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1.发明授权Method for the preparation of a dermal papilla tissue having hair follicle inductive potency 有权用于制备具有毛囊诱导效力的真皮乳头组织的方法公开(公告)号：US07635589B2
公开(公告)日：2009-12-22
申请号：US11720217
申请日：2005-11-29
申请人： Jung-Keug Park , Doo-Hoon Lee , Hee-Hoon Yoon , Youn-Ho Shin , Young Jin Kim
发明人： Jung-Keug Park , Doo-Hoon Lee , Hee-Hoon Yoon , Youn-Ho Shin , Young Jin Kim
IPC分类号： C12N5/06
CPC分类号： C12N5/0627 , C12N2500/32 , C12N2501/12 , C12N2501/135 , C12N2501/155 , C12N2501/165
摘要： The inventive method for the preparation of a dermal papilla tissue in accordance with the present invention makes it possible to form a quantity of the dermal papilla tissues having hair follicle inductive ability, and accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.
摘要翻译： 根据本发明的用于制备真皮乳头组织的本发明的方法使得可以形成一定量的具有毛囊诱导能力的真皮乳头组织，因此可以有效地用于通过细胞治疗脱发 移植。
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2.发明申请Method For the Preparation of a Dermal Papilla Tissue Having Hair Follicle Inductive Potency 有权用于制备具有毛囊感染效力的真皮乳头组织的方法公开(公告)号：US20080145929A1
公开(公告)日：2008-06-19
申请号：US11720217
申请日：2005-11-29
申请人： Jung-Keug Park , Doo-Hoon Lee , Hee-Hoon Yoon , Youn-Ho Shin , Young Jin Kim
发明人： Jung-Keug Park , Doo-Hoon Lee , Hee-Hoon Yoon , Youn-Ho Shin , Young Jin Kim
IPC分类号： C12N5/00
CPC分类号： C12N5/0627 , C12N2500/32 , C12N2501/12 , C12N2501/135 , C12N2501/155 , C12N2501/165
摘要： The inventive method for the preparation of a dermal papilla tissue in accordance with the present invention makes it possible to form a quantity of the dermal papilla tissues having hair follicle inductive ability, and accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.
摘要翻译： 根据本发明的用于制备真皮乳头组织的本发明的方法使得可以形成一定量的具有毛囊诱导能力的真皮乳头组织，因此可以有效地用于通过细胞治疗脱发 移植。
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3.发明授权Method for inducing differentiation of mesenchymal stem cells to nerve cells using sound waves 有权使用声波诱导间充质干细胞分化为神经细胞的方法公开(公告)号：US08753881B2
公开(公告)日：2014-06-17
申请号：US13702982
申请日：2011-06-08
申请人： Jung-Keug Park , Moon Young Yoon , Hyun Jin Cho , Young-Kwon Seo , Song Hee Jeon , Hee Hoon Yoon
发明人： Jung-Keug Park , Moon Young Yoon , Hyun Jin Cho , Young-Kwon Seo , Song Hee Jeon , Hee Hoon Yoon
CPC分类号： C12N5/0619 , C12N5/0618 , C12N13/00 , C12N2506/1346 , C12N2506/1353 , C12N2506/1361 , C12N2506/1369 , C12N2506/1384 , C12N2529/00
摘要： The present invention relates to a method for differentiation of mesenchymal stem cells. More specifically, the invention relates to a method for differentiating mesenchymal stem cells to neural cells by treating the mesenchymal stem cells with low-frequency sound waves. The differentiation method of the present invention can induce differentiation even with low-cost media rather than induced neural differentiation mediums which are expensive due to addition of growth factors, and the neural cells differentiated according to the present invention may be useful for treatment of neurological diseases.
摘要翻译： 本发明涉及分化间充质干细胞的方法。 更具体地，本发明涉及通过用低频声波处理间充质干细胞来将间充质干细胞分化为神经细胞的方法。 本发明的分化方法即使使用低成本培养基也可诱导分化，而不是由于生长因子的添加而引起的神经分化培养基昂贵，根据本发明分化的神经细胞可用于治疗神经系统疾病 。
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4.发明申请Method For The Preparation Of Dermal Papilla Tissue Employing Mesenchymal Stem Cells 有权制备使用间充质干细胞的真皮乳头组织的方法公开(公告)号：US20100261276A1
公开(公告)日：2010-10-14
申请号：US12282760
申请日：2007-07-20
申请人： Jung-Keug Park , Hee-Hoon Yoon , Bo-Young Yoo , Young-Jin Kim , Youn-Ho Shin
发明人： Jung-Keug Park , Hee-Hoon Yoon , Bo-Young Yoo , Young-Jin Kim , Youn-Ho Shin
CPC分类号： C12N5/0627 , C12N2500/32 , C12N2500/38 , C12N2501/12 , C12N2501/39 , C12N2502/025 , C12N2502/1358 , C12N2502/1382 , C12N2502/1388
摘要： A method for the preparation of dermal papilla tissue comprising the step of culturing mesenchymal stem cells in a medium having a specific composition is provided. The method makes it possible to form in vitro a quantity of dermal papilla tissues having hair follicle inducting ability and, accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.
摘要翻译： 提供了一种制备真皮乳头组织的方法，包括在具有特定组成的培养基中培养间充质干细胞的步骤。 该方法能够体外形成具有毛囊诱导能力的真皮乳头组织，因此可以有效地用于通过细胞移植治疗脱发。
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公开(公告)号：US07229827B2
公开(公告)日：2007-06-12
申请号：US10475056
申请日：2002-04-19
申请人： Hyun-Soo Kim , Hee-Hoon Yoon
发明人： Hyun-Soo Kim , Hee-Hoon Yoon
CPC分类号： C12N5/0622 , A61K35/12 , C12N5/0619 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2506/1353
摘要： A method for differentiating mesenchymal stem cells of bone marrow into neural cells comprises culturing the mesenchymal stem cells in a medium containing epidermal growth factor(EGF), basic fibroblast growth factor(bFGF) and hepatocyte growth factor(HGF), and the neural cells produced thereby can be employed for the treatment of a neural disease.
摘要翻译： 将骨髓间充质干细胞分化为神经细胞的方法包括在含有表皮生长因子（EGF），碱性成纤维细胞生长因子（bFGF）和肝细胞生长因子（HGF）的培养基中培养间充质干细胞，并产生神经细胞 从而可用于治疗神经疾病。
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6.发明授权Method for inducing differentiation of adult stem cells and nerve cells using electromagnetic field 有权使用电磁场诱导成体干细胞和神经细胞分化的方法公开(公告)号：US08673605B2
公开(公告)日：2014-03-18
申请号：US13702975
申请日：2011-06-08
申请人： Jung-Keug Park , Sung Min Kim , Soo Chan Kim , Moon Young Yoon , Hyun Jin Cho , Young-Kwon Seo , Hee Hoon Yoon
发明人： Jung-Keug Park , Sung Min Kim , Soo Chan Kim , Moon Young Yoon , Hyun Jin Cho , Young-Kwon Seo , Hee Hoon Yoon
IPC分类号： A01N63/00 , C12N13/00 , C12N5/0793
CPC分类号： C12N5/0619 , C12N5/0618 , C12N13/00 , C12N2506/1346 , C12N2506/1353 , C12N2506/1361 , C12N2506/1369 , C12N2506/1384 , C12N2529/00
摘要： The present invention relates to a method for differentiation of mesenchymal stem cells or dental pulp stem cells. More specifically, the invention relates to a method for differentiating stem cells to neural cells by applying mesenchymal stem cells or dental pulp stem cells with a low-frequency electromagnetic field. The differentiation method according to the present invention can induce differentiation even with low-cost mediums rather than induced neural differentiation mediums which are expensive due to addition of growth factors, and the neural cells differentiated according to the present invention may be useful for treatment of neurological brain diseases.
摘要翻译： 本发明涉及分化间充质干细胞或牙髓干细胞的方法。 更具体地，本发明涉及通过用低频电磁场施用间充质干细胞或牙髓干细胞来分化干细胞与神经细胞的方法。 根据本发明的分化方法即使使用低成本培养基也可诱导分化，而不是由于生长因子的添加而昂贵的诱导神经分化培养基，并且根据本发明分化的神经细胞可用于治疗神经系统 脑疾病
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公开(公告)号：US20100126923A1
公开(公告)日：2010-05-27
申请号：US12593864
申请日：2008-03-28
申请人： Jung Keug Park , Sung Koo Kim , Suk Koo Lee , Young-Jin Kim , Doo-Hoon Lee , Ji-Hyun Lee , Hee-Hoon Yoon , Jae-Nam Ryu , Choon-Hyuck Kwon , Jeong-Kwon Noh , Hey-Jung Park
发明人： Jung Keug Park , Sung Koo Kim , Suk Koo Lee , Young-Jin Kim , Doo-Hoon Lee , Ji-Hyun Lee , Hee-Hoon Yoon , Jae-Nam Ryu , Choon-Hyuck Kwon , Jeong-Kwon Noh , Hey-Jung Park
CPC分类号： A61M1/3472 , A61M1/1698 , A61M1/3489 , C12N5/0671 , C12N2533/74
摘要： The present invention discloses a bioartificial liver system comprising a fixed-bed bioreactor packed with gel beads containing hepatocytes of an animal, a plasma reservoir, a plasma separator, and an efflux chamber, wherein the plasma reservoir is located at a position higher than the bioreactor, a ventilation filter in contact with atmosphere is provided at the top of the plasma reservoir, and the top of the plasma reservoir is directly connected to the efflux chamber via a connecting line. The inventive system satisfactorily performs the essential liver functions without the problems of gel bead damage or channeling.
摘要翻译： 本发明公开了一种生物人造肝系统，其包括固定床生物反应器，该固定床生物反应器填充有含有动物肝细胞，血浆储存器，血浆分离器和流出室的凝胶珠，其中等离子体储存器位于高于生物反应器 在等离子体容器的顶部设置有与气氛接触的通风过滤器，并且等离子体容器的顶部经由连接线直接连接到流出室。 本发明的系统令人满意地执行必要的肝功能，而没有凝胶珠损伤或引流的问题。
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8.发明申请COMPOSITE SUPPORT CONTAINING SILK AND COLLAGEN, AND PREPARATION METHOD THEREOF 审中-公开含有丝和胶原的复合支持物及其制备方法公开(公告)号：US20130073055A1
公开(公告)日：2013-03-21
申请号：US13634720
申请日：2011-03-16
申请人： Jung-Keug Park , Young Kwon Seo , Mi Jung Han , Hwa Sung Lee , Su Rak Eo , Hee Hoon Yoon , Soon Yong Kwon , Hee Jung Park
发明人： Jung-Keug Park , Young Kwon Seo , Mi Jung Han , Hwa Sung Lee , Su Rak Eo , Hee Hoon Yoon , Soon Yong Kwon , Hee Jung Park
CPC分类号： A61L27/24 , A61F2/02 , A61F2/08 , A61F2240/001 , A61L27/32 , A61L27/54 , A61L2300/414 , A61L2430/10 , A61L2430/30 , D03D15/00 , D06B1/00
摘要： Embodiments of the present invention relate to a biodegradable scaffold for replacing tissue or inducing tissue regeneration and a preparation method thereof, wherein the scaffold comprises at least one woven silk tube layer and a collagen layer inside the tube layer. The scaffold is excellent in terms of tissue regeneration and mechanical properties and causes little or no immune response after implantation. Thus, the scaffold can be effectively used as a matrix for the regeneration of ligaments and tendons and the repair of injured muscles.
摘要翻译： 本发明的实施方案涉及用于替代组织或诱导组织再生的生物可降解支架及其制备方法，其中所述支架包括至少一个编织丝管层和所述管层内的胶原层。 支架在组织再生和机械性能方面是优异的，并且在植入后几乎不产生或没有免疫应答。 因此，支架可以有效地用作韧带和腱的再生的基质和损伤的肌肉的修复。
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公开(公告)号：US08329457B2
公开(公告)日：2012-12-11
申请号：US12593864
申请日：2008-03-28
申请人： Jung Keug Park , Sung Koo Kim , Suk Koo Lee , Young-Jin Kim , Doo-Hoon Lee , Ji-Hyun Lee , Hee-Hoon Yoon , Jae-Nam Ryu , Choon-Hyuck Kwon , Jeong-Kwon Noh , Hey-Jung Park
发明人： Jung Keug Park , Sung Koo Kim , Suk Koo Lee , Young-Jin Kim , Doo-Hoon Lee , Ji-Hyun Lee , Hee-Hoon Yoon , Jae-Nam Ryu , Choon-Hyuck Kwon , Jeong-Kwon Noh , Hey-Jung Park
CPC分类号： A61M1/3472 , A61M1/1698 , A61M1/3489 , C12N5/0671 , C12N2533/74
摘要： The present invention discloses a bioartificial liver system comprising a fixed-bed bioreactor packed with gel beads containing hepatocytes of an animal, a plasma reservoir, a plasma separator, and an efflux chamber, wherein the plasma reservoir is located at a position higher than the bioreactor, a ventilation filter in contact with atmosphere is provided at the top of the plasma reservoir, and the top of the plasma reservoir is directly connected to the efflux chamber via a connecting line. The inventive system satisfactorily performs the essential liver functions without the problems of gel bead damage or channeling.
摘要翻译： 本发明公开了一种生物人造肝系统，其包括固定床生物反应器，该固定床生物反应器填充有含有动物肝细胞，血浆储存器，血浆分离器和流出室的凝胶珠，其中等离子体储存器位于高于生物反应器 在等离子体容器的顶部设置有与气氛接触的通风过滤器，并且等离子体容器的顶部经由连接线直接连接到流出室。 本发明的系统令人满意地执行必要的肝功能，而没有凝胶珠损伤或引流的问题。
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10.发明授权Method for the preparation of dermal papilla tissue employing mesenchymal stem cells 有权使用间充质干细胞制备真皮乳头组织的方法公开(公告)号：US08017390B2
公开(公告)日：2011-09-13
申请号：US12282760
申请日：2007-07-20
申请人： Jung-Keug Park , Hee-Hoon Yoon , Bo-Young Yoo , Young-Jin Kim , Youn-Ho Shin
发明人： Jung-Keug Park , Hee-Hoon Yoon , Bo-Young Yoo , Young-Jin Kim , Youn-Ho Shin
CPC分类号： C12N5/0627 , C12N2500/32 , C12N2500/38 , C12N2501/12 , C12N2501/39 , C12N2502/025 , C12N2502/1358 , C12N2502/1382 , C12N2502/1388
摘要： A method for the preparation of dermal papilla tissue comprising the step of culturing mesenchymal stem cells in a medium having a specific composition is provided. The method makes it possible to form in vitro a quantity of dermal papilla tissues having hair follicle inducting ability and, accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.
摘要翻译： 提供了一种制备真皮乳头组织的方法，包括在具有特定组成的培养基中培养间充质干细胞的步骤。 该方法能够体外形成具有毛囊诱导能力的真皮乳头组织，因此可以有效地用于通过细胞移植治疗脱发。
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