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公开(公告)号：US20100237233A1
公开(公告)日：2010-09-23
申请号：US12722863
申请日：2010-03-12
CPC分类号： H01J49/06 , H01J49/421 , H01J49/427
摘要： A sample analysis system incorporates an ion removal mechanism for removing residual ions from the sample analysis system. The ion removal mechanism can be included in an ion optics assembly, which connects an ion mobility filter to a mass analyzer. A sample to be analyzed by the sample analysis system may be entered into an ion mobility filter. The ion mobility filter filters the ions of the sample and passes the filtered group of ions to the ion optics assembly. The ion optics assembly transports the filtered group of ions to a mass analyzer where some or all of the ions in the group are detected. The ion removal mechanism then removes all or substantially all residual ions from the ion optics that were left over from the first filtered group before a second filtered group is passed through.
摘要翻译： 样品分析系统包含用于从样品分析系统中去除残留离子的离子去除机构。 离子去除机构可以包括在将离子迁移过滤器连接到质量分析器的离子光学组件中。 可以将样品分析系统分析的样品输入离子迁移率过滤器。 离子迁移率过滤器过滤样品的离子并将过滤的离子组通过离子光学组件。 离子光学组件将过滤的离子组输送到质量分析器，其中检测到组中的一些或全部离子。 然后离子去除机构在第二过滤组通过之前，从第一过滤组中留下的离子光学元件中除去所有或基本上所有残留的离子。
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公开(公告)号：US09714960B2
公开(公告)日：2017-07-25
申请号：US12899672
申请日：2010-10-07
申请人： John Vandermey
发明人： John Vandermey
CPC分类号： G01R19/003 , G01R19/0084 , G01R21/10 , G01R33/32 , G01R33/36 , H01J49/022
摘要： An apparatus for measuring RF voltage from a quadrupole in a mass spectrometer are provided. The apparatus comprises at least one rectifying diode circuit for rectifying the RF voltage of the quadrupole to produce a rectified RF voltage. The apparatus further comprises at least one operational amplifier configured as a current to voltage converter, a negative input of the at least one operational amplifier connected to the output of at least one diode in the at least one rectifying diode circuit, a positive input of the at least one operational amplifier at ground, and an output of the at least one operational amplifier in a feedback loop with the negative input, to reduce reverse leakage current from the at least one diode.
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公开(公告)号：US08847433B2
公开(公告)日：2014-09-30
申请号：US12945997
申请日：2010-11-15
申请人： John Vandermey
发明人： John Vandermey
CPC分类号： H02M7/48 , H01F19/04 , H01J49/022 , H01J49/422 , H02M2007/4815 , Y02B70/1441 , Y10T307/469 , Y10T307/707 , Y10T307/735
摘要： An apparatus for providing power to a multipole in a mass spectrometer is provided. The apparatus comprises a first resonant LC circuit; at least one inductor for forming a second resonant LC circuit with the multipole, the second resonant LC circuit connected in cascade with the first resonant LC circuit, when the at least one inductor is connected to the multipole; an RF power source for providing an RF signal; and a step-up transformer connected in parallel to the RF power source on a primary side and the first resonant LC circuit on a secondary side, the step-up transformer providing voltage gain for the RF signal thereby reducing the loaded Q of the resonant LC circuits.
摘要翻译： 提供了一种用于向质谱仪中的多极提供功率的装置。 该装置包括第一谐振LC电路; 至少一个电感器，用于当所述至少一个电感器连接到所述多极时，与所述多极形成第二谐振LC电路，所述第二谐振LC电路与所述第一谐振LC电路级联连接; 用于提供RF信号的RF电源; 以及升压变压器并联连接到初级侧的RF电源和次级侧上的第一谐振LC电路，升压变压器为RF信号提供电压增益，从而减小谐振LC的负载Q 电路。
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4.发明申请公开(公告)号：US20110084690A1
公开(公告)日：2011-04-14
申请号：US12899672
申请日：2010-10-07
申请人： John Vandermey
发明人： John Vandermey
IPC分类号： G01R19/22
CPC分类号： G01R19/003 , G01R19/0084 , G01R21/10 , G01R33/32 , G01R33/36 , H01J49/022
摘要： An apparatus for measuring RF voltage from a quadrupole in a mass spectrometer are provided. The apparatus comprises at least one rectifying diode circuit for rectifying the RF voltage of the quadrupole to produce a rectified RF voltage. The apparatus further comprises at least one operational amplifier configured as a current to voltage converter, a negative input of the at least one operational amplifier connected to the output of at least one diode in the at least one rectifying diode circuit, a positive input of the at least one operational amplifier at ground, and an output of the at least one operational amplifier in a feedback look with the negative input, to reduce reverse leakage current from the at least one diode.
摘要翻译： 提供了用于在质谱仪中测量来自四极杆的RF电压的装置。 该装置包括至少一个整流二极管电路，用于整流四极的RF电压以产生整流的RF电压。 该装置还包括配置为电流 - 电压转换器的至少一个运算放大器，连接到至少一个整流二极管电路中的至少一个二极管的输出的至少一个运算放大器的负输入， 位于地的至少一个运算放大器，以及具有负输入的反馈外观中的至少一个运算放大器的输出，以减少来自至少一个二极管的反向泄漏电流。
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5.发明授权公开(公告)号：US06340814B1
公开(公告)日：2002-01-22
申请号：US09353090
申请日：1999-07-15
申请人： John Vandermey
发明人： John Vandermey
IPC分类号： H01J4942
CPC分类号： H01J49/4215 , H01J49/004
摘要： A mass spectroscopy apparatus having two quadrupole mass analyzer stages is disclosed. Both stages are configured to transmit ions of the same mass to charge ratio and they are operated in series to provide a tandem mass analyzer having greater resolution than either stage has separately. The poles of the two quadrupoles are positioned axially and close together to minimize ion loss between the two stages. The RF component of the potential across the two stages are kept in phase such that some poles of the first stage are always 180° out of phase with some poles of the other stage. Capacitors are provided to couple the out of phase poles of the two stages to one another, thereby compensating for a stray capacitance which arises between the in phase poles of the two stages.
摘要翻译： 公开了具有两个四极质量分析器级的质谱仪。 两级配置为传输相同质荷比的离子，并且它们串联运行，以提供具有比任一级分别具有更高分辨率的串联质量分析器。 两个四极的极点轴向定位并靠近在一起，以最小化两个阶段之间的离子损失。 跨两级的电位的RF分量保持相位，使得第一级的一些极点与另一级的一些极点总是为180°异相。 提供电容器以将两级的异相极彼此耦合，从而补偿在两级的同相极之间产生的杂散电容。
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公开(公告)号：US20110278946A1
公开(公告)日：2011-11-17
申请号：US12945997
申请日：2010-11-15
申请人： John Vandermey
发明人： John Vandermey
IPC分类号： H01F38/14
CPC分类号： H02M7/48 , H01F19/04 , H01J49/022 , H01J49/422 , H02M2007/4815 , Y02B70/1441 , Y10T307/469 , Y10T307/707 , Y10T307/735
摘要： An apparatus for providing power to a multipole in a mass spectrometer is provided. The apparatus comprises a first resonant LC circuit; at least one inductor for forming a second resonant LC circuit with the multipole, the second resonant LC circuit connected in cascade with the first resonant LC circuit, when the at least one inductor is connected to the multipole; an RF power source for providing an RF signal; and a step-up transformer connected in parallel to the RF power source on a primary side and the first resonant LC circuit on a secondary side, the step-up transformer providing voltage gain for the RF signal thereby reducing the loaded Q of the resonant LC circuits.
摘要翻译： 提供了一种用于向质谱仪中的多极提供功率的装置。 该装置包括第一谐振LC电路; 至少一个电感器，用于当所述至少一个电感器连接到所述多极时，与所述多极形成第二谐振LC电路，所述第二谐振LC电路与所述第一谐振LC电路级联连接; 用于提供RF信号的RF电源; 以及升压变压器并联连接到初级侧的RF电源和次级侧上的第一谐振LC电路，升压变压器为RF信号提供电压增益，从而减小谐振LC的负载Q 电路。
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7.发明授权Apparatus and method for coupling RF and AC signals to provide power to a multipole in a mass spectrometer 有权用于耦合RF和AC信号以在质谱仪中为多极提供功率的装置和方法公开(公告)号：US08847151B2
公开(公告)日：2014-09-30
申请号：US12946084
申请日：2010-11-15
申请人： John Vandermey , Alexandre Loboda
发明人： John Vandermey , Alexandre Loboda
CPC分类号： H01J49/022 , H01F19/04 , H01J49/422 , H04B2203/5483 , H04B2203/5491
摘要： An apparatus and method for coupling RF and AC signals to provide power to a multipole in a mass spectrometer is provided. A first circuit comprises: an RF power source for providing difference mode power to the multipole via the RF signal; at least one inductor for forming at least one resonant LC circuit with the multipole for providing voltage gain for the RF signal; and a transformer, comprising a secondary tap, the transformer connected in parallel to the RF power source and further connected to the at least one inductor such that the signals injected into the secondary tap are communicated to the at least one resonant LC circuit. A second circuit comprises: an AC power source for providing common mode power to the multipole via the AC signal, an output from the second circuit connected to the secondary tap such that the common mode power is injected into the first circuit and the multipole can be operated in common mode and difference mode simultaneously; and at least one inductor for forming a resonant LC circuit with the multipole via the transformer, to provide voltage gain for the AC signal.
摘要翻译： 提供了一种用于耦合RF和AC信号以在质谱仪中为多极提供功率的装置和方法。 第一电路包括：RF电源，用于经由RF信号向多极提供差模功率; 至少一个电感器，用于与用于为RF信号提供电压增益的多极形成至少一个谐振LC电路; 以及变压器，包括二次抽头，所述变压器并联连接到所述RF电源并进一步连接到所述至少一个电感器，使得注入到所述次级抽头中的信号被传送到所述至少一个谐振LC电路。 第二电路包括：AC电源，用于经由AC信号向多极提供共模功率，来自连接到次级抽头的第二电路的输出，使得共模功率注入到第一电路中，并且多极可以是 同时工作在共模和差模; 以及用于通过变压器与多极形成谐振LC电路的至少一个电感器，以为AC信号提供电压增益。
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公开(公告)号：US08350212B2
公开(公告)日：2013-01-08
申请号：US12722863
申请日：2010-03-12
IPC分类号： H01J49/26
CPC分类号： H01J49/06 , H01J49/421 , H01J49/427
摘要： A sample analysis system incorporates an ion removal mechanism for removing residual ions from the sample analysis system. The ion removal mechanism can be included in an ion optics assembly, which connects an ion mobility filter to a mass analyzer. A sample to be analyzed by the sample analysis system may be entered into an ion mobility filter. The ion mobility filter filters the ions of the sample and passes the filtered group of ions to the ion optics assembly. The ion optics assembly transports the filtered group of ions to a mass analyzer where some or all of the ions in the group are detected. The ion removal mechanism then removes all or substantially all residual ions from the ion optics that were left over from the first filtered group before a second filtered group is passed through.
摘要翻译： 样品分析系统包含用于从样品分析系统中去除残留离子的离子去除机构。 离子去除机构可以包括在将离子迁移过滤器连接到质量分析器的离子光学组件中。 可以将样品分析系统分析的样品输入离子迁移率过滤器。 离子迁移率过滤器过滤样品的离子并将过滤的离子组通过离子光学组件。 离子光学组件将过滤的离子组输送到质量分析器，其中检测到组中的一些或全部离子。 然后离子去除机构在第二过滤组通过之前，从第一过滤组中留下的离子光学元件中除去所有或基本上所有残留的离子。
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9.发明申请APPARATUS AND METHOD FOR COUPLING RF AND AC SIGNALS TO PROVIDE POWER TO A MULTIPOLE IN A MASS SPECTROMETER 有权用于耦合RF和AC信号以将功率提供给质谱仪中的多个的装置和方法公开(公告)号：US20110278917A1
公开(公告)日：2011-11-17
申请号：US12946084
申请日：2010-11-15
申请人： John Vandermey , Alexandre Loboda
发明人： John Vandermey , Alexandre Loboda
IPC分类号： H02J3/00
CPC分类号： H01J49/022 , H01F19/04 , H01J49/422 , H04B2203/5483 , H04B2203/5491
摘要： An apparatus and method for coupling RF and AC signals to provide power to a multipole in a mass spectrometer is provided. A first circuit comprises: an RF power source for providing difference mode power to the multipole via the RF signal; at least one inductor for forming at least one resonant LC circuit with the multipole for providing voltage gain for the RF signal; and a transformer, comprising a secondary tap, the transformer connected in parallel to the RF power source and further connected to the at least one inductor such that the signals injected into the secondary tap are communicated to the at least one resonant LC circuit. A second circuit comprises: an AC power source for providing common mode power to the multipole via the AC signal, an output from the second circuit connected to the secondary tap such that the common mode power is injected into the first circuit and the multipole can be operated in common mode and difference mode simultaneously; and at least one inductor for forming a resonant LC circuit with the multipole via the transformer, to provide voltage gain for the AC signal.
摘要翻译： 提供了一种用于耦合RF和AC信号以在质谱仪中为多极提供功率的装置和方法。 第一电路包括：RF电源，用于经由RF信号向多极提供差模功率; 至少一个电感器，用于与用于为RF信号提供电压增益的多极形成至少一个谐振LC电路; 以及变压器，包括二次抽头，所述变压器并联连接到所述RF电源并进一步连接到所述至少一个电感器，使得注入到所述次级抽头中的信号被传送到所述至少一个谐振LC电路。 第二电路包括：AC电源，用于经由AC信号向多极提供共模功率，来自连接到次级抽头的第二电路的输出，使得共模功率注入到第一电路中，并且多极可以是 同时工作在共模和差模; 以及用于通过变压器与多极形成谐振LC电路的至少一个电感器，以为AC信号提供电压增益。
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公开(公告)号：US07838822B2
公开(公告)日：2010-11-23
申请号：US12260066
申请日：2008-10-28
申请人： John Vandermey
发明人： John Vandermey
CPC分类号： G01N27/624
摘要： In various embodiments the present teachings provide high-voltage, asymmetric-waveform power supplies useful for, e.g., differential mobility spectrometry. In various embodiments, provided are high-voltage, asymmetric-waveform power supplies for high-field asymmetric waveform ion mass spectrometers having field values greater than about 5,000 volts cm−1 and varying in time at rates greater than about 600 kilohertz (KHz).
摘要翻译： 在各种实施例中，本教导提供了用于例如差分迁移率光谱法的高电压，非对称波形电源。 在各种实施例中，提供了用于高场非对称波形离子质谱仪的高电压，非对称波形电源，其具有大于约5,000伏特cm -1的场值，并且以大于约600千赫兹（KHz）的速率随时间变化。
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