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    Recombinant adenovirus with enhanced therapeutic effect and pharmaceutical composition comprising said recombinant adenovirus
    1.
    发明授权
    Recombinant adenovirus with enhanced therapeutic effect and pharmaceutical composition comprising said recombinant adenovirus 有权
    具有增强的治疗效果的重组腺病毒和包含所述重组腺病毒的药物组合物

    公开(公告)号：US09175309B2

    公开(公告)日：2015-11-03

    申请号：US10491313

    申请日：2002-09-28

    申请人： Chae-ok Yun ,  Joo-Hang Kim

    发明人： Chae-ok Yun ,  Joo-Hang Kim

    IPC分类号： C12N15/86 ,  A61K48/00

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2710/10345

    摘要： Disclosed is a recombinant adenovirus with a protein containing a VSV-G epitope derived from vesicular stomatitis virus (VSV). Also, the present invention discloses a pharmaceutical composition comprising such a recombinant adenovirus and a pharmaceutically acceptable carrier. Further, the present invention discloses a recombinant plasmid capable of expressing the recombinant adenovirus and a host cell transformed with the recombinant adenovirus.

    摘要翻译： 公开了具有衍生自水泡性口炎病毒（VSV）的VSV-G表位的蛋白质的重组腺病毒。 此外，本发明公开了包含这种重组腺病毒和药学上可接受的载体的药物组合物。 此外，本发明公开了能够表达重组腺病毒的重组质粒和用重组腺病毒转化的宿主细胞。

    Recombinant Adenoviruses Capable Of Regulating Angiogenesis
    2.
    发明申请
    Recombinant Adenoviruses Capable Of Regulating Angiogenesis 审中-公开
    能够调节血管发生的重组腺病毒

    公开(公告)号：US20100215621A1

    公开(公告)日：2010-08-26

    申请号：US12223166

    申请日：2006-05-30

    申请人： Chae-Ok Yun ,  Joo-Hang Kim ,  Jin Soo Kim ,  Hyun Chul Shin ,  Yoon A. Kang

    发明人： Chae-Ok Yun ,  Joo-Hang Kim ,  Jin Soo Kim ,  Hyun Chul Shin ,  Yoon A. Kang

    IPC分类号： A61K35/76 ,  C12N7/01 ,  A61P35/00 ,  A61P27/02 ,  A61P37/06

    CPC分类号： C12N15/86 ,  A61K48/005 ,  C12N2710/10343

    摘要： The present invention relates to a recombinant adenovirus capable of regulating angiogenesis, which comprises (a) an adenoviral ITR (inverted terminal repeat) nucleotide sequence; and (b) a transcription regulatory sequence for a VEGF-A (vascular endothelial growth factor-A) gene comprising (i) a nucleotide sequence encoding a DNA binding domain comprising a zinc finger domain to bind to a site in a VEGF-A promoter sequence as set forth in nucleotides 1-2362 of SEQ ID NO:1, and (ii) a transcription activation domain or a transcription inhibitory domain linked to the nucleotide sequence encoding the DNA binding domain; and a pharmaceutical composition comprising the recombinant adenovirus.

    摘要翻译： 本发明涉及能够调节血管生成的重组腺病毒，其包含（a）腺病毒ITR（反向末端重复）核苷酸序列; （b）VEGF-A（血管内皮生长因子-A）基因的转录调控序列，其包含（i）编码包含锌指结构域的DNA结合域的核苷酸序列以结合VEGF-A启动子中的位点 序列，如SEQ ID NO：1的核苷酸1-2362所示，和（ii）与编码DNA结合结构域的核苷酸序列连接的转录活化结构域或转录抑制结构域; 和包含重组腺病毒的药物组合物。

    Decorin Gene Delivery System And Cancer Treatment
    3.
    发明申请
    Decorin Gene Delivery System And Cancer Treatment 有权
    Decorin基因递送系统和癌症治疗

    公开(公告)号：US20080132449A1

    公开(公告)日：2008-06-05

    申请号：US11816751

    申请日：2006-02-24

    申请人： Chae-Ok Yun ,  Joo-Hang Kim

    发明人： Chae-Ok Yun ,  Joo-Hang Kim

    IPC分类号： A61K38/00 ,  C12N15/00 ,  A61K31/70

    CPC分类号： A61K48/005 ,  A61K38/162 ,  C07K14/005 ,  C07K14/70578 ,  C12N7/00 ,  C12N2710/10033 ,  C12N2799/022

    摘要： A novel gene delivery system and recombinant adenovirus includes a decorin-encoding sequence to enhance transduction efficiency of transgenes. A pharmaceutical anti-tumor composition includes the recombinant adenovirus, as well as a pharmaceutical composition having improved tissue penetration potency and a pharmaceutical composition for treating a disease or disorder associated with accumulation of excess extracellular matrix.

    摘要翻译： 一种新的基因递送系统和重组腺病毒包括一个核心蛋白聚糖编码序列，以增强转基因的转导效率。 药物抗肿瘤组合物包括重组腺病毒，以及具有改善的组织穿透能力的药物组合物和用于治疗与过量细胞外基质的积累相关的疾病或病症的药物组合物。

    METHOD AND DEVICE FOR SENSING CAPACITANCE CHANGE AND RECORDING MEDIUM IN WHICH PROGRAM FOR EXECUTING METHOD IS RECORDED THEREON, AND METHOD AND DEVICE FOR SENSING TOUCH USING METHOD AND RECORDING MEDIUM IN WHICH PROGRAM FOR EXECUTING METHOD IS RECORDED THEREON
    5.
    发明申请
    METHOD AND DEVICE FOR SENSING CAPACITANCE CHANGE AND RECORDING MEDIUM IN WHICH PROGRAM FOR EXECUTING METHOD IS RECORDED THEREON, AND METHOD AND DEVICE FOR SENSING TOUCH USING METHOD AND RECORDING MEDIUM IN WHICH PROGRAM FOR EXECUTING METHOD IS RECORDED THEREON 有权
    用于传感电容变化的方法和装置以及用于执行方法记录的程序的记录介质以及用于执行方法的方法和记录介质的感测触摸的方法和装置在执行方法记录的程序

    公开(公告)号：US20130113756A1

    公开(公告)日：2013-05-09

    申请号：US13808909

    申请日：2011-07-04

    申请人： Ki-Hang Kim

    发明人： Ki-Hang Kim

    IPC分类号： G06F3/044

    CPC分类号： G06F3/044 ,  G06F3/0416 ,  G06F3/0418

    摘要： Disclosed are an electrostatic capacity change sensing method and apparatus, and a recording medium in which a program executing the method is recorded, a touch sensing method and apparatus, and a recording medium in which a program executing the method is recorded. The electrostatic capacity change sensing method and apparatus are capable of sensing the change in the electrostatic capacity without using the sensing frequency. The touch sensing method and apparatus are capable of sensing touch without using the sensing frequency.

    摘要翻译： 公开了一种静电电容变化感测方法和装置，以及记录有执行方法的程序的记录介质，触摸感测方法和装置以及记录执行方法的程序的记录介质。 静电电容变化检测方法和装置能够在不使用感测频率的情况下感测静电容量的变化。 触摸感测方法和装置能够在不使用感测频率的情况下感测触摸。

    Modified tert promoter with enhanced tumor-specificity and strength and recombinant vector comprising the same
    6.
    发明授权
    Modified tert promoter with enhanced tumor-specificity and strength and recombinant vector comprising the same 有权
    具有增强的肿瘤特异性和强度的修饰的叔启动子和包含其的重组载体

    公开(公告)号：US08067567B2

    公开(公告)日：2011-11-29

    申请号：US10547233

    申请日：2004-02-27

    申请人： Chae-Ok Yun ,  Joo-Hang Kim ,  Jai-Myung Yang

    发明人： Chae-Ok Yun ,  Joo-Hang Kim ,  Jai-Myung Yang

    IPC分类号： C07H21/04 ,  C12N15/63 ,  A01N63/00 ,  A61K48/00

    CPC分类号： C12N15/86 ,  A61K38/45 ,  A61K48/00 ,  C12N9/1276 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85

    摘要： The present invention relates to a transcriptional regulatory sequence with enhanced tumor-specificity and strength and a recombinant vector comprising the transcriptional regulatory sequence. More particularly, the present invention relates to a transcriptional regulatory sequence comprising a human telomere reverse transcriptase (hTERT) promoter linked to a nucleotide sequence that comprises one or more c-Myc binding sites and/or one or more Sp1 binding sites, and a recombinant vector comprising a certain gene that is operably linked to the above transcriptional regulatory sequence.

    摘要翻译： 本发明涉及具有增强的肿瘤特异性和强度的转录调节序列和包含转录调节序列的重组载体。 更具体地，本发明涉及包含与包含一个或多个c-Myc结合位点和/或一个或多个Sp1结合位点的核苷酸序列连接的人端粒逆转录酶（hTERT）启动子的转录调节序列，以及重组 载体包含与上述转录调控序列有效连接的某个基因。

    Photoelectrochemical system for hydrogen production from water
    7.
    发明申请
    Photoelectrochemical system for hydrogen production from water 审中-公开
    用于氢气生产的光电化学系统

    公开(公告)号：US20080131762A1

    公开(公告)日：2008-06-05

    申请号：US11729145

    申请日：2007-03-28

    申请人： Oh-shim Joo ,  Kwang Deog Jung ,  Byoung Koun Min ,  Soo Hang Kim ,  Jun Woo Oh

    发明人： Oh-shim Joo ,  Kwang Deog Jung ,  Byoung Koun Min ,  Soo Hang Kim ,  Jun Woo Oh

    IPC分类号： H01M6/30

    CPC分类号： H01M14/005 ,  C01B3/042 ,  C25B1/003 ,  H01M2300/0002 ,  Y02E60/324 ,  Y02E60/364 ,  Y02E60/368 ,  Y02P20/135

    摘要： The present invention provides a photoelectrochemical (PEC) system for the production of hydrogen from water, which comprises (A) an electrolytic bath comprising an electrode for catalytic oxidation, an electrode for catalytic reduction, an ion separation film disposed between the two electrodes, and an aqueous electrolyte solution into which the two electrodes and the ion separation film are immersed, and (B) a photoelectrode positioned at the outside of the electrolytic bath and electrically connected to the two electrodes. The inventive PEC system is characterized by disposing a photoelectrode at the position which does not contact aqueous electrolyte solution, thus preventing the lowering of the photoelectrode activities, and maximizing the hydrogen production efficiency.

    摘要翻译： 本发明提供一种用于从水中生产氢的光电化学（PEC）系统，其包括（A）包括用于催化氧化的电极的电解浴，用于催化还原的电极，设置在两个电极之间的离子分离膜，以及 浸渍有两个电极和离子分离膜的电解质水溶液，（B）位于电解槽外侧并与两个电极电连接的光电极。 本发明的PEC系统的特征在于在不接触电解质水溶液的位置处设置光电极，防止光电极活性的降低，使氢生产效率最大化。

    Modified tert promoter with enhanced tumor-specificity and strength and recombinant vector comprising the same
    9.
    发明申请
    Modified tert promoter with enhanced tumor-specificity and strength and recombinant vector comprising the same 有权
    具有增强的肿瘤特异性和强度的修饰的叔启动子和包含其的重组载体

    公开(公告)号：US20070059287A1

    公开(公告)日：2007-03-15

    申请号：US10547233

    申请日：2004-02-27

    申请人： Chae-Ok Yun ,  Joo-Hang Kim ,  Jai-Myung Yang

    发明人： Chae-Ok Yun ,  Joo-Hang Kim ,  Jai-Myung Yang

    IPC分类号： A61K48/00 ,  C12N5/08 ,  C12N15/861

    CPC分类号： C12N15/86 ,  A61K38/45 ,  A61K48/00 ,  C12N9/1276 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85

    摘要： The present invention relates to a transcriptional regulatory sequence with enhanced tumor-specificity and strength and a recombinant vector comprising the transcriptional regulatory sequence. More particularly, the present invention relates to a transcriptional regulatory sequence comprising a human telomere reverse transcriptase (hTERT) promoter linked to a nucleotide sequence that comprises one or more c-Myc binding sites and/or one or more Sp1 binding sites, and a recombinant vector comprising a certain gene that is operably linked to the above transcriptional regulatory sequence.

    摘要翻译： 本发明涉及具有增强的肿瘤特异性和强度的转录调节序列和包含转录调节序列的重组载体。 更具体地，本发明涉及包含与包含一个或多个c-Myc结合位点和/或一个或多个Sp1结合位点的核苷酸序列连接的人端粒逆转录酶（hTERT）启动子的转录调节序列，以及重组 载体包含与上述转录调控序列有效连接的某个基因。