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15 条记录 (耗时 0.015 秒)

    NOVEL CHLORIN E6-FOLIC ACID CONJUGATE, PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER COMPRISING THE SAME
    1.
    发明申请
    NOVEL CHLORIN E6-FOLIC ACID CONJUGATE, PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER COMPRISING THE SAME 有权
    新氯酸E6-羧酸共聚物，其制备方法和用于治疗包含其的癌症的药物组合物

    公开(公告)号：US20120059018A1

    公开(公告)日：2012-03-08

    申请号：US12594186

    申请日：2009-04-29

    申请人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

    发明人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

    IPC分类号： A61K31/519 ,  A61P35/00 ,  C07D487/22

    CPC分类号： C07D487/22 ,  A61K41/0071 ,  A61K47/551 ,  C07D519/00

    摘要： The present invention relates to a novel chlorin e6-folic acid conjugate, a preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same, and more particularly, to a novel compound prepared by linking chlorin e6 to folic acid, which effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic therapy for malignant tumors, a preparation method thereof, and a pharmaceutical composition for photodynamic treatment of solid tumors comprising the compound.

    摘要翻译： 本发明涉及一种新的二氢卟吩e6-叶酸结合物，其制备方法和用于治疗癌症的药物组合物，特别涉及通过将二氢卟酚e6连接到叶酸而制备的新型化合物，其中 有效地在各种培养基中产生单线态氧，并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性，从而有效地用于恶性肿瘤的光动力学治疗，其制备方法和用于光动力治疗实体瘤的药物组合物，其包含化合物 。

    PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING CHLORIN E6-FOLIC ACID CONJUGATE COMPOUND AND CHITOSAN
    2.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING CHLORIN E6-FOLIC ACID CONJUGATE COMPOUND AND CHITOSAN 审中-公开
    用于治疗包含氯林E6-乳酸联合化合物和壳多糖的癌症的药物组合物

    公开(公告)号：US20120035180A1

    公开(公告)日：2012-02-09

    申请号：US12594180

    申请日：2009-04-29

    申请人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

    发明人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

    IPC分类号： A61K31/519 ,  A61P35/00

    CPC分类号： A61K31/395 ,  A61K31/519 ,  A61K31/722 ,  A61K41/0071 ,  A61K47/551 ,  A61K2300/00

    摘要： The present invention relates to a pharmaceutical composition for the treatment of cancer comprising a chlorin e6-folic acid conjugate compound and chitosan, and more particularly, to a pharmaceutical composition for photodynamic therapy of solid tumors comprising the novel chlorin e6-folic acid conjugate compound or a pharmaceutically acceptable salt thereof and chitosan, in which the novel compound is prepared by linking chlorin e6 to folic acid, and effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic treatment for malignant tumors.

    摘要翻译： 本发明涉及用于治疗癌症的药物组合物，其包含二氢卟吩e6-叶酸结合化合物和壳聚糖，更具体地，涉及一种用于实体瘤的光动力疗法的药物组合物，其包含新的二氢卟吩e6-叶酸结合物或 其药学上可接受的盐和壳聚糖，其中通过将二氢卟酚e6连接到叶酸来制备新化合物，并且在各种培养基中有效产生单线态氧并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性，从而有效地用于 恶性肿瘤的光动力治疗。

    METHOD FOR GENERATING AND AUTHENTICATING THREE-DIMENSIONAL DYNAMIC OTP WITHOUT PASSWORD INPUT
    5.
    发明申请
    METHOD FOR GENERATING AND AUTHENTICATING THREE-DIMENSIONAL DYNAMIC OTP WITHOUT PASSWORD INPUT 有权

    公开(公告)号：US20230042697A1

    公开(公告)日：2023-02-09

    申请号：US17825184

    申请日：2022-05-26

    申请人： Jong-Seong KIM ,  Eun-Hee LEE ,  Hyun-Min KIM

    发明人： Jong-Seong KIM ,  Eun-Hee LEE ,  Hyun-Min KIM

    IPC分类号： H04L9/08 ,  H04L9/32

    摘要： Disclosed is a method for generating and authenticating a three-dimensional dynamic OTP that does not require input of a password. In the method, a user address received from a user terminal is converted into coordinate values in degrees, minutes, and seconds on latitude and longitude, and set as address coordinates from the coordinates in a unit of seconds and then a two-dimensional reference coordinate system is displayed that is subdivided with the address coordinates as an origin, a two-dimensional function is provided and rotated about an arbitrary axis to form a three-dimensional space by a three-dimensional function, one OTP generation coordinate within the three-dimensional space is provided, and then a one-time password is generated by combining respective coordinate values of x, y, and z axes of the one OTP generation coordinate.

    Single or multiple route map matching apparatus for navigation service and method thereof
    7.
    发明授权
    Single or multiple route map matching apparatus for navigation service and method thereof 有权
    用于导航服务的单路或多路线图匹配装置及其方法

    公开(公告)号：US07493213B2

    公开(公告)日：2009-02-17

    申请号：US10371062

    申请日：2003-02-20

    申请人： Eun-Hee Lee ,  Kyong-Joon Chun ,  Young-Khon Moon

    发明人： Eun-Hee Lee ,  Kyong-Joon Chun ,  Young-Khon Moon

    IPC分类号： G01C21/34

    CPC分类号： G01C21/3415 ,  G01C21/30

    摘要： Disclosed is a single or multi-route map matching apparatus in a system which provides a navigation service via a mobile communication terminal. The map matching apparatus comprises: an information center for calculating an optimum route to a destination inputted by a user based upon a present location of the mobile communication terminal, and generating a format of route data based upon the calculated optimum route; and an Intelligent Transportation System (ITS) terminal for detecting the present location of the mobile terminal to generate location data, processing the route data, performing map matching based upon the location data to determine whether the user travels on a given route or departs from the route, and performing road guidance based upon a result of the map matching.

    摘要翻译： 公开了一种通过移动通信终端提供导航服务的系统中的单路或多路线地图匹配装置。 地图匹配装置包括：信息中心，用于根据移动通信终端的当前位置，计算由用户输入的到目的地的最佳路由，并基于所计算的最优路由生成路由数据的格式; 以及智能交通系统（ITS）终端，用于检测移动终端的当前位置以产生位置数据，处理路线数据，基于位置数据执行地图匹配，以确定用户是否在给定路线上行驶或离开 路线，并根据地图匹配的结果进行道路引导。

    Chlorin e6-folic acid conjugate, preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same
    8.
    发明授权
    Chlorin e6-folic acid conjugate, preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same 有权
    二氢卟吩e6-叶酸结合物，其制备方法和用于治疗癌症的药物组合物

    公开(公告)号：US08735439B2

    公开(公告)日：2014-05-27

    申请号：US12594186

    申请日：2009-04-29

    申请人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

    发明人： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

    IPC分类号： C07D487/22

    CPC分类号： C07D487/22 ,  A61K41/0071 ,  A61K47/551 ,  C07D519/00

    摘要： The present invention relates to a novel chlorin e6-folic acid conjugate, a preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same, and more particularly, to a novel compound prepared by linking chlorin e6 to folic acid, which effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic therapy for malignant tumors, a preparation method thereof, and a pharmaceutical composition for photodynamic treatment of solid tumors comprising the compound as an active ingredient.

    摘要翻译： 本发明涉及一种新的二氢卟吩e6-叶酸结合物，其制备方法和用于治疗癌症的药物组合物，特别涉及通过将二氢卟酚e6连接到叶酸而制备的新型化合物，其中 有效地在各种培养基中产生单线态氧，并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性，从而有效地用于恶性肿瘤的光动力学治疗，其制备方法和用于光动力治疗实体瘤的药物组合物，包括化合物 作为活性成分。

    Telematics system using image data and method for directing a route by using the same
    10.
    发明申请
    Telematics system using image data and method for directing a route by using the same 失效
    使用图像数据的远程信息处理系统和使用该路线的方法

    公开(公告)号：US20050119826A1

    公开(公告)日：2005-06-02

    申请号：US10933764

    申请日：2004-09-03

    申请人： Eun-Hee Lee ,  Yong-Khon Moon

    发明人： Eun-Hee Lee ,  Yong-Khon Moon

    IPC分类号： G01C21/36 ,  G08G1/0962 ,  G08G1/0968 ,  G08G1/123 ,  G01C21/34

    CPC分类号： G08G1/096861 ,  G01C21/3647 ,  G01C21/3658 ,  G08G1/096811 ,  G08G1/09685

    摘要： Disclosed is a telematics system comprising a telematics terminal for storing complex intersection images and providing information related to a present position and a running direction by using the complex intersection images, and a telematics server for sharing ID codes of the complex intersection images stored in the telematics terminal with the telematics terminal and creating route data in response to a request from the telematics terminal, wherein the telematics server adds the ID codes of the complex intersection images to the route data when the route data include complex intersections and transmits the ID codes of the complex intersection images and the route data to the telematics terminal. The telematics system provides route information, which is easily recognized by users.

    摘要翻译： 公开了一种远程信息处理系统，其包括远程信息处理终端，用于通过使用复杂的交叉图像来存储复杂的交叉图像和提供与当前位置和运行方向相关的信息;以及远程信息处理服务器，用于共享存储在远程信息处理中的复杂交叉图像的ID码 终端与远程信息处理终端，并响应于来自远程信息处理终端的请求创建路由数据，其中远程信息处理服务器在路由数据包括复杂交叉点时将复杂交叉路口图像的ID代码添加到路线数据，并且发送 复杂的交叉路口图像和路由数据到远程信息处理终端。 远程信息处理系统提供路由信息，用户可以轻松识别。