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6 条记录 (耗时 0.012 秒)

    THERMOCYCLING DEVICE
    1.
    发明申请
    THERMOCYCLING DEVICE 有权
    热电偶装置

    公开(公告)号：US20110165628A1

    公开(公告)日：2011-07-07

    申请号：US13063961

    申请日：2008-09-23

    申请人： Boudewijn Theodorus Verhaar ,  Jacobus Frederik Molenaar ,  Martijn Cornelis Franciscus Vervoorn

    发明人： Boudewijn Theodorus Verhaar ,  Jacobus Frederik Molenaar ,  Martijn Cornelis Franciscus Vervoorn

    IPC分类号： C12P19/34 ,  C12M1/00

    CPC分类号： B01L7/52 ,  B01L3/50851 ,  B01L2300/18 ,  B01L2300/1838

    摘要： The present invention is related to a thermocycling device (10), comprising at least one sample holder (11), at least one thermal reference (12) and at least one heating and/or cooling device (13), which is arranged between said sample holder(s) and said thermal reference. Said heating and/or cooling device is in thermally conductive contact with said sample holder(s) and with the thermal reference. Furthermore, the device comprises at least one reference heating and/or cooling device (14) for maintaining the temperature of the thermal reference at a predetermined temperature level during cycling and a heat sink (15) which is in thermally conductive contact with said reference heating and/or cooling device (14).

    摘要翻译： 本发明涉及一种热循环装置（10），其包括至少一个样品保持器（11），至少一个热参考（12）和至少一个加热和/或冷却装置（13），其布置在所述 样品架和所述热参考。 所述加热和/或冷却装置与所述样品保持器和热参考物导热接触。 此外，该装置包括至少一个参考加热和/或冷却装置（14），用于在热循环期间将热参考基准的温度保持在预定的温度水平，以及与所述参考加热器导热接触的散热器（15） 和/或冷却装置（14）。

    FLUID ANALYSIS DEVICE AND METHOD
    2.
    发明申请
    FLUID ANALYSIS DEVICE AND METHOD 审中-公开
    流体分析装置和方法

    公开(公告)号：US20100136525A1

    公开(公告)日：2010-06-03

    申请号：US11993508

    申请日：2006-06-23

    申请人： Jacobus Frederik Molenaar ,  Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart

    发明人： Jacobus Frederik Molenaar ,  Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  C12Q1/02

    CPC分类号： B01L3/50857 ,  B01L3/5023 ,  B01L2400/0475

    摘要： The invention provides an analysis device (1) and method, that enables repeatedly pumping a sample fluid (50) with one or more analytes through a substrate (10) with one or more binding materials, even when the wetted substrate has a relatively low bubble pressure. Thereto, the device (1) comprises a first volume (16) and a second volume (18), and a return channel (22) with a valve (24) as well as a pump (20). The pump (20) can establish a pressure difference between the first volume (16) and the second volume (18), to pump the sample fluid (50) through the substrate (10), thereby allowing analyte to bind to the substrate. By opening the valve (24) and establishing a reversed pressure difference, sample fluid (50) bypasses the substrate (10) through the return channel (22). After closing the valve, the device is ready for a subsequent cycle, if desired. The device and method allow the analysis of in principle any amount of sample fluid, and the use of any type of substrate with respect to bubble pressure, and is thus more versatile and robust.

    摘要翻译： 本发明提供了一种分析装置（1）和方法，其使得能够通过具有一种或多种粘合材料的基底（10）将一种或多种分析物反复泵送样品流体（50），即使当润湿的基底具有相对较低的气泡 压力。 此外，装置（1）包括第一容积（16）和第二容积（18），以及具有阀（24）的回流通道（22）以及泵（20）。 泵（20）可以在第一容积（16）和第二容积（18）之间建立压力差，以将样品流体（50）泵送通过衬底（10），从而允许分析物结合衬底。 通过打开阀（24）并建立反向的压力差，样品流体（50）通过返回通道（22）绕过衬底（10）。 关闭阀门后，如果需要，设备可以进行后续循环。 该装置和方法允许原则上分析任何量的样品流体，以及使用相对于气泡压力的任何类型的底物，因此更具通用性和鲁棒性。

    Thermocycling device
    3.
    发明授权
    Thermocycling device 有权
    热循环装置

    公开(公告)号：US08900853B2

    公开(公告)日：2014-12-02

    申请号：US13063961

    申请日：2008-09-23

    申请人： Boudewijn Theodorus Verhaar ,  Jacobus Frederik Molenaar ,  Martijn Cornelis Franciscus Vervoorn

    发明人： Boudewijn Theodorus Verhaar ,  Jacobus Frederik Molenaar ,  Martijn Cornelis Franciscus Vervoorn

    IPC分类号： B01L7/00 ,  B01L3/00

    CPC分类号： B01L7/52 ,  B01L3/50851 ,  B01L2300/18 ,  B01L2300/1838

    摘要： A thermocycling device includes a sample holder, a thermal reference and a heating and cooling device which is arranged between the sample holder and thermal reference. The heating and cooling device is in thermally conductive contact with the sample holder and with the thermal reference. The thermocycling device further includes a reference heating and cooling device for maintaining the temperature of the thermal reference at a predetermined temperature level during cycling, and a heat sink which is in thermally conductive contact with the reference heating and/or cooling device.

    摘要翻译： 热循环装置包括样品保持器，热参考和布置在样品保持器和热参考之间的加热和冷却装置。 加热和冷却装置与样品保持器和热参考件导热接触。 热循环装置还包括参考加热和冷却装置，用于在循环期间将热参考的温度保持在预定的温度水平，以及与参考加热和/或冷却装置导热接触的散热器。

    LITHOGRAPHIC APPARATUS AND DEVICE MANUFACTURING METHOD
    6.
    发明申请
    LITHOGRAPHIC APPARATUS AND DEVICE MANUFACTURING METHOD 审中-公开
    LITHOGRAPHIC装置和装置制造方法

    公开(公告)号：US20090268190A1

    公开(公告)日：2009-10-29

    申请号：US12428110

    申请日：2009-04-22

    申请人： Jacobus Frederik Molenaar ,  Michael Johannes Vervoordeldonk ,  Funda Sahin Nomaler

    发明人： Jacobus Frederik Molenaar ,  Michael Johannes Vervoordeldonk ,  Funda Sahin Nomaler

    IPC分类号： G03B27/58 ,  G03F7/20

    CPC分类号： G03B27/58 ,  G03F7/70816

    摘要： A lithographic apparatus includes a bearing configured to support a first part with respect to a second part of the apparatus in a first direction such that the first part is moveable in a second direction relative to the second part. The bearing passively supports the first part in three degrees of freedom. The first part is coupled to at least one permanent magnet, and the second part is coupled to at least two permanent magnets. The permanent magnet of the first part is positioned substantially between the permanent magnets of the second part. A field orientation of the permanent magnets is substantially parallel to the first direction and the permanent magnet of the first part has a substantially opposite polarity to at least one of the magnets of the second part.

    摘要翻译： 光刻设备包括轴承，该轴承构造成在第一方向上相对于设备的第二部分支撑第一部分，使得第一部件可相对于第二部件在第二方向上移动。 轴承以三自由度被动地支撑第一部分。 第一部分耦合到至少一个永磁体，而第二部分耦合到至少两个永磁体。 第一部分的永磁体基本位于第二部分的永磁体之间。 永磁体的场方位基本上平行于第一方向，并且第一部分的永磁体具有与第二部分的至少一个磁体基本上相反的极性。