公开(公告)号：US20050026134A1

公开(公告)日：2005-02-03

申请号：US10664068

申请日：2003-09-16

申请人： Scott Miller ,  Gennady Malin ,  Howard Schreyer ,  Seth Rodgers ,  Andrey Zarur

发明人： Scott Miller ,  Gennady Malin ,  Howard Schreyer ,  Seth Rodgers ,  Andrey Zarur

IPC分类号： C12M3/00

CPC分类号： B01L3/502746 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/1838 ,  B01L2400/046 ,  B01L2400/0487 ,  B01L2400/086 ,  C12M23/16 ,  C12M29/04 ,  C12M41/26

摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

摘要翻译： 本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。 在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。 反应位点可以非常小，例如，体积小于约1ml。 在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等， 通过使用一个或多个传感器，致动器，处理器和/或控制系统。 在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。 这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。 在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

公开(公告)号：US20070037244A1

公开(公告)日：2007-02-15

申请号：US11584149

申请日：2006-10-20

申请人： Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Zarur

发明人： Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Zarur

IPC分类号： C12Q1/02

CPC分类号： C12M25/02 ,  C12M23/12 ,  C12M23/24 ,  C12M29/04 ,  C12M41/34

摘要： The present invention is directed to materials and reactor systems having humidity and/or gas control. The material may have high oxygen permeability and/or low water vapor permeability. In some cases, the material may have sufficient permeance and/or permeability to allow cell culture to occur in a chip or other reactor system using the material. In certain embodiments, the material may be positioned adjacent to or abut a reaction site within a chip or reactor; in other embodiments, the material may be positioned such that it is in fluidic communication with the reaction site. The material may also be porous and/or transparent in some cases. In one set of embodiments, the material include a polymer that is branched, and/or contains bulky side groups that allow the polymer to have a more open structure. In some cases, the material may include two or more layers. Each layer may have a desired property, which may include, for example, permeability, transparency, cytophilicity, biophilicity, hydrophilicity, or a structural feature. In some embodiments, the material may be chosen so as to promote cell growth within the chip or reactor.

摘要翻译： 本发明涉及具有湿气和/或气体控制的材料和反应器系统。 该材料可能具有高的透氧性和/或低水蒸气渗透性。 在一些情况下，该材料可具有足够的渗透性和/或渗透性，以允许细胞培养在使用该材料的芯片或其它反应器系统中发生。 在某些实施方案中，材料可以位于与芯片或反应器内的反应位置相邻或邻接的位置; 在其它实施方案中，材料可以被定位成使其与反应部位流体连通。 在某些情况下，材料也可以是多孔的和/或透明的。 在一组实施方案中，材料包括分支的聚合物和/或包含允许聚合物具有更开放结构的庞大的侧基。 在一些情况下，材料可以包括两层或更多层。 每个层可以具有期望的性质，其可以包括例如渗透性，透明度，细胞毒性，生物亲和力，亲水性或结构特征。 在一些实施方案中，可以选择材料以促进芯片或反应器内的细胞生长。

公开(公告)号：US20050032204A1

公开(公告)日：2005-02-10

申请号：US10664067

申请日：2003-09-16

申请人： Seth Rodgers ,  Andrey Zarur ,  A. Russo ,  Sean Leblanc ,  Xinyu Li ,  Howard Schreyer

发明人： Seth Rodgers ,  Andrey Zarur ,  A. Russo ,  Sean Leblanc ,  Xinyu Li ,  Howard Schreyer

IPC分类号： C12M1/34 ,  C12Q1/20

CPC分类号： B01L3/5027 ,  B01L2200/028 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/046

摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

摘要翻译： 本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。 在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。 反应位点可以非常小，例如，体积小于约1ml。 在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等， 通过使用一个或多个传感器，致动器，处理器和/或控制系统。 在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。 这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。 在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

公开(公告)号：US20070037278A1

公开(公告)日：2007-02-15

申请号：US11584037

申请日：2006-10-20

申请人： Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Jury

发明人： Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Jury

IPC分类号： C12M1/12

CPC分类号： C12M25/02 ,  C12M23/12 ,  C12M23/24 ,  C12M29/04 ,  C12M41/34

摘要： The present invention is directed to materials and reactor systems having humidity and/or gas control. The material may have high oxygen permeability and/or low water vapor permeability. In some cases, the material may have sufficient permeance and/or permeability to allow cell culture to occur in a chip or other reactor system using the material. In certain embodiments, the material may be positioned adjacent to or abut a reaction site within a chip or reactor; in other embodiments, the material may be positioned such that it is in fluidic communication with the reaction site. The material may also be porous and/or transparent in some cases. In one set of embodiments, the material include a polymer that is branched, and/or contains bulky side groups that allow the polymer to have a more open structure. In some cases, the material may include two or more layers. Each layer may have a desired property, which may include, for example, permeability, transparency, cytophilicity, biophilicity, hydrophilicity, or a structural feature. In some embodiments, the material may be chosen so as to promote cell growth within the chip or reactor.

公开(公告)号：US20070178023A1

公开(公告)日：2007-08-02

申请号：US11603950

申请日：2006-11-22

申请人： A. Russo ,  Phil Bergman ,  Matthew Stebulis ,  James Hope ,  Timothy Johnson ,  Howard Schreyer

发明人： A. Russo ,  Phil Bergman ,  Matthew Stebulis ,  James Hope ,  Timothy Johnson ,  Howard Schreyer

IPC分类号： B01J19/00

CPC分类号： C12P7/40 ,  B01J19/0093 ,  B01J2219/00038 ,  B01L3/5027 ,  C12M23/16 ,  C12M23/58 ,  C12M41/32 ,  C12M41/44 ,  C12P7/6463 ,  C12P13/04 ,  C12P19/34 ,  C12P33/00

摘要： Methods for forming chemical and/or biological products in reactors, and/or analyzing chemical and/or biological interactions in reactors are provided. The methods relate, more specifically, to forming such products and/or carrying out such analyses in small volume reactors with control over overall fluid volume in the reactors. The methods can be used to mimic processes in large scale reactors and/or to obtain reaction or interaction information relevant to large scale reactors (e.g., to adjust/optimize large-scale reactor processes). Advantageously, the methods can allow parameters of small scale reactors to be correlated with those of large scale reactors, where desired.

摘要翻译： 提供了在反应器中形成化学和/或生物产物和/或分析反应器中的化学和/或生物相互作用的方法。 所述方法更具体地涉及在具有对反应器中的总流体体积的控制的小体积反应器中形成这种产物和/或进行这种分析。 该方法可用于模拟大规模反应器中的工艺和/或获得与大规模反应器相关的反应或相互作用信息（例如，调整/优化大规模反应器工艺）。 有利地，如果需要，这些方法可以允许小规模反应器的参数与大规模反应器的参数相关。