN , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
发明人： Bradley Paul MORGAN , Fady Malik , Erica Anne Kraynack , Alexander Ramon Muci , Xiangping Qian , David J. Morgans, JR.
IPC分类号： A61K31/495 , A61P9/04 , A61K31/496 , C07D403/12 , C07D295/26 , C07D413/12
CPC分类号： C07D295/26 , C07D207/14 , C07D213/75 , C07D233/88 , C07D257/06 , C07D261/14 , C07D263/48 , C07D277/46 , C07D285/135 , C07D295/18 , C07D403/12
摘要： Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号：US08119678B2
公开(公告)日：2012-02-21
申请号：US13075076
申请日：2011-03-29
申请人： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
发明人： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC分类号： A61K31/4164
CPC分类号： C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号：US08110595B2
公开(公告)日：2012-02-07
申请号：US11630062
申请日：2005-06-16
申请人： Bradley Paul Morgan , Alex Muci , Pu-Ping Lu , Erica Anne Kraynack , Todd Tochimoto , David J. Morgans, Jr.
发明人： Bradley Paul Morgan , Alex Muci , Pu-Ping Lu , Erica Anne Kraynack , Todd Tochimoto , David J. Morgans, Jr.
IPC分类号： A61K31/40 , C07D261/02 , C07D295/04
CPC分类号： C07D213/75 , C07D211/56 , C07D239/42 , C07D261/14 , C07D263/48 , C07D271/113 , C07D295/26 , C07D401/10 , C07D401/12 , C07D417/00 , C07D417/10 , C07D417/12 , C07D487/04 , C07D491/04 , C07D513/04
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的脲衍生物选择性地调节心肌肉瘤，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US07939534B2
公开(公告)日：2011-05-10
申请号：US11888672
申请日：2007-07-31
申请人： Pu-Ping Lu , Xiangping Qian , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans, Jr.
发明人： Pu-Ping Lu , Xiangping Qian , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans, Jr.
IPC分类号： C07D401/14 , A61K31/44
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
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公开(公告)号：US07932270B2
公开(公告)日：2011-04-26
申请号：US11888625
申请日：2007-07-31
申请人： Pu-Ping Lu , Xiangping Qian , Jeffrey T. Finer , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans, Jr.
发明人： Pu-Ping Lu , Xiangping Qian , Jeffrey T. Finer , Chihyuan (Grace) Chuang , Bradley P. Morgan , David J. Morgans, Jr.
IPC分类号： C07D401/14 , A61K31/44
CPC分类号： C07D401/14 , C07D213/82 , C07D401/12 , C07D405/14
摘要： Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
摘要翻译： 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体以及与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的化学实体，药物组合物和治疗方法。
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公开(公告)号：US07795448B2
公开(公告)日：2010-09-14
申请号：US11124608
申请日：2005-05-06
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： C07D233/64 , C07D231/12 , A61K31/415 , A61K31/4164
CPC分类号： C07D403/12 , A61K31/4172 , A61K31/421 , A61K31/426 , A61K31/4745 , A61K31/538 , A61K31/66 , A61K45/06 , C07C235/48 , C07C235/50 , C07C237/22 , C07C255/44 , C07C255/57 , C07C255/60 , C07C271/28 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D231/12 , C07D235/18 , C07D239/22 , C07D261/08 , C07D271/06 , C07D277/42 , C07D285/12 , C07D295/15 , C07D333/38 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
摘要翻译： 提供式V的化合物及其药学上可接受的盐，其可用于治疗癌症或其它增殖性疾病。
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