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    AGENT FOR ENHANCING THE RESISTANCE OF LIPOSOME AGAINST BIOLOGICAL COMPONENT, AND LIPOSOME MODIFIED WITH THE AGENT
    2.
    发明申请
    AGENT FOR ENHANCING THE RESISTANCE OF LIPOSOME AGAINST BIOLOGICAL COMPONENT, AND LIPOSOME MODIFIED WITH THE AGENT 审中-公开
    用于增强生物组分的脂质体抗性的试剂和用该试剂修饰的脂质体

    公开(公告)号：US20100104623A1

    公开(公告)日：2010-04-29

    申请号：US12449817

    申请日：2008-02-27

    申请人： Hideyoshi Harashima ,  Kentaro Kogure ,  Hidetaka Akita ,  Akitada Iwasa ,  Yoshio Nakamura ,  Shiroh Futaki

    发明人： Hideyoshi Harashima ,  Kentaro Kogure ,  Hidetaka Akita ,  Akitada Iwasa ,  Yoshio Nakamura ,  Shiroh Futaki

    IPC分类号： A61K9/127

    CPC分类号： A61K9/127 ,  A61K38/00 ,  A61K47/42 ,  C07K14/00

    摘要： It is intended to provide a positively charged liposome, particularly having a polyarginine peptide on a surface thereof, which is capable of increasing the resistance to a negatively charged biological component such as a protein in the blood and maintaining a high ability to deliver a substance even in the blood. An agent for enhancing the resistance of liposome against biological component comprising a peptide having at least one of the following characteristics (a) and (b) as an active ingredient: (a) A peptide comprising an amino acid sequence represented by SEQ ID No: 1 or 2; and (b) A peptide comprising an amino acid sequence represented by SEQ ID No: 1 or 2, in which one or more amino acids are deleted, substituted or added, and having an activity for promoting lipid membrane fusion under acidic condition. An agent for enhancing the resistance of liposome against biological component in this invention, being included in a liposome, is capable of increasing the resistance to a negatively charged biological component such as a protein in the blood and maintaining a high ability to deliver a substance even in the blood.

    摘要翻译： 旨在提供带正电荷的脂质体，特别是在其表面具有聚精氨酸肽，其能够增加对带负电的生物成分如血液中的蛋白质的抗性，并且保持高的物质输送能力 在血中 用于增强脂质体对生物成分的抗性的试剂，其包含具有以下特征（a）和（b）中的至少一个作为活性成分的肽：（a）包含SEQ ID No： 1或2; 和（b）包含SEQ ID No：1或2所示的氨基酸序列的肽，其中一个或多个氨基酸缺失，取代或添加，并且具有在酸性条件下促进脂质膜融合的活性。 包含在脂质体中的用于增强本发明中脂质体对抗生物成分的抗性的药剂能够增加对带负电的生物成分如血液中的蛋白质的抗性，并保持高的物质输送能力 在血中

    Liposome Capable of Effective Delivery of Given Substance Into Nucleus
    6.
    发明申请
    Liposome Capable of Effective Delivery of Given Substance Into Nucleus 审中-公开
    能够有效递送给予物质的脂质体

    公开(公告)号：US20090305409A1

    公开(公告)日：2009-12-10

    申请号：US11887030

    申请日：2006-03-24

    申请人： Kentaro Kogure ,  Takashi Nakamura ,  Hidetaka Akita ,  Hideyoshi Harashima ,  Shiroh Futaki

    发明人： Kentaro Kogure ,  Takashi Nakamura ,  Hidetaka Akita ,  Hideyoshi Harashima ,  Shiroh Futaki

    IPC分类号： C12N5/00

    CPC分类号： C12N15/88 ,  A61K48/00

    摘要： Disclosed is a non-viral vector capable of delivering a given substance into the nucleus of a target cell effectively even when the target cells is a undividable cell such as a dendritic cell. A bilamellar liposome having a first lipid membrane and a second lipid membrane successively from the outside, the first lipid membrane having a membrane-fusing ability and the second lipid membrane having on its surface a nuclear transport peptide.

    摘要翻译： 公开了即使当靶细胞是不可分割的细胞例如树突状细胞时，能够有效地将给定物质有效地递送到靶细胞的细胞核中的非病毒载体。 具有从外部连续地具有第一脂质膜和第二脂质膜的第二脂质膜，所述第一脂质膜具有膜融合能力，所述第二脂质膜在其表面上具有核转运肽。

    Vector For Delivering Target Substance Into Nucleus or Cell
    10.
    发明申请
    Vector For Delivering Target Substance Into Nucleus or Cell 审中-公开
    用于将靶物质递送到核或细胞的载体

    公开(公告)号：US20080241917A1

    公开(公告)日：2008-10-02

    申请号：US11992726

    申请日：2006-09-29

    申请人： Hidetaka Akita ,  Asako Kudo ,  Hideyoshi Harashima

    发明人： Hidetaka Akita ,  Asako Kudo ,  Hideyoshi Harashima

    IPC分类号： C12N15/00

    CPC分类号： A61K9/1272 ,  C12N15/88

    摘要： It is intended to provide a vector for delivering a target substance into a nucleus or a cell. This object is achieved by providing a vector for delivering a target substance into a nucleus or a cell which comprises a lipid membrane structure having a lipid membrane containing an anionic lipid such as phosphatidic acid, cardiolipin, etc.

    摘要翻译： 旨在提供用于将靶物质递送到细胞核或细胞中的载体。 该目的通过提供用于将靶物质递送到细胞核或细胞中的载体来实现，该载体包含具有含有阴离子脂质如磷脂酸，心磷脂等的脂质膜的脂质膜结构。