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    Corynebacteria strain for enhancement of 5′-guanosine monophosphate productivity and a method of producing 5′-guanosine monophosphate using the same
    1.
    发明授权
    Corynebacteria strain for enhancement of 5′-guanosine monophosphate productivity and a method of producing 5′-guanosine monophosphate using the same 有权
    用于增强5'-鸟苷一磷酸生产力的棒状杆菌菌株和使用其制备5'-鸟苷酸单磷酸的方法

    公开(公告)号：US08530200B2

    公开(公告)日：2013-09-10

    申请号：US13140302

    申请日：2009-12-17

    申请人： Jinman Cho ,  Hye Won Kim ,  Yoon Seok Oh ,  Jang Hee Park

    发明人： Jinman Cho ,  Hye Won Kim ,  Yoon Seok Oh ,  Jang Hee Park

    IPC分类号： C12P19/32 ,  C12P19/30

    CPC分类号： C12P19/32 ,  C12N9/0006 ,  Y02P20/582

    摘要： Disclosed is a method of producing 5′-guanosine monophosphate using a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type, thereby showing improved ATP productivity. Also, a novel microorganism is disclosed. The method comprises: culturing the corynebacteria strain which is enhanced in malate dehydrogenase activity over the endogenous activity, thus producing ATP in high yield; producing XMP in the culture; adding to the culture an enzyme or microorganism having XMP amination activity; and obtaining GMP from the culture.

    摘要翻译： 公开了一种使用具有比野生型高的苹果酸脱氢酶活性的新型微生物生产5'-鸟苷酸单磷酸酯的方法，从而显示出提高的ATP生产率。 另外，公开了一种新型微生物。 该方法包括：培养在内源性活性中苹果酸脱氢酶活性增强的棒状杆菌菌株，从而以高产率产生ATP; 在文化中生产XMP; 向培养基中加入具有XMP胺化活性的酶或微生物; 并从文化中获得GMP。