公开(公告)号：US07452856B2

公开(公告)日：2008-11-18

申请号：US11093875

申请日：2005-03-29

申请人： Isao Nagaoka ,  Daiju Okuda ,  Shin Yomogida ,  Hiroshi Tamura

发明人： Isao Nagaoka ,  Daiju Okuda ,  Shin Yomogida ,  Hiroshi Tamura

IPC分类号： A61K38/00 ,  C07K17/00

CPC分类号： C07K14/4723

摘要： The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient. The present invention also provides for a peptide comprised of a sequence of cationic and non-polar or polar uncharged amino acids forming an α-helix wherein the amino acids are arranged along the α-helix such that when represented as a helical wheel, there is a substantial bi-lateral symmetry between cationic versus non-polar or polar uncharged amino acids.

摘要翻译： 本发明提供了一种基于CAP11的新型肽，并且提供了抗细菌剂，LPS-细胞结合抑制剂和细菌感染处理剂或内毒素 - 休克抑制剂等药物，每种含有肽作为 活性成分。 肽具有以下氨基酸序列（SEQ ID NO：1）：X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03（其中X01表示阳离子性氨基酸残基或极性不带电荷的氨基酸残基 X02表示非极性氨基酸残基，X03表示阳离子性氨基酸残基，X04表示非极性氨基酸残基或阳离子性氨基酸残基，X05表示非极性氨基酸残基或极性不带电氨基 酸残基）。 各抗菌剂，脂多糖 - 细胞结合抑制剂和药物（例如细菌感染处理剂或内毒素 - 休克抑制剂）均含有作为有效成分的肽。 本发明还提供了由阳离子和非极性或极性不带电荷的氨基酸序列组成的肽，其形成α-螺旋，其中氨基酸沿着α-螺旋排列，使得当以螺旋轮表示时，存在 阳离子与非极性或极性不带电氨基酸之间的实质双侧对称性。

公开(公告)号：US4542578A

公开(公告)日：1985-09-24

申请号：US589886

申请日：1984-03-15

申请人： Masaru Yamano ,  Isao Nagaoka ,  Yukinori Kuwano ,  Hiroshi Kawada ,  Souichi Sakai

发明人： Masaru Yamano ,  Isao Nagaoka ,  Yukinori Kuwano ,  Hiroshi Kawada ,  Souichi Sakai

IPC分类号： H01L31/042 ,  H01L27/142 ,  H01L31/0392 ,  H01L31/04 ,  H01L31/18

CPC分类号： H01L31/03921 ,  H01L31/046 ,  H01L31/0463 ,  Y02E10/50

摘要： Mutually spaced apart TCO film portions are formed on a glass substrate. An amorphous silicon film of PIN junction type is formed to cover these TCO film portions, and an aluminum film is formed thereon. The aluminum film in the vicinity of the gap between adjacent TCO film portions is removed by means of a laser beam, and the amorphous silicon film is removed by reactive plasma etching using the aluminum film as a mask to thereby expose portions of the TCO film. An aluminum-titanium film is formed over the aluminum film and the exposed portions of the TCO film. The aluminum-titanium film is separated by means of a laser beam to form a plurality of photoelectric converting regions. The photoelectric converting regions thus formed on the glass substrate are connected in series.

摘要翻译： 相互间隔开的TCO膜部分形成在玻璃基板上。 形成PIN结型非晶硅膜以覆盖这些TCO膜部分，并在其上形成铝膜。 通过激光束去除相邻的TCO膜部分之间的间隙附近的铝膜，通过使用铝膜作为掩模的反应等离子体蚀刻来去除非晶硅膜，从而暴露部分TCO膜。 在铝膜上和TCO膜的暴露部分上形成铝钛膜。 铝 - 钛膜通过激光束分离以形成多个光电转换区域。 由此形成在玻璃基板上的光电转换区域串联连接。

公开(公告)号：US20090149632A1

公开(公告)日：2009-06-11

申请号：US12148094

申请日：2008-04-16

申请人： Isao Nagaoka ,  Daiju Okuda ,  Shin Yomogida ,  Hiroshi Tamura

发明人： Isao Nagaoka ,  Daiju Okuda ,  Shin Yomogida ,  Hiroshi Tamura

IPC分类号： C07K7/00 ,  C07K1/00

CPC分类号： C07K14/4723

摘要： The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient. The present invention also provides for a peptide comprised of a sequence of cationic and non-polar or polar uncharged amino acids forming an α-helix wherein the amino acids are arranged along the α-helix such that when represented as a helical wheel, there is a substantial bi-lateral symmetry between cationic versus non-polar or polar uncharged amino acids.

摘要翻译： 本发明提供了一种基于CAP11的新型肽，并且提供了抗细菌剂，LPS-细胞结合抑制剂和细菌感染处理剂或内毒素 - 休克抑制剂等药物，每种含有肽作为 活性成分。 肽具有以下氨基酸序列（SEQ ID NO：1）：X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03（其中X01表示阳离子性氨基酸残基或极性不带电荷的氨基酸残基 X02表示非极性氨基酸残基，X03表示阳离子性氨基酸残基，X04表示非极性氨基酸残基或阳离子性氨基酸残基，X05表示非极性氨基酸残基或极性不带电氨基 酸残基）。 各抗菌剂，脂多糖 - 细胞结合抑制剂和药物（例如细菌感染处理剂或内毒素 - 休克抑制剂）均含有作为有效成分的肽。 本发明还提供了由阳离子和非极性或极性不带电荷的氨基酸序列组成的肽，其形成α-螺旋，其中氨基酸沿着α-螺旋排列，使得当以螺旋轮表示时，存在 阳离子与非极性或极性不带电氨基酸之间的实质双侧对称性。

公开(公告)号：US3931136A

公开(公告)日：1976-01-06

申请号：US472632

申请日：1974-05-23

申请人： Kan Mori ,  Hiroharu Ikeda ,  Isao Nagaoka ,  Tooru Shibata ,  Sigeo Kawatani ,  Tatsuhiko Kikuchi

发明人： Kan Mori ,  Hiroharu Ikeda ,  Isao Nagaoka ,  Tooru Shibata ,  Sigeo Kawatani ,  Tatsuhiko Kikuchi

IPC分类号： C08F136/08 ,  C08D1/14 ,  C08D3/12

CPC分类号： C08F136/08

摘要： High molecular weight cis-1,4-polyisoprene is produced by contacting isoprene with a catalyst formed by admixing (A) a titanium tetrachloride, (B) a trihydrocarbylaluminum and (C) a beta-diketone. The activity of this ternary catalyst is not adversely affected by such impurities as cyclopentadiene that are contained in the feed stock isoprene.

摘要翻译： 通过使异戊二烯与（A）四氯化钛，（B）三烃基铝和（C）β-二酮混合形成的催化剂接触来制备高分子量顺式-1,4-聚异戊二烯。 这种三元催化剂的活性不受包含在原料异戊二烯中的杂环如环戊二烯的不利影响。

公开(公告)号：US08242082B2

公开(公告)日：2012-08-14

申请号：US12148094

申请日：2008-04-16

申请人： Isao Nagaoka ,  Daiju Okuda ,  Shin Yomogida ,  Hiroshi Tamura

发明人： Isao Nagaoka ,  Daiju Okuda ,  Shin Yomogida ,  Hiroshi Tamura

IPC分类号： A61K38/10

CPC分类号： C07K14/4723

摘要： The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient. The present invention also provides for a peptide comprised of a sequence of cationic and non-polar or polar uncharged amino acids forming an α-helix wherein the amino acids are arranged along the α-helix such that when represented as a helical wheel, there is a substantial bi-lateral symmetry between cationic versus non-polar or polar uncharged amino acids.

摘要翻译： 本发明提供了一种基于CAP11的新型肽，并且提供了抗细菌剂，LPS-细胞结合抑制剂和细菌感染处理剂或内毒素 - 休克抑制剂等药物，每种含有肽作为 活性成分。 肽具有以下氨基酸序列（SEQ ID NO：1）：X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03（其中X01表示阳离子性氨基酸残基或极性不带电荷的氨基酸残基 X02表示非极性氨基酸残基，X03表示阳离子性氨基酸残基，X04表示非极性氨基酸残基或阳离子性氨基酸残基，X05表示非极性氨基酸残基或极性不带电氨基 酸残基）。 各抗菌剂，脂多糖 - 细胞结合抑制剂和药物（例如细菌感染处理剂或内毒素 - 休克抑制剂）均含有作为有效成分的肽。 本发明还提供了由阳离子和非极性或极性不带电荷的氨基酸序列组成的肽，其形成α-螺旋，其中氨基酸沿α螺旋排列，使得当以螺旋轮表示时，存在 阳离子与非极性或极性不带电氨基酸之间的实质双侧对称性。

公开(公告)号：US20060009374A1

公开(公告)日：2006-01-12

申请号：US11093875

申请日：2005-03-29

申请人： Isao Nagaoka ,  Daiju Okuda ,  Shin Yomogida ,  Hiroshi Tamura

发明人： Isao Nagaoka ,  Daiju Okuda ,  Shin Yomogida ,  Hiroshi Tamura

IPC分类号： A61K38/16 ,  C07K14/195

CPC分类号： C07K14/4723

摘要： The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient. The present invention also provides for a peptide comprised of a sequence of cationic and non-polar or polar uncharged amino acids forming an α-helix wherein the amino acids are arranged along the α-helix such that when represented as a helical wheel, there is a substantial bi-lateral symmetry between cationic versus non-polar or polar uncharged amino acids.

公开(公告)号：US06627621B2

公开(公告)日：2003-09-30

申请号：US09906771

申请日：2001-07-18

申请人： Isao Nagaoka ,  Koji Sakamoto

发明人： Isao Nagaoka ,  Koji Sakamoto

IPC分类号： A61K3170

CPC分类号： A61K31/7008 ,  A23L2/52 ,  A23L33/17

摘要： Glucosamine salts are effective for the inhibition of neutrophil functions, and hence, are useful for the prevention and/or treatment of diseases, caused as a result of an excessive extracellular release of active oxygen and antibiotic proteins by neutrophils, such as respiratory disease syndrome and adult respiratory disease syndrome. Use of glucosamine salts can, therefore, provide neutrophil function inhibitors, preventives and/or remedies for diseases caused as a result of an excessive extracellular release of active oxygen and antibiotic proteins by neutrophils, and also methods for the prevention and/or treatment of such diseases.

公开(公告)号：US4023973A

公开(公告)日：1977-05-17

申请号：US569145

申请日：1975-04-17

申请人： Fumitake Imaizumi ,  Isao Nagaoka ,  Mitsuo Kurokawa ,  Koei Komatsu ,  Yasuyuki Takimoto ,  Hidefumi Kusuda

发明人： Fumitake Imaizumi ,  Isao Nagaoka ,  Mitsuo Kurokawa ,  Koei Komatsu ,  Yasuyuki Takimoto ,  Hidefumi Kusuda

IPC分类号： G03F7/038 ,  G03C1/70 ,  G03C1/68

CPC分类号： G03F7/0388 ,  G03F7/038 ,  Y10S430/111 ,  Y10S430/118 ,  Y10S430/124 ,  Y10S430/128

摘要： A photosensitive composition comprising (1) a maleic anhydride adduct of 1,2-polybutadiene having a molecular weight of 10,000 or higher, (2) at least one photosensitizer and/or at least one photosensitive crosslinking agent, and, if necessary, (3) at least one acrylic monomer. This composition can be developed with water or a polar solvent such as an alcohol, and its layer formed on a support provides a printing plate. When the acrylic monomer is contained, the composition is suitable for use in flexographic printing.

摘要翻译： 一种光敏组合物，其包含（1）分子量为10,000以上的1,2-聚丁二烯的马来酸酐加合物，（2）至少一种光敏剂和/或至少一种光敏交联剂，以及如果需要，（3 ）至少一种丙烯酸类单体。 该组合物可以用水或极性溶剂如醇显影，并且其形成在载体上的层提供印刷版。 当含有丙烯酸单体时，该组合物适用于柔性版印刷。

公开(公告)号：US4049170A

公开(公告)日：1977-09-20

申请号：US679613

申请日：1976-04-23

申请人： Hiroshi Kawakami ,  Isao Nagaoka ,  Yukio Tsukagawa

发明人： Hiroshi Kawakami ,  Isao Nagaoka ,  Yukio Tsukagawa

IPC分类号： E02B15/04 ,  E02B15/10 ,  B65H17/34

CPC分类号： E02B15/08

摘要： A device for pulling up and paying out an oil boom comprises a structural frame, a pair of end pulleys horizontally journaled on the frame, an endless belt engaged with the end pulleys and having a plurality of engaging projections for oil boom and a pusher member for slightly urging the oil boom against the endless belt, the pusher member being resiliently supported by a supporting member with a proper distance held between the bottom portion of the pusher member and the upper surface of the endless belt.

摘要翻译： 用于拉出并支付油斗的装置包括结构框架，在框架上水平地轴颈的一对端滑轮，与端滑轮接合的环形带，并且具有用于油斗的多个接合突起和用于 稍微推动油臂抵靠环形带，推动器构件被支撑构件弹性地支撑，并且在推动构件的底部与环形带的上表面之间保持适当的距离。

公开(公告)号：US4082817A

公开(公告)日：1978-04-04

申请号：US671147

申请日：1976-03-29

申请人： Fumitake Imaizumi ,  Isao Nagaoka ,  Mitsuo Kurokawa ,  Koei Komatsu

发明人： Fumitake Imaizumi ,  Isao Nagaoka ,  Mitsuo Kurokawa ,  Koei Komatsu

IPC分类号： C08C19/28 ,  C08F8/46

CPC分类号： C08C19/28 ,  Y10S525/914

摘要： A process for producing a maleic anhydride adduct of high molecular weight 1,2-polybutadiene by contacting with heat maleic anhydride with high molecular weight 1,2-polybutadiene in the absence of a radical initiator in a halogenated aromatic hydrocarbon solvent. The adduct obtained by this process has a high molecular weight of more than 10,000 and is quite free from gel. Said process enables the addition of maleic anhydride in any desired proportion.