摘要:
A case assembly of a media binder includes a front surface board and a back surface board. Each surface board includes an inwardly facing surface and an outwardly facing surface and a cover sheet, and each cover sheet is wrapped around the outwardly facing surface of one of the surface boards. A marginal edge is attached to the inwardly facing surface of the surface board, and another marginal edge is unattached to the inwardly facing surface of the surface board. An end of the unattached marginal edge includes an extra edge extended from the unattached marginal edge, and the extra edge is folded against the unattached marginal edge. The unattached marginal edge is attached to the inwardly facing surface of an adjacent surface board to form a corner wrap around a corner of the adjacent surface board.
摘要:
A composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.
摘要:
An intranasnal spray device contains a composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.
摘要:
An analgesic and a delivery agent are combined in a pharmaceutical composition such that, on introduction into the nasal cavity of a patient to be treated, the analgesic may be delivered to the bloodstream to produce within 30 minutes a therapeutic plasma concentration, Cther, of 0.2 ng/ml or greater which is maintained for a duration Tmaint of at least 2 hours. The analgesic may be an opioid analgesic or a non-steroidal anti-inflammatory drug.
摘要翻译:将镇痛剂和递送剂组合在药物组合物中,使得在引入待治疗的患者的鼻腔中时,止痛剂可以在30分钟内递送到血流中,治疗血浆浓度Cther为0.2 ng / ml或更高,其保持持续至少2小时的Tmaint。 止痛剂可以是阿片样镇痛药或非甾体抗炎药。
摘要:
A powder composition for intranasal delivery includes a benzodiazepine drug and chitosan, a salt of chitosan, a derivative of chitosan or a salt of a derivative of chitosan.
摘要:
There is provided a powder formulation for nasal delivery including a protein having a molecular weight of 10 kDa or greater and chitosan or a derivative thereof or a salt of chitosan or a salt of a derivative of chitosan. Preferably the protein is human growth hormone.
摘要:
A cutting platform for use with an agricultural harvesting machine includes at least one platform section having a frame, a plurality of float arms movably coupled with the frame, an endless belt carried by the plurality of float arms, a cutterbar assembly carried by the plurality of float arms, and a plurality of crop ramps extending from the cutterbar assembly. The plurality of crop ramps are movable relative to each other and overly a leading edge of the endless belt. The endless belt and the cutterbar assembly are movable in a localized manner across the cutting platform in upwards and downwards directions.
摘要:
A method of producing a metal element of an electronic device on a substrate, including the steps of: forming a mixture of a material comprising metal atoms with a liquid, depositing the material from the liquid mixture onto a substrate, and then irradiating at least part of the deposited material with light to increase the electrical conductivity of the deposited material. A method of producing one or more elements of an electronic device, including the steps of: providing a substrate including one or more underlying elements of the electronic device and a thermally patternable layer overlying said one or more underlying elements; and using said one or more underlying elements to locally generate heat and thereby selectively induce a change in corresponding portions of said thermally patternable layer; and wherein either the change selectively induced in said corresponding portions directly results in the definition of one or more elements of the electronic device in a position determined by that of said one or more underlying elements, or alternatively including the additional step of using the change selectively induced in said one or more corresponding portions to facilitate the formation of one or more elements of the electronic device in a position determined by that of said one or more underlying elements. A method of producing an element of an electronic device, including the steps of: (a) providing a substrate; (b) depositing on said substrate a layer of a switchable material, which changes its physical or chemical properties upon irradiation with light or heating causing a change of its surface energy properties; (c) irradiatively inducing at selected regions of a layer of switchable material a change in physical or chemical properties that alters the surface energy of said selected regions and thereby forming a surface energy pattern on its surface; and (d) without removing said layer of switchable material in either irradiated selected regions or non-irradiated regions from the substrate depositing over the surface energy pattern produced in step (c) a material for forming an element of the electronic device such that the surface energy pattern controls the deposition of said material.
摘要:
A mechanism for attaching a harvesting assembly to a combine having a multicoupler which connects hydraulic lines on the combine with hydraulic lines on the harvesting assembly as two halves of the multicoupler are brought together, and a latching mechanism which mechanically couples the harvesting assembly to the combine, the latching mechanism being operatively connected with the multicoupler to shift between latched and unlatched modes as the multicoupler is shifted between connected and unconnected modes.
摘要:
There is provided a composition for the nasal delivery of a cannabinoid which comprises a cannabinoid in a biphasic delivery system or a cannabinoid in a microsphere delivery system.