公开(公告)号：US08700341B2

公开(公告)日：2014-04-15

申请号：US13009708

申请日：2011-01-19

申请人： Richard P. Rava ,  Brian K. Rhees ,  John P. Burke

发明人： Richard P. Rava ,  Brian K. Rhees ,  John P. Burke

IPC分类号： G01N33/48 ,  G01N33/50 ,  G01N31/00 ,  G06F19/12

CPC分类号： G06F19/22 ,  C12Q1/6827 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/156 ,  G06F17/10 ,  G06F17/11 ,  G06F19/12 ,  G06F19/18 ,  G06F19/24 ,  C12Q2537/16 ,  C12Q2537/165

摘要： Methods are disclosed for resolving measurement problems such problems in measuring chromosomal copy number. Some disclosed methods involve first selecting a primary assay element characteristic to partition. Such characteristic may be a source of experimental variability such as the GC content of measured DNA sequences. Additionally, the disclosed methods may employ an abundance or copy number function to transform the assay element frequencies into an abundance, dose, copy number score, or the like. In some cases, the disclosed methods estimate an amount of certain fetal DNA in a sample. The methods can further compare the estimated amount to a measured amount of fetal DNA in the sample. The comparison can be used to determine the fetal sex or aneuploidy.

摘要翻译： 公开了用于解决测量染色体拷贝数测量问题的方法。 一些公开的方法涉及首先选择分析特征的主要测定元件。 这种特征可能是实验变异性的来源，例如测量的DNA序列的GC含量。 另外，所公开的方法可以使用丰度或拷贝数函数将测定元件频率转换为丰度，剂量，拷贝数分数等。 在一些情况下，所公开的方法估计样品中某些胎儿DNA的量。 该方法可以进一步将估计量与样品中测量的胎儿DNA量进行比较。 比较可用于确定胎儿的性别或非整倍体。

公开(公告)号：US1087225A

公开(公告)日：1914-02-17

申请号：US1912737906

申请日：1912-12-20

申请人： JOHN P BURKE ,  JOHN T HELBERT ,  FRANK H DRIVER ,  FAHRNEY JOHN J

发明人： FAHRNEY JOHN J

CPC分类号： B60B9/28

公开(公告)号：US4375251A

公开(公告)日：1983-03-01

申请号：US182042

申请日：1980-08-28

申请人： John P. Burke ,  Alastair J. Young

发明人： John P. Burke ,  Alastair J. Young

IPC分类号： F16D51/20 ,  F16D65/56

CPC分类号： F16D65/563 ,  F16D51/20

摘要： An internal drum brake of the kind including a strut between a hand brake lever pivoted on one shoe and the other shoe, has a wear adjuster comprising a pair of screw-threaded members with a pawl and pawl wheel for relative rotation thereof on operation of the service brake system, the axis of the screw-threaded members intercepting the line of action between the shoe and an abutment which limits return movement of the shoe to a brake-released position, one of the members having a spacer between the shoe and the abutment, the spacing effect of the spacer being changed on relative rotation of the screw-threaded members.

摘要翻译： 这种类型的内部鼓式制动器包括在一个转动在一个鞋上的手制动杆与另一个鞋之间的支柱之间的支柱，具有一个磨损调节器，该磨损调节器包括一对带有棘爪和棘爪轮的螺纹构件， 所述螺纹构件的轴线拦截所述鞋和基座之间的作用线，所述作用线将所述鞋的返回运动限制到制动器释放位置，所述构件中的一个在所述鞋和所述支座之间具有间隔件 间隔件的间隔效应随着螺纹件的相对转动而改变。

公开(公告)号：US4303006A

公开(公告)日：1981-12-01

申请号：US103420

申请日：1979-12-13

申请人： John P. Burke ,  Alastair J. Young

发明人： John P. Burke ,  Alastair J. Young

IPC分类号： B60T13/569 ,  F16J3/06 ,  F01B11/02

CPC分类号： F16J3/06 ,  B60T13/569

摘要： This invention relates to a rolling diaphragm apparatus in which an annular diaphragm is secured by its outer and inner peripheries respectively to a housing and a piston between which the diaphragm seals against fluid leakage. One of said peripheries is formed as a bead which locates in an annular seat on the part to which said one periphery is attached, the bead being retained on its seat by a resilient retaining ring that snaps into position on the seat part. The bead has a substantially radially directed face and a substantially axially directed face, both of said faces engaging with corresponding faces on the retaining ring which snaps into positive engagement with the seat part.Such a construction is particularly useful in vacuum boosters for motor vehicle braking systems.

摘要翻译： 本发明涉及一种滚动隔膜装置，其中环形隔膜通过其外周和内周分别固定到壳体和活塞，隔膜在其间密封以防止流体泄漏。 所述周边中的一个形成为位于所述一个周边附接到的部分上的环形座中的胎圈，所述胎圈通过卡扣到座椅部件上的位置的弹性保持环保持在其座椅上。 胎圈具有基本上径向指向的面和基本轴向定向的面，两个所述表面与保持环上的相应表面接合，卡扣与座部件呈正接合。 这种结构在用于机动车辆制动系统的真空增压器中特别有用。

公开(公告)号：US4282800A

公开(公告)日：1981-08-11

申请号：US83225

申请日：1979-10-10

申请人： Alastair J. Young ,  John P. Burke

发明人： Alastair J. Young ,  John P. Burke

IPC分类号： E05B65/38 ,  F01B19/00

CPC分类号： E05B77/50 ,  Y10T70/65

摘要： This invention relates to fluid pressure servo motors having two operatively independent fluid chambers, each chamber having a piston means therein movable in response to a fluid pressure differential so as to alter in use a two position device from one to the other of said two positions, each piston means having a lost motion means connection to allow the idle return of the piston in the event of cessation of the fluid pressure differential, wherein the two pistons are co-axial and move in opposite directions in response to the pressure differential and one piston is fixed to a stirrup formed as a wire loop which bridges the other piston to act in use against said device.

摘要翻译： 本发明涉及具有两个可操作地独立的流体室的流体压力伺服电动机，每个室具有活塞装置，该活塞装置可响应于流体压差而可移动，从而在使用中改变位于所述两个位置之一的两个位置装置， 每个活塞装置具有空转装置意味着在停止流体压力差的情况下允许活塞空转，其中两个活塞是同轴的并响应于压力差在相反方向上运动，一个活塞 被固定到形成为线圈的马镫，所述马镫桥连接另一个活塞以在使用中作用于所述装置。

公开(公告)号：US09447453B2

公开(公告)日：2016-09-20

申请号：US13445778

申请日：2012-04-12

申请人： Richard P. Rava ,  Brian K. Rhees ,  John P. Burke

发明人： Richard P. Rava ,  Brian K. Rhees ,  John P. Burke

IPC分类号： C12Q1/68 ,  G06F19/22 ,  G06F19/24 ,  G06F19/18 ,  C07H21/04

CPC分类号： G06F19/22 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/156 ,  G06F19/18 ,  G06F19/24 ,  G06F19/26 ,  C12Q2535/122 ,  C12Q2537/16 ,  C12Q2537/165

摘要： Methods of reliably estimating genomic fraction (e.g., fetal fraction) from polymorphisms such as small base variations or insertions-deletions are disclosed. Sequenced data from a multigenomic source is used to determine allele counts for one or more of the polymorphisms. For one or more of the polymorphisms, zygosity is assigned, and genomic fraction is determined from the zygosity and allele counts. Certain embodiments employ SNPs as the relevant polymorphism. The disclosed methods can be applied as part of an intentional, pre-designed re-sequencing study targeted against known polymorphisms or can be used in a retrospective analysis of variations found by coincidence in overlapping sequences generated from maternal plasma (or any other setting where a mixture of DNA from several people are present).

摘要翻译： 公开了从诸如小碱基变异或插入缺失的多态性可靠地估计基因组分数（例如胎儿级分）的方法。 来自多基因组源的序列数据用于确定一个或多个多态性的等位基因计数。 对于一个或多个多态性，分配接合性，并且从接合度和等位基因计数确定基因组分数。 某些实施方案使用SNP作为相关多态性。 所公开的方法可以作为针对已知多态性的有意的，预先设计的重排序研究的一部分来应用，或者可以用于回顾性分析由母体血浆（或任何其他设置 来自几个人的DNA的混合物存在）。

公开(公告)号：US20120264121A1

公开(公告)日：2012-10-18

申请号：US13445778

申请日：2012-04-12

申请人： Richard P. Rava ,  Brian K. Rhees ,  John P. Burke

发明人： Richard P. Rava ,  Brian K. Rhees ,  John P. Burke

IPC分类号： C12Q1/68 ,  G06F19/20 ,  C12M1/34

CPC分类号： G06F19/22 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/156 ,  G06F19/18 ,  G06F19/24 ,  G06F19/26 ,  C12Q2535/122 ,  C12Q2537/16 ,  C12Q2537/165

摘要： Methods of reliably estimating genomic fraction (e.g., fetal fraction) from polymorphisms such as small base variations or insertions-deletions are disclosed. Sequenced data from a multigenomic source is used to determine allele counts for one or more of the polymorphisms. For one or more of the polymorphisms, zygosity is assigned, and genomic fraction is determined from the zygosity and allele counts. Certain embodiments employ SNPs as the relevant polymorphism. The disclosed methods can be applied as part of an intentional, pre-designed re-sequencing study targeted against known polymorphisms or can be used in a retrospective analysis of variations found by coincidence in overlapping sequences generated from maternal plasma (or any other setting where a mixture of DNA from several people are present).

摘要翻译： 公开了从诸如小碱基变异或插入缺失的多态性可靠地估计基因组分数（例如胎儿级分）的方法。 来自多基因组源的序列数据用于确定一个或多个多态性的等位基因计数。 对于一个或多个多态性，分配接合性，并且从接合度和等位基因计数确定基因组分数。 某些实施方案使用SNP作为相关多态性。 所公开的方法可以作为针对已知多态性的有意的，预先设计的重排序研究的一部分来应用，或者可以用于回顾性分析由母体血浆（或任何其他设置 来自几个人的DNA的混合物存在）。

公开(公告)号：US20110177517A1

公开(公告)日：2011-07-21

申请号：US13009708

申请日：2011-01-19

申请人： Richard P. Rava ,  Brian K. Rhees ,  John P. Burke

发明人： Richard P. Rava ,  Brian K. Rhees ,  John P. Burke

IPC分类号： C12Q1/68

CPC分类号： G06F19/22 ,  C12Q1/6827 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/156 ,  G06F17/10 ,  G06F17/11 ,  G06F19/12 ,  G06F19/18 ,  G06F19/24 ,  C12Q2537/16 ,  C12Q2537/165

摘要： Methods are disclosed for resolving measurement problems such problems in measuring chromosomal copy number. Some disclosed methods involve first selecting a primary assay element characteristic to partition. Such characteristic may be a source of experimental variability such as the GC content of measured DNA sequences. Additionally, the disclosed methods may employ an abundance or copy number function to transform the assay element frequencies into an abundance, dose, copy number score, or the like. In some cases, the disclosed methods estimate an amount of certain fetal DNA in a sample. The methods can further compare the estimated amount to a measured amount of fetal DNA in the sample. The comparison can be used to determine the fetal sex or aneuploidy.

摘要翻译： 公开了用于解决测量染色体拷贝数测量问题的方法。 一些公开的方法涉及首先选择分析特征的主要测定元件。 这种特征可能是实验变异性的来源，例如测量的DNA序列的GC含量。 另外，所公开的方法可以使用丰度或拷贝数函数将测定元件频率转换为丰度，剂量，拷贝数分数等。 在一些情况下，所公开的方法估计样品中某些胎儿DNA的量。 该方法可以进一步将估计量与样品中测量的胎儿DNA量进行比较。 比较可用于确定胎儿的性别或非整倍体。

公开(公告)号：US20090163177A1

公开(公告)日：2009-06-25

申请号：US11962148

申请日：2007-12-21

申请人： Steven Clarke Bearden ,  Alvin W. Lee ,  John P. Burke

发明人： Steven Clarke Bearden ,  Alvin W. Lee ,  John P. Burke

IPC分类号： H04Q7/20

CPC分类号： H04L67/18 ,  H04L51/066 ,  H04L67/02 ,  H04L67/12 ,  H04L67/306 ,  H04L67/36 ,  H04M7/0012 ,  H04M2201/42 ,  H04W4/029

摘要： Described are computer-based methods and apparatuses, including computer program products, for providing a user interface for guest communication and information delivery. The user interface is provided on a computing device located in, for example, a guest's hotel room. The computing device is part of a system that can include internal and external networks, webportals, e-mail modules, document modules, and information storage modules. The guest uses the user interface to perform tasks that might otherwise require multiple resources. Guests may make telephone calls, send electronic messages, receive electronic messages, have electronic messages received by the hotel forwarded to other e-mail addresses, browse the Internet, and/or retrieve information on hotel services using the same computing device.

摘要翻译： 描述了基于计算机的方法和装置，包括用于提供客户通信和信息传递的用户界面的计算机程序产品。 用户界面设置在位于例如客人酒店房间的计算设备上。 计算设备是可以包括内部和外部网络，Webportals，电子邮件模块，文档模块和信息存储模块的系统的一部分。 客户端使用用户界面执行可能需要多个资源的任务。 客人可以拨打电话，发送电子邮件，接收电子邮件，将酒店收到的电子邮件转发到其他电子邮件地址，浏览互联网和/或使用相同的计算设备检索酒店服务信息。

公开(公告)号：US4391162A

公开(公告)日：1983-07-05

申请号：US183579

申请日：1980-09-02

申请人： John P. Burke

发明人： John P. Burke

IPC分类号： B60T13/573 ,  B60T13/24 ,  G05G1/00

CPC分类号： B60T13/244 ,  Y10S403/07 ,  Y10T74/2142

摘要： A vacuum assisted booster having an input rod with a thrust member thereon, an output rod with a piston head thereon, and an elastomeric disc located between the thrust member and the piston head. The piston head has an axial bore therein and the thrust member has an axial projection that extends through the elastomeric disc into the bore. The projection is anchored to the piston head by a cap fitted to the head and which allows some forward movement of the thrust member to apply a load to the elastomeric disc but limits axial separation of the piston head and thrust member on the return stroke.

摘要翻译： 一种真空辅助助力器，其具有在其上具有推力构件的输入杆，其上具有活塞头的输出杆和位于推力构件和活塞头之间的弹性体盘。 活塞头在其中具有轴向孔，并且推力构件具有延伸穿过弹性体盘进入孔的轴向突出部。 突起通过安装在头部上的帽固定到活塞头，并且允许推力构件的一些向前运动以向弹性体盘施加负载，但是限制活塞头和推动构件在返回冲程上的轴向间隔。