公开(公告)号：US08486714B2

公开(公告)日：2013-07-16

申请号：US12110848

申请日：2008-04-28

申请人： John A Favuzzi ,  Merritt M Martin ,  Jonathan R Sweda ,  Lauren Bland ,  Robert L Lathrop ,  John E Van Bosch ,  Kristopher S Buchanan

发明人： John A Favuzzi ,  Merritt M Martin ,  Jonathan R Sweda ,  Lauren Bland ,  Robert L Lathrop ,  John E Van Bosch ,  Kristopher S Buchanan

IPC分类号： G01N1/10

CPC分类号： G01N1/30 ,  B01L3/508 ,  G01N1/312 ,  G01N35/1002 ,  G01N35/109 ,  Y10T436/2575

摘要： The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid residues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.

公开(公告)号：US07875245B2

公开(公告)日：2011-01-25

申请号：US11156760

申请日：2005-06-20

申请人： John A. Favuzzi ,  Kristopher S. Buchanan ,  Michael T. Barber ,  Loren L. Bland ,  Dawn M. Rohrbacker ,  Robert M. Clark ,  Gordon A. Feingold ,  Benno M. Guggenheimer ,  Marc E. Key ,  Merritt M. Martin, Jr. ,  Robert L. Lathrop ,  Jeffery L. Rau ,  Jonathan R. Sweda ,  Douglas F. Sweet ,  John E. Van Bosch ,  Lars Winther ,  Rosanne Welcher

发明人： John A. Favuzzi ,  Kristopher S. Buchanan ,  Michael T. Barber ,  Loren L. Bland ,  Dawn M. Rohrbacker ,  Robert M. Clark ,  Gordon A. Feingold ,  Benno M. Guggenheimer ,  Marc E. Key ,  Merritt M. Martin, Jr. ,  Robert L. Lathrop ,  Jeffery L. Rau ,  Jonathan R. Sweda ,  Douglas F. Sweet ,  John E. Van Bosch ,  Lars Winther ,  Rosanne Welcher

IPC分类号： B01L3/02

CPC分类号： G01N35/0092 ,  B01L3/508 ,  B01L7/00 ,  B01L9/06 ,  B01L2200/025 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/0822 ,  B01L2300/1822 ,  G01N1/312 ,  G01N35/00029 ,  G01N35/00871 ,  G01N35/0095 ,  G01N35/0099 ,  G01N35/1002 ,  G01N35/1004 ,  G01N35/1011 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00445 ,  G01N2035/00455 ,  G01N2035/00534 ,  G01N2035/00633 ,  G01N2035/00673 ,  G01N2035/00752 ,  G01N2035/00861 ,  G01N2035/00881 ,  G01N2035/102 ,  G01N2035/1058 ,  Y02A90/26 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention concerns a method and apparatus for automatic processing a biological sample on a carrier, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system using a sample process parameter input that may be independent and an independent process parameter memory that does not interrupt process operation when being used, such that samples may be added or removed without interrupting the processing of other samples. Also included is an image capture function for sample and reagent identification and process monitoring, as well as temperature regulation and environmental control functions.

摘要翻译： 本发明涉及一种用于通过根据处理方案以预定顺序施加预定量的试剂来自动地处理载体上的生物样品的方法和装置，所述方法和装置可以机器人地处理，所述处理包括预处理步骤，在 自适应处理控制系统使用可以是独立的样本过程参数输入和在使用时不中断处理操作的独立过程参数存储器，使得可以添加或移除样本而不中断其他样本的处理。 还包括用于样品和试剂识别和过程监测以及温度调节和环境控制功能的图像捕获功能。

公开(公告)号：US20090325309A1

公开(公告)日：2009-12-31

申请号：US12110848

申请日：2008-04-28

申请人： John A. Favuzzi ,  Merritt M. Martin ,  Jonathan R. Sweda ,  Lauren Bland ,  Robert L. Lathrop ,  John E. Van Bosch ,  Kristopher S. Buchanan

发明人： John A. Favuzzi ,  Merritt M. Martin ,  Jonathan R. Sweda ,  Lauren Bland ,  Robert L. Lathrop ,  John E. Van Bosch ,  Kristopher S. Buchanan

IPC分类号： G01N1/30 ,  B01L3/02 ,  B01L3/00

CPC分类号： G01N1/30 ,  B01L3/508 ,  G01N1/312 ,  G01N35/1002 ,  G01N35/109 ,  Y10T436/2575

摘要： The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid residues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.

摘要翻译： 本发明涉及用于处理布置在显微镜载片上的生物样品的装置的试剂递送系统，包括具有一个或多个试剂容器的试剂部分; 其中布置有至少一个显微镜载玻片的滑动部分; 用于将一部分试剂分配到预定显微镜载玻片上的探针和用于处理探针的装置。 探针包括连续证明管道元件，其延伸穿过刚性探针构件并将探针尖端连接到气动调压装置。 试剂容器适于与探针尖端配合。 以这种方式，由于没有组装部件构成可保留流体的探针的内部体积，所以实现了高的保持和非常低的流体残余的携带。