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    Methods for DNA amplificating and sequencing
    1.
    发明授权
    Methods for DNA amplificating and sequencing 有权
    DNA扩增和测序方法

    公开(公告)号：US06428986B1

    公开(公告)日：2002-08-06

    申请号：US09601943

    申请日：2000-08-10

    Applicant: Aviva Lapidot ,  Robert Iakobashvili ,  Gennady Malin

    Inventor： Aviva Lapidot ,  Robert Iakobashvili ,  Gennady Malin

    IPC: C12P1934

    CPC classification number: C12Q1/6848 ,  C12Q1/6869 ,  C12Q2527/125 ,  C12Q2531/113

    Abstract: The osmoprotectants proline, 2-methyl-4-carboxy-3,4,5,6-tetrahydropyrimidine (“THP(B)”, and 2-methyl-4-carboxy-5-hydroxy-3,4,5,6,-tetrahydropyrimidine (“THP(A)”) are capable of increasing the thermal stability of DNA polymerases at elevated temperatures. THP(B) is further effective in lowering the melting temperature of double-stranded DNA. Proline, THP(A) and THP(B) are thus useful in procedures involving melting of double-stranded DNA and/or polymerase-mediated DNA synthesis, such as in primer extension, in PCR (polymerase chain reaction) amplification and in DNA sequencing.

    Abstract translation: 维生素脯氨酸2-甲基-4-羧基-3,4,5,6-四氢嘧啶（“THP（B）”和2-甲基-4-羧基-5-羟基-3,4,5,6， 四氢嘧啶（“THP（A）”）能够在升高的温度下增加DNA聚合酶的热稳定性，THP（B）在降低双链DNA的解链温度方面更有效，脯氨酸，THP（A）和THP （B）因此可用于在PCR（聚合酶链式反应）扩增和DNA测序中涉及熔解双链DNA和/或聚合酶介导的DNA合成的方法，例如引物延伸。

    Systems and methods for control of pH and other reactor environment conditions
    2.
    发明申请
    Systems and methods for control of pH and other reactor environment conditions 审中-公开
    用于控制pH和其他反应器环境条件的系统和方法

    公开(公告)号：US20050026134A1

    公开(公告)日：2005-02-03

    申请号：US10664068

    申请日：2003-09-16

    Applicant: Scott Miller ,  Gennady Malin ,  Howard Schreyer ,  Seth Rodgers ,  Andrey Zarur

    Inventor： Scott Miller ,  Gennady Malin ,  Howard Schreyer ,  Seth Rodgers ,  Andrey Zarur

    IPC: C12M3/00

    CPC classification number: B01L3/502746 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/1838 ,  B01L2400/046 ,  B01L2400/0487 ,  B01L2400/086 ,  C12M23/16 ,  C12M29/04 ,  C12M41/26

    Abstract: The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

    Abstract translation: 本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。 在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。 反应位点可以非常小，例如，体积小于约1ml。 在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等， 通过使用一个或多个传感器，致动器，处理器和/或控制系统。 在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。 这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。 在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

    Methods for DNA amplification and sequencing
    3.
    发明授权
    Methods for DNA amplification and sequencing 有权
    DNA扩增和测序方法

    公开(公告)号：US07387878B2

    公开(公告)日：2008-06-17

    申请号：US11513206

    申请日：2006-08-31

    Applicant: Aviva Lapidot ,  Robert Iakobashvili ,  Gennady Malin

    Inventor： Aviva Lapidot ,  Robert Iakobashvili ,  Gennady Malin

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/6848 ,  C12Q1/6869 ,  C12Q2527/125 ,  C12Q2531/113

    Abstract: The osmoprotectants proline, 2-methyl-4-carboxy-3,4,5,6-tetrahydropyrimidine (“THP(B)”, and 2-methyl-4-carboxy-5-hydroxy-3,4,5,6,-tetrahydropyrimidine (“THP(A)”) are capable of increasing the thermal stability of DNA polymerases at elevated temperatures. THP(B) is further effective in lowering the melting temperature of double-stranded DNA. Proline, THP(A) and THP(B) are thus useful in procedures involving melting of double-stranded DNA and/or polymerase-mediated DNA synthesis, such as in primer extension, in PCR (polymerase chain reaction) amplification and in DNA sequencing.

    Abstract translation: 维生素脯氨酸2-甲基-4-羧基-3,4,5,6-四氢嘧啶（“THP（B）”和2-甲基-4-羧基-5-羟基-3,4,5,6， 四氢嘧啶（“THP（A）”）能够在升高的温度下提高DNA聚合酶的热稳定性，THP（B）在降低双链DNA的解链温度方面更有效，脯氨酸，THP（A）和THP （B）因此可用于在PCR（聚合酶链式反应）扩增和DNA测序中涉及熔解双链DNA和/或聚合酶介导的DNA合成的方法，例如引物延伸。

    Methods for DNA amplification and sequencing
    4.
    发明申请
    Methods for DNA amplification and sequencing 有权
    DNA扩增和测序方法

    公开(公告)号：US20070212760A1

    公开(公告)日：2007-09-13

    申请号：US11513206

    申请日：2006-08-31

    Applicant: Aviva Lapidot ,  Robert Iakobashvili ,  Gennady Malin

    Inventor： Aviva Lapidot ,  Robert Iakobashvili ,  Gennady Malin

    IPC: C12P19/34

    CPC classification number: C12Q1/6848 ,  C12Q1/6869 ,  C12Q2527/125 ,  C12Q2531/113

    Abstract: The osmoprotectants proline, 2-methyl-4-carboxy-3,4,5,6-tetrahydropyrimidine (“THP(B)”, and 2-methyl-4-carboxy-5-hydroxy-3,4,5,6,-tetrahydropyrimidine (“THP(A)”) are capable of increasing the thermal stability of DNA polymerases at elevated temperatures. THP(B) is further effective in lowering the melting temperature of double-stranded DNA. Proline, THP(A) and THP(B) are thus useful in procedures involving melting of double-stranded DNA and/or polymerase-mediated DNA synthesis, such as in primer extension, in PCR (polymerase chain reaction) amplification and in DNA sequencing.

    Abstract translation: 维生素脯氨酸2-甲基-4-羧基-3,4,5,6-四氢嘧啶（“THP（B）”和2-甲基-4-羧基-5-羟基-3,4,5,6， 四氢嘧啶（“THP（A）”）能够在升高的温度下增加DNA聚合酶的热稳定性，THP（B）在降低双链DNA的解链温度方面更有效，脯氨酸，THP（A）和THP （B）因此可用于在PCR（聚合酶链式反应）扩增和DNA测序中涉及熔解双链DNA和/或聚合酶介导的DNA合成的方法，例如引物延伸。

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