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公开(公告)号：US08642014B2
公开(公告)日：2014-02-04
申请号：US12512972
申请日：2009-07-30
申请人： Ewald A. Terpetschnig , Leonid D. Patsenker , Oleksii Klochko , Yuliia Kudriavtseva , Anatoliy L. Tatarets , Inna G. Yermolenko , Yevgen A. Povrozin
发明人： Ewald A. Terpetschnig , Leonid D. Patsenker , Oleksii Klochko , Yuliia Kudriavtseva , Anatoliy L. Tatarets , Inna G. Yermolenko , Yevgen A. Povrozin
IPC分类号： A61B5/00 , C07D513/00 , C07D245/00 , F21V9/16 , G01N1/30
CPC分类号： C07D471/18 , A61K49/0032 , A61K49/0052 , C07D471/22 , C07D491/22 , C07D493/22 , C07D498/22 , C07D513/18 , C09B57/007 , G01N33/582
摘要： Luminescent reporter compounds that are rotaxanes having the structure where B—Z—C is a reporter molecule based on a cyanine, squaric acid, or other reporter, and K is a macrocycle that encircles and interlocks with the reporter molecule. Applications of the reporter compounds are provided, as well as reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing the reporter compounds.
摘要翻译： 具有B-Z-C为基于花青，方酸，或其它报道基的报告基因分子结构的轮烷的发光报道化合物，K为与报告分子包围并互锁的大环。 提供了报告化合物的应用，以及用于合成报告化合物的反应性中间体，以及合成报告化合物的方法。
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公开(公告)号：US20100266507A1
公开(公告)日：2010-10-21
申请号：US12512972
申请日：2009-07-30
申请人： Ewald A. Terpetschnig , Leonid D. Patsenker , Oleksii Klochko , Yuliia Kudriavtseva , Anatoliy L. Tatarets , Inna G. Yermolenko , Yevgen A. Povrozin
发明人： Ewald A. Terpetschnig , Leonid D. Patsenker , Oleksii Klochko , Yuliia Kudriavtseva , Anatoliy L. Tatarets , Inna G. Yermolenko , Yevgen A. Povrozin
IPC分类号： A61K49/00 , C07D471/22 , C07D495/14 , C07D491/22 , C07H21/00 , C07H17/00 , C07K2/00 , C07K14/42 , A61P43/00 , C12N5/071 , C07K1/113 , C40B50/00 , G01N33/567 , G01J1/58
CPC分类号： C07D471/18 , A61K49/0032 , A61K49/0052 , C07D471/22 , C07D491/22 , C07D493/22 , C07D498/22 , C07D513/18 , C09B57/007 , G01N33/582
摘要： Luminescent reporter compounds that are rotaxanes having the structure where B—Z—C is a reporter molecule based on a cyanine, squaric acid, or other reporter, and K is a macrocycle that encircles and interlocks with the reporter molecule. Applications of the reporter compounds are provided, as well as reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing the reporter compounds.
摘要翻译： 具有B-Z-C为基于花青，方酸，或其它报道基的报告基因分子结构的轮烷的发光报道化合物，K为与报告分子包围并互锁的大环。 提供了报告化合物的应用，以及用于合成报告化合物的反应性中间体，以及合成报告化合物的方法。
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公开(公告)号：US20110143387A1
公开(公告)日：2011-06-16
申请号：US12906893
申请日：2010-10-18
申请人： Leonid D. Patsenker , Inna G. Yermolenko , Iryna A. Fedyunyaeva , Yelena N. Obukhova , Olga N. Semenova , Ewald A. Terpetschnig
发明人： Leonid D. Patsenker , Inna G. Yermolenko , Iryna A. Fedyunyaeva , Yelena N. Obukhova , Olga N. Semenova , Ewald A. Terpetschnig
IPC分类号： C12Q1/02 , C07D471/06 , C07D239/72 , C07D239/70 , C07K14/00 , C07H21/04 , C07K2/00 , C12N5/00 , C12N5/04 , C12N1/00 , G01N21/76 , G01N21/64
CPC分类号： C07D403/12 , C07D209/60 , C07D219/02 , C07D221/14 , C07D239/74 , C07D285/14 , C07D307/77 , C07D413/14 , C07D471/04 , C07D471/06 , C07D471/14 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1044 , C09K2211/1048
摘要： Luminescent labels based on aromatic and heterocyclic compounds, including reactive intermediates used to synthesize these compounds, and methods of synthesizing and using these reporter compounds. These labels combine high photostabilities, large Stokes' shifts and contain a pyrimidinium moiety as a water-soluble group. These luminescent compounds relate generally to the following structure: The methods relate generally to the synthesis and/or use of reporter compounds for fluorescence lifetime or fluorescence polarization based applications.
摘要翻译： 基于芳族和杂环化合物的发光标记，包括用于合成这些化合物的反应性中间体，以及合成和使用这些报告化合物的方法。 这些标签结合了高光稳定性，大的斯托克斯变化，并含有作为水溶性基团的嘧啶鎓部分。 这些发光化合物通常涉及以下结构：该方法一般涉及用于荧光寿命或基于荧光偏振的应用的报告化合物的合成和/或使用。
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公开(公告)号：US09034655B2
公开(公告)日：2015-05-19
申请号：US12906893
申请日：2010-10-18
申请人： Leonid D. Patsenker , Inna G. Yermolenko , Iryna A. Fedyunyaeva , Yelena N. Obukhova , Olga N. Semenova , Ewald A. Terpetschnig
发明人： Leonid D. Patsenker , Inna G. Yermolenko , Iryna A. Fedyunyaeva , Yelena N. Obukhova , Olga N. Semenova , Ewald A. Terpetschnig
IPC分类号： C07D239/70 , C07D403/12 , C07D209/60 , C07D219/02 , C07D221/14 , C07D239/74 , C07D285/14 , C07D307/77 , C07D413/14 , C07D471/04 , C07D471/06 , C07D471/14 , C09K11/06 , C12Q1/02
CPC分类号： C07D403/12 , C07D209/60 , C07D219/02 , C07D221/14 , C07D239/74 , C07D285/14 , C07D307/77 , C07D413/14 , C07D471/04 , C07D471/06 , C07D471/14 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1044 , C09K2211/1048
摘要： Luminescent labels based on aromatic and heterocyclic compounds, including reactive intermediates used to synthesize these compounds, and methods of synthesizing and using these reporter compounds. These labels combine high photostabilities, large Stokes' shifts and contain a pyrimidinium moiety as a water-soluble group. These luminescent compounds relate generally to the following structure: The methods relate generally to the synthesis and/or use of reporter compounds for fluorescence lifetime or fluorescence polarization based applications.
摘要翻译： 基于芳族和杂环化合物的发光标记，包括用于合成这些化合物的反应性中间体，以及合成和使用这些报告化合物的方法。 这些标签结合了高光稳定性，大的斯托克斯变化，并含有作为水溶性基团的嘧啶鎓部分。 这些发光化合物通常涉及以下结构：该方法一般涉及用于荧光寿命或基于荧光偏振的应用的报告化合物的合成和/或使用。
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公开(公告)号：US20130231604A1
公开(公告)日：2013-09-05
申请号：US13411539
申请日：2012-03-03
IPC分类号： A61M37/00 , C07D209/18 , C07D209/10 , C07D209/90 , C07D277/62 , C07D403/14 , C07D471/10 , C07D403/06 , C07D417/06 , C07F15/00 , C07D487/22 , C07D209/08 , C07D293/12
CPC分类号： A61K41/0057 , A61K31/403 , A61K31/404 , A61K31/438 , A61K41/0071 , A61N1/30 , A61N5/062 , A61N5/10 , A61N2005/0659 , A61N2005/0663 , C07D209/04 , C07D209/08 , C07D209/10 , C07D209/18 , C07D209/24 , C07D209/58 , C07D209/60 , C07D277/62 , C07D277/64 , C07D293/12 , C07D401/02 , C07D403/06 , C07D403/14 , C07D417/06 , C07D471/10 , C07D487/22 , C09B23/086 , C09B23/105 , C09B47/00 , C09B62/00
摘要： Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications.
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公开(公告)号：US20140200333A1
公开(公告)日：2014-07-17
申请号：US14238829
申请日：2012-08-14
申请人： Ewald Terpetschnig , Inna G. Yermolenko , Olena M. Obukhova , Anatoliy Tatarets , Leonid D. Patsenker
发明人： Ewald Terpetschnig , Inna G. Yermolenko , Olena M. Obukhova , Anatoliy Tatarets , Leonid D. Patsenker
IPC分类号： C07D471/06 , C07D403/14
CPC分类号： C07D471/06 , C07D207/46 , C07D209/10 , C07D209/18 , C07D403/10 , C07D403/14 , C09K11/06
摘要： Dendronic reporters are described which incorporate a high density of luminescent or non-luminescent dyes at periphery sites and a focal point group that is reactive, ionic or a conjugated substance. Such dendronic reporters are capable of sensing analytes, or are otherwise useful in luminescent assays. Additionally, methods of synthesis are described.
摘要翻译： 描述了在周边位置掺入高密度的发光或非发光染料的Dendronic报道器，以及作为反应性离子或共轭物质的焦点基团。 这种树突状记录能够感测分析物，否则可用于发光测定。 另外，描述了合成方法。
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公开(公告)号：US08748446B2
公开(公告)日：2014-06-10
申请号：US13411539
申请日：2012-03-03
IPC分类号： A61K31/438 , A61K31/404 , A61K31/403 , A61N5/10 , C07D401/02 , C07D209/58 , C07D209/04
CPC分类号： A61K41/0057 , A61K31/403 , A61K31/404 , A61K31/438 , A61K41/0071 , A61N1/30 , A61N5/062 , A61N5/10 , A61N2005/0659 , A61N2005/0663 , C07D209/04 , C07D209/08 , C07D209/10 , C07D209/18 , C07D209/24 , C07D209/58 , C07D209/60 , C07D277/62 , C07D277/64 , C07D293/12 , C07D401/02 , C07D403/06 , C07D403/14 , C07D417/06 , C07D471/10 , C07D487/22 , C09B23/086 , C09B23/105 , C09B47/00 , C09B62/00
摘要： Halo-organic heterocyclic compounds are described, which have the formulas Ring A is an aromatic ring bound to at least two halogen atoms, at least one of which is iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications.
摘要翻译： 描述了卤代有机杂环化合物，其具有下式：环A是与至少两个卤素原子结合的芳环，其中至少一个是碘或溴。 还描述了基于这些杂环化合物的聚甲炔染料，以及这些聚甲炔染料的树枝状大分子化合物和共轭物。 聚甲炔染料的特征在于在诸如光动力学治疗，光动力学抗微生物化学疗法的应用中增强的性质，例如亮度，光稳定性，敏感性和/或选择性亲和力，使其可用于靶向癌细胞，致病微生物和/或其他生物材料 （PACT），癌症治疗，选择性去除或附着生物材料，抗微生物涂层材料以及其他诊断，分析，频谱移位，沉积/生长和分析应用。
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公开(公告)号：US07250517B2
公开(公告)日：2007-07-31
申请号：US10724580
申请日：2003-11-28
CPC分类号： C07H21/00 , C09B23/0066 , C09B23/02 , C09B57/007 , C09K11/06 , C09K2211/1007 , C09K2211/1022 , C09K2211/1029 , C09K2211/1037 , C09K2211/1044 , C09K2211/1048 , C09K2211/1051 , C09K2211/1074 , C09K2211/1081 , G01N33/582 , Y10T436/143333
摘要： The invention provides reporter compounds based on squaric, croconic, and/or rhodizonic acid, among others, reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing and using the reporter compounds, among others.The reporter compounds relate generally to the following structure: Here, Z is a four, five, or six-member aromatic ring, and A, B, C, D, E, and F are substituents of Z, where F is absent when Z is a five-member ring, and where E and F are absent when Z is a four-member ring. A, B, C, D, E, and F are selected from a variety of elements and groups, including but not necessarily limited to O, S, Se, Te, N—Rc, C(Rf)(Rg), W1, and W2
摘要翻译： 本发明提供了基于方圆，克罗克和/或铑酸等的报告化合物，其中包括用于合成报告化合物的反应性中间体，以及合成和使用报告化合物等的方法。 报道化合物一般涉及以下结构：这里，Z是四，五或六元芳环，A，B，C，D，E和F是Z的取代基，其中当Z不存在时，F不存在 是一个五元环，当Z是四元环时，E和F不存在。 A，B，C，D，E和F选自各种元素和基团，包括但不限于O，S，Se，Te，NR C， （R＆gt;＆gt;），W＆lt; 1＆gt;和＆lt; 2＆gt;
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公开(公告)号：US20120035346A1
公开(公告)日：2012-02-09
申请号：US13144890
申请日：2010-01-15
申请人： Ewald A. Terpetschnig , Leonid D. Patsenker , Larysa Markova , Iryna A. Fedyunyaeva , Olga S. Kolosova , Sergiy Starko , Anatoliy Tatarets
发明人： Ewald A. Terpetschnig , Leonid D. Patsenker , Larysa Markova , Iryna A. Fedyunyaeva , Olga S. Kolosova , Sergiy Starko , Anatoliy Tatarets
CPC分类号： G01N33/582 , A61K49/0032 , C07F9/5728 , C09B23/0033 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , C12Q1/02 , C12Q1/6818 , C12Q1/6869
摘要： Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkage are selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye, or a styryl dye.
摘要翻译： 基于含有至少一种烷基膦酸酯或取代的烷基 - 膦酸酯基团的聚甲炔染料的染料和光致发光化合物，包括合成前体，合成方法及其应用。 某些实施方案包括杂环系统和聚甲炔键，使得得到的聚甲炔染料是花青染料，部花青染料或苯乙烯基染料。
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公开(公告)号：US08552027B2
公开(公告)日：2013-10-08
申请号：US13144890
申请日：2010-01-15
申请人： Ewald A. Terpetschnig , Leonid D. Patsenker , Larsya Markova , Iryna A. Fedyunyaeva , Olga S. Kolosova , Sergiy Starko , Anatoliy Tatarets
发明人： Ewald A. Terpetschnig , Leonid D. Patsenker , Larsya Markova , Iryna A. Fedyunyaeva , Olga S. Kolosova , Sergiy Starko , Anatoliy Tatarets
IPC分类号： C07D499/24 , A61K31/44
CPC分类号： G01N33/582 , A61K49/0032 , C07F9/5728 , C09B23/0033 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , C12Q1/02 , C12Q1/6818 , C12Q1/6869
摘要： Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkage are selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye, or a styryl dye.
摘要翻译： 基于含有至少一种烷基膦酸酯或取代的烷基 - 膦酸酯基团的聚甲炔染料的染料和光致发光化合物，包括合成前体，合成方法及其应用。 某些实施方案包括杂环系统和聚甲炔键，使得得到的聚甲炔染料是花青染料，部花青染料或苯乙烯基染料。
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