公开(公告)号：US20180345351A1

公开(公告)日：2018-12-06

申请号：US15835723

申请日：2017-12-08

申请人： Dale Natoli ,  James Boyer

发明人： Dale Natoli ,  James Boyer

IPC分类号： B21D37/04 ,  B21D28/34 ,  B26D7/26 ,  B26F1/14

摘要： A punch assembly having a head with an approximately flat top, an engagement projection and a groove; and a cylindrical punch having a tip end and a head engaging end, wherein the head engaging end has mounted thereon opposing pivoting arms having projections; the arms held by pivot pins and a compression spring mounted between the arms in a closed position; wherein the engagement projection of the head is pressed between the arms and snaps into place; and the projections are securely engaged in the groove.

公开(公告)号：US09073926B2

公开(公告)日：2015-07-07

申请号：US13513973

申请日：2010-12-01

申请人： Stephen James Boyer ,  Jennifer Burke ,  Xin Guo ,  Thomas Martin Kirrane, Jr. ,  Roger John Snow ,  Yunlong Zhang

发明人： Stephen James Boyer ,  Jennifer Burke ,  Xin Guo ,  Thomas Martin Kirrane, Jr. ,  Roger John Snow ,  Yunlong Zhang

IPC分类号： A61K31/55 ,  C07D487/04 ,  C07D471/04 ,  C07D471/14

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D471/14

摘要： The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 本发明涉及式（I）的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

公开(公告)号：US08938636B1

公开(公告)日：2015-01-20

申请号：US13475143

申请日：2012-05-18

申请人： Peter Hochschild ,  Alexander Lloyd ,  Wilson Cheng-Yi Hsieh ,  Robert Edman Felderman ,  Michael James Boyer Epstein

发明人： Peter Hochschild ,  Alexander Lloyd ,  Wilson Cheng-Yi Hsieh ,  Robert Edman Felderman ,  Michael James Boyer Epstein

IPC分类号： G06F1/12 ,  H04L7/00 ,  G06F15/16 ,  G06F11/00 ,  G01S19/01

CPC分类号： G06F1/12 ,  G01S19/01 ,  G06F11/1675 ,  H04J3/0661 ,  H04J3/0667 ,  H04L7/0008 ,  H04L7/0012 ,  H04L7/0016 ,  H04L43/106 ,  H04L67/10

摘要： The present technology proposes techniques for generating globally coherent timestamps. This technology may allow distributed systems to causally order transactions without incurring various types of communication delays inherent in explicit synchronization. By globally deploying a number of time masters that are based on various types of time references, the time masters may serve as primary time references. Through an interactive interface, the techniques may track, calculate and record data relative to each time master thus providing the distributed systems with causal timestamps.

摘要翻译： 本技术提出了用于产生全局一致的时间戳的技术。 该技术可以允许分布式系统导致事务的顺序排序，而不会导致显式同步中固有的各种类型的通信延迟。 通过全球部署多个基于各种时间参考的时间主机，时间主机可以作为主要的时间参考。 通过交互式界面，这些技术可以跟踪，计算和记录相对于每个时间主机的数据，从而为分布式系统提供因果时间戳。

公开(公告)号：US08676375B2

公开(公告)日：2014-03-18

申请号：US13406076

申请日：2012-02-27

申请人： Joseph Arthur Kraus ,  Jeremy James Boyer ,  Joseph Mack ,  Michael DeChellis ,  Michael Koo

发明人： Joseph Arthur Kraus ,  Jeremy James Boyer ,  Joseph Mack ,  Michael DeChellis ,  Michael Koo

IPC分类号： G06F7/00 ,  B65H1/00 ,  G05B1/00

CPC分类号： H01L21/681 ,  H01L21/67259 ,  H01L21/67276 ,  H01L21/6838

摘要： An automated cassette-to-cassette substrate handling system includes a cassette storage module for storing a plurality of substrates in cassettes before and after processing. A substrate carrier storage module stores a plurality of substrate carriers. A substrate carrier loading/unloading module loads substrates from the cassette storage module onto the plurality of substrate carriers and unloads substrates from the plurality of substrate carriers to the cassette storage module. A transport mechanism transports the plurality of substrates between the cassette storage module and the plurality of substrate carriers and transports the plurality of substrate carriers between the substrate carrier loading/unloading module and a processing chamber. A vision system recognizes recesses in the plurality of substrate carriers corresponding to empty substrate positions in the substrate carrier. A processor receives data from the vision system and instructs the transport mechanism to transport substrates to positions on the substrate carrier in response to the received data.

摘要翻译： 一种自动盒式磁带盒式基板处理系统，包括：盒式存储模块，用于在处理之前和之后将多个基板存储在盒中。 衬底载体存储模块存储多个衬底载体。 衬底载体装载/卸载模块将衬底从盒存储模块加载到多个衬底载体上，并将衬底从多个衬底载体卸载到盒存储模块。 传送机构将多个基板传送到盒存储模块和多个基板载体之间，并将多个基板载体传送到基板载体装载/卸载模块和处理室之间。 视觉系统识别对应于衬底载体中的空衬底位置的多个衬底载体中的凹部。 处理器从视觉系统接收数据并且指示传送机构响应于所接收的数据将衬底传送到衬底载体上的位置。

公开(公告)号：US20130137680A1

公开(公告)日：2013-05-30

申请号：US13513973

申请日：2010-12-01

申请人： Stephen James Boyer ,  Jennifer Burke ,  Xin Guo ,  Thomas Martin Kirrane, JR. ,  Roger John Snow ,  Yunlong Zhang

发明人： Stephen James Boyer ,  Jennifer Burke ,  Xin Guo ,  Thomas Martin Kirrane, JR. ,  Roger John Snow ,  Yunlong Zhang

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D471/14

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D471/14

摘要： The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 本发明涉及式（I）的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

公开(公告)号：US20130109679A1

公开(公告)日：2013-05-02

申请号：US13513954

申请日：2010-11-30

申请人： Stephen James Boyer ,  Donghong Amy Gao ,  Xin Guo ,  Thomas Martin Kirrane, JR. ,  Christopher Ronald Sarko ,  Roger John Snow ,  Fariba Soleymanzadeh ,  Yunlong Zhang

发明人： Stephen James Boyer ,  Donghong Amy Gao ,  Xin Guo ,  Thomas Martin Kirrane, JR. ,  Christopher Ronald Sarko ,  Roger John Snow ,  Fariba Soleymanzadeh ,  Yunlong Zhang

IPC分类号： C07D487/04 ,  C07D487/20 ,  C07D491/20

CPC分类号： C07D487/04 ,  C07D487/20 ,  C07D491/20

摘要： Disclosed are novel compounds which inhibit RSK, methods of making such compounds and pharmaceutical compositions comprising such compounds. Also disclosed are methods of treating RSK2 regulated disorders using compounds of the invention.

摘要翻译： 公开了抑制RSK的新化合物，制备这些化合物的方法和包含这些化合物的药物组合物。 还公开了使用本发明化合物治疗RSK2调节性疾病的方法。

公开(公告)号：US06903101B1

公开(公告)日：2005-06-07

申请号：US09636519

申请日：2000-08-10

申请人： Jacques P. Dumas ,  Stephen James Boyer ,  Teddy Kite Joe ,  Holia N. Hatoum-Mokdad ,  Harold C. E. Kluender ,  Wendy Lee ,  Dhanapalan Nagarathnam ,  Robert N. Sibley ,  Ning Su

发明人： Jacques P. Dumas ,  Stephen James Boyer ,  Teddy Kite Joe ,  Holia N. Hatoum-Mokdad ,  Harold C. E. Kluender ,  Wendy Lee ,  Dhanapalan Nagarathnam ,  Robert N. Sibley ,  Ning Su

IPC分类号： C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D401/08 ,  A61K31/502 ,  A61P35/00

CPC分类号： C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

摘要： Substituted and Fused pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.

摘要翻译： 具有血管发生抑制活性的取代和稠合的哒嗪和广义结构式，其中含有A，B，D，E和L的环是含氮杂环; 基团X和Y可以是各种定义的连接单元中的任何一种; R 1和R 2可以是独立的取代基或一起可以是环定义的桥; 环J可以是芳基，吡啶基或环烷基; 和G基团可以是各种定义的取代基中的任何一种。 还公开了含有这些材料的药物组合物，以及使用这些材料治疗具有异常血管生成或超敏性过程特征的病症的哺乳动物的方法。

公开(公告)号：US20050056087A1

公开(公告)日：2005-03-17

申请号：US10957500

申请日：2004-10-01

申请人： Ronald Kiess ,  Robert Noel ,  James Wright ,  James Boyer ,  Matthew Bell

发明人： Ronald Kiess ,  Robert Noel ,  James Wright ,  James Boyer ,  Matthew Bell

IPC分类号： G01L23/18 ,  G01L23/22 ,  G01L3/26

CPC分类号： G01L23/22 ,  G01L23/18

摘要： An ignition coil, spark plug, and pressure sensor for an internal combustion engine are, in a preferred embodiment, integrated into a single assembly and mounted directly on a plug hole of an internal combustion engine. A hard spark plug shell serves as a pressure member and on which a strain gage is affixed. Changes in the pressure in the combustion chamber deform the shell, causing a corresponding change in the resistance of the strain gage. A bridge circuit or the like is used to measure the resistance change thereby providing a direct indication of cylinder pressure.

摘要翻译： 在优选实施例中，用于内燃机的点火线圈，火花塞和压力传感器被集成到单个组件中并直接安装在内燃机的插头孔上。 硬火花塞壳用作压力构件，并在其上固定应变计。 燃烧室中的压力变化使壳体变形，导致应变计的电阻相应变化。 桥接电路等用于测量电阻变化，从而提供气缸压力的直接指示。

公开(公告)号：US06689883B1

公开(公告)日：2004-02-10

申请号：US09672294

申请日：2000-09-28

申请人： Jacques P. Dumas ,  Stephen James Boyer ,  Julie A. Dixon ,  Teddy Kite Joe ,  Harold C. E. Kluender ,  Wendy Lee ,  Dhanapalan Nagarathnam ,  Robert N. Sibley ,  Ning Su

发明人： Jacques P. Dumas ,  Stephen James Boyer ,  Julie A. Dixon ,  Teddy Kite Joe ,  Harold C. E. Kluender ,  Wendy Lee ,  Dhanapalan Nagarathnam ,  Robert N. Sibley ,  Ning Su

IPC分类号： C07D23714

CPC分类号： C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： Substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.

摘要翻译： 含有A，B，D，E和L的环的具有血管生成抑制活性的取代的哒嗪和广泛结构的哒嗪是苯基或含氮杂环; 基团X和Y可以是各种定义的连接单元中的任何一种; R 1和R 2可以被定义为独立的取代基或一起可以是环定义的桥; 环J可以是芳基，吡啶基或环烷基; 和G基团可以是各种定义的取代基中的任何一种。 还公开了含有这些材料的药物组合物，以及使用这些材料治疗具有异常血管生成或超敏性过程特征的病症的哺乳动物的方法。

公开(公告)号：US08945383B2

公开(公告)日：2015-02-03

申请号：US13422657

申请日：2012-03-16

申请人： Michael J. Sherman ,  Lori Foix ,  Steven J. Haehn ,  Erik Robert Klimpel ,  David William Fisher ,  David T. Bardwell ,  Steven Karl Wilson ,  James Boyer Larson ,  Stephen P. Huda ,  Frank A. Brigano

发明人： Michael J. Sherman ,  Lori Foix ,  Steven J. Haehn ,  Erik Robert Klimpel ,  David William Fisher ,  David T. Bardwell ,  Steven Karl Wilson ,  James Boyer Larson ,  Stephen P. Huda ,  Frank A. Brigano

IPC分类号： B01D35/30

CPC分类号： B01D35/147 ,  B01D35/30 ,  B01D2201/302 ,  B01D2201/307 ,  B01D2201/308 ,  C02F1/003 ,  C02F2201/006 ,  F16K17/36

摘要： The present invention presents a filtration system with an integrated manifold valve. The filtration system employs only one pivotal component—the pivoting of the manifold. The manifold valve includes a dual aperture design for a two-fold alignment scheme with the ingress and egress lines of the fluid source. The invention is free of multi-component rotary valve with internal, rotatable parts, or an activation component, such as a handle, for initiating the rotary valve, allowing the user to rotate the rotational components thereof. The reduction in moveable components in this design reduces the likelihood of failure and increases the reliability of the filtration system.