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    Systems and methods for control of pH and other reactor environment conditions
    2.
    发明申请
    Systems and methods for control of pH and other reactor environment conditions 审中-公开
    用于控制pH和其他反应器环境条件的系统和方法

    公开(公告)号：US20050026134A1

    公开(公告)日：2005-02-03

    申请号：US10664068

    申请日：2003-09-16

    Applicant: Scott Miller ,  Gennady Malin ,  Howard Schreyer ,  Seth Rodgers ,  Andrey Zarur

    Inventor： Scott Miller ,  Gennady Malin ,  Howard Schreyer ,  Seth Rodgers ,  Andrey Zarur

    IPC: C12M3/00

    CPC classification number: B01L3/502746 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/1838 ,  B01L2400/046 ,  B01L2400/0487 ,  B01L2400/086 ,  C12M23/16 ,  C12M29/04 ,  C12M41/26

    Abstract: The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

    Abstract translation: 本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。 在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。 反应位点可以非常小，例如，体积小于约1ml。 在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等， 通过使用一个或多个传感器，致动器，处理器和/或控制系统。 在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。 这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。 在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

    Reactor systems having a light-interacting component
    5.
    发明申请
    Reactor systems having a light-interacting component 审中-公开
    具有光相互作用组分的反应器系统

    公开(公告)号：US20070099292A1

    公开(公告)日：2007-05-03

    申请号：US11584343

    申请日：2006-10-20

    Applicant: Scott Miller ,  Sean LeBlanc ,  Seth Rodgers ,  Andrey Zarur

    Inventor： Scott Miller ,  Sean LeBlanc ,  Seth Rodgers ,  Andrey Zarur

    IPC: C12M1/34

    CPC classification number: B01L3/502715 ,  B01L2200/025 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/046 ,  G01N2021/0346

    Abstract: Various aspects of the present invention relate to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like. If waveguides are used, they may be fashioned out of any material able to transmit light to or from the reaction site. The chip may contain a reaction site having a volume of less than about 1 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light-activated in certain cases. Other facilitated reactions may include the production or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, or more than one reaction site.

    Abstract translation: 本发明的各个方面涉及适用于芯片和其它反应器系统的光相互作用组件。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。 如果使用波导，则它们可以从能够将光透射到反应位点的任何材料形成。 芯片可以含有体积小于约1ml的反应位点。 在一些实施例中，芯片可以以能够支撑活细胞的方式构造。 该芯片可以用于成像或分析，或者芯片可以用于促进在某些情况下可能是光敏感或光激活的化学或生物反应。 其他促进反应可能包括化学或生物物种的生产或消费。 在一些实施方案中，芯片可以包括多于一种组分或组分类型，或多于一个反应位点。

    Materials and reactor systems having humidity and gas control
    6.
    发明申请
    Materials and reactor systems having humidity and gas control 审中-公开

    公开(公告)号：US20070037278A1

    公开(公告)日：2007-02-15

    申请号：US11584037

    申请日：2006-10-20

    Applicant: Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Jury

    Inventor： Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Jury

    IPC: C12M1/12

    CPC classification number: C12M25/02 ,  C12M23/12 ,  C12M23/24 ,  C12M29/04 ,  C12M41/34

    Abstract: The present invention is directed to materials and reactor systems having humidity and/or gas control. The material may have high oxygen permeability and/or low water vapor permeability. In some cases, the material may have sufficient permeance and/or permeability to allow cell culture to occur in a chip or other reactor system using the material. In certain embodiments, the material may be positioned adjacent to or abut a reaction site within a chip or reactor; in other embodiments, the material may be positioned such that it is in fluidic communication with the reaction site. The material may also be porous and/or transparent in some cases. In one set of embodiments, the material include a polymer that is branched, and/or contains bulky side groups that allow the polymer to have a more open structure. In some cases, the material may include two or more layers. Each layer may have a desired property, which may include, for example, permeability, transparency, cytophilicity, biophilicity, hydrophilicity, or a structural feature. In some embodiments, the material may be chosen so as to promote cell growth within the chip or reactor.

    Microreactor architecture and methods
    7.
    发明申请
    Microreactor architecture and methods 审中-公开
    微反应器结构和方法

    公开(公告)号：US20050032204A1

    公开(公告)日：2005-02-10

    申请号：US10664067

    申请日：2003-09-16

    Applicant: Seth Rodgers ,  Andrey Zarur ,  A. Russo ,  Sean Leblanc ,  Xinyu Li ,  Howard Schreyer

    Inventor： Seth Rodgers ,  Andrey Zarur ,  A. Russo ,  Sean Leblanc ,  Xinyu Li ,  Howard Schreyer

    IPC: C12M1/34 ,  C12Q1/20

    CPC classification number: B01L3/5027 ,  B01L2200/028 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/046

    Abstract: The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

    Abstract translation: 本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。 在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。 反应位点可以非常小，例如，体积小于约1ml。 在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等， 通过使用一个或多个传感器，致动器，处理器和/或控制系统。 在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。 这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。 在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

    Gas control in a reactor
    9.
    发明申请
    Gas control in a reactor 审中-公开
    反应堆中的气体控制

    公开(公告)号：US20050271560A1

    公开(公告)日：2005-12-08

    申请号：US11147415

    申请日：2005-06-07

    Applicant: Seth Rodgers ,  A. Russo ,  Timothy Johnston ,  Sean LeBlanc

    Inventor： Seth Rodgers ,  A. Russo ,  Timothy Johnston ,  Sean LeBlanc

    IPC: B01J19/00 ,  B01L3/00 ,  C12M20060101

    CPC classification number: B01J19/0093 ,  B01J2219/00837 ,  B01J2219/00862 ,  B01J2219/00869 ,  B01J2219/00907 ,  B01J2219/00952 ,  B01J2219/00963 ,  B01J2219/0097 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/10 ,  B01L2400/0457 ,  B01L2400/0688 ,  B01L2400/086

    Abstract: Chemical, biological, and/or biochemical reaction systems, including chips or reactors, may be configured so as to restrain immiscible materials such as gas bubbles from interfering with the determination of environmental factors associated with the chip according to one aspect of the invention. In another aspect, a chip or other reaction system may be configured to maintain a gas headspace in the chip or other reaction system. In certain embodiments, impediments such as physical barriers may be used to contain gas bubbles within a gas containing region, or otherwise away from a detection region. In other embodiments, surface tension properties may be used to control the location of gas bubbles. The chip or other reaction systems may include reaction site containers that can be very small, for example, having a volume of less than about 2 ml. In certain embodiments, chips or other reaction systems of the invention include one or more reaction sites, which, in some cases, may be defined by reaction site containers. According to another aspect of the invention, a reaction site container may be shaped to limit the formation of gas bubbles during the filling of the reaction site container with liquid by providing reaction site container shapes that do not include sharp angles or abrupt changes in reaction site container width.

    Abstract translation: 包括芯片或反应器的化学，生物和/或生物化学反应系统可以被配置为根据本发明的一个方面来抑制诸如气泡的不混溶材料干扰与芯片相关的环境因素的确定。 在另一方面，芯片或其它反应系统可以被配置为在芯片或其他反应系统中保持气体顶部空间。 在某些实施方案中，阻挡物例如物理屏障可以用于在含气体区域内或以其他方式远离检测区域容纳气泡。 在其它实施例中，可以使用表面张力特性来控制气泡的位置。 芯片或其他反应系统可以包括可以非常小的反应位点容器，例如具有小于约2ml的体积。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点，其在一些情况下可由反应位点容器限定。 根据本发明的另一方面，反应部位容器可以成形为通过提供不包括尖锐角度的反应部位容器形状或反应部位的突然变化来限制在用液体填充反应部位容器期间产生气泡的形成 容器宽度。

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