-
公开(公告)号：US20110143387A1
公开(公告)日：2011-06-16
申请号：US12906893
申请日：2010-10-18
申请人： Leonid D. Patsenker , Inna G. Yermolenko , Iryna A. Fedyunyaeva , Yelena N. Obukhova , Olga N. Semenova , Ewald A. Terpetschnig
发明人： Leonid D. Patsenker , Inna G. Yermolenko , Iryna A. Fedyunyaeva , Yelena N. Obukhova , Olga N. Semenova , Ewald A. Terpetschnig
IPC分类号： C12Q1/02 , C07D471/06 , C07D239/72 , C07D239/70 , C07K14/00 , C07H21/04 , C07K2/00 , C12N5/00 , C12N5/04 , C12N1/00 , G01N21/76 , G01N21/64
CPC分类号： C07D403/12 , C07D209/60 , C07D219/02 , C07D221/14 , C07D239/74 , C07D285/14 , C07D307/77 , C07D413/14 , C07D471/04 , C07D471/06 , C07D471/14 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1044 , C09K2211/1048
摘要： Luminescent labels based on aromatic and heterocyclic compounds, including reactive intermediates used to synthesize these compounds, and methods of synthesizing and using these reporter compounds. These labels combine high photostabilities, large Stokes' shifts and contain a pyrimidinium moiety as a water-soluble group. These luminescent compounds relate generally to the following structure: The methods relate generally to the synthesis and/or use of reporter compounds for fluorescence lifetime or fluorescence polarization based applications.
摘要翻译： 基于芳族和杂环化合物的发光标记，包括用于合成这些化合物的反应性中间体，以及合成和使用这些报告化合物的方法。 这些标签结合了高光稳定性，大的斯托克斯变化，并含有作为水溶性基团的嘧啶鎓部分。 这些发光化合物通常涉及以下结构：该方法一般涉及用于荧光寿命或基于荧光偏振的应用的报告化合物的合成和/或使用。
-
公开(公告)号：US07250517B2
公开(公告)日：2007-07-31
申请号：US10724580
申请日：2003-11-28
CPC分类号： C07H21/00 , C09B23/0066 , C09B23/02 , C09B57/007 , C09K11/06 , C09K2211/1007 , C09K2211/1022 , C09K2211/1029 , C09K2211/1037 , C09K2211/1044 , C09K2211/1048 , C09K2211/1051 , C09K2211/1074 , C09K2211/1081 , G01N33/582 , Y10T436/143333
摘要： The invention provides reporter compounds based on squaric, croconic, and/or rhodizonic acid, among others, reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing and using the reporter compounds, among others.The reporter compounds relate generally to the following structure: Here, Z is a four, five, or six-member aromatic ring, and A, B, C, D, E, and F are substituents of Z, where F is absent when Z is a five-member ring, and where E and F are absent when Z is a four-member ring. A, B, C, D, E, and F are selected from a variety of elements and groups, including but not necessarily limited to O, S, Se, Te, N—Rc, C(Rf)(Rg), W1, and W2
摘要翻译： 本发明提供了基于方圆，克罗克和/或铑酸等的报告化合物，其中包括用于合成报告化合物的反应性中间体，以及合成和使用报告化合物等的方法。 报道化合物一般涉及以下结构：这里，Z是四，五或六元芳环，A，B，C，D，E和F是Z的取代基，其中当Z不存在时，F不存在 是一个五元环，当Z是四元环时，E和F不存在。 A，B，C，D，E和F选自各种元素和基团，包括但不限于O，S，Se，Te，NR C， （R＆gt;＆gt;），W＆lt; 1＆gt;和＆lt; 2＆gt;
-
公开(公告)号：US20120035346A1
公开(公告)日：2012-02-09
申请号：US13144890
申请日：2010-01-15
申请人： Ewald A. Terpetschnig , Leonid D. Patsenker , Larysa Markova , Iryna A. Fedyunyaeva , Olga S. Kolosova , Sergiy Starko , Anatoliy Tatarets
发明人： Ewald A. Terpetschnig , Leonid D. Patsenker , Larysa Markova , Iryna A. Fedyunyaeva , Olga S. Kolosova , Sergiy Starko , Anatoliy Tatarets
CPC分类号： G01N33/582 , A61K49/0032 , C07F9/5728 , C09B23/0033 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , C12Q1/02 , C12Q1/6818 , C12Q1/6869
摘要： Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkage are selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye, or a styryl dye.
摘要翻译： 基于含有至少一种烷基膦酸酯或取代的烷基 - 膦酸酯基团的聚甲炔染料的染料和光致发光化合物，包括合成前体，合成方法及其应用。 某些实施方案包括杂环系统和聚甲炔键，使得得到的聚甲炔染料是花青染料，部花青染料或苯乙烯基染料。
-
公开(公告)号：US07411068B2
公开(公告)日：2008-08-12
申请号：US10986446
申请日：2004-11-10
申请人： Ewald A. Terpetschnig , Anatoliy Tatarets , Olga Galkina , Iryna Fedyunyaeva , Leonid Patsenker
发明人： Ewald A. Terpetschnig , Anatoliy Tatarets , Olga Galkina , Iryna Fedyunyaeva , Leonid Patsenker
IPC分类号： C07D215/12 , G01N21/76 , C12Q1/68
CPC分类号： C07H21/00 , C09B23/0066 , C09B23/02 , C09B57/007 , C09K11/06 , C09K2211/1007 , C09K2211/1022 , C09K2211/1029 , C09K2211/1037 , C09K2211/1044 , C09K2211/1048 , C09K2211/1051 , C09K2211/1074 , C09K2211/1081 , G01N33/582 , Y10T436/13
摘要： The invention provides reporter compounds based on squaric, croconic, and/or rhodizonic acid, among others, reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing and using the reporter compounds, among others.The reporter compounds relate generally to the following structure Here, Z is a four, five, or six-member aromatic ring, and A, B, C, D, E, and F are substituents of Z, where F is absent when Z is a five-member ring, and where E and F are absent when Z is a four-member ring. A, B, C, D, E, and F are selected from a variety of elements and groups, including but not necessarily limited to O, S, Se, Te, N—Ra, C(Rb)(Rc), W1, and W2.
摘要翻译： 本发明提供了基于方圆，克罗克和/或铑酸等的报告化合物，其中包括用于合成报告化合物的反应性中间体，以及合成和使用报告化合物等的方法。 报道化合物一般涉及以下结构：其中Z为四，五或六元芳环，A，B，C，D，E和F为Z的取代基，当Z为Z时，F不存在 一个五元环，当Z是四元环时，E和F不存在。 A，B，C，D，E和F选自多种元素和基团，包括但不限于O，S，Se，Te，NR，C（R， （S），（B），（S），W＆lt; 1＆gt;和W 2。
-
公开(公告)号：US08552027B2
公开(公告)日：2013-10-08
申请号：US13144890
申请日：2010-01-15
申请人： Ewald A. Terpetschnig , Leonid D. Patsenker , Larsya Markova , Iryna A. Fedyunyaeva , Olga S. Kolosova , Sergiy Starko , Anatoliy Tatarets
发明人： Ewald A. Terpetschnig , Leonid D. Patsenker , Larsya Markova , Iryna A. Fedyunyaeva , Olga S. Kolosova , Sergiy Starko , Anatoliy Tatarets
IPC分类号： C07D499/24 , A61K31/44
CPC分类号： G01N33/582 , A61K49/0032 , C07F9/5728 , C09B23/0033 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , C12Q1/02 , C12Q1/6818 , C12Q1/6869
摘要： Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkage are selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye, or a styryl dye.
摘要翻译： 基于含有至少一种烷基膦酸酯或取代的烷基 - 膦酸酯基团的聚甲炔染料的染料和光致发光化合物，包括合成前体，合成方法及其应用。 某些实施方案包括杂环系统和聚甲炔键，使得得到的聚甲炔染料是花青染料，部花青染料或苯乙烯基染料。
-
公开(公告)号：US06538129B1
公开(公告)日：2003-03-25
申请号：US09684627
申请日：2000-10-06
IPC分类号： C07H2104
CPC分类号： C07H21/00
摘要： Luminescent compounds, reactive intermediates used to synthesize luminescent compounds, and methods of synthesizing and using luminescent compounds. These compounds may be based on squaric, croconic, and rhodizonic acid, and their analogs, among others, and relate generally to the structure: where Z is a four, five, or six-member aromatic ring, and A, B, C, D, E, and F are substituents of Z, in any order, that may include O, S, Se, Te, C(Ra)(Rb), N—Rc, N(Rd)(Re), W1, and W2. Generally, each compound includes at least one of W1 or W2, where W1 and W2 have the structures: respectively. The compounds may include a reactive group and/or a carrier. The luminescent compounds may be useful in both free and conjugated forms as probes, labels, and/or indicators.
摘要翻译： 发光化合物，用于合成发光化合物的反应性中间体，以及合成和使用发光化合物的方法。 这些化合物可以基于方格，克罗克酸和铑酸，以及它们的类似物，其中通常涉及以下结构：其中Z是四，五或六元芳环，A，B，C， D，E和F是Z的取代基，可以包括O，S，Se，Te，C（Ra）（Rb），N-Rc，N（Rd）（Re），W1和W2 。 通常，每个化合物包括W1或W2中的至少一个，其中W1和W2分别具有以下结构： 化合物可以包括反应性基团和/或载体。 发光化合物可以以游离和缀合形式用作探针，标记和/或指示剂。
-
公开(公告)号：US07070921B2
公开(公告)日：2006-07-04
申请号：US09844655
申请日：2001-04-27
IPC分类号： G01N21/75
CPC分类号： C07K7/06 , B01L3/50853 , C07K7/08 , C12Q1/485 , G01N33/5308 , G01N33/542 , G01N33/566 , G01N33/582 , G01N35/028 , G01N35/1011 , G01N35/1074 , G01N2035/00237 , G01N2035/0405 , G01N2035/0425 , G01N2035/0462 , G01N2333/9121 , Y10S436/80 , Y10S436/805
摘要： Assays for detecting molecular modifications such as phosphate modifications and the presence and/or activity of enzymes and other agents involved in facilitating or otherwise regulating such modifications.
-
公开(公告)号：US09034655B2
公开(公告)日：2015-05-19
申请号：US12906893
申请日：2010-10-18
申请人： Leonid D. Patsenker , Inna G. Yermolenko , Iryna A. Fedyunyaeva , Yelena N. Obukhova , Olga N. Semenova , Ewald A. Terpetschnig
发明人： Leonid D. Patsenker , Inna G. Yermolenko , Iryna A. Fedyunyaeva , Yelena N. Obukhova , Olga N. Semenova , Ewald A. Terpetschnig
IPC分类号： C07D239/70 , C07D403/12 , C07D209/60 , C07D219/02 , C07D221/14 , C07D239/74 , C07D285/14 , C07D307/77 , C07D413/14 , C07D471/04 , C07D471/06 , C07D471/14 , C09K11/06 , C12Q1/02
CPC分类号： C07D403/12 , C07D209/60 , C07D219/02 , C07D221/14 , C07D239/74 , C07D285/14 , C07D307/77 , C07D413/14 , C07D471/04 , C07D471/06 , C07D471/14 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1044 , C09K2211/1048
摘要： Luminescent labels based on aromatic and heterocyclic compounds, including reactive intermediates used to synthesize these compounds, and methods of synthesizing and using these reporter compounds. These labels combine high photostabilities, large Stokes' shifts and contain a pyrimidinium moiety as a water-soluble group. These luminescent compounds relate generally to the following structure: The methods relate generally to the synthesis and/or use of reporter compounds for fluorescence lifetime or fluorescence polarization based applications.
摘要翻译： 基于芳族和杂环化合物的发光标记，包括用于合成这些化合物的反应性中间体，以及合成和使用这些报告化合物的方法。 这些标签结合了高光稳定性，大的斯托克斯变化，并含有作为水溶性基团的嘧啶鎓部分。 这些发光化合物通常涉及以下结构：该方法一般涉及用于荧光寿命或基于荧光偏振的应用的报告化合物的合成和/或使用。
-
公开(公告)号：US20140086844A1
公开(公告)日：2014-03-27
申请号：US14047878
申请日：2013-10-07
申请人： Ewald A. Terpetschnig , Leonid D. Patsenker , Larysa Markova , Iryna A. Fedyunyaeva , Olga S. Kolosova , Sergiy Starko , Anatoliy Tatarets
发明人： Ewald A. Terpetschnig , Leonid D. Patsenker , Larysa Markova , Iryna A. Fedyunyaeva , Olga S. Kolosova , Sergiy Starko , Anatoliy Tatarets
CPC分类号： G01N33/582 , A61K49/0032 , C07F9/5728 , C09B23/0033 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , C12Q1/02 , C12Q1/6818 , C12Q1/6869
摘要： Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkages selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye or a styryl dye.
摘要翻译： 基于含有至少一种烷基膦酸酯或取代的烷基 - 膦酸酯基团的聚甲炔染料的染料和光致发光化合物，包括合成前体，合成方法及其应用。 某些实施方案包括选择的杂环体系和聚甲炔键，使得得到的聚甲炔染料是花青染料，部花青染料或苯乙烯基染料。
-
公开(公告)号：US08642014B2
公开(公告)日：2014-02-04
申请号：US12512972
申请日：2009-07-30
申请人： Ewald A. Terpetschnig , Leonid D. Patsenker , Oleksii Klochko , Yuliia Kudriavtseva , Anatoliy L. Tatarets , Inna G. Yermolenko , Yevgen A. Povrozin
发明人： Ewald A. Terpetschnig , Leonid D. Patsenker , Oleksii Klochko , Yuliia Kudriavtseva , Anatoliy L. Tatarets , Inna G. Yermolenko , Yevgen A. Povrozin
IPC分类号： A61B5/00 , C07D513/00 , C07D245/00 , F21V9/16 , G01N1/30
CPC分类号： C07D471/18 , A61K49/0032 , A61K49/0052 , C07D471/22 , C07D491/22 , C07D493/22 , C07D498/22 , C07D513/18 , C09B57/007 , G01N33/582
摘要： Luminescent reporter compounds that are rotaxanes having the structure where B—Z—C is a reporter molecule based on a cyanine, squaric acid, or other reporter, and K is a macrocycle that encircles and interlocks with the reporter molecule. Applications of the reporter compounds are provided, as well as reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing the reporter compounds.
摘要翻译： 具有B-Z-C为基于花青，方酸，或其它报道基的报告基因分子结构的轮烷的发光报道化合物，K为与报告分子包围并互锁的大环。 提供了报告化合物的应用，以及用于合成报告化合物的反应性中间体，以及合成报告化合物的方法。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.014 秒)
