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    G protein coupled receptor protein and use thereof
    3.
    发明授权
    G protein coupled receptor protein and use thereof 有权
    G蛋白偶联受体蛋白及其用途

    公开(公告)号：US09034327B2

    公开(公告)日：2015-05-19

    申请号：US13322304

    申请日：2009-09-07

    Applicant: Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hee Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

    Inventor： Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hee Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

    IPC: G01N33/53 ,  C07K14/705 ,  G01N33/50

    CPC classification number: C07K14/705 ,  G01N33/5041

    Abstract: Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.

    Abstract translation: 公开了新型GPCR（G蛋白偶联受体）蛋白和编码其的基因。 还提供了蛋白质和基因的使用。 特别地，考虑了新型GPCR（G蛋白偶联受体）多肽，编码它的多核苷酸，携带多核苷酸或其片段的重组载体，用该载体转化的宿主细胞，用载体感染的转基因动物。 另外，含有能够测定GPCR多核苷酸的mRNA或蛋白质的表达量的试剂，癌症诊断用试剂盒，含有该组合物的检测癌标记物的组合物，以及检测GPCR多肽的方法和 提供编码多肽的基因。 此外，用于治疗和预防癌症的组合物包含抑制GPCR多肽或编码GPCR蛋白的抗体表达的寡核苷酸以及筛选GPCR蛋白或癌症治疗剂的调节剂的方法， 提供。

    Method for diagnosis/prognosis of cancers using an epigenetic marker consisting of a specific single CpG site in TTP promoter and treatment of cancers by regulating its epigenetic status
    5.
    发明授权
    Method for diagnosis/prognosis of cancers using an epigenetic marker consisting of a specific single CpG site in TTP promoter and treatment of cancers by regulating its epigenetic status 有权
    使用由TTP启动子中的特定单个CpG位点组成的表观遗传标记和通过调节其表观遗传学状态来治疗癌症的癌症的诊断/预后的方法

    公开(公告)号：US08703419B2

    公开(公告)日：2014-04-22

    申请号：US13514913

    申请日：2010-09-08

    Applicant: Young Il Yeom ,  Bo Hwa Sohn ,  In Young Park ,  Jung Ju Lee ,  Yejin Jang ,  Suk-jin Yang ,  Kyung Chan Park ,  Hyang-sook Yoo ,  Jong Young Choi

    Inventor： Young Il Yeom ,  Bo Hwa Sohn ,  In Young Park ,  Jung Ju Lee ,  Yejin Jang ,  Suk-jin Yang ,  Kyung Chan Park ,  Hyang-sook Yoo ,  Jong Young Choi

    IPC: C12N15/10

    CPC classification number: C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12Q1/6886 ,  C12Q2600/154

    Abstract: The present invention relates to a method for the diagnosis and prognosis of cancers using an epigenetic marker consisting of a specific single CpG site in TTP (Tristetraprolin) promoter and treatment of cancers by regulating its epigenetic status. Particularly, the present invention relates to a method for the diagnosis and prognosis of liver cancer by measuring specific methylation of C, the 32nd residue of the nucleic acid sequence represented by SEQ. ID. NO. 41, and a method for treatment of cancer by regulating the same. The present invention can be effectively used for the diagnosis and/or treatment of liver cancer characterized by TTP down-regulation and methylation of C, the 32nd residue of the nucleic acid sequence represented by SEQ. ID. NO. 41. The present invention can be further applied for the diagnosis and treatment of other cancers or inflammatory diseases that are characterized by TTP down-regulation and methylation of C, the 32nd residue of the nucleic acid sequence represented by SEQ. ID. NO. 41.

    Abstract translation: 本发明涉及使用由TTP（Tristetraprolin）启动子中的特定单个CpG位点组成的表观遗传标记和通过调节其表观遗传学状态来治疗癌症来诊断和预后的方法。 特别地，本发明涉及通过测定由SEQ ID NO：1表示的核酸序列的第32个残基的C的特异性甲基化来诊断和预测肝癌的方法。 ID。 没有。 41，以及通过调节癌症治疗癌症的方法。 本发明可有效地用于诊断和/或治疗特征为TTP下调和甲基化的肝癌，即SEQ SEQ ID NO：1所示的核酸序列的第32个残基。 ID。 没有。 41.本发明可以进一步应用于以TTP下调和甲基化为特征的其他癌症或炎性疾病的诊断和治疗，C是SEQ ID NO：1所示的核酸序列的第32个残基。 ID。 没有。 41。

    NOVEL G PROTEIN COUPLED RECEPTOR PROTEIN AND USE THEREOF
    6.
    发明申请
    NOVEL G PROTEIN COUPLED RECEPTOR PROTEIN AND USE THEREOF 有权
    新型G蛋白偶联受体蛋白及其用途

    公开(公告)号：US20120141488A1

    公开(公告)日：2012-06-07

    申请号：US13322304

    申请日：2009-09-07

    Applicant: Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hae Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

    Inventor： Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hae Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

    IPC: A61K39/395 ,  G01N33/53 ,  G01N33/566 ,  G01N27/447 ,  A61K31/7088 ,  A61P35/00 ,  A61P35/04 ,  C12Q1/68 ,  C12Q1/02

    CPC classification number: C07K14/705 ,  G01N33/5041

    Abstract: Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.

    Abstract translation: 公开了新型GPCR（G蛋白偶联受体）蛋白和编码其的基因。 还提供了蛋白质和基因的使用。 特别地，考虑了新型GPCR（G蛋白偶联受体）多肽，编码它的多核苷酸，携带多核苷酸或其片段的重组载体，用该载体转化的宿主细胞，用载体感染的转基因动物。 另外，含有能够测定GPCR多核苷酸的mRNA或蛋白质的表达量的试剂，癌症诊断用试剂盒，含有该组合物的检测癌标记物的组合物，以及检测GPCR多肽的方法和 提供编码多肽的基因。 此外，用于治疗和预防癌症的组合物包含抑制GPCR多肽或编码GPCR蛋白的抗体表达的寡核苷酸以及筛选GPCR蛋白或癌症治疗剂的调节剂的方法， 提供。

    Marker comprising anti-CK8/18 complex autoantibody and its use for diagnosing cancer
    7.
    发明授权
    Marker comprising anti-CK8/18 complex autoantibody and its use for diagnosing cancer 有权
    包括抗CK8 / 18复合自身抗体及其用于诊断癌症的标记物

    公开(公告)号：US09234893B2

    公开(公告)日：2016-01-12

    申请号：US14000221

    申请日：2012-02-20

    Applicant: Eun Wie Cho ,  Chang Gyu Heo ,  Jeong Heon Ko ,  Mi Kyung Woo ,  Hyang Sook Yoo ,  Hai Min Hwang

    Inventor： Eun Wie Cho ,  Chang Gyu Heo ,  Jeong Heon Ko ,  Mi Kyung Woo ,  Hyang Sook Yoo ,  Hai Min Hwang

    IPC: C07K16/18 ,  G01N33/574 ,  C07K7/06 ,  C07K16/30

    CPC classification number: G01N33/574 ,  C07K7/06 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/32 ,  C07K2317/34 ,  G01N33/57415 ,  G01N2333/4742

    Abstract: The present invention relates to a cytokeratin 8/18 complex-specific autoantibody or a fragment comprising an antigen-binding site (paratope) thereof, the use thereof in the diagnosis of breast cancer, a polypeptide having an amino acid sequence of an epitope specifically binding to the autoantibody, a composition for diagnosing breast cancer comprising an agent capable of measuring an expression level of the autoantibody or the fragment comprising an antigen-binding site thereof, a hybridoma cell line producing the autoantibody, and a kit for diagnosing breast cancer comprising the composition of the present invention. Further, the present invention relates to a method for diagnosing breast cancer, comprising the step of detecting the cytokeratin 8/18 complex-specific autoantibody or the fragment comprising the antigen-binding site thereof using the composition of the present invention, and a method for screening a therapeutic agent for breast cancer using the autoantibody.

    Abstract translation: 本发明涉及细胞角蛋白8/18复合物特异性自身抗体或包含其抗原结合位点（其相互作用）的片段，其在乳腺癌诊断中的应用，具有表位特异性结合的表位氨基酸序列的多肽 涉及自身抗体的用于诊断乳腺癌的组合物，其包含能够测量自身抗体表达水平的试剂或包含其抗原结合位点的片段，产生该自身抗体的杂交瘤细胞系和用于诊断乳腺癌的试剂盒， 本发明的组合物。 此外，本发明涉及一种诊断乳腺癌的方法，包括使用本发明的组合物检测细胞角蛋白8/18复合物特异性自身抗体或包含其抗原结合位点的片段的方法， 使用自身抗体筛选乳腺癌的治疗剂。

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