公开(公告)号：US4842999A

公开(公告)日：1989-06-27

申请号：US895450

申请日：1986-08-11

申请人： Steven A. Fuller ,  John G. R. Hurrell

发明人： Steven A. Fuller ,  John G. R. Hurrell

IPC分类号： G01N33/577 ,  A61K39/00 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/435 ,  C07K14/44 ,  C07K16/00 ,  C07K16/20 ,  C07K19/00 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12Q1/70 ,  C12R1/90 ,  C12R1/91 ,  G01N33/569

CPC分类号： C07K16/20 ,  Y10S435/948 ,  Y10S530/82

摘要： This invention relates to a vaccine for canine heartworm. The invention further relates to a diagnostic test capable of discerning the presence of the canine heartworm parasite even in occult infections. The invention discloses kits and test strips suitable for diagnosing canine heartworm infections.

摘要翻译： 本发明涉及犬心丝虫疫苗。 本发明还涉及即使在隐匿性感染中也能辨别犬心虫寄生虫的存在的诊断测试。 本发明公开了适用于诊断犬心丝虫感染的试剂盒和测试条。

公开(公告)号：US6110696A

公开(公告)日：2000-08-29

申请号：US494668

申请日：1995-06-26

申请人： Mary E. Brown ,  Hans-Joachim Guder ,  John G. R. Hurrell ,  Lance S. Kuhn ,  Robert J. McEnroe ,  Rebecca W. Muddiman ,  Mary Luann Ochs

发明人： Mary E. Brown ,  Hans-Joachim Guder ,  John G. R. Hurrell ,  Lance S. Kuhn ,  Robert J. McEnroe ,  Rebecca W. Muddiman ,  Mary Luann Ochs

IPC分类号： C12Q1/00 ,  G01N33/535 ,  G01N33/542 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N33/581 ,  C12Q1/001 ,  G01N33/535 ,  G01N33/542 ,  G01N33/5438 ,  Y10S435/817 ,  Y10S435/968

摘要： A diagnostic kit, method, and apparatus for electrochemically determining the presence or concentration of an analyte in a sample. A mixture is formed which includes the sample, an enzyme acceptor polypeptide, an enzyme donor polypeptide, and a labeled substrate. The enzyme donor polypeptide is capable of combining with the enzyme acceptor polypeptide to form an active enzyme complex. The formation of such the active enzyme complex is responsive to the presence or concentration of the analyte in the fluid sample. The active enzyme hydrolyzes the labeled substrate, resulting in the generation of an electroactive label, which can then be oxidized at the surface of an electrode. A current resulting from the oxidation of the electroactive compound can be measured and correlated to the concentration of the analyte in the sample.

公开(公告)号：USD275234S

公开(公告)日：1984-08-21

申请号：US371048

申请日：1982-04-23

申请人： Howard M. Chandler ,  Kevin Healey ,  John G. R. Hurrell

设计人： Howard M. Chandler ,  Kevin Healey ,  John G. R. Hurrell

公开(公告)号：US4769216A

公开(公告)日：1988-09-06

申请号：US836779

申请日：1986-03-06

申请人： Howard M. Chandler ,  Kevin Healey ,  John G. R. Hurrell

发明人： Howard M. Chandler ,  Kevin Healey ,  John G. R. Hurrell

IPC分类号： B01L3/02 ,  C12Q1/58 ,  G01N33/53 ,  G01N33/535 ,  G01N33/543 ,  G01N35/00 ,  G01N35/10 ,  G01N31/22

CPC分类号： G01N33/54366 ,  B01L3/022 ,  C12Q1/58 ,  G01N33/5302 ,  G01N33/535 ,  G01N2035/00237 ,  G01N2035/1055 ,  G01N2035/1062 ,  Y10S435/81 ,  Y10S436/808

摘要： A device for use in detecting or determining the presence of antigenic or haptenic substances or antibodies in a sample comprises a plurality of tubular or capillary elements (1, 2, 3, 4, 5, 6), each having antibodies or antigenic or haptenic substances attached to an internal surface thereof, and means (11) for causing fluids to pass simultaneously or sequentially through the plurality of capillary elements. A method and test kit for detecting and determining the presence of antigenic or haptenic substances or antibodies in a sample by the enzyme-linked immunosorbent assay technique is characterized by use of urease as the enzyme in an antibody-enzyme or antigen-enzyme conjugate, with urea being used as the enzyme substrate and the presence of ammonia being detected or determined using di-bromo-o-cresolsulfonphthalein.

公开(公告)号：US4590157A

公开(公告)日：1986-05-20

申请号：US413364

申请日：1982-08-06

申请人： Howard M. Chandler ,  Kevin Healey ,  John G. R. Hurrell

发明人： Howard M. Chandler ,  Kevin Healey ,  John G. R. Hurrell

IPC分类号： B01L3/02 ,  C12Q1/58 ,  G01N33/53 ,  G01N33/535 ,  G01N33/543 ,  G01N35/00 ,  G01N35/10 ,  G01N33/50 ,  C12N9/96

CPC分类号： B01L3/022 ,  C12Q1/58 ,  G01N33/5302 ,  G01N33/535 ,  G01N33/54366 ,  G01N2035/00237 ,  G01N2035/1055 ,  G01N2035/1062 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/975

摘要： A method and test kit are disclosed for detecting the presence of antigens or antibodies in a sample by an enzme-linked immuno-sorbent assay using urease as the enzyme, urea as the enzyme substrate and di-bromo-o- cresolsulfonphthalein as the indicator.

摘要翻译： PCT No.PCT / AU81 / 00191 Sec。 371日期1982年8月6日 102（e）日期1982年8月6日PCT提交1981年12月22日PCT公布。 第WO82 / 02211号公报 日期：1982年7月8日。公开了一种方法和测试试剂盒，用于通过使用脲酶作为酶，尿素作为酶底物的酶联免疫吸附测定法检测样品中抗原或抗体的存在以及二溴 - 邻苯二酚磺酞作为指标。