公开(公告)号：US20060285987A1

公开(公告)日：2006-12-21

申请号：US11463455

申请日：2006-08-09

Applicant: Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

Inventor： Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

IPC: F04B39/00

CPC classification number: A61M15/0065 ,  A61M15/00 ,  A61M15/0068 ,  A61M15/0071 ,  A61M15/0081 ,  A61M2205/7545 ,  B05B11/00412 ,  B05B11/3001 ,  B05B11/3067 ,  B05B11/308 ,  B05B11/309 ,  B05B11/3091 ,  F04B53/125 ,  Y10T137/7909 ,  Y10T137/7913 ,  Y10T137/7916

Abstract: A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.

Abstract translation: 用于加压流体的小型化装置。 该装置包括提供流体路径和阀构件的中空活塞。 阀构件被构造成用于轴向移动，使得阀轴保持平行于活塞轴线。 阀构件设置在中空活塞的一端。 阀构件可以部分地或完全地设置在中空活塞内。 该装置特别适用于机械操作的雾化器，以在不使用推进剂气体的情况下产生液体药物的可吸入气溶胶。

公开(公告)号：US5964416A

公开(公告)日：1999-10-12

申请号：US726219

申请日：1996-10-04

Applicant: Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser

Inventor： Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser

IPC: A61M11/00 ,  A47K5/12 ,  A61M15/00 ,  B05B9/043 ,  B05B11/00 ,  B05B11/06 ,  B65D83/76 ,  F04B9/14 ,  F04B53/10 ,  F04B53/12 ,  F16K20060101

CPC classification number: A61M15/0065 ,  A61M15/0068 ,  B05B11/3001 ,  B05B11/3067 ,  B05B11/308 ,  B05B11/3091 ,  F04B53/125 ,  A61M15/00 ,  A61M2205/7545 ,  B05B11/0043 ,  B05B11/309 ,  Y10T137/7909 ,  Y10T137/7913 ,  Y10T137/7916

Abstract: A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.

公开(公告)号：US06497373B2

公开(公告)日：2002-12-24

申请号：US10143006

申请日：2002-05-13

Applicant: Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

Inventor： Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

IPC: B05B9043

CPC classification number: A61M15/0065 ,  A61M15/00 ,  A61M15/0068 ,  A61M15/0071 ,  A61M15/0081 ,  A61M2205/7545 ,  B05B11/00412 ,  B05B11/3001 ,  B05B11/3067 ,  B05B11/308 ,  B05B11/309 ,  B05B11/3091 ,  F04B53/125 ,  Y10T137/7909 ,  Y10T137/7913 ,  Y10T137/7916

Abstract: A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.

Abstract translation: 用于加压流体的小型化装置。 该装置包括提供流体路径和阀构件的中空活塞。 阀构件被构造成用于轴向移动，使得阀轴保持平行于活塞轴线。 阀构件设置在中空活塞的一端。 阀构件可以部分地或完全地设置在中空活塞内。 该装置特别适用于机械操作的雾化器，以在不使用推进剂气体的情况下产生液体药物的可吸入气溶胶。

公开(公告)号：US06402055B1

公开(公告)日：2002-06-11

申请号：US09354663

申请日：1999-07-16

Applicant: Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

Inventor： Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

IPC: B05B9043

CPC classification number: A61M15/0065 ,  A61M15/00 ,  A61M15/0068 ,  A61M15/0071 ,  A61M15/0081 ,  A61M2205/7545 ,  B05B11/00412 ,  B05B11/3001 ,  B05B11/3067 ,  B05B11/308 ,  B05B11/309 ,  B05B11/3091 ,  F04B53/125 ,  Y10T137/7909 ,  Y10T137/7913 ,  Y10T137/7916

Abstract: A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.

公开(公告)号：US06918547B2

公开(公告)日：2005-07-19

申请号：US10807447

申请日：2004-03-24

Applicant: Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

Inventor： Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

IPC: A61M11/00 ,  A47K5/12 ,  A61M15/00 ,  B05B9/043 ,  B05B11/00 ,  B05B11/06 ,  B65D83/76 ,  F04B9/14 ,  F04B53/10 ,  F04B53/12 ,  F16K20060101

CPC classification number: A61M15/0065 ,  A61M15/00 ,  A61M15/0068 ,  A61M15/0071 ,  A61M15/0081 ,  A61M2205/7545 ,  B05B11/00412 ,  B05B11/3001 ,  B05B11/3067 ,  B05B11/308 ,  B05B11/309 ,  B05B11/3091 ,  F04B53/125 ,  Y10T137/7909 ,  Y10T137/7913 ,  Y10T137/7916

Abstract: A miniaturized device for producing high pressure in a fluid imposes stringent requirements on the manufacturing process.The device according to the invention consists of a hollow piston displaceably mounted in a cylinder and a valve member which is guided by the hollow piston and mounted so as to be axially movable relative to the hollow piston. The valve member is arranged at one end of the hollow piston inside or immediately in front of the end of the hollow piston.The device is used in a mechanically operated high pressure atomizer. This consists of a two part housing which comprises a pump housing with nozzle, a blocking mechanism, a spring housing with spring, a non-pressurized storage container for the fluid and a medical counter integrated in the spring housing.The valve operates without any auxiliary force, closes very rapidly and is sealed tight against high pressure. The atomizer is safe and simple to operate and environmentally friendly. The fluid is metered extremely accurately.The atomizer is used, for example, to produce an inhalable aerosol of a liquid medicament without the use of propellant gas, at 320 bar, for example.

Abstract translation: 用于在流体中产生高压的小型化装置对制造过程施加了严格的要求。 根据本发明的装置包括可移动地安装在气缸中的中空活塞和由中空活塞引导并安装成可相对于中空活塞轴向移动的阀构件。 阀构件布置在中空活塞的一端处于中空活塞的端部的内部或紧邻中空活塞端部的前方。 该设备用于机械操作的高压雾化器。 这包括两部分壳体，其包括具有喷嘴的泵壳体，阻塞机构，具有弹簧的弹簧壳体，用于流体的非加压存储容器和集成在弹簧壳体中的医疗计数器。 阀门没有任何辅助作用力，非常快速地关闭，并在高压下密封。 雾化器操作安全，操作简单，环保。 流体测量非常准确。 例如，雾化器用于例如在320巴下产生液体药物的可吸入气溶胶，而不使用推进剂气体。

公开(公告)号：US20050252990A1

公开(公告)日：2005-11-17

申请号：US11165496

申请日：2005-06-24

Applicant: Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

Inventor： Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

IPC: A61M11/00 ,  A47K5/12 ,  A61M15/00 ,  B05B9/043 ,  B05B11/00 ,  B05B11/06 ,  B65D83/76 ,  F04B9/14 ,  F04B53/10 ,  F04B53/12 ,  F16K20060101

CPC classification number: A61M15/0065 ,  A61M15/00 ,  A61M15/0068 ,  A61M15/0071 ,  A61M15/0081 ,  A61M2205/7545 ,  B05B11/00412 ,  B05B11/3001 ,  B05B11/3067 ,  B05B11/308 ,  B05B11/309 ,  B05B11/3091 ,  F04B53/125 ,  Y10T137/7909 ,  Y10T137/7913 ,  Y10T137/7916

Abstract: A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.

Abstract translation: 用于加压流体的小型化装置。 该装置包括提供流体路径和阀构件的中空活塞。 阀构件被构造成用于轴向移动，使得阀轴保持平行于活塞轴线。 阀构件设置在中空活塞的一端。 阀构件可以部分地或完全地设置在中空活塞内。 该装置特别适用于机械操作的雾化器，以在不使用推进剂气体的情况下产生液体药物的可吸入气溶胶。

公开(公告)号：US5833088A

公开(公告)日：1998-11-10

申请号：US776864

申请日：1997-07-14

Applicant: Heinrich Kladders ,  Bernhard Freund ,  Wulf Bachtler ,  Joachim Jaeger ,  Joachim Eicher

Inventor： Heinrich Kladders ,  Bernhard Freund ,  Wulf Bachtler ,  Joachim Jaeger ,  Joachim Eicher

IPC: B65D83/00 ,  A61J1/00 ,  A61J1/14 ,  B65D39/04 ,  B65D51/00 ,  B65D51/16

CPC classification number: A61J1/1406 ,  B65D39/04 ,  B65D51/002 ,  B65D51/1688 ,  A61M2207/00

Abstract: A closure cap for sealing containers without gas bubbles displaces some of the contents of the container when fitted onto the neck of the container and at the same time allows any trapped gas to escape through one or more vents before the closure cap engages in the closure position.

Abstract translation: PCT No.PCT / EP95 / 03183 Sec。 371日期1997年7月14日 102（e）日期1997年7月14日PCT提交1995年8月11日PCT公布。 出版物WO96 / 06011 日期1996年2月29日没有气泡的密封容器的封盖盖装配在容器的颈部上时将容器的一些内容物置换，同时允许任何被困气体在封闭帽之前通过一个或多个通风口逸出 从事关闭位置。

公开(公告)号：US20100216648A1

公开(公告)日：2010-08-26

申请号：US12708783

申请日：2010-02-19

Applicant: Peer F. STAEHLER ,  Raphael CARAPITO ,  Cord F. STAEHLER ,  Mark MATZAS ,  Jack T. LEONARD ,  Joachim JAEGER ,  Markus BEIER

Inventor： Peer F. STAEHLER ,  Raphael CARAPITO ,  Cord F. STAEHLER ,  Mark MATZAS ,  Jack T. LEONARD ,  Joachim JAEGER ,  Markus BEIER

IPC: C40B20/08 ,  C12M1/34 ,  C12Q1/68

CPC classification number: C12N15/1093 ,  C12Q1/6869

Abstract: The invention relates to methods and devices for preparing synthetic nucleic acids.

Abstract translation: 本发明涉及用于制备合成核酸的方法和装置。

公开(公告)号：US07104470B2

公开(公告)日：2006-09-12

申请号：US11165496

申请日：2005-06-24

Applicant: Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

Inventor： Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

IPC: B05B9/043

CPC classification number: A61M15/0065 ,  A61M15/00 ,  A61M15/0068 ,  A61M15/0071 ,  A61M15/0081 ,  A61M2205/7545 ,  B05B11/00412 ,  B05B11/3001 ,  B05B11/3067 ,  B05B11/308 ,  B05B11/309 ,  B05B11/3091 ,  F04B53/125 ,  Y10T137/7909 ,  Y10T137/7913 ,  Y10T137/7916

Abstract: A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.

公开(公告)号：US06726124B2

公开(公告)日：2004-04-27

申请号：US10292470

申请日：2002-11-13

Applicant: Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

Inventor： Joachim Jaeger ,  Pasquale Cirillo ,  Joachim Eicher ,  Johannes Geser ,  Bernhard Freund ,  Bernd Zierenberg

IPC: B05B9043

CPC classification number: A61M15/0065 ,  A61M15/00 ,  A61M15/0068 ,  A61M15/0071 ,  A61M15/0081 ,  A61M2205/7545 ,  B05B11/00412 ,  B05B11/3001 ,  B05B11/3067 ,  B05B11/308 ,  B05B11/309 ,  B05B11/3091 ,  F04B53/125 ,  Y10T137/7909 ,  Y10T137/7913 ,  Y10T137/7916

Abstract: A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.

Abstract translation: 用于加压流体的小型化装置。 该装置包括提供流体路径和阀构件的中空活塞。 阀构件被构造成用于轴向移动，使得阀轴保持平行于活塞轴线。 阀构件设置在中空活塞的一端。 阀构件可以部分地或完全地设置在中空活塞内。 该装置特别适用于机械操作的雾化器，以在不使用推进剂气体的情况下产生液体药物的可吸入气溶胶。