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公开(公告)号：US06383513B1
公开(公告)日：2002-05-07
申请号：US09595086
申请日：2000-06-16
IPC分类号： A61K9113
CPC分类号： A61K31/352 , A61K9/0043 , A61K9/1075 , A61K9/1652 , A61K9/1658 , A61K9/19 , A61K31/35
摘要： There is provided a composition for the nasal delivery of a cannabinoid which comprises a cannabinoid in a biphasic delivery system or a cannabinoid in a microsphere delivery system.
摘要翻译： 提供了一种用于鼻输送大麻素的组合物，其在双相递送系统中包含大麻素，或在微球递送系统中包含大麻素。
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公开(公告)号：US06730735B2
公开(公告)日：2004-05-04
申请号：US10350714
申请日：2003-01-24
申请人： Stanley Stewart Davis , Wu Lin , Fabio Bignotti , Paolo Ferruti
发明人： Stanley Stewart Davis , Wu Lin , Fabio Bignotti , Paolo Ferruti
IPC分类号： C08G8100
CPC分类号： A61K9/5146 , A61K9/0034 , A61K9/0043 , A61K9/1652 , A61K9/5161 , A61K9/5192 , A61K47/61 , C08B37/003 , C08G81/00
摘要： PEG-chitosan conjugates comprising chitosan and polyethylene glycol moieties or derivatives thereof which are bonded together and their use in medicine is described. In one embodiment, the conjugate comprises a chitosan moiety or a derivative thereof and a polyethylene glycol moiety or a derivative thereof which are bonded together via the amino function on the chitosan by the use of an activated chitosan species. In another embodiment, the conjugate comprises a chitosan moiety or a derivative thereof and a polyethylene glycol moiety or a derivative thereof which are bonded together, the chitosan portion of the conjugate having a molecular weight in the range of from 10 kilodaltons to 1000 kilodaltons.
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公开(公告)号：US6001395A
公开(公告)日：1999-12-14
申请号：US983156
申请日：1998-03-30
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K31/70 , A61K38/00 , A61K38/04 , A61K38/22 , A61K38/27 , A61K38/28 , A61K39/00 , A61K39/08 , A61K39/145 , A61K39/35 , A61K47/34 , A61K47/48
CPC分类号： A61K9/1647 , A61K9/146 , Y10S977/795 , Y10S977/897 , Y10S977/906 , Y10S977/915 , Y10S977/917
摘要： The invention provides a composition for delivery of an active agent comprising a plurality of lamellar particles of a biodegradable polymer which is at least in part crystalline, and an active agent adsorbed to at least most of the particles. Preferably the biodegradablepolymer is at least 5% by weight crystalline. Preferred biodegradable polymers are poly(L-lactide) (L.PLA) or copolymers or blends of L.PLA. The particles are especially useful for the immobilization of antigens or allergens for vaccines.
摘要翻译： PCT No.PCT / GB96 / 01695 Sec。 371日期1998年3月30日 102（e）1998年3月30日PCT PCT 1996年7月15日PCT公布。 出版物WO97 / 02810 日本1997年1月30日本发明提供了用于递送活性剂的组合物，其包含至少部分为结晶的多个可生物降解聚合物的片状颗粒，以及吸附于至少大部分颗粒的活性剂。 优选地，可生物降解的聚合物是至少5重量％的结晶。 优选的可生物降解的聚合物是聚（L-丙交酯）（L.PLA）或L.PLA的共聚物或共混物。 这些颗粒特别适用于疫苗的抗原或过敏原的固定化。
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公开(公告)号：US06677438B1
公开(公告)日：2004-01-13
申请号：US09462190
申请日：2000-07-21
IPC分类号： C07K100
CPC分类号： C08G65/334 , A61K47/60 , C07K1/1077 , C08G65/329 , Y10S530/815 , Y10S530/816
摘要： A process for attaching a polyethylene glycol compound to a macromolecule to prepare a conjugate or adduct between the polyethylene glycol compound and the macromolecule is described. The process comprises the steps of (1) preparing an activated PEG or an activated PEG derivative by incorporating an acrylic ester, an acrylic thioester or an acrylamido group into the PEG or PEG derivative; (2) reacting the activated PEG or PEG derivative with a macromolecular material comprising one or more sulphydryl groups, primary amino groups and/or secondary amino groups and (3) recovering the conjugate of the PEG or PEG derivative and the macromolecular material.
摘要翻译： 描述了将聚乙二醇化合物连接到大分子以制备聚乙二醇化合物和大分子之间的缀合物或加合物的方法。 该方法包括以下步骤：（1）通过在丙二醇或PEG衍生物中加入丙烯酸酯，丙烯酸酯或丙烯酰胺基来制备活化的PEG或活化的PEG衍生物; （2）使活化的PEG或PEG衍生物与包含一个或多个巯基，伯氨基和/或仲氨基的大分子物质反应，和（3）回收PEG或PEG衍生物和高分子材料的共轭物。
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5.发明授权公开(公告)号：US06413941B1
公开(公告)日：2002-07-02
申请号：US09101254
申请日：1998-08-03
申请人： Martin Charles Garnett , Fiona Caroline Maclaughlin , Stanley Stewart Davis , Fabio Bignotti , Paolo Ferruti
发明人： Martin Charles Garnett , Fiona Caroline Maclaughlin , Stanley Stewart Davis , Fabio Bignotti , Paolo Ferruti
IPC分类号： A61K3170
CPC分类号： A61K47/645 , A61K47/59 , A61K47/593 , A61K47/595 , A61K47/60
摘要： A composition for delivering a biologically active polyanionic molecule comprising a linear polymer with a backbone comprising amido and tertiary amino groups arranged regularly on the backbone and biologically active polyanionic molecule bound to the polymer. Preferably, the linear polymer comprises a poly(amidoamine). Preferably, the biologically active polyanionic molecule is a nucleic acid, more preferably a DNA. The compositions are useful for delivering nucleic acids to a cell in a cell transformation, transfection or gene therapy method.
摘要翻译： 一种用于递送生物活性聚阴离子分子的组合物，其包含具有骨架的线性聚合物，所述骨架包含主链上规则排列的酰氨基和叔氨基，并且与聚合物结合的生物活性聚阴离子分子。 优选地，线性聚合物包含聚（酰氨基胺）。 优选地，生物活性聚阴离子分子是核酸，更优选DNA。 该组合物可用于在细胞转化，转染或基因治疗方法中将核酸递送至细胞。
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公开(公告)号：US5869103A
公开(公告)日：1999-02-09
申请号：US750738
申请日：1997-04-04
CPC分类号： A61K9/1647 , A61K9/1641
摘要： Provided are biodegradable microparticles, which exhibit a linear release profile of active agent, and methods for making the microparticles. The microparticles include a mixture of a biodegradable polymer, a water soluble polymer, and an active agent. Preferred biodegradable polymers include lactide homopolymers or copolymers of lactide and glycolide, and preferred water soluble polymers include poly(ethylene glycol) (PEG) or PEG copolymers. The microparticles are made using an emulsion/solvent extraction method, in which the continuous phase of the secondary emulsion contains an organic solvent that is miscible with the organic solvent in the primary emulsion.
摘要翻译： PCT No.PCT / GB95 / 01426 Sec。 371日期1997年04月4日 102（e）日期1997年4月4日PCT Filed 1995年6月19日PCT公布。 第WO95 / 35097号公报 日期1995年12月28日提供了可生物降解的微粒，其表现出活性剂的线性释放曲线，以及制备微粒的方法。 微粒包括可生物降解聚合物，水溶性聚合物和活性剂的混合物。 优选的可生物降解聚合物包括丙交酯均聚物或丙交酯和乙交酯的共聚物，优选的水溶性聚合物包括聚（乙二醇）（PEG）或PEG共聚物。 使用乳液/溶剂萃取方法制备微粒，其中第二乳液的连续相含有与初级乳液中的有机溶剂混溶的有机溶剂。
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公开(公告)号：US06635254B2
公开(公告)日：2003-10-21
申请号：US09948319
申请日：2001-09-06
IPC分类号： A61K3938
CPC分类号： A61K47/6927 , Y10S977/775 , Y10S977/906
摘要： Lamellar particles are provided comprising a biodegradable and biocompatible polymer and carrying a cationic charge on their surface. These particles are prepared by mixing a preformed negatively charged lamellar particle with a positively charged material. Compositions using these particles may include genetic material or antigens, for example, and may be used as a drug delivery system, such as a sustained release system.
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公开(公告)号：US5922357A
公开(公告)日：1999-07-13
申请号：US714081
申请日：1997-03-04
CPC分类号： A61K9/5146 , A61K9/146 , A61K9/167 , A61K9/1694 , A61K9/5153 , A61K9/5161 , A61K9/5192 , C08J3/005 , C08J3/12 , C08J3/126 , Y10S514/951 , Y10S514/963 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： The invention relates to microspheres which are suitable for biomedical uses which have a diameter in the range of 10 nm to 2 mm and which comprise a substantially spherical core particle of a non-water-soluble polymer and an outer surface layer consisting substantially of a water-soluble polymer. The water-soluble polymer is conjugated to polyethylene glycol and the non-water-soluble core particle is attached to the water-soluble polymer by the polyethylene glycol moiety. The microspheres are prepared by dissolving the non-water-soluble polymer in a suitable first solvent, dispersing the polymer solution in a solution of the PEG/water-soluble polymer conjugate and evaporating the first solvent to form microspheres in which the PEG anchors the water-soluble polymer to the core particle.
摘要翻译： PCT No.PCT / GB95 / 00686 Sec。 371日期1997年3月4日 102（e）1997年3月4日PCT PCT 1995年3月27日PCT公布。 公开号WO95 / 26376 日期1996年10月5日本发明涉及适用于生物医学用途的微球，其直径在10nm至2mm的范围内，并且包含非水溶性聚合物的基本上球形的核心颗粒和外表面层 基本上由水溶性聚合物组成。 水溶性聚合物与聚乙二醇结合，非水溶性核心颗粒通过聚乙二醇部分连接到水溶性聚合物上。 微球通过将非水溶性聚合物溶解在合适的第一溶剂中制备，将聚合物溶液分散在PEG /水溶性聚合物共轭物的溶液中并蒸发第一溶剂以形成微球，其中PEG锚定水 可溶性聚合物。
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