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1.发明申请Pyrazole or Triazole Compounds and Their Use for the Manufacture of a Medicament for Treating Somatic Mutation-Related Diseases 有权吡唑或三唑化合物及其用于制造治疗体细胞突变相关疾病的药物的用途公开(公告)号：US20080280869A1
公开(公告)日：2008-11-13
申请号：US11577177
申请日：2005-10-13
申请人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Jeffrey A. Campbell , Hongyu Ren , Guangming Chen
发明人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Jeffrey A. Campbell , Hongyu Ren , Guangming Chen
IPC分类号： A61K31/4196 , C07D233/88 , C07D249/08 , C07D231/12 , C07D491/04 , C07D271/06 , A61P35/00 , C12N5/06 , A61P37/02 , A61K31/4245 , A61K31/415 , C07D403/10 , A61K31/4168
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
摘要翻译： 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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2.发明授权Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation related diseases 有权吡唑或三唑化合物及其用于制备用于治疗体细胞突变相关疾病的药物的用途公开(公告)号：US09051342B2
公开(公告)日：2015-06-09
申请号：US11577177
申请日：2005-10-13
申请人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Jeffrey A. Campbell , Hongyu Ren , Guangming Chen
发明人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Jeffrey A. Campbell , Hongyu Ren , Guangming Chen
IPC分类号： A61K31/397 , A61K31/41 , A61K31/415 , C07F9/653 , C07D231/12 , C07D233/64 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D413/12
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
摘要翻译： 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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公开(公告)号：US20080119473A1
公开(公告)日：2008-05-22
申请号：US11577189
申请日：2005-10-13
申请人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Hongyu Ren
发明人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Hongyu Ren
IPC分类号： A61K31/53 , C07D239/42 , A61K31/435
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
摘要翻译： 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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公开(公告)号：US09315467B2
公开(公告)日：2016-04-19
申请号：US11577189
申请日：2005-10-13
申请人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Hongyu Ren
发明人： Neil Almstead , Gary M. Karp , Richard Wilde , Ellen Welch , Hongyu Ren
IPC分类号： A61K31/53 , C07D239/42 , C07D401/04 , A61K31/435 , C07D231/12 , C07D233/64 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D413/12 , C07F9/653 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
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公开(公告)号：US20090253699A1
公开(公告)日：2009-10-08
申请号：US11577191
申请日：2005-10-13
申请人： Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
发明人： Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
IPC分类号： A61K31/5377 , A61K31/4245 , C07D271/10 , C12N5/00 , C07D413/02 , A61K31/433 , C07D285/12 , A61K31/421 , C07D263/30 , A61K31/415 , C07D231/10 , A61K31/426 , C07D277/20 , C07D307/02 , A61K31/34 , A61P37/06 , A61P7/00 , A61P25/00 , A61P9/00 , A61P29/00
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
摘要翻译： 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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公开(公告)号：US09611230B2
公开(公告)日：2017-04-04
申请号：US11577191
申请日：2005-10-13
申请人： Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
发明人： Neil G. Almstead , Guangming Chen , Gary M. Karp , Ellen Welch , Richard Wilde , Jeffrey A. Campbell
IPC分类号： C07D271/10 , C07D271/107 , C07D251/24 , C07D231/12 , C07D233/64 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D413/12 , C07F9/653 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
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7.发明申请Compounds for Nonsense Suppression, Use of These Compounds for the Manufacture of a Medicament for Treating Somatic Mutation-Related Diseases 审中-公开无意义抑制的化合物，这些化合物用于制造用于治疗体细胞突变相关疾病的药物的用途公开(公告)号：US20080269191A1
公开(公告)日：2008-10-30
申请号：US11577176
申请日：2005-10-13
申请人： Richard Wilde , Ellen Welch , Gary M. Karp
发明人： Richard Wilde , Ellen Welch , Gary M. Karp
IPC分类号： A61K31/4439 , C07D413/04 , A61K31/423 , C07D263/57 , C07D413/14 , A61P35/00 , C12N5/06
CPC分类号： C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
摘要翻译： 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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8.发明申请Use of acetylamino benzoic acid compounds for nonsense suppression and the treatment of disease 失效使用乙酰氨基苯甲酸化合物进行无味抑制和治疗疾病公开(公告)号：US20070203123A1
公开(公告)日：2007-08-30
申请号：US11789625
申请日：2007-04-24
申请人： Richard Wilde , Ellen Welch , James Takasugi , Neil Almstead , Steven Rubenstein , Holger Beckmann
发明人： Richard Wilde , Ellen Welch , James Takasugi , Neil Almstead , Steven Rubenstein , Holger Beckmann
IPC分类号： A61K31/55 , A61K31/445 , A61K31/24 , A61K31/195 , A61K31/277
CPC分类号： C07C235/24 , C07C235/74 , C07C323/60 , C07C327/42 , C07C2601/08 , C07C2602/08 , C07C2602/10 , C07D207/273 , C07D209/48 , C07D213/74 , C07D239/38 , C07D257/04 , C07D271/10 , C07D317/64
摘要： Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新型乙酰氨基苯甲酸化合物，使用方法和包含乙酰氨基苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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9.发明申请Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases 有权使用核苷化合物进行无意义抑制和遗传性疾病的治疗公开(公告)号：US20060166926A1
公开(公告)日：2006-07-27
申请号：US11048659
申请日：2005-01-21
申请人： Richard Wilde , Neil Almstead , Ellen Welch , Holger Beckmann
发明人： Richard Wilde , Neil Almstead , Ellen Welch , Holger Beckmann
IPC分类号： A61K31/7072 , A61K31/506 , C07D405/02 , C07H19/048
CPC分类号： A61K31/506 , A61K31/7072 , C07H19/00
摘要： The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
摘要翻译： 本发明包括核苷化合物，包含该化合物的组合物和通过施用这些化合物或组合物来治疗或预防与无义突变mRNA相关的疾病的方法。
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10.发明申请Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations 审中-公开核苷化合物及其用于治疗与体细胞突变相关的癌症和疾病的用途公开(公告)号：US20080090774A1
公开(公告)日：2008-04-17
申请号：US11906665
申请日：2007-10-02
申请人： Richard Wilde , Paul Kennedy , Neil Almstead , Ellen Welch , James Takasugi , Westley Friesen
发明人： Richard Wilde , Paul Kennedy , Neil Almstead , Ellen Welch , James Takasugi , Westley Friesen
IPC分类号： A61K31/706 , A61P35/00
CPC分类号： C07H19/00
摘要： The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
摘要翻译： 本发明包括核苷化合物，包含该化合物的组合物和通过施用这些化合物或组合物来治疗或预防与无义突变mRNA相关的疾病的方法。
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