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1.发明申请Blood Retainable Device Exhibiting Selective Degradability in Tumor Tissue 审中-公开血液保留装置展示肿瘤组织中的选择性降解性公开(公告)号：US20090022782A1
公开(公告)日：2009-01-22
申请号：US11817096
申请日：2006-02-24
申请人： Hidetaka Akita , Hiroto Hatakeyama , Yukio Nagasaki , Hiroshi Kikuchi , Hideo Kobayashi , Hideyoshi Harashima , Motoi Oishi
发明人： Hidetaka Akita , Hiroto Hatakeyama , Yukio Nagasaki , Hiroshi Kikuchi , Hideo Kobayashi , Hideyoshi Harashima , Motoi Oishi
IPC分类号： A61K9/127 , C07K7/00 , A61K31/7088 , A61K31/715 , A61K31/7105 , A61P31/00
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1272 , A61K31/711 , A61K47/60 , A61K47/62 , C07K7/08
摘要： A phospholipid derivative useful for the preparation of liposomes for efficient uptake of an antitumor agent or a gene intracellularly by a target tumor cell, which comprises a residue of an alcohol compound and a residue of a phospholipid, and comprising a peptide between the residue of an alcohol compound and the residue of a phospholipid, and wherein (a) the alcohol compound is an alcohol compound selected from poly(alkylene glycols) and the like, (b) the phospholipid is a phospholipid selected from phosphatidylethanolamines, phosphatidylcholines, phosphatidylserines and the like, and (c) the peptide is a peptide comprising a substrate peptide that can serve as a substrate of a matrix metalloproteinase, provided that one amino acid residue or an oligopeptide containing 2 to 8 amino acid residues may bind to one or both ends of the substrate peptide.
摘要翻译： 一种用于制备脂质体以有效吸收目标肿瘤细胞的细胞内抗肿瘤剂或细胞基因的磷脂衍生物，其包含醇化合物和磷脂残基的残基，并且包含在 醇化合物和磷脂的残基，其中（a）醇化合物是选自聚（亚烷基二醇）等的醇化合物，（b）磷脂是选自磷脂酰乙醇胺，磷脂酰胆碱，磷脂酰丝氨酸等的磷脂 ，和（c）肽是包含可用作基质金属蛋白酶底物的底物肽的肽，条件是含有2-8个氨基酸残基的一个氨基酸残基或寡肽可以结合到 底物肽。
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公开(公告)号：US20080097087A1
公开(公告)日：2008-04-24
申请号：US11578560
申请日：2005-04-14
IPC分类号： C07H21/04
CPC分类号： C08G65/329 , A61K47/543 , A61K47/60 , A61K47/6907 , A61K48/00 , C07H21/04 , C08G65/3322 , C08G65/334 , C08L2203/02
摘要： The invention provides a conjugate of functional oligonucleotide with poly(ethylene oxide), polyion complex of the conjugate with cationic polymer, and micelle thereof. The micelle improves stability of the oligonucleotide in animal cells and its specific bindability to target gene.
摘要翻译： 本发明提供功能性寡核苷酸与聚（环氧乙烷），缀合物与阳离子聚合物的聚离子络合物及其胶束的缀合物。 胶束提高寡核苷酸在动物细胞中的稳定性及其与靶基因的特异性结合力。
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公开(公告)号：US20080064863A1
公开(公告)日：2008-03-13
申请号：US11661810
申请日：2005-08-24
申请人： Yukio Nagasaki , Kazunori Kataoka , Motoi Oishi
发明人： Yukio Nagasaki , Kazunori Kataoka , Motoi Oishi
IPC分类号： C07H21/02
CPC分类号： C12N15/111 , A61K47/549 , A61K47/60 , A61K47/6455 , C08G65/332 , C08G65/334 , C08L2203/02 , C12N15/88 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： A polyion complex is provided, comprising a double stranded nucleic acid containing a poly(ethylene oxide)-modified oligo- or poly-nucleotide and a polycationic compound, which is an effective delivery means of a gene to a target cell.
摘要翻译： 提供聚阴离子配合物，其包含含有聚（环氧乙烷） - 修饰的寡聚核苷酸和多核苷酸的双链核酸和聚阳离子化合物，其是靶细胞的基因的有效递送方式。
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公开(公告)号：US07642343B2
公开(公告)日：2010-01-05
申请号：US11578560
申请日：2005-04-14
CPC分类号： C08G65/329 , A61K47/543 , A61K47/60 , A61K47/6907 , A61K48/00 , C07H21/04 , C08G65/3322 , C08G65/334 , C08L2203/02
摘要： The invention provides a conjugate of functional oligonucleotide with poly(ethylene oxide), polyion complex of the conjugate with cationic polymer, and micelle thereof. The micelle improves stability of the oligonucleotide in animal cells and its specific bindability to target gene.
摘要翻译： 本发明提供功能性寡核苷酸与聚（环氧乙烷），缀合物与阳离子聚合物的聚离子络合物及其胶束的缀合物。 胶束提高寡核苷酸在动物细胞中的稳定性及其与靶基因的特异性结合力。
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公开(公告)号：US08980241B2
公开(公告)日：2015-03-17
申请号：US12990575
申请日：2008-12-04
申请人： Yukio Nagasaki , Toru Yoshitomi , Hirofumi Matsui , Aki Hirayama , Takashi Mamiya , Akira Matsumura , Kensuke Suzuki , Hideo Tsurushima , Aiki Marushima , Kazuko Toh , Daisuke Miyamoto
发明人： Yukio Nagasaki , Toru Yoshitomi , Hirofumi Matsui , Aki Hirayama , Takashi Mamiya , Akira Matsumura , Kensuke Suzuki , Hideo Tsurushima , Aiki Marushima , Kazuko Toh , Daisuke Miyamoto
IPC分类号： A61K31/74 , C08F8/30 , A23L1/30 , A61K47/48 , A61K49/08 , A61K49/12 , A61K49/18 , A61K49/20 , B82Y5/00 , C08G65/333 , C08G65/334 , C08G73/10 , C08L71/02 , C08L23/00 , C08L25/00 , C08L71/03 , C08L79/00
CPC分类号： C08F8/30 , A23L33/10 , A61K47/58 , A61K47/60 , A61K49/085 , A61K49/126 , A61K49/1806 , A61K49/1824 , A61K49/20 , B82Y5/00 , C08G65/33396 , C08G65/334 , C08G65/3344 , C08G73/1071 , C08G2261/126 , C08L23/00 , C08L25/00 , C08L71/02 , C08L71/03 , C08L79/00 , C08L2203/02 , C08L2205/05 , C08F297/00 , C08L2666/02 , C08L25/04
摘要： A method of covalently bonding a cyclic nitroxide radical compound to a hydrophobic block of a specific hydrophylic-phobic block copolymer, and polymerized cyclic nitroxide radical compound copolymerized in this manner, as well as use of such a compound, for instance, in the medical field are provided. The compound demonstrates long term stability in vivo under reductive environment.
摘要翻译： 将环状氮氧自由基化合物共价键合到特定的亲水疏水性嵌段共聚物的疏水性嵌段的方法，以及以这种方式共聚的聚合的环状氮氧自由基化合物的方法，以及使用这种化合物，例如在医疗领域 被提供。 该化合物在还原环境下在体内表现出长期的稳定性。
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公开(公告)号：US20070059843A1
公开(公告)日：2007-03-15
申请号：US10575551
申请日：2004-09-06
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N33/5432
摘要： This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.
摘要翻译： 本发明提供一种检测分析物的方法，其包括制备在其核心中具有可带电基团的微粒和在其壳中的亲水性聚合物链; 通过在细颗粒和分析物的表面上的特定残基之间形成生物特异性键，并通过不纯蛋白与所述颗粒之间的静电相互作用同时形成粘结来获得凝集物; 并且随后通过提高离子强度来仅切割后一种键。 因此，本发明提供了使用凝集反应以快速且高灵敏度检测分析物的方法。
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7.发明申请Diamine having quinoxaline unit, polyimide precursor, polyimide and use thereof 审中-公开二胺具有喹喔啉单元，聚酰亚胺前体，聚酰亚胺及其用途公开(公告)号：US20060128937A1
公开(公告)日：2006-06-15
申请号：US10561152
申请日：2004-06-16
CPC分类号： G02F1/133723 , C07D241/42 , C08G73/0694 , C08G73/1085 , G02F2001/133796
摘要： A diaminobenzene compound is disclosed which is represented by the formula (1). By reacting this compound with a tetracarboxylic acid (derivative), there can be obtained a polyimide which has charge carrier transport properties and is excellent in heat resistance, film strength and thin-film properties.
摘要翻译： 公开了由式（1）表示的二氨基苯化合物。 通过使该化合物与四羧酸（衍生物）反应，可以得到具有电荷载流子传输性并且耐热性，膜强度和薄膜性质优异的聚酰亚胺。
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公开(公告)号：US07037517B2
公开(公告)日：2006-05-02
申请号：US10470574
申请日：2003-09-01
CPC分类号： A61F2/14 , A61F2/16 , A61F2250/0056 , A61K9/0051 , A61K9/1075
摘要： The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.
摘要翻译： 本发明涉及一种涂覆的生物医学装置，所述胶束具有亲水性外壳和疏水性内芯，或疏水性外壳和亲水性内芯，所述胶束由HLB值为约1至约 医疗装置可以在其上具有一个涂层或多个涂层。 本发明还涉及胶束作为药物载体的用途。
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公开(公告)号：US20060040396A1
公开(公告)日：2006-02-23
申请号：US10507624
申请日：2003-03-13
申请人： Yoshinobu Baba , Kazumori Kataoka , Mari Tabuchi , Yukio Nagasaki , Yasuko Tanaka , Chie Kuwahara
发明人： Yoshinobu Baba , Kazumori Kataoka , Mari Tabuchi , Yukio Nagasaki , Yasuko Tanaka , Chie Kuwahara
CPC分类号： G01N27/44747 , Y10T436/108331
摘要： By using an electrophoretic buffer comprising a polymerized polymer micelle formed by the steps comprising dispersing into an aqueous medium a block copolymer represented by HPLS-HPBS-PLZA, wherein HPLS is a hydrophilic polymer segment, HPBS is a hydrophobic polymer segment, and PLZA is a polymerizable group having an ethylenically unsaturated double bond, and polymerizing the block copolymer as a buffer for a capillary electrophoresis or a microchip electrophoresis, pressurizing the sample after introduction at a given pressure for a given time period, and electrophoresing in an electrophoretic electric field, a polymer compound such as DNA can be separated rapidly and in high separation ability.
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公开(公告)号：US06927033B2
公开(公告)日：2005-08-09
申请号：US10275904
申请日：2001-05-10
IPC分类号： C08G63/688 , G01N21/41 , G01N33/543 , G01N33/544 , G01N33/545 , G01N33/53
CPC分类号： G01N33/545 , C08G63/688 , G01N33/54353 , G01N33/544 , Y10S435/817
摘要： A polymer composition is provided, which contains a polymer or copolymer having a mercapto group at one end and functional group or ligand at the other end and also having a polyethylene glycol segment. Such a composition can form a biosensor surface of reduced non-specific adsorbability for proteins and the like.
摘要翻译： 提供一种聚合物组合物，其包含在一端具有巯基的聚合物或共聚物，另一端具有官能团或配体，并且还具有聚乙二醇部分。 这种组合物可以形成对蛋白质等降低的非特异性吸附性的生物传感器表面。
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