Macrolide antibiotics and their use for medical purposes
    7.
    发明授权
    Macrolide antibiotics and their use for medical purposes 有权
    大环内酯抗生素及其用于医疗用途

    公开(公告)号:US08114864B2

    公开(公告)日:2012-02-14

    申请号:US12515695

    申请日:2007-11-09

    IPC分类号: A61K31/395 C07D487/04

    CPC分类号: A61K31/429 C07D513/08

    摘要: The invention provides novel Thuggacin-Type macrolide compounds which form rearrangement products forming a lacton bond to different carbon atoms. The novel compounds can be produced by fermentation of Sorangium cellulosum and Chondromyces crocatus and can be isolated by adsorption and chromoatograhic processing steps. The compounds are found to have antibiotic activity. The invention also relates to Thuggacin A, Thuggacin B, Thuggacin C, 13-Methyl-Thuggacin A, Thuggacin CMC-A, Thuggacin CMC-B and Thuggacin CMC-C AS Antimycobacterial Agents.

    摘要翻译: 本发明提供了形成与不同碳原子形成内酯键的重排产物的新型Thuggacin型大环内酯化合物。 新型化合物可以通过发酵纤维素和软骨软体来生产,可以通过吸附和色谱处理步骤进行分离。 发现这些化合物具有抗生素活性。 本发明还涉及Thuggacin A,Thuggacin B,Thuggacin C,13-甲基 - Thuggacin A,Thuggacin CMC-A,Thuggacin CMC-B和Thuggacin CMC-C AS抗分枝杆菌。

    NOVEL MACROLIDE ANTIBIOTICS AND THEIR USE FOR MEDICAL PURPOSES
    8.
    发明申请
    NOVEL MACROLIDE ANTIBIOTICS AND THEIR USE FOR MEDICAL PURPOSES 有权
    新型抗肿瘤药物及其用于医疗用途的药物

    公开(公告)号:US20100113757A1

    公开(公告)日:2010-05-06

    申请号:US12515695

    申请日:2007-11-09

    IPC分类号: C07H17/08

    CPC分类号: A61K31/429 C07D513/08

    摘要: The invention provides novel Thuggacin-Type macrolide compounds which form rearrangement products forming a lacton bond to different carbon atoms. The novel compounds can be produced by fermentation of Sorangium cellulosum and Chondromyces crocatus and can be isolated by adsorption and chromoatograhic processing steps. The compounds are found to have antibiotic activity. The invention also relates to Thuggacin A, Thuggacin B, Thuggacin C, 13-Methyl-Thuggacin A, Thuggacin CMC-A, Thuggacin CMC-B and Thuggacin CMC-C AS Antimycobacterial Agents.

    摘要翻译: 本发明提供了形成与不同碳原子形成内酯键的重排产物的新型Thuggacin型大环内酯化合物。 新型化合物可以通过发酵纤维素和软骨软体来生产,可以通过吸附和色谱处理步骤进行分离。 发现这些化合物具有抗生素活性。 本发明还涉及Thuggacin A,Thuggacin B,Thuggacin C,13-甲基 - Thuggacin A,Thuggacin CMC-A,Thuggacin CMC-B和Thuggacin CMC-C AS抗分枝杆菌。

    Biologically active compounds obtainable from Sorangium cellulosum
    10.
    发明申请
    Biologically active compounds obtainable from Sorangium cellulosum 有权
    从山梨酸纤维素获得的生物活性化合物

    公开(公告)号:US20070021480A1

    公开(公告)日:2007-01-25

    申请号:US11486140

    申请日:2006-07-13

    IPC分类号: A61K31/424 C07D491/14

    CPC分类号: C07D498/18 C07D498/22

    摘要: The present invention relates to a novel group of compounds having antibiotic, antifungal and/or cytostatic properties, which are obtainable from myxobacteria, especially of the genus Sorangium, preferably Sorangium cellulosum. One representative of this group of compoundsis currently named Disorazole Z and Disorazole Z-epoxide, respectively, with specific substituents and specific unsaturated bonds to its cyclic core structure:

    摘要翻译: 本发明涉及一种具有抗生素,抗真菌和/或细胞生长抑制性质的新型化合物,其可从粘液细菌,特别是Sorangium属,优选Sorangium cellulosum获得。 这组化合物的一个代表目前分别名为Disorazole Z和Disorazole Z-环氧化物,具有特定的取代基和特定的不饱和键与其环状核心结构: