-
公开(公告)号：US20110281745A1
公开(公告)日：2011-11-17
申请号：US12857510
申请日：2010-08-16
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01J2219/0074 , B01L3/50853 , B01L2200/025 , B01L2200/12 , B01L2300/0819 , B01L2300/12 , B82Y30/00 , G01N21/6452 , G01N33/505 , G01N33/5052 , G01N33/531 , G01N33/543 , G01N33/54366 , G01N33/577 , G01N33/6854 , Y10S436/809
摘要： Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.
-
公开(公告)号：US20110281764A1
公开(公告)日：2011-11-17
申请号：US12857508
申请日：2010-08-16
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01J2219/0074 , B01L3/50853 , B01L2200/025 , B01L2200/12 , B01L2300/0819 , B01L2300/12 , B82Y30/00 , G01N21/6452 , G01N33/505 , G01N33/5052 , G01N33/531 , G01N33/543 , G01N33/54366 , G01N33/577 , G01N33/6854 , Y10S436/809 , Y10T436/24
摘要： Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.
-
公开(公告)号：US20110046008A1
公开(公告)日：2011-02-24
申请号：US12857506
申请日：2010-08-16
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01J2219/0074 , B01L3/50853 , B01L2200/025 , B01L2200/12 , B01L2300/0819 , B01L2300/12 , B82Y30/00 , G01N21/6452 , G01N33/505 , G01N33/5052 , G01N33/531 , G01N33/543 , G01N33/54366 , G01N33/577 , G01N33/6854 , Y10S436/809 , Y10T436/24
摘要： Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.
摘要翻译： 提供了筛选测定和进行这种测定的方法。 在某些实施例中，可以设计测定和方法以确定两种或更多种类是否可以彼此结合。 在一些实例中，测定和方法可用于确定已知抗原是否与未知单克隆抗体结合。
-
公开(公告)号：US07776553B2
公开(公告)日：2010-08-17
申请号：US11523124
申请日：2006-09-18
IPC分类号： G01N33/53 , G01N33/533 , G01N33/534 , G01N33/569 , G01N21/00
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01J2219/0074 , B01L3/50853 , B01L2200/025 , B01L2200/12 , B01L2300/0819 , B01L2300/12 , B82Y30/00 , G01N21/6452 , G01N33/505 , G01N33/5052 , G01N33/531 , G01N33/543 , G01N33/54366 , G01N33/577 , G01N33/6854 , Y10S436/809
摘要： Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.
摘要翻译： 提供了筛选测定和进行这种测定的方法。 在某些实施例中，可以设计测定和方法以确定两种或更多种类是否可以彼此结合。 在一些实例中，测定和方法可用于确定已知抗原是否与未知单克隆抗体结合。
-
公开(公告)号：US10081684B2
公开(公告)日：2018-09-25
申请号：US14127736
申请日：2012-06-28
IPC分类号： C07K1/06 , C12P21/04 , C07K16/46 , C07K19/00 , C12N9/00 , C12N9/10 , C07K1/107 , C07K16/18 , C12N9/52 , C12N15/62
CPC分类号： C07K16/468 , C07K1/107 , C07K1/1072 , C07K16/18 , C07K2317/31 , C07K2317/569 , C07K2317/62 , C07K2319/00 , C07K2319/21 , C12N9/52 , C12N15/62
摘要： Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.
-
公开(公告)号：US08865479B2
公开(公告)日：2014-10-21
申请号：US12857510
申请日：2010-08-16
IPC分类号： G01N33/53 , B82Y30/00 , B01L3/00 , G01N33/531 , G01N33/543 , G01N21/64 , G01N33/68 , G01N33/577 , G01N33/50
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01J2219/0074 , B01L3/50853 , B01L2200/025 , B01L2200/12 , B01L2300/0819 , B01L2300/12 , B82Y30/00 , G01N21/6452 , G01N33/505 , G01N33/5052 , G01N33/531 , G01N33/543 , G01N33/54366 , G01N33/577 , G01N33/6854 , Y10S436/809
摘要： Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.
-
公开(公告)号：US20140249296A1
公开(公告)日：2014-09-04
申请号：US14127736
申请日：2012-06-28
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K1/107 , C07K1/1072 , C07K16/18 , C07K2317/31 , C07K2317/569 , C07K2317/62 , C07K2319/00 , C07K2319/21 , C12N9/52 , C12N15/62
摘要： Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.
摘要翻译： 提供了用于在靶蛋白上安装点击化学手柄的方法和试剂，以及包括点击化学手段的修饰蛋白质。 此外，本文公开了包含通过点击化学结合的两种蛋白质的嵌合蛋白，例如双特异性抗体，以及用于其生成和使用的方法。
-
公开(公告)号：US20110321183A1
公开(公告)日：2011-12-29
申请号：US13145644
申请日：2010-02-01
CPC分类号： C12N9/48 , A01K2217/00 , C12N9/80
摘要： The present invention relates to methods for ligation. The invention provides novel reagents and methods for ligating an acyl donor compound with an acyl acceptor compound. Provided acyl donor compounds comprise a transamidase recognition sequence that allows ligation with a nucleophilic acyl acceptor in the presence of transamidase. The invention further provides kits comprising acyl donor compounds and optionally comprising other reagents for ligation.
摘要翻译： 本发明涉及结扎方法。 本发明提供了用于将酰基供体化合物与酰基受体化合物连接的新型试剂和方法。 如果酰基供体化合物包含转移酰胺酶识别序列，其允许在转酰胺酶存在下与亲核酰基受体结合。 本发明还提供了包含酰基供体化合物和任选地包含其它用于连接的试剂的试剂盒。
-
公开(公告)号：US08940501B2
公开(公告)日：2015-01-27
申请号：US13145644
申请日：2010-02-01
CPC分类号： C12N9/48 , A01K2217/00 , C12N9/80
摘要： The present invention relates to methods for ligation. The invention provides novel reagents and methods for ligating an acyl donor compound with an acyl acceptor compound. Provided acyl donor compounds comprise a transamidase recognition sequence that allows ligation with a nucleophilic acyl acceptor in the presence of transamidase. The invention further provides kits comprising acyl donor compounds and optionally comprising other reagents for ligation.
摘要翻译： 本发明涉及结扎方法。 本发明提供了用于将酰基供体化合物与酰基受体化合物连接的新型试剂和方法。 如果酰基供体化合物包含转移酰胺酶识别序列，其允许在转酰胺酶存在下与亲核酰基受体结合。 本发明还提供了包含酰基供体化合物和任选地包含其它用于连接的试剂的试剂盒。
-
公开(公告)号：US20100152054A1
公开(公告)日：2010-06-17
申请号：US11523124
申请日：2006-09-18
IPC分类号： C40B30/04
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01J2219/0074 , B01L3/50853 , B01L2200/025 , B01L2200/12 , B01L2300/0819 , B01L2300/12 , B82Y30/00 , G01N21/6452 , G01N33/505 , G01N33/5052 , G01N33/531 , G01N33/543 , G01N33/54366 , G01N33/577 , G01N33/6854 , Y10S436/809
摘要： Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.
摘要翻译： 提供了筛选测定和进行这种测定的方法。 在某些实施例中，可以设计测定和方法以确定两种或更多种类是否可以彼此结合。 在一些实例中，测定和方法可用于确定已知抗原是否与未知单克隆抗体结合。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.029 秒)
