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    Mitigating Ocular Toxicity
    2.
    发明申请
    Mitigating Ocular Toxicity 有权

    公开(公告)号：US20250160636A1

    公开(公告)日：2025-05-22

    申请号：US18835384

    申请日：2023-02-07

    Applicant: GlaxoSmithKline Intellectual Property Development Limited

    Inventor： Mala Kiran TALEKAR ,  Jeffery Lanier PAINTER, JR.

    IPC: A61B3/00 ,  A61B3/028 ,  C07K16/28 ,  G16H20/10 ,  G16H50/30

    Abstract: Aspects of the disclosure are directed to mitigating ocular toxicity in patients undergoing treatment for B-cell disorders, including cancers. Such treatment may include administering a therapeutically effective dose of a component of a B-cell disorder therapy, monitoring for signs of ocular toxicity, and, if such signs are present, adjusting the dose of that component for a subsequent administration. Monitoring for signs of ocular toxicity may include performing an ophthalmic examination of the patient, including performing a visual assessment and corneal assessment of the patient. The ophthalmic examination may include selecting visual assessment options from predefined and selectable visual assessment options and include selection corneal assessment options from predefined and selectable corneal assessment options. An overall keratopathy visual acuity (KVA) grade may be determined based on the selected visual acuity assessment options and the selected corneal assessment options.

    Modular aseptic production system
    9.
    发明授权
    Modular aseptic production system 有权

    公开(公告)号：US12043436B2

    公开(公告)日：2024-07-23

    申请号：US17896538

    申请日：2022-08-26

    Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

    Inventor： Francesco Sanmartin

    IPC: A61L2/04 ,  B65B3/00 ,  B65B7/28 ,  B65B43/42 ,  B65B55/02 ,  B65B59/04

    CPC classification number: B65B59/04 ,  A61L2/04 ,  B65B3/003 ,  B65B7/2821 ,  B65B43/42 ,  B65B55/025 ,  A61L2202/21

    Abstract: A modular production system including a plurality of production modules connected in a linear series to form a production tunnel, and collectively defining a production channel, and wherein at least one fluid inlet port defined along the production tunnel, said inlet port is in fluid communication with a pressurized fluid source, whereby influx of fluid from said fluid source through said fluid inlet port acts to maintain the fluid pressure within the production channel at a higher pressure than the atmospheric pressure outside of the production tunnel; and wherein one of said production modules positioned between said proximal-most and distal-most production modules comprises a depyrogenator and/or sterilization module, comprising a transparent tubular body, and an irradiation source positioned external to said transparent tubular body, said irradiation source capable of heating the internal environment of the depyrogenation and/or sterilization module to a temperature sufficient to depyrogenate or sterilize articles passing therethrough, and associated processes.

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