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    Ruthenium complexes useful as carriers for immunologically active materials
    1.
    发明授权
    Ruthenium complexes useful as carriers for immunologically active materials 失效
    钌配合物可用作免疫活性材料的载体

    公开(公告)号：US4745076A

    公开(公告)日：1988-05-17

    申请号：US773956

    申请日：1985-09-09

    申请人： Francis Muller ,  Dieter Schmidt

    发明人： Francis Muller ,  Dieter Schmidt

    IPC分类号： C07D213/79 ,  A61K39/00 ,  C07D471/04 ,  C07F15/00 ,  G01N33/533 ,  C07F7/00 ,  G01N33/536

    CPC分类号： C07F15/0053 ,  G01N33/533 ,  Y10S436/80

    摘要： The invention relates to a ruthenium complex having the formulaRu.sup.2+ L.sub.1 L.sub.2 L.sub.3 Iwherein L.sub.1, L.sub.2 and L.sub.3 are the same or different are equal to a bi- or polycyclic ligand with at least two nitrogen-containing heterocycles, whereby at least one of these ligands is substituted with at least one group conferring water-solubility, and whereby at least one of these ligands is substituted, optionally via a spacer group, with at least one reactive group, and whereby the ligands L.sub.1, L.sub.2 and L.sub.3 are attached to the ruthenium via nitrogen atoms.The invention is further related to such ruthenium complexes having coupled thereto an immunologically active material, for example, antigens, haptens or antibodies and to the use of said ruthenium complexes in fluorescence spectroscopy. Specific ligands L.sub.1, L.sub.2 and L.sub.3 which are useful in the ruthenium complexes of the invention are, e.g., 2,2'-bipyridine, 1,10-phenanthroline benzbathophenanthroline or bathophenanthroline groups. Groups which are useful for conferring water-solubility on said ligand are, e.g. sulfonic acid groups which are preferably present in the form of their salts. Useful spacer groups are e.g. an alkylene groupcontaining 1-8 carbon atoms and which is optionally substituted with --SO.sub.2 --NH--, --S--, --O--, --COO-- or --CO--NH-- groups. Useful reactive groups to which the immunologically active material is coupled, are e.g. --COOH, --I, --NH.sub.2, --NCS or --SO.sub.2 Hal groups. The ruthenium complexes according to the present invention can be detected with great sensitivity by fluorescence spectroscopy and are thus useful in fluorescense immunoassays.

    摘要翻译： 本发明涉及具有式Ru2 + L1L2L3I的钌络合物，其中L1，L2和L3相同或不等于具有至少两个含氮杂环的双环或多环配体，其中这些配体中的至少一个为 被至少一个赋予水溶性的基团取代，并且其中这些配体中的至少一个任选经由间隔基与至少一个反应性基团取代，并且其中配体L1，L2和L3通过 氮原子。 本发明还涉及这样的钌络合物，其与其偶联有免疫活性材料，例如抗原，半抗原或抗体，以及在荧光光谱学中使用所述钌络合物。 可用于本发明的钌配合物的具体配体L1，L2和L3是例如2,2'-联吡啶，1,10-菲咯啉苯并噻吩并或红菲绕啉基团。 可用于赋予所述配体上的水溶性的基团例如。 磺酸基团，其优选以其盐的形式存在。 有用的间隔基团是例如 含有1-8个碳原子的亚烷基，其任选被-SO 2 -NH - ， - S - ， - O - ， - CO-或-CO-NH-基团取代。 免疫活性材料偶联的有用的反应性基团是例如。 -COOH，-I，-NH 2，-NCS或-SO 2 Hal基团。 根据本发明的钌络合物可以通过荧光光谱法以高灵敏度检测，因此可用于荧光免疫测定。

    Ruthenium complexes useful as carriers for immunologically active materials
    2.
    发明授权
    Ruthenium complexes useful as carriers for immunologically active materials 失效
    钌配合物可用作免疫活性材料的载体

    公开(公告)号：US5075447A

    公开(公告)日：1991-12-24

    申请号：US153128

    申请日：1988-02-08

    申请人： Francis Muller ,  Dieter Schmidt

    发明人： Francis Muller ,  Dieter Schmidt

    IPC分类号： C07F15/00 ,  G01N33/533

    CPC分类号： C07F15/0053 ,  G01N33/533

    摘要： The invention relates to a ruthenium complex having the formulaRu.sup.2+ L.sub.1 L.sub.2 L.sub.3 Iwherein L.sub.1, L.sub.2 and L.sub.3 are the same or different are equal to a bi- or polycyclic ligand with at least two nitrogen-containing heterocycles, whereby at least one of these ligands is substituted with at least one group conferring water-solubility, and whereby at least one of these ligands is substituted, optionally via a spacer group, with at least one reactive group, and whereby the ligands L.sub.1, L.sub.2 and L.sub.3 are attached to the ruthenium via nitrogen atoms.The invention is further related to such ruthenium complexes having coupled thereto an immunologically active material, for example, antigens, haptens or antibodies and to the use of said ruthenium complexes in fluorescence spectroscopy. Specific ligands L.sub.1, L.sub.2 and L.sub.3 which are useful in the ruthenium complexes of the invention are, e.g., 2,2'-bipyridine, 1,10-phenanthroline benzbathophenanthroline or bathophenanthroline groups. Groups which are useful for conferring water-solubility on said ligand are, e.g. sulfonic acid groups which are preferably present in the form of their salts. Useful spacer groups are e.g. an alkylene group containing 1-8 carbon atoms and which is optionally substituted with --SO.sub.2 --NH--, --S--, --O--, --COO-- or --CO--NH-- groups. Useful reactive groups to which the immunologically active material is coupled, are e.g. --COOH, --I, --NH.sub.2, --NCS or --SO.sub.2 Hal groups. The ruthenium complexes according to the present invention can be detected with great sensitivity by fluorescence spectroscopy and are thus useful in fluorescence immunoassays.

    摘要翻译： 本发明涉及具有式Ru2 + L1L2L3I的钌络合物，其中L1，L2和L3相同或不等于具有至少两个含氮杂环的双环或多环配体，其中至少一种这些配体 被至少一个赋予水溶性的基团取代，并且其中这些配体中的至少一个任选地经由间隔基与至少一个反应性基团取代，并且由此将配体L1，L2和L3连接到钌上 通过氮原子。 本发明还涉及这样的钌络合物，其与其偶联有免疫活性材料，例如抗原，半抗原或抗体，以及在荧光光谱学中使用所述钌络合物。 可用于本发明的钌配合物的具体配体L1，L2和L3是例如2,2'-联吡啶，1,10-菲咯啉苯并噻吩并或红菲绕啉基团。 可用于赋予所述配体上的水溶性的基团例如。 磺酸基团，其优选以其盐的形式存在。 有用的间隔基团是例如 含有1-8个碳原子的亚烷基，其任选被-SO 2 -NH - ， - S - ， - O - ， - CO-或-CO-NH-基团取代。 免疫活性材料偶联的有用的反应性基团是例如。 -COOH，-I，-NH 2，-NCS或-SO 2 Hal基团。 根据本发明的钌络合物可以通过荧光光谱法以高灵敏度检测，因此可用于荧光免疫测定。

    Liquid crystal dichroic display with a high brightness contrast
    5.
    发明授权
    Liquid crystal dichroic display with a high brightness contrast 失效
    液晶二向色显示屏具有高亮度对比度

    公开(公告)号：US4639090A

    公开(公告)日：1987-01-27

    申请号：US736816

    申请日：1985-05-22

    申请人： Jean-Frederic Clerc ,  Francis Muller

    发明人： Jean-Frederic Clerc ,  Francis Muller

    IPC分类号： G09G3/18 ,  G02F1/133 ,  G02F1/1335 ,  G02F1/137 ,  G02F1/13

    CPC分类号： G02F1/13737 ,  G02F2201/12 ,  G02F2203/02

    摘要： The display comprises a cholesteric liquid crystal film in which are embedded dye molecules between the two walls separated by a shim. One wall is at least partly covered by a reflecting coating reversing the polarization of a circularly polarized electromagnetic wave. The optical anisotropy .DELTA.n and the helix pitch p are such that the least absorbed wave on passing through the cell has an ellipticity equal to or greater than .pi./8.

    摘要翻译： 该显示器包括一胆甾型液晶膜，其中两个壁之间的嵌入染料分子被垫片隔开。 一个壁至少部分地被反射涂层反转圆偏振电磁波的偏振部分地覆盖。 光学各向异性DELTA n和螺旋间距p使得通过电池的最小吸收波具有等于或大于pi / 8的椭圆率。

    Novel process salts compositions and use
    6.
    发明申请
    Novel process salts compositions and use 有权
    新型加工盐组合物和用途

    公开(公告)号：US20060276503A1

    公开(公告)日：2006-12-07

    申请号：US10570410

    申请日：2004-08-30

    申请人： Gary Breen ,  Michael Forth ,  Susan Kopelman ,  Francis Muller ,  Francis Sanderson

    发明人： Gary Breen ,  Michael Forth ,  Susan Kopelman ,  Francis Muller ,  Francis Sanderson

    IPC分类号： C07D455/02

    CPC分类号： C07D451/04 ,  A61K9/0014 ,  A61K31/439

    摘要： The present invention provides a novel process for preparing pleuromutilin derivatives, novel salts of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or solvates thereof, novel pharmaceutical compositions or formulations for topical administration comprising mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or a pharmaceutically acceptable salt or solvate thereof and their use in medical therapy, particularly antibacterial therapy.

    摘要翻译： 本发明提供了一种新颖的制备截短纤维蛋白衍生物的方法，其中含有新型药物组合物或制剂的新霉素14-（外-8-甲基-8-氮杂双环[3.2.1]辛-3-基硫烷基） - 乙酸酯或其溶剂化物 用于局部给药，其包含mutin 14-（外-8-甲基-8-氮杂双环[3.2.1]辛-3-基硫烷基） - 乙酸酯或其药学上可接受的盐或溶剂化物，以及它们在药物治疗，特别是抗菌治疗中的用途。

    Detection of nucleic acids using a hairpin forming oligonucleotide primer and an energy transfer detection system
    7.
    发明授权
    Detection of nucleic acids using a hairpin forming oligonucleotide primer and an energy transfer detection system 失效
    使用发夹形成寡核苷酸引物和能量转移检测系统检测核酸

    公开(公告)号：US5573906A

    公开(公告)日：1996-11-12

    申请号：US35010

    申请日：1993-03-22

    申请人： Wilhelm Bannwarth ,  Francis Muller

    发明人： Wilhelm Bannwarth ,  Francis Muller

    IPC分类号： C07H21/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/50 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/6818 ,  C07H21/00 ,  C12Q1/6853

    摘要： A process for the detection of a nucleic acid sequence in a homogeneous assay format using an energy transfer system is disclosed. This process utilizes a 5' labeled primer containing a selfcomplementary sequence in an amplification or extension process together with a subsequent detection step using a 3' labeled probe for the amplified or extended region. The labels will be close together in space after hybridizing the probe close to the short piece of double-stranded DNA resulting from backfolding of the selfcomplementary region of the primer which has been incorporated into the amplified or extended product. A new primer for use in this process is also disclosed.

    摘要翻译： 公开了一种使用能量转移系统以同质分析形式检测核酸序列的方法。 该方法利用在扩增或延伸过程中含有自身互补序列的5'标记的引物连同随后的检测步骤，使用3'标记的扩增区或延伸区的探针。 将探针杂交后，将探针与杂交到已扩增或扩增产物中的引物的自身互补区域的折叠产生的短链双链DNA杂交后，标签将在空间紧密。 还公开了用于该方法的新引物。