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1.发明授权Method for reducing calcification of biological tissue used implantable bioprostheses 失效使用可植入生物假体减少生物组织钙化的方法
公开(公告)号：US5882850A
公开(公告)日：1999-03-16
申请号：US949617
申请日：1997-10-14
申请人： Eugene Khor , Aileen Wee , Weng Keong Loke , Bee Li Tan
发明人： Eugene Khor , Aileen Wee , Weng Keong Loke , Bee Li Tan
CPC分类号： A61L27/3604 , A61L27/3625 , A61L27/3687 , A61L27/507 , A61L27/60 , A61L2400/02 , Y10S623/916
摘要： Biological materials are treated with an organic chemical agent, dimethyl sulfoxide, to delay the onset of in vivo calcification. The biological materials so treated become resistant to calcification over a prolonged period with no known deleterious effects to the host. The procedure involves the incubation of the natural biological materials in the chemical agent, prior to or after glutaraldehyde fixation, at room temperature or at temperatures up to 60.degree. C. Materials that can be treated with this process include biological materials intended for bioprostheses use, such as porcine aortic valves, porcine aortic valve leaflets, bovine, equine and porcine pericardium, aortic homografts, reconstituted collagen, and the like suitable for invasive, or in-dwelling use in a human or animal body.
摘要翻译： 生物材料用有机化学试剂二甲基亚砜处理，以延缓体内钙化的发生。 如此处理的生物材料在长时间内变得耐钙化，对宿主没有已知的有害影响。 该方法包括将天然生物材料在化学试剂中，在戊二醛固定之前或之后，在室温或高达60℃的温度下孵育。可用该方法处理的材料包括用于生物预处理的生物材料， 例如猪主动脉瓣，猪主动脉瓣小叶，牛，马和猪心包膜，主动脉同种移植物，重建胶原蛋白等，适合在人体或动物身上进行侵入或住宅使用。
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公开(公告)号：US5821285A
公开(公告)日：1998-10-13
申请号：US936541
申请日：1997-09-24
CPC分类号： C08K3/0008 , C08K3/34
摘要： The method relates to the preparation of dry chitin forms of consistent shape that incorporates an advantageous additive such as fillers or reinforcement during the preparation process to give dry forms of chitin with consistent shape typically known as filler containing chitin or chitin composites.
摘要翻译： 该方法涉及制备一致形状的干几丁质形式，其在制备过程中引入有利的添加剂如填料或增强剂，以产生具有一般形状的干燥形式的几丁质，通常称为含有几丁质或几丁质复合材料的填料。
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公开(公告)号：US20110136935A1
公开(公告)日：2011-06-09
申请号：US12675424
申请日：2007-08-30
申请人： Eugene Khor , Chang Ming Guo , Hong Wu , Lee Yong Lim
发明人： Eugene Khor , Chang Ming Guo , Hong Wu , Lee Yong Lim
CPC分类号： C08F290/06 , A61K6/0067 , A61K6/0085 , A61L24/0015 , A61L24/0084 , A61L24/10 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/428 , A61L2300/64 , A61L2430/02 , C08F251/00 , C08F251/02 , C08F283/00 , C08F283/06 , C08F290/061 , C08F290/062 , C08L51/02 , C08L53/00 , C08L5/08 , C08L2666/02 , A61K6/097 , A61K6/087 , C08L33/14 , C08L89/00 , C08L71/02 , C08L29/04 , C08L1/286 , C08L1/284 , A61K6/083 , A61K6/0038 , A61K6/0041
摘要： The present invention provides a composition comprising: at least one viscosity-enhancing agent; and at least one macromonomer. In particular, the composition may be a bone cement composition and/or a dental cement composition. The composition may be used in medicine. The composition may be used in orthopedic and/or periodontal applications. The present invention also provides uses of the composition.
摘要翻译： 本发明提供一种组合物，其包含：至少一种粘度增强剂; 和至少一种大分子单体。 特别地，组合物可以是骨水泥组合物和/或牙科粘固剂组合物。 该组合物可用于医药。 该组合物可用于矫形和/或牙周应用。 本发明还提供了组合物的用途。
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公开(公告)号：US6025479A
公开(公告)日：2000-02-15
申请号：US899164
申请日：1997-07-23
CPC分类号： C08B37/003 , C08L5/08
摘要： This invention relates to a method of preparing a form of chitin that has consistent shape in the dry form, is treated chemically such that it will swell when exposed to water to form a gel. The gel can be dried to give the dry form. The gel formation upon absorption/swelling in the presence of water and drying to give the dried form is reversible. The extent of swelling can be varied by suitably varying the chemical treatment.
摘要翻译： 本发明涉及一种制备具有干燥形式一致形状的壳多糖形式的方法，化学处理使其在暴露于水中时会溶胀以形成凝胶。 可以将凝胶干燥以得到干燥形式。 在水的存在下吸收/溶胀时的凝胶形成并干燥得到干燥形式是可逆的。 膨胀的程度可以通过适当地改变化学处理来改变。
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