公开(公告)号：US5021600A

公开(公告)日：1991-06-04

申请号：US393787

申请日：1989-08-15

申请人： Franco Cardinali ,  Maria G. Longobardi ,  Giuseppe C. Viscomi ,  Alessandra Ziggiotti

发明人： Franco Cardinali ,  Maria G. Longobardi ,  Giuseppe C. Viscomi ,  Alessandra Ziggiotti

IPC分类号： B01J20/283 ,  B01J20/10 ,  B01J20/281 ,  B01J20/32 ,  C07F7/02 ,  C07F7/18 ,  G01N30/88

CPC分类号： C07F7/1896 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/286 ,  B01J20/3071 ,  B01J20/3078 ,  B01J20/3085 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3246 ,  B01J2220/54 ,  B01J2220/58

摘要： A new mono-silylating agent of general formula (I)(R.sub.1,R.sub.2,R.sub.3)Si--NH--CO--O--Si(R.sub.1,R.sub.2,R.sub.3) (I)is described as well as its use in the preparation of chromatographic supports based on silica with functional groups covalently bonded thereto, the so-called "bonded stationary phases".The new compounds are easy and safe to prepare from the coresponding mono-halosilanes with ammonium carbamate, and their use as silylating agents leads to stationary phases with a higher degree of surface coating than that attainable with the corresponding chlorosilanes.

公开(公告)号：US5043423A

公开(公告)日：1991-08-27

申请号：US573687

申请日：1990-08-28

申请人： Giuseppe C. Viscomi ,  Franco Cardinali ,  Maria G. Longobardi

发明人： Giuseppe C. Viscomi ,  Franco Cardinali ,  Maria G. Longobardi

IPC分类号： C07K1/14 ,  B01D15/42 ,  C07K1/18 ,  C07K5/02 ,  C07K5/06 ,  G01N30/02

CPC分类号： C07K1/18 ,  B01D15/422 ,  C07K5/0212 ,  G01N30/02

摘要： This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.

公开(公告)号：US4816560A

公开(公告)日：1989-03-28

申请号：US74054

申请日：1987-07-16

申请人： Antonio S. Verdini ,  Fabio Bonelli ,  Antonello Pessi ,  Franco Cardinali ,  Diana Boraschi ,  Stefano Censini ,  Romano Di Trapani

发明人： Antonio S. Verdini ,  Fabio Bonelli ,  Antonello Pessi ,  Franco Cardinali ,  Diana Boraschi ,  Stefano Censini ,  Romano Di Trapani

IPC分类号： A61K39/39 ,  A61K38/00 ,  A61K38/43 ,  A61P31/04 ,  A61P35/00 ,  A61P37/04 ,  C07C271/22 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/10

CPC分类号： C07K5/0212 ,  C07C271/22 ,  C07C323/00

摘要： New partially retro-inverted tuftsin analogues of general formula I ##STR1## wherein R represents the side-chain of the amino acids threonine, methionine or leucineR.sup.1 represents the side-chain of the amino acids lysine or arginineR.sup.2 is hydrogen or a metabolically labile acyl group,all the asymmetric carbon atoms are either of the S- or R-configuration, or, alternatively, the first, third, and fourth asymmetric carbons, starting from the N-terminal residue, are of the S-configuration while the second one is of the R- or (R,S)-configuration, and the corresponding pharmacologically acceptable salts, esters and amides. The new compounds which share the same pharmacological properties of tuftsin, are much more stable toward the enzymatic degradation than the parent molecule.

摘要翻译： 其中R表示氨基酸苏氨酸，甲硫氨酸或亮氨酸的侧链，R1表示氨基酸赖氨酸或精氨酸R2是氢的侧链。 或代谢不稳定的酰基，所有不对称碳原子是S-或R-构型，或者，替代地，从N末端残基开始的第一，第三和第四不对称碳为S- 构型，而第二种是R-或（R，S）构型，以及相应的药学上可接受的盐，酯和酰胺。 具有与绒毛蛋白相同的药理学性质的新化合物对于酶降解比母体分子更稳定。